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Micro-pills of Niuhuang Shangqing Wan Contg. calculus Bovis, and its prepn. method

A technology for clearing micro-pills and bezoars, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of hard texture, lost dosage form improvement, poor disintegration, etc., achieves smooth and neat appearance, shortens disintegration, etc. Solution time, good taste effect

Active Publication Date: 2007-01-31
BEIJING TONGRENTANG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine micropills generally refer to the water pan pills made by pan-preparation method, which are made of crude drug powder layer by layer. The texture is relatively hard, the disintegration is poor, and the dosage is also large. It is not suitable for the dosage form improvement of bezoar supernatant. , that is to say, if the bezoar supernatant is prepared into pellets in the traditional sense by the conventional pan-preparation method, the beneficial effect of the improved dosage form is not significant, and the meaning of dosage form improvement is lost

Method used

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  • Micro-pills of Niuhuang Shangqing Wan Contg. calculus Bovis, and its prepn. method

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The amount of the original medicinal material used in this embodiment is a prescription amount recorded in the instructions.

[0039] Rhubarb and Scutellaria baicalensis were extracted with 5 times the amount of 70% ethanol under reflux for 3 times, each time for 1.5 hours, the ethanol was recovered under reduced pressure, concentrated to a relative density of 1.05-1.20 (60°C), and set aside. Mint, chrysanthemum, Nepeta, Angelica dahurica, and Forsythia add 6 times the amount of water to extract the volatile oil for 2 hours, filter, add 6 times the amount of water to decoct the residue for 45 minutes, filter, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.15 Extract at -1.25°C (60°C) for later use; the volatile oil is clathrated with beta-cyclodextrin, placed in the refrigerator overnight, filtered, dried at 35-55°C, crushed into fine powder, and set aside for later use. Add 10 flavors of gardenia and other remaining medicines (...

Embodiment 2

[0046] Chinese medicine component and proportioning are identical with embodiment 1, and accelerator is polyvinylpolypyrrolidone 700g, and in the preparation method, accelerator adds once (that is all accelerator finally with bezoar and borneol fine powder, extract powder and Volatile oil beta-cyclodextrin inclusion compound mixing), other steps are the same as in Example 1.

Embodiment 3

[0048] The components and proportioning of the traditional Chinese medicine are the same as in Example 1, the accelerator is 500 g of micropowder silica gel, and the preparation method and steps are the same as in Example 1.

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Abstract

A cow-bezoar microbolus for clearing away heat of the upper part of the body, an improvement on cow-bezoar bolus for higher curative effect, features that is contains the promoter chosen from microcrystalline cellulose, superfine silica gel powder, polyvidone, cross-linking polyvidone and compressible starch beside the components said cow-bezoar bolus has. Its preparing process is also disclosed.

Description

technical field [0001] The invention provides a pellet preparation, especially a pellet preparation containing all the medicinal ingredients of the traditional Chinese medicine (pill) preparation Niuhuangshangqing pills. A new type of micropill dosage form has been developed, using the screened forming agent and extrusion spheronization preparation method, so that the disintegration and molding properties of the micropill are better than those obtained by the traditional method, and the dosage is significantly reduced. Background technique [0002] Niuhuang Shangqing Pill is a traditional Chinese patent medicine. Currently, there are pills (6g / pill, twice a day), tablets (0.3g / piece, 4 pieces at a time, twice a day) and capsules (0.3g / grain, twice a day). 3 capsules each time, 2 times a day) dosage form, with definite clinical curative effect and wide application range, it is a commonly used clinical drug, and the preparation process is directly processed by crude drug powde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61P1/02A61P1/10A61P11/04A61P29/00A61K35/413A61K33/06A61K31/045
Inventor 顾海鸥李建荣张绍来仝燕李银王智民薛海晨刘柏刚张维钧
Owner BEIJING TONGRENTANG CO LTD
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