The invention relates to a progesterone composition, progesterone foam gel and a preparation method thereof. The invention finds that
choline carbenoic acid can effectively improve the
solubility of progesterone in water. According to the progesterone foam gel, progesterone is dissolved in an
aqueous solution containing
choline carbenoic acid, then the progesterone foam gel,
poloxamer and a
propellant are prepared into the progesterone foam gel, the progesterone content in the progesterone foam gel is high, the progesterone foam gel can fully cover
vaginal mucosa after administration, the contact area between a
drug and
vaginal tissue is increased, and the progesterone foam gel has
temperature response gelling performance and pH response gelling performance at the same time; after vaginal administration, the gel can be quickly converted from foam to gel and is adhered to
vaginal mucosa, and the gel is good in self-healing performance and can
resist a
vaginal discharge mechanism, so that relatively good adhesion and continuous action at a medication part are realized. Meanwhile, the progesterone foam gel can promote
permeation and absorption of progesterone through
vaginal mucosa, enrichment of progesterone in the
uterus after vaginal administration is remarkably improved, and side effects of the
whole body are avoided.