61 results about "GLYCERYL OLEATE" patented technology

The invention provides a preparation method of a low-sulfur diesel oil anti-wear agent, and belongs to the technical field of carbon-containing fuel processing, and the preparation method comprises the following steps: adding sodium oleate, tetrabutylammonium bromide and xylene into a three-necked flask, uniformly stirring and mixing, heating, dropwise adding 3-chloro-1, 2-propylene glycol, continuously heating until reflux, centrifuging, and carrying out rotary evaporation to obtain glyceryl monooleate; the preparation method comprises the following steps: dispersing NCC in xylene, adding lauric acid and p-toluenesulfonic acid, and carrying out heating, reflux reaction, cooling, centrifugation, washing and drying under the protection of an inert atmosphere to obtain modified NCC; the preparation method comprises the following steps: heating and melting glyceryl monooleate, adding silane modified silicon dioxide, stirring, carrying out ultrasonic treatment, cooling to obtain a modified nano-composite, adding the modified NCC and a stabilizer, stirring, and carrying out ultrasonic uniform mixing to obtain the low-sulfur diesel oil anti-wear agent. The diesel oil anti-wear agent provided by the invention can improve the wear resistance of diesel oil under the condition that the addition amount is relatively low, and improve the low-temperature fluidity and demulsifying performance.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The application relates to the technical field of inks, and discloses a long-acting coagulation ink formula, a preparation method and application, the ink comprising a water-based polyurethane emulsion, pigments, a defoaming agent and a dispersing agent; the water-based polyurethane emulsion formula is polytetrahydrofuran glycol, glycerol monooleate, isophorone diisocyanate, a chain extender and a hindered phenol crosslinking agent; the hindered phenol crosslinking agent is prepared and introduced into a molecular chain segment of the water-based polyurethane binder, linear water-based polyurethane macromolecules are linked in the form of chemical bonds, a crosslinked network structure is formed, molecular chain movement is limited, aggregation is not easy, gel during storage can be reduced, and the hindered phenol is linked to the polyurethane molecular chain through chemical bonds, free radicals are captured by the hindered phenol groups, and the phenomenon of ink skinning, gelation and coagulation of the polyurethane ink caused by oxidation during storage and use is avoided; the ink has excellent stability, adhesion, skinning resistance, rubbing resistance and alcohol resistance.

The application discloses a 100% natural source reverse micelle essential oil and a preparation method thereof, and the preparation raw materials comprise 0.6-13 parts of emulsifiers and 20-100 parts of natural source oils in terms of mass fraction. The combination of PCA glyceryl oleate and polyglycerol nonionic surfactants has a mass ratio of (0.5-0.8):(2-2.5), and the combination of polyglyceryl-2 isostearate and polyglyceryl-4 oleate has a mass ratio of (1-1.5):(0.8-1), so that the reverse micelle essential oil can be constructed, the essential oil has the advantages that the essential oil is skin-friendly and non-greasy, can be compatible with hydrophilic active ingredients and oleophilic active ingredients, and can effectively moisturize and nourish the skin.

The application discloses a refining method of glyceryl oleate series products. The glyceryl oleate mixture is used as raw material, the mixture is melted by heating, then the melted liquid is flowed through a panel containing different temperature zones, and crystals are separated in the corresponding temperature zones by using the difference of solidification points of different components, so that glyceryl monooleate, glycerol, glyceryl dioleate and glyceryl trioleate are obtained respectively. The separation of each component in the glyceryl oleate mixture is realized. The method does not introduce solvent and adsorbent, is green and environment-friendly, and the obtained products can meet the demand of high-purity glyceryl monooleate and glyceryl dioleate for biological products.

The invention belongs to the technical field of metal monatomic catalysis, and discloses an application of a metal monatomic catalyst in catalysis of cleavage reaction of glyceryl oleate. The metal monatomic catalyst is prepared by taking a metal organic framework material as a precursor and zinc, copper, magnesium and cobalt as metals. The metal monatomic catalyst disclosed by the invention is relatively high in catalytic activity, and the selectivity of long-chain alkane or olefin in the generated product is relatively high, so that the condensation point of the product can be reduced, and the low-temperature fluidity of the product can be improved.

