Pharmaceutical composition containing total glucosides of paeony and pentoxifylline and application of pharmaceutical composition

A technology of pentoxifylline and total glucosides of paeony, applied in the field of medicine, can solve problems such as missing the best period of disease, and achieve the effects of cheap medicine, low economic burden, and reduced content

Inactive Publication Date: 2012-12-19
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional "pyramid" treatment mode starts with patients receiving disease education, physical therapy and the use of non-steroidal anti-inflammatory drugs, which lasts at least 6 months to 1 year, and transitions to slow-acting drugs when the curative effect is not good , the use of immunosuppressants often misses the best period for early control of the disease, leading to disease progression

Method used

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  • Pharmaceutical composition containing total glucosides of paeony and pentoxifylline and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Extraction and purification of total glucosides of paeony

[0019] Take clean and dried Radix Paeoniae Alba, crush it, add 10 times the weight of 70% (v / v) ethanol, heat and extract at 65-75°C for 3 times, each time for 3 hours, combine the extracts, filter, and recover the solvent from the filtrate under reduced pressure , concentrated in vacuum into crude extract of Radix Paeoniae Alba; the crude extract of Radix Paeoniae Alba was dissolved in 20 times the weight of 70% (v / v) ethanol, adjusted to pH = 6 with sodium hydroxide solution, and HPD with polystyrene skeleton -300 macroporous adsorption resin to adsorb the solution. After the adsorption is saturated, first absorb the impurities with water until the Molish reaction is negative, and then use 70% (v / v) ethanol with 10 times the amount of resin, at a flow rate of 3 times the amount of resin / hour Elution, recovery of the eluate, concentration, drying, to obtain total glucosides of paeony as light yellow-...

Embodiment 2

[0021] Example 2 Study on anti-inflammatory immune effect of total glucosides of paeony combined with pentoxifylline on rheumatoid arthritis rats

[0022] Healthy male SD rats, clean grade, body weight (170±10) g. The rats were randomly divided into five groups, model control group, normal control group, total glucosides of paeony group, pentoxifylline group, and combined medication group, with 12 rats in each group. Except for the normal control group, the other 3 groups were treated according to the literature (Xiong Cai, Hua Zhou, Yuen Fan Wong, et al. Suppression of the onset and progression of collagen-induced arthritis in rats by QzFGJS, a preparation from an anti-arthritic Chinese herbal formula [J].Journal of Ethno—pharmacology 2007(110):39-48.) method to prepare the collagen-induced arthritis model, the rats in the experimental group were given intragastric administration on the 7th day after the model was established, once a day, continuously For 6 weeks, the normal...

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Abstract

The invention discloses a pharmaceutical composition containing total glucosides of paeony and pentoxifylline. The weight ratio of the total glucosides of paeony to the pentoxifylline is (5-20):1. The pharmaceutical composition is remarkable in curative effect in the aspect of anti-inflammatory immunity and is especially suitable for treating rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing total glucosides of paeony and pentoxifylline and its application, in particular to a pharmaceutical composition containing total glucosides of paeony and pentoxifylline which can cure diabetic patients and application. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly characterized by chronic progressive joint lesions, characterized by symmetrical polyarthritis, pain and swelling of hands, wrists, elbows, knees and foot joints Morning stiffness is common. Patients may have extra-articular manifestations such as fever, anemia, subcutaneous nodules, vasculitis, pericarditis, and enlarged lymph nodes. Synovitis, along with the progression of the disease, can spread to connective tissues such as articular cartilage, bone tissue, joint ligament, sarcolemma and serosa, heart, lung and eye later....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P19/02A61P29/00A61K31/522
Inventor 王学政鲁俞江尤斌林爱弟陈旦凤陈胜胜杨海玲孙卓亚
Owner NINGBO LIWAH PHARM CO LTD
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