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Enveloping process for micro-capsule animal medicament

A capsule-type, animal-based technology, applied in the direction of microcapsules, drug delivery, capsule delivery, etc., can solve the problems of large production volume, high production cost, and large energy consumption of animal drugs, and achieve improved drug bioavailability and product coating The effect of simple process and low production cost requirements

Active Publication Date: 2012-01-18
GUANGDONG WENS DAHUANONG BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And because the coating materials are coated on the surface of the drug capsule core or powder through the atomizer of the outflow bed through the steps of liquid-atomization-coagulation, the coating process takes a long time, and the fluidized bed liquid mist widely used at present Compared with the chemical coating process, the fluidized bed liquid atomization coating process has a coating time of 12 to 18 hours per batch, which consumes a lot of energy, often causes particles to stick together and reduces the product yield, and the production cost is high. And the production efficiency is low, which is not enough to meet the requirements of large production volume and low cost of animal drugs

Method used

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  • Enveloping process for micro-capsule animal medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: Production formula and process of sour nimulin moisture-proof microcapsules

[0049] 1.1 Capsule core drug powder formula: by weight

[0050] 10 parts of warnemulin hydrochloride

[0051]Microcrystalline cellulose: 30 parts

[0052] Starch: 25 parts

[0053] Talc powder: 28 parts;

[0054] 1.2 Coating powder: in terms of weight percentage, it is composed of 98% talcum powder and 2% HPMC; the dosage accounts for 5% of the weight of the capsule core medicine powder;

[0055] 1.3 Polishing powder: the dosage accounts for 2% of the total weight of capsule core medicine powder;

[0056] 1.4 Purified water: 70 parts according to the measurement standard of capsule core drug powder formula;

[0057] Step 1: Weigh the material

[0058] According to the above formula, weigh each component in a three-dimensional mixer and mix for 30 minutes for later use, and weigh purified water, coating powder, and polishing powder for later use;

[0059] The second st...

Embodiment 2

[0074] Embodiment 2: Production formula and process of sour nimulin moisture-proof microcapsules

[0075] 1.1 Capsule core drug powder formula: by weight

[0076] 15 parts of warnemulin hydrochloride

[0077] Microcrystalline cellulose: 35 parts

[0078] Starch: 30 parts

[0079] Talcum powder: 30 parts;

[0080] 1.2 Coating powder: by weight percentage, it is composed of 92% talcum powder and 8% HPMC; the dosage is 8% of the total weight of capsule core drug powder;

[0081] 1.3 Polishing powder: the dosage is 2% of the total weight of capsule core drug powder;

[0082] 1.4 Purified water: 75 parts according to the measurement standard of capsule core drug powder formula;

[0083] Step 1: Weigh the material

[0084] According to the above formula, weigh each component in a three-dimensional mixer and mix for 30 minutes for later use, and weigh purified water, coating powder, and polishing powder for later use;

[0085] The second step: making soft material

[00...

Embodiment 3

[0100] Example 3: Production formula and process of taste-masking microcapsules enrofloxacin

[0101] 1.1 Capsule core drug powder formula: 50 parts by weight of enrofloxacin, 40 parts of microcrystalline cellulose;

[0102] 1.2 Coating powder: by weight percentage, it is composed of 90% 200-mesh monoglyceride stearate superfine powder, 5% HPMC, and 5% sweetener; the dosage accounts for 8% of the total weight of the capsule core medicine powder;

[0103] 1.3 Polishing powder: the dosage accounts for 2% of the total weight of capsule core medicine powder;

[0104] 1.4 Purified water: 60 parts according to the measurement standard of capsule core medicine powder formula;

[0105] Step 1: Weigh the material

[0106] According to the above formula, weigh each component in a three-dimensional mixer and mix for 30 minutes for later use, and weigh purified water, coating powder, and polishing powder for later use;

[0107] The second step: making soft material

[0108] ...

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Abstract

The invention relates to the field of processing of animal medicaments, in particular to an enveloping process for a micro-capsule animal medicament. The enveloping process for the micro-capsule animal medicament comprises the following steps of: weighing materials; preparing soft materials; granulating by extruding and rolling; drying with a fluidized bed; coating; polishing; drying with the fluidized bed; sieving; detecting a product and the like to prepare the micro-capsule animal medicament. Compared with a fluidized bed liquid atomizing enveloping process, the enveloping process related to be invention has the most outstanding advantages of high production efficiency, simple product enveloping process, difficulty in causing the phenomenon of sticking, reduction in the energy consumption of a unit product by over 60 percent, capability of meeting the practical requirements of the animal medicament on large production amount and low production cost and contribution to wide popularization and application of the micro-capsule animal medicament.

Description

[0001] technical field [0002] The invention relates to the field of animal drug processing, in particular to a coating process of microencapsulated animal drugs. [0003] Background technique [0004] Microcapsule technology was first invented by Professor Worcester of the University of Wisconsin in the 1940s. He prepared microcapsules by air suspension method and successfully applied them to the coating of drugs. In the 1950s, Green of NcR (National Cash Register Company) in the United States prepared gelatin microcapsules by phase separation composite coacervation method and made them into carbonless copy paper, and obtained a patent. In the 1960s, the polymer polymerization method was applied to the manufacture of microcapsules, and inspiring achievements were made. With the development of new pharmaceutical technologies, the particle size of microcapsules ranges from micrometer to nanometer. In modern pharmaceutical technology, drug microencapsulation coating techn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/07A61K9/50A61K31/122A61K31/496A61K31/706
Inventor 杨利军陈瑞爱方炳虎林海丹颜进炽陈良柱吴广辉
Owner GUANGDONG WENS DAHUANONG BIOTECH
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