Aceclofenac preparation method

A technology of aceclofenac and acid hydrolysis, which is applied in the preparation of organic compounds, chemical instruments and methods, and preparation of cyanide reactions, etc., can solve the problems of poor purity of crude products, difficulty in controlling the degree of acid hydrolysis, and difficulty in obtaining it. Achieve the effect of high selectivity, high conversion rate and easy refining
CN103086907AActive Publication Date: 2013-05-08HENAN DONGTAI PHARM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HENAN DONGTAI PHARM
Publication Date
2013-05-08

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Abstract

The invention relates to an aceclofenac preparation method and belongs to the chemical pharmaceutical field. The method comprises a step that acidolysis of aceclofenac tert-butyl ester is carried out in a mixed solution comprising a low-molecular-weight organic acid and hydrogen halide to obtain aceclofenac. The method which allows the acidolysis of aceclofenac tert-butyl ester to be carried out in the mixed solution comprising the low-molecular-weight organic acid and hydrogen halide has the advantages of high selectivity, reduction of the fracture of the ethoxy group in aceclofenac tert-butyl ester to a lowest limit, high acidolysis reaction conversion rate, extremely-low content of diclofenac in obtained aceclofenac, easy aceclofenac refining, and high aceclofenac purity.
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Description

technical field

[0001] The invention relates to a preparation method of an anti-inflammatory and analgesic drug, in particular to a preparation method of aceclofenac, which belongs to the field of chemical pharmacy. Background technique

[0002] Aceclofenac, chemical name is 2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid, English name: Aceclofenac, structural formula is:

[0003]

[0004] This product is a newly synthesized orally effective non-steroidal anti-inflammatory analgesic (NSAIDs), which belongs to the phenylacetic acid anti-inflammatory, antipyretic and analgesic drugs. In structure, it is similar to diclofenac, aclofenac and fenclofenac In clinical practice, compared with other non-steroidal drugs (NSAIDs) in its pharmacological effects, it has a wide range of anti-inflammatory effects, strong analgesic and antipyretic effects, and gastric Toxic effect is characteristic, and the preparation method of aceclofenac reported in the literature mostly uses d...

Claims

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