12results about How to "Stable release rate" patented technology

The invention provides a compound phospholipid gel sustained release preparation and a preparation method thereof. The preparation mainly comprises a local anesthetic, a non-steroidal anti-inflammatory drug, phospholipid and water for injection. The preparation can be injected around a surgical incision or directly instilled or coated at the surgical incision to achieve the purpose of long-acting analgesia, and is used for postoperative analgesia.

The invention relates to the technical field of biomedical administration, and particularly discloses double-layer hydrogel suitable for the interior of a bladder. The double-layer hydrogel comprises a hydrophilic adhesion slow-release layer and a hydrophobic protective layer; the hydrophilic adhesive slow-release layer and the hydrophobic protective layer are respectively obtained by curing a hydrophilic adhesive slow-release hydrogel precursor solution and a hydrophobic protective hydrogel precursor solution. By adopting a layered progressive double-hydrogel synergistic structure, an integrated administration barrier of mucous membrane adsorption-drug sustained release-physical protection is formed, so that the double-layer hydrogel has excellent bladder mucous membrane adhesion performance in a water environment and a stable and controllable drug sustained release effect, and the problems that an existing bladder perfusion drug is easily diluted and washed by urine, and the drug sustained release effect is poor are solved. The medicine action time is short, and the bioavailability is low.

The present application relates to a cement-based immobilized manganese ore-agricultural and forestry waste composite denitrification filler and its preparation method and application. The filler comprises a cement-based porous framework, and agricultural and forestry waste powder and manganese ore powder co-dispersed and immobilized in the cement-based porous framework; the agricultural and forestry waste powder is selected from one or more of sawdust powder, corn cob powder and straw powder; the redox characteristics of manganese oxides in the manganese ore powder are used to strengthen the organic matter degradation and denitrification process, realizing heterotrophic denitrification and manganese-mediated autotrophic denitrification synergistic denitrification. In preparation, the solid raw materials are dry mixed, water and a foaming agent are added for shaping, and the shaped product is watered and cured at 20-30 DEG C for 7-14 days to obtain the composite filler. The filler can continuously provide carbon source and autotrophic denitrification electron donor within a certain period, and provide an interface for microbial attachment, and is suitable for advanced denitrification of low C / N nitrate-containing wastewater such as tail water of a municipal sewage plant.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an olanzapine long-acting injection and a preparation method thereof. According to the invention, olanzapine micro powder is dispersed in a medium composed of oil for injection and at least one non-aqueous solvent miscible with water for subcutaneous injection. The combined olanzapine injection can quickly become sticky after subcutaneous injection to form a harder drug storage, so that burst release is reduced, a stable drug release rate is obtained, and different drug release rates can be obtained by adjusting the types and proportions of the oil for injection and at least one non-aqueous solvent miscible with water; the prescription and preparation are simple, and large-scale production is facilitated.

The application relates to the technical field of supramolecules, in particular to a pillar[n]arene derivative-DCOIT slow-release supramolecular self-assembly body, application and a preparation method. The supramolecular self-assembly body loads DCOIT by taking a pillar[n]arene derivative as a molecular carrier; the pillar[n]arene serving as the carrier can form a supramolecular assembly body with DCOIT through hydrogen bond interaction between pi and CH2, the host-guest complexation of the two is strong, and the pillar[n]arene derivative can effectively control the slow release of DCOIT; the supramolecular self-assembly body is good in safety and stability, low in cost, beneficial to industrialized production, and wide in application field; the method is simple in operation, low in preparation cost, easy to realize, and beneficial to industrial promotion.

The application discloses emulsified temperature-resistant salt-resistant polyacrylamide and a preparation method thereof. The polyacrylamide is prepared by using acrylamide, acrylic acid, 2-acrylamide-2-methylpropanesulfonic acid and N-dodecyl acrylamide as monomers, and using a composite initiator through aqueous solution polymerization to obtain a quaternary copolymer. The polymer has good emulsification, temperature resistance and salt resistance, and has a high viscosity retention rate under the conditions of a temperature of 50-75 DEG C and a salinity of 5000-35000 mg / L. The preparation process is simple and practical, and is beneficial to industrial production.

