7results about How to "Stable release rate" patented technology

The invention relates to the technical field of biomedical administration, and particularly discloses double-layer hydrogel suitable for the interior of a bladder. The double-layer hydrogel comprises a hydrophilic adhesion slow-release layer and a hydrophobic protective layer; the hydrophilic adhesive slow-release layer and the hydrophobic protective layer are respectively obtained by curing a hydrophilic adhesive slow-release hydrogel precursor solution and a hydrophobic protective hydrogel precursor solution. By adopting a layered progressive double-hydrogel synergistic structure, an integrated administration barrier of mucous membrane adsorption-drug sustained release-physical protection is formed, so that the double-layer hydrogel has excellent bladder mucous membrane adhesion performance in a water environment and a stable and controllable drug sustained release effect, and the problems that an existing bladder perfusion drug is easily diluted and washed by urine, and the drug sustained release effect is poor are solved. The medicine action time is short, and the bioavailability is low.

The present application relates to a cement-based immobilized manganese ore-agricultural and forestry waste composite denitrification filler and its preparation method and application. The filler comprises a cement-based porous framework, and agricultural and forestry waste powder and manganese ore powder co-dispersed and immobilized in the cement-based porous framework; the agricultural and forestry waste powder is selected from one or more of sawdust powder, corn cob powder and straw powder; the redox characteristics of manganese oxides in the manganese ore powder are used to strengthen the organic matter degradation and denitrification process, realizing heterotrophic denitrification and manganese-mediated autotrophic denitrification synergistic denitrification. In preparation, the solid raw materials are dry mixed, water and a foaming agent are added for shaping, and the shaped product is watered and cured at 20-30 DEG C for 7-14 days to obtain the composite filler. The filler can continuously provide carbon source and autotrophic denitrification electron donor within a certain period, and provide an interface for microbial attachment, and is suitable for advanced denitrification of low C / N nitrate-containing wastewater such as tail water of a municipal sewage plant.

The application relates to the technical field of supramolecules, in particular to a pillar[n]arene derivative-DCOIT slow-release supramolecular self-assembly body, application and a preparation method. The supramolecular self-assembly body loads DCOIT by taking a pillar[n]arene derivative as a molecular carrier; the pillar[n]arene serving as the carrier can form a supramolecular assembly body with DCOIT through hydrogen bond interaction between pi and CH2, the host-guest complexation of the two is strong, and the pillar[n]arene derivative can effectively control the slow release of DCOIT; the supramolecular self-assembly body is good in safety and stability, low in cost, beneficial to industrialized production, and wide in application field; the method is simple in operation, low in preparation cost, easy to realize, and beneficial to industrial promotion.

The application discloses emulsified temperature-resistant salt-resistant polyacrylamide and a preparation method thereof. The polyacrylamide is prepared by using acrylamide, acrylic acid, 2-acrylamide-2-methylpropanesulfonic acid and N-dodecyl acrylamide as monomers, and using a composite initiator through aqueous solution polymerization to obtain a quaternary copolymer. The polymer has good emulsification, temperature resistance and salt resistance, and has a high viscosity retention rate under the conditions of a temperature of 50-75 DEG C and a salinity of 5000-35000 mg / L. The preparation process is simple and practical, and is beneficial to industrial production.

This invention belongs to the field of pharmaceutical formulation technology, and specifically relates to a sulfonamide derivative sustained-release granule and its preparation method. The sulfonamide derivative sustained-release granule includes a drug-loaded layer, a sustained-release layer I, and a sustained-release layer II. The drug-loaded layer includes a blank pellet core and an active ingredient layer, wherein the active ingredient is a compound of formula I. This invention prepares the drug into sustained-release granules with uniform particle size, precisely controls the particle size distribution of the blank pellet core and the sustained-release granules, and sequentially performs two sustained-release layer coatings on the drug-loaded layer, adjusting the type and amount of excipients in each layer to obtain sustained-release granules that are gritty, palatable, and easy to swallow. These sustained-release granules can be flexibly dosed according to clinical needs; by measuring different volumes, the dosage requirements of patients of different weights or ages can be met. Only one dose is required daily, achieving precise and convenient oral administration for children, while obtaining suitable sustained-release characteristics with a stable release rate and no burst release.

This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.

The utility model discloses a clothes airing machine capable of performing feedback control on the rotating speed of a motor, which comprises a main machine and an airing rod, a driving device is arranged in the main machine, and the driving device comprises the motor, a wire twisting disc for winding and unwinding a steel wire rope and a feedback controller; the motor controls the stranding disc to rotate; the stranding disc comprises an upper cover, a partition plate and a bottom plate, a first cavity for radially winding a steel wire rope is formed between the upper cover and the partition plate, and a second cavity for radially winding the steel wire rope is formed between the partition plate and the bottom plate; and the feedback controller comprises a roller with a wire slot and a speed sensor, and adopts a variable-diameter wire twisting disc to adjust the rotating speed of a motor for controlling the rotation of the wire twisting disc, so that the winding and unwinding speed of the steel wire rope is uniform, and the uniform lifting speed of the airing rod is further met.