159results about How to "Stable release rate" patented technology

The present invention discloses one kind of powder material capable of generating negative ion and its preparation process. The powder material consists of tourmaline material 20-70 wt%, mixed RE material or mixed RE oxide material 20-60 wt%, semiconductor catalyst material 5-20 wt%, and auxiliary exciting material 4-15 wt%. Its preparation process includes the following steps: 1. crushing and roasting tourmaline material; 2. grinding tourmaline material in a grinding set into superfine powder; 3. adding surface treating agent for surface treatment; 4. grinding the other materials to size smaller than 1 micron; and 5. dispersing all the materials inside one high speed dispersing machine, sieving and drying. The powder material has a negative ion releasing rate up to 6000-10000 /cu cm.

The invention provides sustained-release chlorine dioxide gel comprising the following components by weight percent: 0.1% to 5.0% of chlorine dioxide precursor, 1.0% to 10.0% of gel, 0.01% to 2.0% of chelating agent, 0.1% to 10.0% of inclusion agent, 30% to 70% of activating agent, 0.1% to 5.0% of sustained-release agent, 0.1% to 5.0% of stabilizing agent and deionized water in balancing amount. The sustained-release chlorine dioxide gel of the invention is capable of conducting the stable sustained-release process at a certain rate for 3 to 6 months, so the sustained-release chlorine dioxidegel has the advantages of long release period, uniform and stable release rate and lasting effect; the sustained-release chlorine dioxide gel is capable of not only removing formaldehyde from indoor air in an effective, safe and lasting way and ensuring the high removal rate of formaldehyde, but also disinfecting and sterilizing the indoor air continuously and thoroughly purifying the indoor air;moreover, the invention dispenses with high-purity chlorine dioxide gas and further has the advantages of simple preparation method and convenient operation.

The invention provides a film forming compound with modified starch as the main component, a film forming material containing the compound, and more particularly a hard-shell natural capsule made from the compound. The compound contains no or very little animal protein such as gelatin, etc. The compound can partially or completely replace the gelatin from animals for producing natural hard-shell capsules. The prepared natural capsule shell product has the advantages of excellent film forming property, high strength, good flexibility, high transparency, decomposability and microbial pollution resistance. The main component of the compound, modified starch, has stable quality and highly controllable performance.

The invention relates to a mustard essential oil biofungicide, comprising the following components by parts by weight: 2-20 parts of mustard essential oil, 10-30 parts of embedding agent, 5-30 parts of carrier, 5-20 parts of binder, 5-15 parts of dispersing agent and 1-20 parts of filler. The biofungicide has the characteristics that: application method is simple and less influenced by external environment; the biofungicide is pollution-free, nuisanceless and non-toxic without side effect; platy or powdery fungicide is added into a packing container before storing, the biofungicide is applicable to storing and refreshing of multiple fruits and vegetables, forms a protective gas layer in the packing environment, effectively inhibits or kills off main postharvest pathogenic bacteria, improves disease resistance of fruits and vegetables, reduces rotting caused by common pathogenic bacteria in storing process and prolongs storing and refreshing time of fruits and vegetables.

A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

The invention discloses a colchicine double-layer osmotic pump controlled-release tablet and a method for preparing the same. The controlled-release tablet comprises a double-layer tablet core consisting of a drug containing layer and a pushing layer, and a layer of coating membrane which is coated on the outer surface of the double-layer tablet core and belongs to a semipermeable coating membrane, and the coating membrane is provided with a drug release hole on the surface of the drug containing layer, wherein in the tablet core, the drug containing layer contains the colchicine of which the weight percentage against the weight percentage of the double-layer tablet core is between 0.1 and 1.0 percent and a suspending agent, osmotic pressure active matters and pharmaceutic adjuvants; the pushing layer contains an expanding agent, a permeation enhancer, a retarder and a binder, a wetting agent, a lubricant and a bulking agent; and the weight gain of the coating membrane against the weight of the tablet core is between 10 and 20 percent, and the aperture of the drug release hole on the surface of the drug containing layer of the coating membrane is between 0.2 and 2 millimeters. The colchicine double-layer osmotic pump controlled-release tablet has the characteristics of stable drug release rate after being taken and easy control of the accumulation release degree during special time, can effectively reduce taking frequency so as to improve the compliance of patients and has better safety and effectiveness.

