Enrofloxacin slow-release micropill for livestocks, and preparation method of same

A technology of enrofloxacin and sustained-release pellets, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problem of limiting the application field of enrofloxacin and affecting convenience And economy, enrofloxacin taste bitter and other issues, to achieve the effect of improving the color change when exposed to light, reducing the number of medications, and improving bioavailability

Inactive Publication Date: 2012-08-29
ZHENGZHOU FUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But existing oral enrofloxacin taste is bitter, and palatability is not good, and when using enrofloxacin common preparation directly mixing material or drinking water can affect the animal's food intake, especially not suitable for the oral use of the sensitive pig of taste, this It limits the application field of enrofloxacin and affects the convenience and economy of its use. In addition, the color of enrofloxacin becomes darker when it encounters light, and if it is made into ordinary solid preparations, it will easily produce color unevenness if it is not properly stored, which will affect the quality of the medicine. promotion of

Method used

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  • Enrofloxacin slow-release micropill for livestocks, and preparation method of same
  • Enrofloxacin slow-release micropill for livestocks, and preparation method of same
  • Enrofloxacin slow-release micropill for livestocks, and preparation method of same

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Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 enrofloxacin sustained-release pellets

[0022] Raw materials: enrofloxacin, microcrystalline cellulose, corn starch, medicinal dextrin, sodium carboxymethyl starch, sodium carboxymethyl cellulose, ethyl cellulose, talcum powder.

[0023] Preparation process: Mix the auxiliary materials microcrystalline cellulose, corn starch, medicinal dextrin and sodium carboxymethyl starch in a weight ratio of 1:1:1:2, and fully mix with enrofloxacin, add 0.3% carboxymethyl starch Sodium methyl cellulose is a soft material made of binder. The soft material is placed in an extrusion-spheronizer, the extrusion speed is set at 15r / min, and the spheronization speed is 100r / min to make a pellet core.

[0024] Place the pellet core in a fluidized bed to dry, and coat the surface of the pellet with an ethyl cellulose film coating until the weight gain is 6%. The parameters are: the fluidized bed is preheated to 40°C, the coating temperature is 30°C, atomized ...

Embodiment 2

[0026] Ingredients: Enrofloxacin, Microcrystalline Cellulose, Corn Starch, Crospovidone, Sodium Carboxymethyl Cellulose, Cellulose Acetate, Titanium Dioxide.

[0027] Preparation process: Mix the auxiliary materials microcrystalline cellulose, corn starch, and crospovidone according to the weight ratio of 1:1:2, and fully mix them with enrofloxacin, and use 0.5% sodium carboxymethylcellulose as the viscosity The soft material is prepared from the mixture, the soft material is placed in the extrusion-spheronizer, the extrusion speed is set to 20r / min, and the spheronization speed is 200r / min to make the pellet core.

[0028] Put the pellet core in a fluidized bed to dry, and coat the surface of the pellet with a cellulose acetate film coating until the weight gain is 8%. The parameters are: fluidized bed preheated to 45°C, coating temperature 40°C, atomization pressure 0.6MPa, spray liquid flow rate 30ml / min, after spraying, continue to dry for 30min, then dry and sieve, take 2...

Embodiment 3

[0030] Raw materials: enrofloxacin, microcrystalline cellulose, lactose, sodium starch glycolate, maltodextrin, starch, acrylic resin, talc.

[0031] Preparation process: Mix the auxiliary materials microcrystalline cellulose, lactose, maltodextrin and sodium carboxymethyl starch in a weight ratio of 2:1:2:2, and fully mix with enrofloxacin, and use 8% starch slurry as Adhesives are used to make soft materials, the soft materials are placed in the extrusion-spheronizer, the extrusion speed is set to 25r / min, and the spheronization speed is 500r / min to make pellet cores.

[0032] Place the pellet core in a fluidized bed to dry, and coat the surface of the pellet with a polyacrylic resin film coating until the weight gain is 10%. The parameters are: fluidized bed preheated to 50°C, coating temperature 45°C, atomization pressure 0.7MPa, spray liquid flow rate 50ml / min, after spraying, continue to dry for 30min, then dry and sieve, take 20-40 mesh pellets, namely enrofloxacin sust...

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Abstract

The invention relates to the field of pharmaceutical preparations and particularly relates to a slow-release micropill preparation containing enrofloxacin and a preparation method of the preparation. The slow-release micropill provided by the invention is formed by coating an enrofloxacin micropill; the enrofloxacin micropill comprises enrofloxacin and auxiliary material and is formed through extruding and rounding; the auxiliary material is any one or more of microcrystalline cellulose, starch, cane sugar, artificial gum, lactose and sodium carboxymethyl starch; according to weight percent, the auxiliary material in the micropill accounts for 70% to 95%; and coating is made of high-molecular enteric material, film forming material, opaquer and the like. The slow-release micropill preparation has the characteristics of slow release and high bioavailability, can be used for treating bacteria and mycoplasma infection of livestocks, and has better curative effect on chronic respiratory diseases, colibacillosis and salmonellosis, and the frequency of medicine taking can be reduced; and in addition, the slow-release micropill provided by the invention has the advantages that the stability of medicine is improved, and peculiar bitter of enrofloxacin can be covered completely, so that feeding intake of the animals is not influenced, and the recovery rate is improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a slow-release pellet preparation containing enrofloxacin and a preparation method thereof. Background technique [0002] Enrofloxacin (Enrofloxacin), also known as ethyl ciprofloxacin, enrofloxacin. Systematic name: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. This product is currently designated as a special drug for animals by the state, and it is a chemically synthesized third-generation quinolone antibacterial drug. Enrofloxacin in its mother ring C 6 The fluorine atom introduced above is a characteristic substituent of fluoroquinolones, which can enhance the inhibitory ability to bacterial DNA helicase and improve the ability to inhibit G + Bacteria, such as the antibacterial effect of Staphylococcus; C 7 The piperazinyl group introduced at the position can not only enhance the antibacterial ability of the drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/496A61K47/36A61K47/38A61P31/04
CPCY02A50/30
Inventor 苑青艳赵新双袁宝青李红娇申瑞芳王建芳
Owner ZHENGZHOU FUYUAN ANIMAL PHARMA
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