The invention belongs to the field of pharmaceutical preparations, and provides an assembly material for indissolvable active transdermal mucosal drug delivery and a preparation method thereof. According to the invention, lipid cubic-phase nanoparticles composed of glyceryl monooleate, cholesterol, glycerol dioleate and caprylic / capric triglyceride are adopted, the design of DSPE-PEG2000 surface stability and ion coordinated regulation is combined, and high drug loading capacity and nanoscale particle size control are realized through a continuous process of melting, hydration, high-pressure homogenization and cubic-phase curing surface treatment. The preparation method solves the technical problems that high loading capacity of insoluble active ingredients and long-term colloidal stability are difficult to consider, cubic phase structure stability and surface charge controllability are contradictory in a tissue-friendly environment, and high drug loading capacity and devitrification prevention are difficult to couple under a low-temperature processing window, and has wide application value in the field of transdermal and mucosal local drug delivery.

A metal oxide dispersion composition with excellent stability over time, excellent non-stickiness, and good usability is provided. This metal oxide dispersion composition contains the following components (A) to (C): (A) polyhydroxystearic acid, (B) silicone-treated metal oxide, and (C) glyceryl oleate, wherein the metal oxide of component (B) is a metal oxide other than titanium dioxide.

This invention provides viscose macrobiofibers containing antioxidant active components and a method for preparing them. [Solution] The viscose macrobio fiber prepared by reacting raw materials by weight of 20-24 parts COFs carrier, 5-8 parts plant-derived antioxidant active component, 200-240 parts spinning solution, 2-4 parts sodium dodecyl sulfate, 2-4 parts glyceryl monooleate, 3-5 parts cyclodextrin, 2-4 parts titanium dioxide, and 3-5 parts silane coupling agent, has the antioxidant active component attached to the COFs carrier during the preparation process. In the prepared viscose macrobio fiber, the COFs carrier functions as the backbone of the viscose macrobio fiber, and the ends of the COFs carrier are exposed to or close to the surface of the viscose macrobio fiber. The antioxidant active component on the COFs carrier is easily transferred to the surface of the fiber, and the viscose macrobio fiber has a good antioxidant effect.

The invention discloses a scraping massage cream for dredging meridians and collaterals and a use method thereof, and particularly relates to the technical field of scraping massage cream, the scraping massage cream for dredging meridians and collaterals comprises the following raw materials by weight: 5-15 parts of crocus sativus oil, 3-10 parts of ginger root oil, 8-20 parts of holly essential oil, 10-30 parts of a polygonum cuspidatum extract, 40-60 parts of matrix oil, 3-8 parts of an emulsifier, and 0.5-2 parts of a preservative. According to the scraping massage cream capable of dredging the channels and collaterals and the use method of the scraping massage cream, the transdermal enhancer composed of azone and glyceryl oleate is added, and a special preparation process of the polygonum cuspidatum extract is adopted, so that the transdermal absorption rate of the massage cream is remarkably increased, and the transdermal permeability coefficient is increased to 2.78 * 10 <-3 > cm / h and is greatly increased compared with 1.12 * 10 <-3 > of a control group; active ingredients can be effectively transmitted to muscles and meridians and collaterals, natural vegetable oil is adopted as base oil, and the kinematic viscosity of the base oil is controlled within a proper range.

The invention provides a silicon nitride green body and a preparation method and application thereof.The silicon nitride green body comprises silicon nitride powder, a penetrating agent and a wetting agent, the penetrating agent comprises at least one of fatty alcohol-polyoxyethylene ether and nonylphenol polyoxyethylene ether, the wetting agent comprises at least one of glyceryl trioleate, glyceryl monooleate and polyoxyethylene ester, and the silicon nitride green body comprises silicon nitride powder, silicon nitride powder and silicon nitride powder. The total mass of the wetting agent and the penetrating agent is greater than or equal to 1% of the mass of the silicon nitride powder. Due to the special composition of the silicon nitride green body, the problems of warping, wrinkling and cracking can be effectively reduced while the high solid content is maintained.

