Linoleic acid modified glucan and preparation method of high-molecular liposome

A technology of linoleic acid and dextran, which is applied in the field of medicine, can solve the problems of poor biocompatibility, average transdermal effect, and high cytotoxicity, and achieve good stability, good transdermal performance, and reduced cytotoxicity. Effect

Inactive Publication Date: 2014-02-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The emergence of polymer vesicles based on amphiphilic polymers, that is, polymer liposomes, has effectively solved some of the shortcomings of traditional liposomes, but the transdermal effect of most existing polymer liposomes is general, and because of Material inherent issues tend to have higher cytotoxicity and poorer biocompatibility

Method used

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Examples

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Embodiment 1

[0030] Synthesis of linoleic acid modified dextran. Take 1g of dextran with a molecular weight of 5000, 3g of linoleic acid and add them into a beaker, then add 182mL of dimethyl sulfoxide solvent, 0.6g of EDC and 0.15g of DMAP into the beaker, stir magnetically, and react at room temperature for 3 hours. After the reaction, put the product into a dialysis bag with a molecular weight of 1000 for dialysis for 3 days, and freeze-dry to obtain linoleic acid-modified dextran. Such as figure 1 As shown in the 1H-NMR analysis results, 0.8ppm and 1.2ppm are the characteristic absorption peaks of —CH3 and —CH2 in linoleic acid respectively, indicating that the linoleic acid modified dextran was successfully synthesized.

Embodiment 2

[0032] Synthesis of linoleic acid modified dextran. Take 5 g of dextran with a molecular weight of 20,000 and 1 g of linoleic acid into a beaker, then add 45 mL of dimethyl sulfoxide solvent, 1 g of EDC and 0.5 g of DMAP into the beaker, stir magnetically, and react at room temperature for 12 hours. After the reaction, put the product into a dialysis bag with a molecular weight of 5000 for dialysis for 10 days, and freeze-dry to obtain linoleic acid-modified dextran.

Embodiment 3

[0034] Synthesis of linoleic acid modified dextran. Add 1 g of dextran with a molecular weight of 10,000 and 1 g of linoleic acid into a beaker, then add 100 mL of dimethyl sulfoxide solvent, 0.5 g of EDC and 0.2 g of DMAP into the beaker, stir magnetically, and react at room temperature for 8 hours. After the reaction, put the product into a dialysis bag with a molecular weight of 3500 for dialysis for 7 days, and freeze-dry to obtain linoleic acid-modified dextran.

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Abstract

The invention relates to linoleic acid modified glucan and a preparation method of a polymeric liposome. Glucan reacts with linoleic acid to form an amphiphilic high-molecular linoleic acid modified glucan. Then the linoleic acid modified glucan is dissolved in dichloromethane, and prepared into high-molecular liposome according to a reverse evaporation method.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a linoleic acid-modified dextran and a method for preparing polymer liposomes. Background technique [0002] The drug delivery system refers to the use of modern preparation technology or the use of special materials to disperse the drug in a special, complex and ingenious system, in order to achieve the purpose of releasing the drug in the expected manner and rate and delivering it to the desired site or target. Drug delivery system (drug delivery system) is referred to as DDS, also known as new dosage form or modern drug dosage form. [0003] Among them, the transdermal drug delivery system is an important branch of the drug delivery system, which refers to a drug delivery system that enters the body circulation through the skin at a certain rate to produce a therapeutic effect. A well-designed transdermal drug delivery system can effectively control the amount of drug enter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02A61K47/36A61K9/127
Inventor 常津宋昊王生
Owner TIANJIN UNIV
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