Long-acting diclofenac transdermal patch and preparation technology thereof
A technology of diclofenac and transdermal patch, which is applied in the field of medicine, and can solve problems such as ready-to-use, lower drug transdermal penetration rate, and pressure-sensitive adhesives that cannot be prepared in advance.
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Embodiment 1
[0037] Embodiment 1: Preparation of long-acting diclofenac patch, drug content per unit area: 2.00mg / cm 2
[0038]
[0039] Preparation process: Precisely weigh diclofenac and add it to a mixed solution of acetone and water to fully dissolve it, add menthol, macrogol glyceride oleate and propylene glycol, shake and mix well. Pour the above mixture into the pressure sensitive adhesive base and stir well. Mix ultrasonically for 20 min until there are no bubbles. Pour the drug glue mixture into a suitable applicator, pull it slowly at a constant speed on the side of the release film with silicone oil, so that the drug glue mixture is evenly coated on the release film, dry at 70°C for 20 minutes, take it out, and attach the backing lining.
Embodiment 2
[0040] Embodiment 2: Preparation of long-acting diclofenac sodium patch, drug content per unit area: 1.00mg / cm 2
[0041]
[0042] Preparation process: Precisely weigh diclofenac sodium and add it to a mixed solution of acetone and water to fully dissolve it, add peppermint oil, oleic acid and azone, shake and mix well. Pour the above mixture into the pressure sensitive adhesive base and stir well. Mix ultrasonically for 20 min until there are no bubbles. Pour the drug glue mixture into a suitable applicator, pull it slowly at a constant speed on the side of the release film with silicone oil, so that the drug glue mixture is evenly coated on the release film, dry at 70°C for 20 minutes, take it out, and attach the backing lining.
Embodiment 3
[0043] Embodiment 3: Preparation of long-acting diclofenac potassium patch, drug content per unit area: 0.50mg / cm 2
[0044]
[0045] Preparation process: Accurately weigh an appropriate amount of diclofenac potassium and add it to a mixed solution of ethanol and water to fully dissolve it, add menthol, caprylic acid macrogol glyceride and isopropanol, shake and mix well. Pour the above mixture into the pressure sensitive adhesive base and stir well. Mix ultrasonically for 20 min until there are no bubbles. Pour the drug glue mixture into a suitable applicator, pull it slowly at a constant speed on the side of the release film with silicone oil, so that the drug glue mixture is evenly coated on the release film, dry at 70°C for 20 minutes, take it out, and attach the backing lining.
PUM
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