The invention relates to the technical field of pharmaceutical preparations, in particular to a self-nano-emulsification drug delivery system as well as a preparation method and related application thereof. The self-nano emulsifying composition comprises total glucosides of paeony, dihydroartemisinin and auxiliary materials, the auxiliary materials comprise, by mass, 10-45% of an oil phase, 20-68% of RH40 and 12-72% of ethyl alcohol, and the oil phase comprises glyceryl monooleate and medium chain triglyceride. Compared with the prior art, the self-nano-emulsion composition provided by the embodiment of the invention carries total glucosides of paeony and hydrophobic dihydroartemisinin together, realizes simultaneous administration of water-insoluble components and water-soluble components, and improves bioavailability.

This invention discloses a universal method and composition for solving the pilling problem in cold-formulated cosmetics. Adding an effective amount of glyceryl oleate, citrate / caprylic / capric triglyceride to a cosmetic composition containing a pilling-prone cold-formulated emulsifier can significantly reduce or eliminate pilling. This substance has been discovered for the first time to have a novel anti-pilling application, effective against pilling caused by the emulsifier's own characteristics, high dosage, electrolyte interference, or the addition of large molecules, and is universally applicable to different types of cold-formulated emulsifier systems. This invention is particularly suitable for systems using electrolyte-rich natural plant extracts as the aqueous phase, fundamentally solving the pilling problem and providing a reliable solution for preparing high-feel, all-natural cold-formulated cosmetics.

According to the cyclic carbonated glyceryl monooleate and the preparation method thereof provided by the invention, the cyclic carbonated design of glyceryl monooleate and dimethyl carbonate under the catalysis of organic base is adopted, and coordinated regulation and control of an acid value, a zinc form and a carbonic acid esterification degree are realized through a zinc complexing intermediate strategy; the esterification degree of carbonic acid of the product reaches 0.70-0.80, the acid value is controlled to be 0.02-0.10 mgKOH / g, the mass fraction of zinc carboxylate in the total zinc is not lower than 80%, the viscosity at 40 DEG C is 100-800 mPa.s, gelling can be achieved within 24 hours under the condition of 25-40 DEG C when the product reacts with aliphatic diamine, and the product has the advantages of being high in stability, good in stability and good in stability. The invention solves the contradiction between the processing fluidity and room temperature curing rate of the non-isocyanate polyurethane precursor, between the green mild process and narrow-range structure control, and between the zinc complexing stability and low metal residue appeal, and has wide application value in the fields of environment-friendly polyurethane coatings, adhesives, sealants and the like.

The application belongs to the technical field of lubricating oil, and particularly relates to an environment-friendly wear-resistant lubricating oil and a preparation method thereof. The environment-friendly wear-resistant lubricating oil comprises the following components in parts by weight: base oil 50-70 parts; poly-A olefin 60-80 parts; lanthanum dialkyldithiophosphate 2-4 parts; boron nitride@MoS2 composite material 0.5-1.5 parts; dimer acid and glycerol monooleate co-modified cerium oxide 1-3 parts; antioxidant 3-5 parts; preservative 2-4 parts; and silane coupling agent 1-3 parts. The environment-friendly wear-resistant lubricating oil prepared by the application has excellent wear resistance and relatively strong adaptability by adding the boron nitride@MoS2 composite material and cooperating with the modified cerium oxide and other materials.

The invention relates to the technical field of biological medicine, in particular to pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles as well as a preparation method and application thereof. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles comprise the following components: glyceryl monooleate, polyethylene glycol 400, poloxamer 407, D (+)-glucose and pogostemon cablin alcohol. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticle is of a core-shell structure, a shell is of a skeleton structure jointly formed by the glyceryl monooleate, the polyethylene glycol 400, the poloxamer 407 and the D (+)-glucose, and a core is the pogostemon cablin alcohol. The patchouli alcohol lipid cubic liquid crystal nanoparticles are good in in-vitro stability, have a slow release effect compared with free drugs, and have good development and application prospects in the field of chemotherapeutic intestinal injury treatment.

