37 results about "GLYCERYL OLEATE" patented technology

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The application relates to the technical field of inks, and discloses a long-acting coagulation ink formula, a preparation method and application, the ink comprising a water-based polyurethane emulsion, pigments, a defoaming agent and a dispersing agent; the water-based polyurethane emulsion formula is polytetrahydrofuran glycol, glycerol monooleate, isophorone diisocyanate, a chain extender and a hindered phenol crosslinking agent; the hindered phenol crosslinking agent is prepared and introduced into a molecular chain segment of the water-based polyurethane binder, linear water-based polyurethane macromolecules are linked in the form of chemical bonds, a crosslinked network structure is formed, molecular chain movement is limited, aggregation is not easy, gel during storage can be reduced, and the hindered phenol is linked to the polyurethane molecular chain through chemical bonds, free radicals are captured by the hindered phenol groups, and the phenomenon of ink skinning, gelation and coagulation of the polyurethane ink caused by oxidation during storage and use is avoided; the ink has excellent stability, adhesion, skinning resistance, rubbing resistance and alcohol resistance.

The application discloses a 100% natural source reverse micelle essential oil and a preparation method thereof, and the preparation raw materials comprise 0.6-13 parts of emulsifiers and 20-100 parts of natural source oils in terms of mass fraction. The combination of PCA glyceryl oleate and polyglycerol nonionic surfactants has a mass ratio of (0.5-0.8):(2-2.5), and the combination of polyglyceryl-2 isostearate and polyglyceryl-4 oleate has a mass ratio of (1-1.5):(0.8-1), so that the reverse micelle essential oil can be constructed, the essential oil has the advantages that the essential oil is skin-friendly and non-greasy, can be compatible with hydrophilic active ingredients and oleophilic active ingredients, and can effectively moisturize and nourish the skin.

The application discloses a refining method of glyceryl oleate series products. The glyceryl oleate mixture is used as raw material, the mixture is melted by heating, then the melted liquid is flowed through a panel containing different temperature zones, and crystals are separated in the corresponding temperature zones by using the difference of solidification points of different components, so that glyceryl monooleate, glycerol, glyceryl dioleate and glyceryl trioleate are obtained respectively. The separation of each component in the glyceryl oleate mixture is realized. The method does not introduce solvent and adsorbent, is green and environment-friendly, and the obtained products can meet the demand of high-purity glyceryl monooleate and glyceryl dioleate for biological products.

The invention belongs to the field of pharmaceutical preparations, and provides an assembly material for indissolvable active transdermal mucosal drug delivery and a preparation method thereof. According to the invention, lipid cubic-phase nanoparticles composed of glyceryl monooleate, cholesterol, glycerol dioleate and caprylic / capric triglyceride are adopted, the design of DSPE-PEG2000 surface stability and ion coordinated regulation is combined, and high drug loading capacity and nanoscale particle size control are realized through a continuous process of melting, hydration, high-pressure homogenization and cubic-phase curing surface treatment. The preparation method solves the technical problems that high loading capacity of insoluble active ingredients and long-term colloidal stability are difficult to consider, cubic phase structure stability and surface charge controllability are contradictory in a tissue-friendly environment, and high drug loading capacity and devitrification prevention are difficult to couple under a low-temperature processing window, and has wide application value in the field of transdermal and mucosal local drug delivery.

A metal oxide dispersion composition with excellent stability over time, excellent non-stickiness, and good usability is provided. This metal oxide dispersion composition contains the following components (A) to (C): (A) polyhydroxystearic acid, (B) silicone-treated metal oxide, and (C) glyceryl oleate, wherein the metal oxide of component (B) is a metal oxide other than titanium dioxide.

This invention provides viscose macrobiofibers containing antioxidant active components and a method for preparing them. [Solution] The viscose macrobio fiber prepared by reacting raw materials by weight of 20-24 parts COFs carrier, 5-8 parts plant-derived antioxidant active component, 200-240 parts spinning solution, 2-4 parts sodium dodecyl sulfate, 2-4 parts glyceryl monooleate, 3-5 parts cyclodextrin, 2-4 parts titanium dioxide, and 3-5 parts silane coupling agent, has the antioxidant active component attached to the COFs carrier during the preparation process. In the prepared viscose macrobio fiber, the COFs carrier functions as the backbone of the viscose macrobio fiber, and the ends of the COFs carrier are exposed to or close to the surface of the viscose macrobio fiber. The antioxidant active component on the COFs carrier is easily transferred to the surface of the fiber, and the viscose macrobio fiber has a good antioxidant effect.

The invention relates to the technical field of pharmaceutical preparations, in particular to a self-nano-emulsification drug delivery system as well as a preparation method and related application thereof. The self-nano emulsifying composition comprises total glucosides of paeony, dihydroartemisinin and auxiliary materials, the auxiliary materials comprise, by mass, 10-45% of an oil phase, 20-68% of RH40 and 12-72% of ethyl alcohol, and the oil phase comprises glyceryl monooleate and medium chain triglyceride. Compared with the prior art, the self-nano-emulsion composition provided by the embodiment of the invention carries total glucosides of paeony and hydrophobic dihydroartemisinin together, realizes simultaneous administration of water-insoluble components and water-soluble components, and improves bioavailability.