The invention belongs to the powder preparing technique. The rigid micro powder slow-release grinding aid is characterized in that: it is formed by mechanical mixed liquid grinding aid and rigid micro powder carrier, wherein, each component is in following mass percentages: the rigid micro powder carrier in 50-200 deals, and the liquid grinding aid in 5-45 deals; said rigid micro powder carrier is the slag or rigid mine powder with micro crack or porous structure; the specific surface area of rigid micro powder carrier is not less than the specific surface area of produced powder; the rigidity of rigid micro powder carrier is not less than the one of produced powder. Compared to present common grinding aid, the invention has stable release speed, double grinding aid functions and prolonged grinding aid property. Therefore, it has wider application prospect in power preparation.

The invention relates to the technical field of pharmaceutical preparation, in particular to an asiatic acid sustained-release microsphere used for injection and a preparation method thereof. A biodegradable chitosan is taken as a carrier, an asiatic acid is taken as principal agent, and the asiatic acid sustained-release microsphere used for injection is obtained by the technology of cross-linked emulsion. Due to the obtained medicament carried microspheres, the surfaces are relatively smooth; the particle diameters range from 20mum to 110mum; and the medicament loading rate of the microspheres ranges from 4.8% to 15.6%. The asiatic acid microsphere has the characteristics that the burst effect is modest (the burst size on the first day is smaller than 15%); the release rate is stable; the sustained release time is long (4-10 weeks); and the asiatic acid microsphere is biodegradable. The implantation and the removal by operation before and after the medicament is used are avoided.

The invention discloses a long-acting air pollution control agent which is prepared from colloid A and colloid B. The colloid A and the colloid B are each prepared from a reactant, a carrier and a conditioner. The conditioner comprises a pH conditioner for adjusting the pH value of the colloids and a character conditioner for adjusting the character of the colloids. According to the long-acting air pollution control agent, the pH of the system is kept through a pH buffering solution, it is ensured that the reaction is conducted at a constant speed, and the release speed of chlorine dioxide is more stable; the colloids can be degraded and are free of residues after being used; acid with strong corrosivity is not contained, and the agent is safer to store, transport and use; the air pollution control agent has one purpose of removing air pollutants in micro spaces; by means of isolated package, the colloids do not make contact, the safe storage and transportation of the product are ensured, and the shelf life is greatly prolonged.

The invention belongs to the technical field of drug preparations, and relates to a Metoprolol succinate sustained release tablet and a preparation method thereof. The sustained release tablet includes a tablet film coating material and a tablet core coated with the coating, the tablet core comprises a pellet and accessories, the pellet comprises, from the inside to the outside, a blank pill core,a drug-loading coating layer, a sustained release coating layer and a protective coating layer, the drug-loading coating layer comprises Metoprolol succinate and a drug-loading pellet coating adhesive, the sustained release coating layer comprises a sustained release pellet coating layer coating material, a pore forming agent, a plasticizer and an anti adhesion agent, the protective coating layerincludes a protection pellet coating adhesive, the accessories include a filler, a disintegrating agent and a lubricating agent. The sustained layer of the release tablet is externally wrapped with the protective layer, and the problems of slow release ability reduction and unqualified content uniformity caused by excess fluidity and the like due to the damage of the sustained release layer can be solved.