The application belongs to the technical field of surface treatment of silicon nitride fibers, and particularly relates to a surface treatment agent for silicon nitride fibers, a preparation method and application thereof. The raw materials of the surface treatment agent include 20-40 parts of polytetrafluoroethylene, 4-12 parts of an impregnating agent and 4-12 parts of a lubricant. The lubricant is selected from one or more of polyethylene wax, silicone oil, dimethyl silicone oil, polyphthalamide, trimethylolpropane oleate, glycerol trioleate, isooctyl acrylate and isooctyl methacrylate. The surface treatment agent prepared by the application can effectively act on the silicon nitride fibers under the synergistic effect of the lubricant and the impregnating agent. After secondary sizing, the bundle property, wear resistance, stiffness and bending resistance of the silicon nitride fibers are improved, the weaving performance requirements of the silicon nitride fibers are met, the process is simple, the cost is low, the application is suitable for industrial production, and the application can be widely applied.

The invention belongs to the technical field of lubricating oil, and particularly relates to environment-friendly wear-resistant lubricating oil and a preparation method thereof. The lubricating oil composition comprises the following components in parts by weight: 50-70 parts of base oil; 60 to 80 parts of poly A olefin; 2 to 4 parts of lanthanum dialkyl dithiophosphate; 0.5 to 1.5 parts of a boron nitride MoS2 composite material; 1-3 parts of dimer acid and glyceryl monooleate co-modified cerium oxide; 3-5 parts of an antioxidant; 2-4 parts of a preservative; and 1-3 parts of a silane coupling agent. According to the environment-friendly wear-resistant lubricating oil disclosed by the invention, the boron nitride MoS2 composite material is added and matched with materials such as modified cerium oxide, so that the prepared environment-friendly wear-resistant lubricating oil has excellent wear resistance and relatively high adaptability.

The invention relates to high-water-solubility compound sulfachlorpyridazine sodium powder, which is mainly prepared from the following raw materials in percentage by weight: 55 to 65 percent of sulfachlorpyridazine sodium, 10 to 15 percent of trimethoprim, 15 to 25 percent of hydroxypropyl-beta-cyclodextrin, 3 to 8 percent of polyvinylpyrrolidone, 0.02 to 0.05 percent of xanthan gum, 0.1 to 0.3 percent of sodium alginate, 0.5 to 1.0 percent of glyceryl monooleate and the balance of water. And 1-2% of citric acid-sodium citrate buffer salt. The compound sulfachlorpyridazine sodium powder can significantly improve the solubility and dissolution rate of TMP in water, improve the absorption synchronism of sulfachlorpyridazine sodium and TMP in animal bodies, enhance the physical stability of a preparation, prevent precipitation after storage and dissolution, effectively cover the bitter taste of TMP, and improve the palatability of drinking water for livestock and poultry.

The invention discloses a lipid liquid crystal and application of the lipid liquid crystal in controlled release of anthocyanin. The lipid liquid crystal is prepared from an oil phase, anthocyanin and water, wherein the oil phase is prepared from glyceryl monolinoleate, glyceryl monooleate, mannosylerythritol lipid and linoleic acid; wherein the oil phase part contains the following components in percentage by mass: 1.0-3.6% of linoleic acid and the balance of a mixture of glyceryl monolinoleate, glyceryl monooleate and mannosylerythritol lipid, and the mass ratio of the glyceryl monolinoleate to the glyceryl monooleate to the mannosylerythritol lipid is 8.5: 1: 0.5; 25-40% of an aqueous solution containing anthocyanin; the change of the crystal form structure of the lipid liquid crystal is induced by adjusting the pH condition to control the release rate difference of the anthocyanin, so that the controlled release is realized. The lipid liquid crystals of the present invention are particularly suited for shipping and targeted delivery of anthocyanins.

This invention belongs to the field of pharmaceutical formulations and provides an assembly material and preparation method for transdermal and mucosal drug delivery of poorly soluble active ingredients. The invention utilizes lipid cubic phase nanoparticles composed of monooleate glycerol, cholesterol, dioleate glycerol, and caprylic / capric triglycerides. Combined with the surface stabilization and ion-synergistic regulation design of DSPE-PEG2000, a continuous process of melting-hydration-high pressure homogenization-cubic phase curing surface treatment is employed to achieve high drug loading and nanoscale particle size control. This invention solves the technical problems of balancing high loading of poorly soluble active ingredients with long-term colloidal stability, the contradiction between cubic phase structure stability and surface charge controllability in tissue-friendly environments, and the difficulty of achieving high drug loading and preventing crystallization coupling under low-temperature processing windows. It has broad application value in the fields of transdermal and mucosal local drug delivery.