This invention belongs to the field of pharmaceutical formulation technology, and specifically relates to a sulfonamide derivative sustained-release granule and its preparation method. The sulfonamide derivative sustained-release granule includes a drug-loaded layer, a sustained-release layer I, and a sustained-release layer II. The drug-loaded layer includes a blank pellet core and an active ingredient layer, wherein the active ingredient is a compound of formula I. This invention prepares the drug into sustained-release granules with uniform particle size, precisely controls the particle size distribution of the blank pellet core and the sustained-release granules, and sequentially performs two sustained-release layer coatings on the drug-loaded layer, adjusting the type and amount of excipients in each layer to obtain sustained-release granules that are gritty, palatable, and easy to swallow. These sustained-release granules can be flexibly dosed according to clinical needs; by measuring different volumes, the dosage requirements of patients of different weights or ages can be met. Only one dose is required daily, achieving precise and convenient oral administration for children, while obtaining suitable sustained-release characteristics with a stable release rate and no burst release.

The diaphragm type silk fibroin microneedle patch sequentially comprises a medicine storage layer, a diaphragm layer and a blank microneedle layer, the blank microneedle layer is composed of silk fibroin and comprises a base body and a needle body extending outwards from the base body, and the side, away from the needle body, of the diaphragm layer is covered with the medicine storage layer; the medicine storage layer comprises silk fibroin and tranexamic acid, and the diaphragm layer is located between the medicine storage layer and the blank microneedle layer. According to the tranexamic acid-loaded diaphragm type silk fibroin microneedle patch containing the medicine storage layer, the release duration (14 h in vitro and 24 h in vivo) can be increased, a large tranexamic acid concentration difference can be formed between the microneedle and the skin, stable pushing force is provided for transdermal release of tranexamic acid, the stable medicine release rate is achieved after a certain time, and the transdermal effect of the tranexamic acid is improved. Therefore, the purpose of long-time stable administration is achieved.

The invention relates to the technical field of natural plant essential oils for calming the mind and promoting sleep, and in particular to natural plant essential oils for calming the mind and promoting sleep, a preparation method and a sleeping patch. The natural plant essential oils are prepared from the following components by weight: 20-25 parts of linalool; 15-20 parts of citral; 10-15 parts of alpha-pinene; 8-12 parts of carvacrol; 6-10 parts of (R)-(-)-carvone; 5-9 parts of nerolidol; 4-8 parts of geraniol; 5-10 parts of beta-cyclodextrin; 3-7 parts of soybean lecithin; 1-3 parts of vitamin E; 2-6 parts of spiny jujube kernel oil and 1-4 parts of bergamot oil; linalool and alpha-pinene achieve comprehensive regulation of the sleep-wake cycle, significantly improve the levels of GABA and 5-HT in the brain, shorten the sleep latency and prolong the sleep time; the spiny jujube kernel oil has the effects of sedation, sleep-promoting and anti-anxiety; and the bergamot oil has the effects of sedation, anti-depression and mood improvement.

This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.

The invention discloses a sample gas extraction device for testing the total sulfur and effective sulfur content of non-metallic powder, and relates to the field of sulfur content testing instruments for non-metallic powder materials, including a furnace body with a furnace head installed on the top, a quartz sample tube installed in the furnace body, and the top of the quartz sample tube is sealed and connected to the furnace head through a sealing ring; a crucible support base is installed at the bottom of the furnace body, and the crucible support base is installed with a crucible support through a connecting piece, and the crucible support is used to hold samples; a lifting cylinder connected to the crucible support base is arranged below the furnace body; a top-blown oxygen path joint and a sample gas outlet connected to the quartz sample tube are respectively provided on the furnace head, and a detector is connected to the outer end of the sample gas outlet; a reflector is arranged on the inner wall of the furnace body, and an infrared heating tube is arranged between the reflector and the quartz sample tube. The invention has high temperature control accuracy, stable SO2 release rate, and can effectively improve the accuracy of sulfur analysis.

The utility model discloses a clothes airing machine capable of performing feedback control on the rotating speed of a motor, which comprises a main machine and an airing rod, a driving device is arranged in the main machine, and the driving device comprises the motor, a wire twisting disc for winding and unwinding a steel wire rope and a feedback controller; the motor controls the stranding disc to rotate; the stranding disc comprises an upper cover, a partition plate and a bottom plate, a first cavity for radially winding a steel wire rope is formed between the upper cover and the partition plate, and a second cavity for radially winding the steel wire rope is formed between the partition plate and the bottom plate; and the feedback controller comprises a roller with a wire slot and a speed sensor, and adopts a variable-diameter wire twisting disc to adjust the rotating speed of a motor for controlling the rotation of the wire twisting disc, so that the winding and unwinding speed of the steel wire rope is uniform, and the uniform lifting speed of the airing rod is further met.