Anti-candidiasis albrican cream and preparation method thereof

A technology of cream and cocci, which is applied in the field of anti-candida cream and its preparation, can solve the problems of high toxicity and cannot be used as the first choice for people's long-term medication, and achieve high water content, hinder water evaporation, and increase hydration Effect

Inactive Publication Date: 2009-09-02
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can effectively treat diseases, they are highly toxic and cannot be used as the first choice for people's long-term medication.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Add 1.5% western medicine to dimethyl sulfoxide, put in a water bath at 70°C to 80°C and stir to melt, then add 12% white petrolatum, 11% stearyl alcohol, and 4% glyceryl monostearate and stir to dissolve Form an oily solution and keep the temperature at 70°C to 80°C. Add 4.5% traditional Chinese medicine extract into distilled water, heat and stir to dissolve, then add 12% glycerin, 6% Tween-80, 0.5% sodium benzoate, put in a water bath at 70°C to 80°C and stir to dissolve, finally add 20% urea and stir Evenly, keep the temperature 70 ℃ ~ 80 ℃. Make the temperature of the water phase slightly higher than that of the oil phase, and at the same time slowly add the water phase into the oil phase, stir while adding, at a speed of 800-1000rpm / min, stir for 30 minutes to complete the emulsification, stir until cold, and the product is ready. After testing, the cold-resistant, heat-resistant and centrifugal tests of the cream are all qualified.

Embodiment 2

[0028] Example 2: Add 1% western medicine to dimethyl sulfoxide, put in a water bath at 70°C to 80°C and stir to melt, then add 8% white petrolatum, 7% stearyl alcohol, and 4% glyceryl monostearate and stir to dissolve Form an oily solution and keep the temperature at 70°C to 80°C. Add 3% traditional Chinese medicine extract into distilled water, heat and stir to dissolve, then add 12% glycerin, 6% Tween 80, 0.5% sodium benzoate, put in a water bath at 70°C to 80°C and stir to dissolve, finally add 20% urea and stir well , keep the temperature 70 ℃ ~ 80 ℃. Make the temperature of the water phase slightly higher than that of the oil phase, and at the same time slowly add the water phase into the oil phase, stir while adding, at a speed of 800-1000rpm / min, stir for 30 minutes to complete the emulsification, stir until cold, and the product is ready. After testing, the cold-resistant, heat-resistant and centrifugal tests of the cream are all qualified.

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PUM

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Abstract

The invention relates to Chinese and western medicament compound cream for preventing and treating onychomycosis infected by candidiasis albrican and a preparation method thereof. The cream is yellow cream formed by evenly dispersing mixture of a Chinese medicament extract and a western medicament in a substrate by use of the action of a mixed emulsifying agent. The cream prepared by the method has the advantages of even dispersed main medicament, even and smooth cream, proper viscosity, as long as easily coating on skin, mucous membrane and wound surface, and meeting the requirement of Chinese pharmacopoeia with controllable quality. Pharmacodynamic research proves that the cream has actions of preventing and treating the onychomycosis infected by Candida albicans, and has assistant treatment action on secondary inflammation because of mycotic infection, such as whitlow.

Description

technical field [0001] The invention relates to an anti-candida cream and a preparation method thereof, in particular to a traditional Chinese and western medicine compound cream for preventing and treating onychomycosis caused by candida infection and a preparation method thereof. Background technique [0002] Candidiasis (Cyathula officinalis Kuan) is a fungal disease caused by Candida, especially Candida albicans. The pathogen can invade the skin and mucous membranes as well as viscera. The majority of candidiasis is caused by endogenous or exogenous infection, and with the advancement of modern medicine, various organ transplants, cardiac surgery and various catheter techniques have made the incidence of this disease obvious. Upward trend. At present, antifungal drugs such as nystatin, amphotericin B, ketoconazole, and itraconazole are mostly used for the treatment of candidiasis. Although these drugs can effectively treat diseases, their toxicity is relatively large,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/06A61K47/34A61K47/16A61P31/10A61P17/00A61K31/4174A61K47/26
Inventor 殷中琼魏琴贾仁勇
Owner SICHUAN AGRI UNIV
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