Composite calcium carbonate and vitamin D3 chewable tablet for children and preparation method thereof

Abstract

The invention relates to the field of pharmaceuticals, in particular to a composite calcium carbonate and vitamin D3 chewable tablet for children and a preparation method thereof. The chewable tablet is composed of, by weight, 50-75% of calcium carbonate, 0.05-0.2% of vitamin D3 powder, 22-40% of sorbitol, 0.6-2.4% of citric acid, 0.1-0.6% of aspartame, 0.2-0.6% of essence, 0.05-0.2% of pigment and 2-6% of magnesium stearate. The chewable tablet is suitable for large-scale industrial production, and taste, color and smell of the chewable tablet are adjusted by reasonably proportioning the components and content, so that medication compliance of the children is improved.

Description

technical field

[0001] The invention relates to the field of pharmacy, in particular to a compound calcium carbonate and vitamin D3 chewable tablet for children and a preparation method thereof. Background technique

[0002] Calcium is called "the cornerstone of life" and plays a pivotal role in children's bone development, brain development, tooth development and prevention of lead poisoning. Children are in the period of growth and development, and need to take calcium products from outside to meet the needs of body growth and development.

[0003] The vitamin D calcium chewable tablets for children in the related art and / or its preparation process have the following defects: (1) the raw and auxiliary materials with the largest amount in the prescription are calcium carbonate and sorbitol, which first need to be granulated, and calcium carbonate and sorbitol Alcohol has poor viscosity and unsatisfactory granulation, which brings difficulty to granulation; (2) vitamin D3 c...

Examples

preparation example Construction

[0019] Present embodiment also provides a kind of preparation method of compound calcium carbonate and vitamin D3 chewable tablet for children, comprising the steps:

[0020] 1) Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder;

[0021] 2) place the calcium carbonate of recipe quantity in wet mixing granulator, add binding agent and make soft material;

[0022] 3) The soft material is granulated through a 10-30 mesh sieve;

[0023] 4) The granules are dried with hot air circulation at 40-70°C, and the moisture content is controlled below 1%;

[0024] 5) The vitamin D3 powder of the prescription amount is mixed with the added sorbitol, citric acid, aspartame, essence and fine particles (obtained from particle sieving in step 4) according to the equal dilution method, and the mixture is uniformly mixed with that in step 4) The obtained dry granules and magnesium stearate are blended together, and compressed into tablets.

[0025] In...

Embodiment 1

[0035] Mix by weight:

[0036]

[0037] Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder; place the prescribed amount of calcium carbonate in a wet mixing granulator, add binder to make soft material; pass the soft material through a 10-30 mesh sieve to granulate ;The granules are dried by hot air circulation at 40-70℃, and the water content is controlled below 1%; the prescribed amount of vitamin D3 powder is mixed with the added sorbitol, citric acid, aspartame, essence and fine granules according to the equal dilution method ; The mixture is blended with dry granules and magnesium stearate, and compressed into tablets.

Embodiment 2

[0039] Mix by weight:

[0040]

[0041] Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder; place the prescribed amount of calcium carbonate in a wet mixing granulator, add binder to make soft material; pass the soft material through a 10-30 mesh sieve to granulate ;The granules are dried by hot air circulation at 40-70℃, and the water content is controlled below 1%; the prescribed amount of vitamin D3 powder is mixed with the added sorbitol, citric acid, aspartame, essence and fine granules according to the equal dilution method ; The mixture is blended with dry granules and magnesium stearate, and compressed into tablets.

technical field

[0001] The invention relates to the field of pharmacy, in particular to a compound calcium carbonate and vitamin D3 chewable tablet for children and a preparation method thereof. Background technique

[0002] Calcium is called "the cornerstone of life" and plays a pivotal role in children's bone development, brain development, tooth development and prevention of lead poisoning. Children are in the period of growth and development, and need to take calcium products from outside to meet the needs of body growth and development.

[0003] The vitamin D calcium chewable tablets for children in the related art and / or its preparation process have the following defects: (1) the raw and auxiliary materials with the largest amount in the prescription are calcium carbonate and sorbitol, which first need to be granulated, and calcium carbonate and sorbitol Alcohol has poor viscosity and unsatisfactory granulation, which brings difficulty to granulation; (2) vitamin D3 c...

Examples

preparation example Construction

[0019] Present embodiment also provides a kind of preparation method of compound calcium carbonate and vitamin D3 chewable tablet for children, comprising the steps:

[0020] 1) Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder;

[0021] 2) place the calcium carbonate of recipe quantity in wet mixing granulator, add binding agent and make soft material;

[0022] 3) The soft material is granulated through a 10-30 mesh sieve;

[0023] 4) The granules are dried with hot air circulation at 40-70°C, and the moisture content is controlled below 1%;

[0024] 5) The vitamin D3 powder of the prescription amount is mixed with the added sorbitol, citric acid, aspartame, essence and fine particles (obtained from particle sieving in step 4) according to the equal dilution method, and the mixture is uniformly mixed with that in step 4) The obtained dry granules and magnesium stearate are blended together, and compressed into tablets.

[0025] In...

Embodiment 1

[0035] Mix by weight:

[0036]

[0037] Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder; place the prescribed amount of calcium carbonate in a wet mixing granulator, add binder to make soft material; pass the soft material through a 10-30 mesh sieve to granulate ;The granules are dried by hot air circulation at 40-70℃, and the water content is controlled below 1%; the prescribed amount of vitamin D3 powder is mixed with the added sorbitol, citric acid, aspartame, essence and fine granules according to the equal dilution method ; The mixture is blended with dry granules and magnesium stearate, and compressed into tablets.

Embodiment 2

[0039] Mix by weight:

[0040]

[0041] Dissolve part of sorbitol and pigment in an appropriate amount of purified water as a binder; place the prescribed amount of calcium carbonate in a wet mixing granulator, add binder to make soft material; pass the soft material through a 10-30 mesh sieve to granulate ;The granules are dried by hot air circulation at 40-70℃, and the water content is controlled below 1%; the prescribed amount of vitamin D3 powder is mixed with the added sorbitol, citric acid, aspartame, essence and fine granules according to the equal dilution method ; The mixture is blended with dry granules and magnesium stearate, and compressed into tablets.

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