68 results about "Diclofenac Acid" patented technology

The invention provides a sustained-release capsule of diclofenac potassium, which is an anti-inflammation and analgesic drug, and a production method thereof. The diclofenac potassium sustained-release capsule is produced by preparing diclofenac potassium into sustained-release pellets and then filling the pellets into the capsule; the diclofenac potassium sustained-release pellet consists of a blank pellet core, a main drug layer coated outside of the pellet core and containing diclofenac potassium and a sustained-release coating layer covered on the main drug layer. The diclofenac potassium sustained-release capsule of the invention has fine preparation stability and prominent release effect.

The present invention relates to reduction of side effects of diclofenac or a salt thereof An agent for reducing side effects of diclofenac or a salt thereof which comprises ornoprostil. It is expected that a combination agent of diclofenac or a non-toxic salt thereof and ornoprostil is comparable to even superior to marketed diclofenac tablets or Arthrotec tables in effects and fast-acting property while showing little side effects (particularly digestive disorders, gastric ulcer, diarrhea/vomiting and renal disorder) and exerting excellent antipyretic, analgesic and antiinlfammatory effects. Also, by formulating the combination agent into a preparation of separation type pharmaceutical preparation, the stability of ornoprostil can be improved.

The invention relates to a method for removing drugs in soil by utilizing magnetism molecular imprinting-electromagnetism grating combination. The drugs are one or more of carbamazepine, clofibric acid or diclofenac. The method comprises the following specific steps of: fully mixing preprocessed soil and a magnetism molecularly imprinted polymer, absorbing the drugs in the soil on the surface of the magnetism molecular imprinting, and separating the water soil and the magnetism molecularly imprinted polymer after reaction through an electromagnetism grid; and absorbing the magnetism molecular imprinting on the grid through a magnetic field generated by the electromagnetism grid after electrification, and effectively separating the magnetism molecular imprinting and the grid. The method provided by the invention has the advantages that the operation is simple, the effect is obvious, the arbamazepine, the clofibric acid and the diclofenac and the like in the soil are removed in one time, the drugs absorbed on the magnetism molecular imprinting are recovered and separated through the electromagnetism grid; a magnetism molecular imprinting technology is utilized to restore the soil polluted by the drugs and has the advantages that the cost is low, the restoring efficiency is high and the like; and an electromagnetism grid device is utilized to recycle the resources, so that secondary pollution is not caused.

The invention relates to matrix diclofenac potassium sustained-release pellet capsules and a production process thereof. The matrix diclofenac potassium sustained-release pellet capsules are prepared by filling matrix diclofenac potassium sustained-release pellets into gastric-soluble capsule shells. The matrix diclofenac potassium sustained-release pellets are prepared in one step by extrusion and rolling. The formula of the matrix diclofenac potassium sustained-release pellets comprises basic remedy diclofenac potassium 10-50%, matrix agent 1-20%, diluent 20-80%, antioxidant 0.1-5%, antisticking agent 0.1-5%, absorption promoting agent 1-10%, and any available wetting agent as balance, wherein the matrix agent is hydrophilic gel matrix agent, or hydrophilic gel matrix agent and erodiblematrix agent, or hydrophilic gel matrix agent and insoluble matrix agent. The matrix diclofenac potassium sustained-release pellet capsules provided by the invention have the advantages of high bioavailability, long in vivo holdup time, regular drug release, good in vivo (Beagle dogs) absorption and reproducibility, good sustained-release effect, simple production process, short production period, and no flying of dust during production, and are suitable for industrial production.

The invention discloses a deep processing method of wastewater during production of diclofenac. The deep processing method comprises the following steps of: pretreating (filtering and pH adjusting) wastewater during production of diclofenac, and forming a adsorbing gradient fluidized bed in an adsorption reaction tank by adopting an adsorption nanomaterial, so that organic matters in the wastewater during production of the diclofenac are adsorbed onto the nanomaterial; and adding a high polymer composite flocculant to carry out reinforced flocculation after the absorption is balanced, so that the nanomaterial forms a floc so as to achieve solid-liquid separation after precipitation, wherein the absorption nanomaterial is recycled after being regenerated through salt and alkali desorption. The COD (Chemical Oxygen Demand) Cr of the wastewater, during production of the diclofenac, treated by the deep processing method, can be reduced to be below 2000mg/L, the CODCr removal rate is more than 85 percent, and the vast majority of resources in the wastewater can be recycled. According to the deep processing method, wastewater processing and resource recycling can be synchronously carried out, and remarkable economical, social and environment benefits can be achieved.

