Method for preparing absorbent fibrin hemostatic plaster

Abstract

The invention which belongs to medical instrument techmology field involving a preparation method of hemostasis tiedan that can absorb fibrous protein.This method is that adding the roboflavin,fibrinogen and thrombin freeze dry powder according to certain proportion into the mortar,then add anhydrous ethanol to the mortar and stirring into uniform distribution suspension,then put the uniform distribution into the flat chassis to make the surface of adhesive olynthus contact,at last,the adhesive olynhus which adhesion of mixed dry powder particle is vacuumized and drying disinfected.The hemostasis tiedan that mentioned in this invention is good at the body biocompatibility and can be degradated in vivo thoroughly.This hemostasis tiedan which is combined with the biochemical hemostasis and mechanical hemostasis can not only rein up capillary permeability blood,also can rein up the arterioles and vein hemorrhage,so that expanding the range of the clinical application greatly and this hemostasis tiedan can be used to hemostasis of visceral operation and large body surface trauma.Also,this hemostasis tiedan increase the function of drug release and partial administration by adding antibiotics and anticancer drug in the glue olynthus.

Description

technical field [0001] The invention relates to a preparation method of an absorbable fibrin hemostatic patch, which belongs to the technical field of medical devices. Background technique [0002] At present, the surgical hemostatic dressing in the hospital mostly uses gelatin sponge. This material has poor hydrophilicity, is not fully absorbed by the body, is prone to produce scar tissue, and has poor hemostatic effect. It is already an obsolete product. There is also a fibrin sealant that has appeared in recent years and has a certain range of clinical applications, but it also has the following disadvantages: [0003] 1. Before use, fibrinogen and thrombin need to be dissolved separately under the operating table, which takes about ten minutes. In case of insoluble products, it needs to be heated in a water bath. After dissolving, it needs to be assembled into a spray device. The use process is cumbersome and time-consuming. affect the surgical procedure; [0004] 2. I...

AI Technical Summary

Problems solved by technology

[0003] 1. Before use, fibrinogen and thrombin need to be dissolved separately under the operating table, which takes about ten minutes. In case of insoluble products, it needs to be heated in a water bath. After dissolving, it needs to be assembled into a spray device. The use process is cumbersome and time-consuming. affect the surgical procedure;

[0004] 2. It can only stop capillary bleeding, so it cannot meet most clinical needs;

[0005] 3. Poor adhesion to the wound surface, easy to be washed off by normal saline or tissue fluid, and easy to cause the organs to fall off when peristalsis

This is because ordinary hemostatic bandage compression alone cannot stop arterial and venous bleeding well.