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355results about How to "Uniform content" patented technology

Lysine hydrochloride/zinc gluconate composite particle and preparation method of composite particle

The invention discloses a lysine hydrochloride / zinc gluconate composite particle and a preparation method of the composite particle. The lysine hydrochloride / zinc gluconate composite particle is prepared from the following components in parts by weight: 10-15 parts of lysine hydrochloride, 3-4 parts of zinc gluconate, 0.5-2 parts of sweetening agent, 1.0-2.5 parts of citric acid, 60-90 parts of filling agent, 3-5 parts of povidone K30 and 0.5-1.0 part of essence. The composite particle is free of sugar and especially suitable for patients with diabetes mellitus. In addition, the composite particle is small in difference of weight ratios between raw material amount and accessory material amount; the prepared particle is uniform; after packaging, the content in each bag is relatively uniform; the granularity is changed from 10-13% to 5-8%; due to the adoption of the povidone K30, the strength of the particle is changed from 8-13N to 15-20N; the particle is good in pressure resistance and has a small possibility of being crushed in the packaging process and the transportation process; meanwhile, the particle is excellent in mobility; a repose angle is changed from 35-45 degrees to 25-30 degrees; carr index is changed from 20-30% to 10-20%.
Owner:海南慧谷药业有限公司

Pramipexole dihydrochloride sustained-release preparation and preparing method thereof

ActiveCN108159007AUniform and stable contentAvoid the defect of different release volumeOrganic active ingredientsNervous disorderOral medicationMedicine
The invention discloses a pramipexole dihydrochloride sustained-release preparation and a preparing method thereof, and belongs to the field of pharmaceutical preparations. The invention provides thepramipexole dihydrochloride sustained-release preparation which is prepared from the following raw and auxiliary materials by weight: 1-5 parts of pramipexole dihydrochloride, 35-140 parts of a sustained-release material, 130-400 parts of a skeleton material, 300-750 parts of a diluent, 10-20 parts of a flow aid, and 5-15 parts of a lubricant. The invention also provides the preparing method of the sustained-release preparation, wherein the preparing method includes the following steps: (1) taking pramipexole dihydrochloride, and crushing; (2) mixing the sustained-release material and pramipexole dihydrochloride evenly; (3) adding the skeleton material and the diluent, and mixing evenly; (4) making the mixture obtained in the step (3) into dry particles; (5) mixing the dry particles with the lubricant and the flow aid, to obtain an intermediate; and (6) tabletting. Under the specific ratio and granulating process, the sustained-release preparation has the advantages of uniform content,stable release and reliable quality, can be released evenly in various dissolving media with different pH, and is suitable for oral administration once a day.
Owner:CHENGDU BAIYU PHARMA CO LTD
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