The invention relates to a tablet of isosorbide mononitrate, in particular to a double-layer osmotic pump controlled release tablet of isosorbide mononitrate, which belongs to the field of medicine preparation. A single-chamber double-layer osmotic pump tablet of the isosorbide mononitrate is characterized in that a semi-transparent coating film cover a double-layer core body consisting of a medicine-containing layer and a boosting layer; and the coating film is provided with a medicine releasing pore on the surface of the medicine-containing layer. The gastrointestinal tract water enters a double-layer tablet chip through the semi-transparent film; the medicines forms a mixed suspension liquid or solution when contacting water in the medicine-containing layer; a penetration enhancer enables the solution of the medicine-containing layer to be hypertonic so that an osmotic pressure difference exists between the inner side and the outer side of the film, which is beneficial to pumping the medicines out; and the pressure is generated in the boosting layer through water absorption, dissolution and expansion of a penetrating agent so as to further boost a medicine liquid to eject the pore.

The invention relates to a chemical oxygenemergency self-rescue breathing device, which comprises a mask (1), a rebreathing bag (11), an air regeneration tank (5), and an air loop sequentially passing through the mask (1), a one-wayair outlet (4), the air regeneration tank (5), the rebreathing bag (11), one-way air inlets (2,3) and the mask (1). A plurality of supports (7) are arranged in the air regeneration tank (5) and are horizontally fixed on the inner wall of the air regeneration tank (5) to divide the air regeneration tank (5) into a plurality of interconnected subspaces with approximatevolumes; the subspaces are filled with air regenerants (8). The device is provided with a plurality of supports, so that chemical reaction can be quickly conducted to the outer wall of the air regeneration tank in a heating manner so as to improve the heat balance of a circulation air circuit, the reliability of the air regeneration process is controlled, the temperature of fresh air is reduced, and the use comfort of personnel is improved.

A coated layer for modifying the surface of vascular scaffold by controlling the content of polyoxyethene in the coated layer to regulate its medicine-carrying performance and the release of medicinal is a polysulfone-polyoxyethene block copolymer with 10000-300000 for its number average molecular weight. Its preparing process features that said block copolymer is coated on the surface of said vascular scaffold directly or after the medicine is added to its solution.

The invention discloses a huperzine A single-layer osmotic pump controlled-release tablet. The controlled-release tablet comprises a tablet core containing huperzine A and pharmaceutic adjuvants in effective dosage, and a semipermeable coating membrane coating the tablet core, wherein the coating membrane is provided with a drug release hole. The controlled-release tablet is characterized in that: the tablet core contains the following components in percentage by weight: 0.01 to 1.0 percent of huperzine A, 1.0 to 10 percent of retarder and 1.0 to 40 percent of permeation enhancer; and the weight ratio of polyethylene glycol 6,000 contained in the coating liquid to cellulose acetate is (0.05-0.25):1, and the weight gain of the coating membrane against the weight of the tablet core is between 5 and 25 percent. The controlled-release tablet has the advantages that the drug release rate is stable, the blood consentration of patients is relatively constant after the patients take the controlled-release tablet, and the drug taking frequency of the patients is reduced, so that the controlled-release tablet is a novel drug formulation which is safer, more effective, stable, controllable and convenient for application in clinically treating senile dementia.

The invention discloses a slow-release chlorine dioxide-supporting zeolite carrier and a preparation method thereof. The preparation method comprises the following steps: S1, adding a surfactant intoan acid solution, soaking zeolite in the acid solution, and performing solid-liquid separation to obtain modified zeolite; S2, impregnating the modified zeolite in a transition metal salt solution, and then performing solid-liquid separation and calcinating to obtain transition metal supported zeolite, wherein the transition metal supported zeolite is used as a carrier for supporting chlorine dioxide. The invention has the beneficial effects as follows: the prepared slow-release chlorine dioxide-supporting zeolite carrier can release chlorine dioxide gas steadily with a stable release rate; activation energy and overpotential of a sodium chlorite self-oxidation reaction in an acidic environment are reduced, and the purpose of slowly activating sodium chlorite to release the chlorine dioxide gas is achieved.

