Salvia miltiorrhiza effective-component synchronous site-specific drug delivery mini-pill and preparation method thereof

Abstract

The invention discloses a salvia miltiorrhiza effective-component synchronous site-specific drug delivery mini-pill and a preparation method thereof, belonging to the technical field of drugs. The effective salvia miltiorrhiza component synchronous site-specific drug delivery mini-pill is a pill-shaped preparation obtained by the following steps of: respectively adding a right amount of excipients to salvianolic acid and tanshinone to prepare a mini-pill with the diameter being smaller than 2.5 mm; then respectively coating stomachic coating and enteric coating on the mini-pill with the diameter being smaller than 2.5 mm; and mixing according to the ratio of 1:1. The preparation method can adopt an extrusion-spheronization method and a fluidized bed coating method. Compared with the prior art, the invention solves the problem of effective-component synchronous site-specific delivery, can enhance the bioavailability and is beneficial to stabilizing the effective components; the salvia miltiorrhiza effective-component synchronous site-specific drug delivery mini-pill has outstanding curative effect on cardiovascular and cerebrovascular diseases, such as hypertension, cerebral thrombosis, coronary heart disease, and the like; in addition, the preparation method can adopt conventional process equipment and has the advantages of high production efficiency, stable product quality, validity period more than two years and easy industrialized production.

Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to a synchronously positioned drug-releasing pellet of active ingredients of salvia miltiorrhiza and a preparation method thereof. Background technique

[0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant of the genus Salvia in the family Lamiaceae. This product can dispel blood stasis and relieve pain, dissipate blood stasis and relieve pain, and is used to treat chest pain, coronary heart disease, angina pectoris, myocardial infarction, etc. It is widely used clinically, promotes blood circulation, stimulates menstrual flow, clears heart and troubles, has mild effect, has no obvious toxic and side effects, can be taken for a long time, and considers the rhythm of the onset of coronary heart disease, so this prescription is suitable for the research of timed release preparations.

[0003] At present, there are many kinds of Danshen prepara...