The invention relates to a non-steroidal anti-inflammatory demulcent drug, which is a diclofenac epolamine gel preparation for relieving moderate pain in muscles, soft tissues and articulations. The gel preparation adopts 0.1-8.0 percent (weight percentage) of diclofenac epolamine as a main activated ingredient, 0-20 percent of grease, 0-5 percent of surfactant, 5-20 percent of cosolvent, a pH regulator, 5-20 percent of bacteriostat, 0.5-2.0 percent of gel substrate, etc. and purified water. PH value of the preparation is 6.0-8.0. The invention also provides a preparation method of the gel. The gel preparation of the invention has the advantages of good stability and good skin coupling effect, and can promote absorption of the skin to the drug and improve bioavailability and curative effect; at the same time, the substrate has stable property and no irritation to the skin, can be easily smeared and washed, has no greasiness, is beneficial to releasing of drug, especially water soluble drug and has good safety and clinical practicability.

The invention relates to a local application emplastrum with analgesic activity and simultaneously capability of enabling hematoma reabsorption, which comprises a basal layer, a pharmaceutically acceptable diclofenac salt, a hydrogel matrix form adhesion layer with heparin or heparitin, and a protective membrane capable of being removed in use.

The invention belongs to the technical field of pharmaceutical preparations for animals, and discloses a novel diclofenac injection and a preparation method thereof. The diclofenac injection comprisesdiclofenac existing in a dispersed form, diclofenac sodium dissolved in a system, a temperature-sensitive in-situ gel matrix, polyethylene glycol, sodium alginate, a polymer retardant and water for injection, wherein the temperature-sensitive in-situ gel matrix consists of poloxamer 407 and poloxamer 188. The diclofenac injection specifically comprises the following components in percentage by mass of 2-18 percent of the diclofenac, 0-8 percent of the diclofenac sodium, 10-25 percent of the poloxamer 407, 0.1-16 percent of the poloxamer 188, 0.1-7 percent of polyethylene glycol, 0.02-5 percent of sodium alginate, 0.01-5 percent of the polymer retardant, 0.001-2 percent of a bacteriostatic agent and the balance of the water for injection. According to the diclofenac injection disclosed bythe invention, the gelling temperature is 31-35 DEG C, the gelling time is within 15 seconds, the diclofenac injection exists in a liquid state at room temperature, and a gel storage can be quickly formed at an injection part during intramuscular injection or subcutaneous injection administration.

The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.

The invention belongs to the fields of natural medicines and medicine therapy, and discloses a conjugate containing diclofenac, a preparing method thereof and uses of the conjugate. The conjugate is formed by coupling glycyrrhetinic acid and the diclofenac and has a structure shown as a formula (I) as follows. The method includes reacting the glycyrrhetinic acid and the diclofenac in anhydrous dichloromethane at room temperature overnight under catalysis of pyridine and 4-dimethylaminopyridine, performing filtration, allowing a filtration product to pass through a silica gel chromatographic column, performing rotary evaporation, and performing drying treatment to obtain a product. In-vitro MTT detection experiments found that the conjugate has good inhibiting effects on tumor cell strains (MCF-7, BC-3 and HepG2 cells), the IC50 value of the conjugate is 3-4 times lower than that of the glycyrrhetinic acid, and the conjugate has low toxicity for normal liver cells L-O2. The compound can treat cancer in a manner that two medicine molecules are coupled to form a target prodrug, overcomes a problem that the glycyrrhetinic acid has low solubility, combines the diclofenac that is an anti-inflammatory drug to enhance anticancer activity, and achieves effects of removing cancer cells through a route of enhancing cell apoptosis.

The invention discloses a long-acting diclofenac transdermal patch and a preparation technology thereof and belongs to the technical field of medicine. The preparation is mainly prepared from a diclofenac bulk pharmaceutical chemical, a penetration enhancer, a dispersing solvent and a polyacrylate pressure-sensitive adhesive. The long-acting diclofenac transdermal patch and the preparation technology thereof have the following advantages: (1) the drug can be released from a matrix continuously for 12-48 h, the drug remaining amount is low, the percutaneous absorption is excellent, and the drug delivery times and dosage can be reduced; (2) a product has no skin irritation and has good adhesion and flexibility; (3) the main drug and the additives are stable in a viscose matrix; (4) the preparation technology is simple, convenient and pollution-free.