The invention discloses a tofacitinib citrate enteric-coated sustained-release pellet and a preparation method thereof. The tofacitinib citrate enteric-coated sustained-release pellet contains a matrix type drug-containing pellet core and an enteric coating which coats the pellet core, wherein the matrix type drug-containing pellet core comprises a compound matrix type sustained-release material which is two or three selected from a group consisting of a hydrophilic gel matrix material, a corrosive matrix material and a non-corrosive matrix material. The tofacitinib citrate enteric-coated sustained-release pellet of the invention is stable in drug release and smooth in extrusion; the pellet is a multi-unit administration preparation, has the advantages of small local irritation and high bioavailability and guarantees the effectiveness and safety of drug usage; and the sustained-release pellet can reduce the drug taking frequency of patients and improve the compliance of patients in drug taking.

The invention relates to a pine moth sex pheromone microcapsule and a preparation method thereof, belonging to the field of embedding technology for the pine moth sex pheromone microcapsule. The microcapsule comprises a microcapsule wall material and a microcapsule core material, wherein the microcapsule wall material is a prepolymer liquid formed by reaction among methyl methacrylate, methacrylic acid and an initiator, the microcapsule core material comprises pine moth sex pheromone and liquid paraffin, and pine moth sex pheromone is cis-5,trans-7-dodecadienal, cis-5,trans-7-codlemone, cis-5,trans-7-dodecadienyl acetate and/or cis-5-dodecadienyl acetate. The microcapsule provided by the invention has the advantages of sensitivity, specificity, high efficiency, a long lasting period, degradability, good biocompatibility, no pollution to the environment, low price, etc., can be used for population monitoring and large-scale trapping and killing and control of pine moth, is capable of accurately predicating next-generation population occurrence density and has good economic benefits and ecological benefits.

The invention relates to the field of agricultural planting, and discloses a multifunctional soil improvement agent and a preparation method thereof. The soil improvement agent comprises a quick-release layer and a slow-release layer. The quick-release layer consists of the following substances: earthworm soil 10-20wt%, a soil anti-hardening agent 5-10wt%, insecticidal constituents 5-10wt%, weeding particles 20-30wt%, a plural gel carrier 35-45wt%, modified oxidized calcium 3-5wt% and an adhesive 0.5-1.5wt%; and the slow-release layer consists of the following substances: earthworm soil 10-20wt%, a soil anti-hardening agent 5-10wt%, insecticidal constituents 5-10wt%, weeding particles 20-30wt% and cyclodextrin 40-50wt%. The multifunctional soil improvement agent can improve water-retaining property and breathability of soil, and has effects of killing insects, weeding and improving soil fertility, further has long-acting slow-release effect, and can continuously and stably release active ingredients.

The invention provides a memantine hydrochloride slow release-donepezil quick release compound capsule. The compound capsule is prepared by jointly filling a capsule with memantine hydrochloride slow release pellets and donepezil quick release granules; the memantine hydrochloride slow release pellets are prepared by using medicinal empty pellet cores as original cores, dissolving memantine hydrochloride serving as main drug and proper excipients to form coating liquid, spraying the coating liquid to the bottom of a fluidized bed to form a drug-containing layer and sequentially coating the fluidized bed with an isolating layer and a slow release layer from inside to outside; the donepezil quick release granules are formed by subjecting donepezil hydrochloride serving as main drug and proper excipients to wet-process granulation, and the slow release pellets and quick release granules are filled into one same capsule according to a certain proportion of the main drug.

Provided is a preparation method of a hydrogel patch substrate with gradient drug concentration. The preparation method of the hydrogel patch substrate with the gradient drug concentration uses a centrifugation method to achieve cross linking agent gradient distribution, and therefore hydrogel of gradient cross linking is acquired. The design is ingenious, and the method is simple and practicable. Cross linking density gradient of hydrogel is regulated by temperature in the process of centrifugation, centrifugal speed, and centrifugal time. The higher temperature is, the higher the centrifugal speed is, and the longer the centrifugal time is, the larger the gradient is, and therefore concentration gradient load in the hydrogel of drugs is achieved. The preparation method of the hydrogel patch substrate with the gradient drug concentration is suitable for a transdermal drug delivery patch substrate as drug gradient slow release.