The invention discloses a positive ion saliva metabolite marker related to brain glioma, a product and application of the positive ion saliva metabolite marker, and relates to the field of biological medicine. The positive ion saliva metabolite marker is prepared from one or more of glyceryl monolinoleate, 1-palmitic acid-2-oleic acid-3-linoleic acid glyceryl, 2, 6-dimethoxyphenol, 20-hydroxyarachidonic acid, 3, 5-dihydroxybenzyl alcohol, rapeseed sterol, histidyl alanyl lysine, pethidine and palmitoleic acid glycolamide. The invention provides a kit which comprises a detection reagent for detecting the positive ion saliva metabolite marker. The invention provides a computer program product related to brain glioma. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of brain glioma, and provides a new tool for clinical diagnosis.

The invention belongs to the technical field of nucleotide compositions, and relates to an anti-aging enhanced PDRN compound composition and a preparation method thereof, and the preparation method comprises the following steps: preparing a high-stability PDRN compound; preparing an anti-aging enhanced liquid crystal oil phase carrier; and assembling the PDRN water phase solution and the liquid crystal oil phase solution. The preparation method comprises the following steps: mixing glyceryl monooleate, cetyl-PG hydroxyethyl palmitamide and behenyl alcohol, heating, cooling, adding capryloyl salicylic acid and a beta-glucan-pterostilbene solution, uniformly mixing, cooling at a constant speed, preliminarily forming a lamellar liquid crystal oil phase in the solution, and quenching to shape a liquid crystal structure, so as to obtain the liquid crystal composition. The prepared liquid crystal oil phase enables a subsequent water-in-oil system to have high stability, cetyl-PG hydroxyethyl palmitamide and capryloyl salicylic acid can synergistically increase the transdermal rate of the water-in-oil system, and pterostilbene and beta-glucan can enhance the slow release stability of the system and can synergistically improve the anti-aging ability of the PDRN composite composition to the skin.

The invention discloses a skin wound nursing ointment based on fish scale gelatin and a preparation method thereof, particularly relates to the technical field of skin nursing, and relates to the skin wound nursing ointment based on the fish scale gelatin and the preparation method thereof. The skin wound nursing ointment based on the fish scale gelatin is prepared from glyceryl monooleate, deionized water, docosyl, Span 60, a fish scale gelatin protein extract, an antibacterial component extract and sodium silicate. According to the method, the fish scale collagen is subjected to directional enzymolysis under the low-temperature condition by adopting the restrictive endonuclease extracted from deep-sea psychrophilic bacteria, the collagen peptide with the ultra-small molecular weight is accurately prepared, the active peptide fragments have excellent cell permeability and migration guiding capacity, the wound healing speed is remarkably increased, and the treatment effect is remarkably improved.

To provide a metal oxide dispersion composition which has excellent stability over time, excellent non-stickiness, and good usability. The following components (A) to (C): (A) Polyhydroxystearic acid (B) Silicone-treated metal oxide (C) Glyceryl oleate wherein the metal oxide of component (B) is a metal oxide other than titanium oxide.

The invention relates to a preparation method of high-performance modified silicon carbide, and belongs to the technical field of silicon carbide ceramic, the preparation method comprises the following steps: S1, dispersing silicon carbide powder into deionized water, adding a fatty glyceride modifier, and uniformly mixing to obtain silicon carbide slurry; s2, performing ultrasonic treatment, solid-liquid separation and heat treatment curing on the silicon carbide slurry to obtain modified silicon carbide. The fatty glyceride modifier is at least one of monopalmityl glyceride, diglyceride, glyceryl monooleate, glyceryl dioleate and glyceryl monostearate. The preparation method disclosed by the invention is simple in process, low in energy consumption and low in production cost, an organic silicon dispersing agent does not need to be additionally added into the product, the pH value of a modified system is neutral, and the process is environment-friendly and green. Slurry prepared from the prepared silicon carbide modified powder is high in solid content, low in viscosity and good in stability.