The synthesis and evaluation of gastroprotective effect of different tryptamine derivatives. Tryptamine derivatives have been synthesized by formation of amide or ester with some known anti oxidant molecules. These derivatives show excellent antioxidant property in vitro. Among all the derivatives the compound SEGA (3a), that was prepared by the combination of serotonin with gallic acid shows the greater antioxidant property than the other synthesized compounds both in vivo and in vitro. SEGA(3a) shows the gastroprotective effect against NSAIDs (indomethacin or diclofenac)-induced gastropathy in dose dependent manner and also accelerates the healing from injury. It prevents the NSAIDs-induced mitochondrial oxidative stress in vivo. This derivative prevents NSAID-induced mitochondrial oxidative stress-mediated apoptosis in vivo by preventing the activation of caspase 9 and caspase-3 and restores NSAIDs-mediated collapse of mitochondroial transmembrane potential and dehydrogenase activity. SEGA (3a) plays an important role as an iron chelator as well as intra mitochondrial ROS scavenger. Thus, SEGA (3a) is a potent antioxidant antiapototic molecule, which efficiently prevents NSAID-induced gastropathy and stress or alcohol-mediated gastric damage.

The invention belongs to the technical field of wastewater treatment and relates to a device and method for treating diclofenac wastewater in a low-temperature environment. A cathode bar (13) of the device is connected with a direct-current power supply (1) through a cathode wire (2), an anode plate (14) is connected with the upper end of a spiral coil (11) of an electromagnetic field generating device, the lower end of the spiral coil (11) of the electromagnetic field generating device is connected with the direct-current power supply (1) through an anode wire (3) and a slide resistor (22). The device is simple in structure and compact in arrangement and achieves the removal purpose through physical, chemical and biological treatment conducted on the diclofenac wastewater under the low-temperature condition.

The invention discloses a diclofenac-glycine-resveratrol conjugate, a preparation method and an application. The conjugate is formed by coupling glycine serving as a linking arm with diclofenac and resveratrol respectively; diclofenac and glycine are linked by an amido bond; a diclofenac-glycine conjugate is linked with resveratrol by multiple sites of ester bonds. Due to introduction of glycine,the solubility of the conjugate is increased, due to introduction of diclofenac and resveratrol, the anti-arthritis effect of the conjugate is significantly enhanced, adverse reactions are reduced, and safety is higher. The synthesis method of the conjugate is simple and suitable for industrial production.

An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

The invention discloses a method for removing diclofenac in sewage in a strengthened manner on the basis of enriched nitrifying bacteria. The method includes steps of 1), domesticating and enriching the nitrifying bacteria to obtain enriched and domesticated nitrifying sludge; 2), allowing the sewage to automatically flow into secondary sedimentation tanks and carrying out solid-liquid separation;3), carrying out sewage treatment on the enriched and domesticated nitrifying sludge in MBR (membrane bioreactor) devices; 4), analyzing treatment results for effluent. The method has the advantagesof simple equipment, simplicity and convenience in operation, low cost and the like. Besides, the method is free of pollution and high in stability; the diclofenac in the sewage can be effectively removed by the aid of the method, accordingly, the requirements on sewage discharge can be met, environmental pollution can be prevented, and economic treatment effects can be realized; the shortcomingsof existing purification processes can be overcome by the aid of the method, the shortcomings of poor diclofenac removal effects and instable operation in the prior art can be overcome by the aid of the method, and gap of domestic and overseas related technologies for removing diclofenac in water sources can be filled.

The novel positively charged pro-drugs of diclofenac in the general formula(1) 'Structure 1' were designed and synthesized. The compounds of the general formula(1) 'Structure 1' indicated above can be prepared from functional derivatives of diclofenac (for example acid halides or mixed anhydrides), by reaction with suitable alcohols, thiols, or amines. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs in water, but also bonds to the negative charge on the phosphate head group of membranes and push the pro-drug into the cytosol. The experiment results suggest that the pro-drug, diethylaminoethyl 2[(2,6-dichlorophenyl)amino]benzene acetate.AcOH diffuses through human skin ~250 times faster than do 2[(2,6-dichlorophenyl)amino]benzene acetic acid (diclofenac) and ethyl 2[(2,6-dichlorophenyl)amino]benzene acetate. In plasma, more than 90% of these pro-drugs can change back to the drug in a few minutes. The prodrugs can be used medicinally in treating any diclofenac-treatable conditions in humans or animals and be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of diclofenac, most notably GI disturbances such as dyspepsia, gastroduodenal bleeding, gastric ulcerations, and gastritis. Controlled transdermal administration systems of the prodrug enables the diclofenac to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of diclofenac.

The present disclosure provides an external preparation comprising lactic acid salt of lidocaine and diclofenac or a salt thereof, wherein lactic acid salt of lidocaine is contained in an amount of 2-5 moles per mole of diclofenac or a salt thereof, which exhibits the improved transdermal absorbability of lidocaine and diclofenac which are active ingredients as well as the skin permeability suitable for clinical use.