The application belongs to the technical field of lubricating grease, and particularly relates to a kind of lubricating grease and its preparation method and application. The components of the lubricating grease include, by weight, 100 parts of base oil; 25-35 parts of thickening agent; 4-8 parts of OD modified h-BN; 2-4 parts of monolein glyceride modified MoS2@ laminated mica; 3-5 parts of anti-rust agent; 0.4-0.8 parts of antioxidant; and 1-3 parts of dispersant. The application improves the dispersibility and stability of h-BN and MoS2@ laminated mica in the lubricating grease by using OD modified h-BN and monolein glyceride modified MoS2@ laminated mica, and the components cooperate with each other to promote the lubricating grease to have excellent wear resistance and other properties.

The invention relates to the technical field of biology, and particularly provides a lipid nanoparticle editing system and pharmaceutical application thereof. The system comprises (a) LNP formed by compounding cationic lipid RD007, 1, 2-dioleoyl-3-trimethyl ammonium-propane, glyceryl oleate, DMG-PEG2000 and DMG-PEG2000-MAL and mRNA capable of compositely coding dCas9-DNMT3A, (b) lipid nanoparticles formed by coupling a macrophage surface marker F4 / 80 antibody and the LNP and specifically targeting macrophages, and (c) the LNP has the characteristic of high expression in lung tissues. The system disclosed by the invention can be used for preparing a drug and delivering the nano editing system to lung macrophages in a targeting manner, so that dCas9-DNMT3A expression is realized, epigenetic silencing is induced, macrophage metabolism is reprogrammed, pathogenic gene expression is reduced, and the purpose of treating lung fibrosis diseases is achieved.

FIELD: cosmetics.SUBSTANCE: cosmetic composition in the form of a cream-gel for skin cleansing contains purified water; an emulsifier consisting of cetyl alcohol, glyceryl stearate, PEG-75 stearate, ceteth-20 and steareth-20; glycerin; coco-glucoside; a co-surfactant consisting of purified water, glyceryl oleate and coco-glucoside; cetearyl alcohol; caprylic / capric triglyceride; panthenol; butylene glycol; squalane; oat extract; sodium acrylate / sodium acryloyldimethyl taurate copolymer; cocamidopropyl betaine; cholesterol; ceramide complex including: ceramides NP, AP, AS, NG, glycosphingolipids, hydrogenated lecithin and auxiliary components; fructooligosaccharides; hydroxyacetophenone; preservative consisting of 1,2-hexanediol and caprylyl glycol; tocopheryl acetate; fragrance; arginine and disodium EDTA, in a certain ratio of components, wt.%.EFFECT: relisble removal of impurities from the skin's surface, restoration of the damaged protective barrier of the skin during washing without causing excessive dryness of the skin, relief of irritation and moisturization of the skin.1 cl, 3 tbl, 4 ex

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses an anti-schizophrenia lyotropic liquid crystal long-acting injection and a preparation method and application thereof, and the anti-schizophrenia lyotropic liquid crystal long-acting injection is composed of an anti-schizophrenia drug, an amphiphilic compound and an organic solvent; the anti-schizophrenia medicine is selected from any one of brexpiprazole, cariprazine and aripiprazole; the amphiphilic compound is selected from any one or more of soybean phosphatidylcholine, egg yolk phosphatidylcholine, glyceryl monooleate, glyceryl monopalmitate, glyceryl dioleate, glyceryl trioleate, vitamin E acetate and phytantriol; the organic solvent is selected from one or more of ethanol, N-methyl pyrrolidone, dimethyl sulfoxide and 1, 2-propylene glycol. The anti-schizophrenia lyotropic liquid crystal in-situ gel long-acting injection forms a stable semi-solid drug reservoir through solvent exchange after administration so as to play a therapeutic effect in long-acting treatment of positive schizophrenia and negative schizophrenia and prevention of schizophrenia relapse.