This invention discloses a universal method and composition for solving the pilling problem in cold-formulated cosmetics. Adding an effective amount of glyceryl oleate, citrate / caprylic / capric triglyceride to a cosmetic composition containing a pilling-prone cold-formulated emulsifier can significantly reduce or eliminate pilling. This substance has been discovered for the first time to have a novel anti-pilling application, effective against pilling caused by the emulsifier's own characteristics, high dosage, electrolyte interference, or the addition of large molecules, and is universally applicable to different types of cold-formulated emulsifier systems. This invention is particularly suitable for systems using electrolyte-rich natural plant extracts as the aqueous phase, fundamentally solving the pilling problem and providing a reliable solution for preparing high-feel, all-natural cold-formulated cosmetics.

According to the cyclic carbonated glyceryl monooleate and the preparation method thereof provided by the invention, the cyclic carbonated design of glyceryl monooleate and dimethyl carbonate under the catalysis of organic base is adopted, and coordinated regulation and control of an acid value, a zinc form and a carbonic acid esterification degree are realized through a zinc complexing intermediate strategy; the esterification degree of carbonic acid of the product reaches 0.70-0.80, the acid value is controlled to be 0.02-0.10 mgKOH / g, the mass fraction of zinc carboxylate in the total zinc is not lower than 80%, the viscosity at 40 DEG C is 100-800 mPa.s, gelling can be achieved within 24 hours under the condition of 25-40 DEG C when the product reacts with aliphatic diamine, and the product has the advantages of being high in stability, good in stability and good in stability. The invention solves the contradiction between the processing fluidity and room temperature curing rate of the non-isocyanate polyurethane precursor, between the green mild process and narrow-range structure control, and between the zinc complexing stability and low metal residue appeal, and has wide application value in the fields of environment-friendly polyurethane coatings, adhesives, sealants and the like.

The application belongs to the technical field of lubricating oil, and particularly relates to an environment-friendly wear-resistant lubricating oil and a preparation method thereof. The environment-friendly wear-resistant lubricating oil comprises the following components in parts by weight: base oil 50-70 parts; poly-A olefin 60-80 parts; lanthanum dialkyldithiophosphate 2-4 parts; boron nitride@MoS2 composite material 0.5-1.5 parts; dimer acid and glycerol monooleate co-modified cerium oxide 1-3 parts; antioxidant 3-5 parts; preservative 2-4 parts; and silane coupling agent 1-3 parts. The environment-friendly wear-resistant lubricating oil prepared by the application has excellent wear resistance and relatively strong adaptability by adding the boron nitride@MoS2 composite material and cooperating with the modified cerium oxide and other materials.

The invention relates to the technical field of biological medicine, in particular to pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles as well as a preparation method and application thereof. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles comprise the following components: glyceryl monooleate, polyethylene glycol 400, poloxamer 407, D (+)-glucose and pogostemon cablin alcohol. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticle is of a core-shell structure, a shell is of a skeleton structure jointly formed by the glyceryl monooleate, the polyethylene glycol 400, the poloxamer 407 and the D (+)-glucose, and a core is the pogostemon cablin alcohol. The patchouli alcohol lipid cubic liquid crystal nanoparticles are good in in-vitro stability, have a slow release effect compared with free drugs, and have good development and application prospects in the field of chemotherapeutic intestinal injury treatment.

The application belongs to the technical field of surface treatment of silicon nitride fibers, and particularly relates to a surface treatment agent for silicon nitride fibers, a preparation method and application thereof. The raw materials of the surface treatment agent include 20-40 parts of polytetrafluoroethylene, 4-12 parts of an impregnating agent and 4-12 parts of a lubricant. The lubricant is selected from one or more of polyethylene wax, silicone oil, dimethyl silicone oil, polyphthalamide, trimethylolpropane oleate, glycerol trioleate, isooctyl acrylate and isooctyl methacrylate. The surface treatment agent prepared by the application can effectively act on the silicon nitride fibers under the synergistic effect of the lubricant and the impregnating agent. After secondary sizing, the bundle property, wear resistance, stiffness and bending resistance of the silicon nitride fibers are improved, the weaving performance requirements of the silicon nitride fibers are met, the process is simple, the cost is low, the application is suitable for industrial production, and the application can be widely applied.

The invention relates to high-water-solubility compound sulfachlorpyridazine sodium powder, which is mainly prepared from the following raw materials in percentage by weight: 55 to 65 percent of sulfachlorpyridazine sodium, 10 to 15 percent of trimethoprim, 15 to 25 percent of hydroxypropyl-beta-cyclodextrin, 3 to 8 percent of polyvinylpyrrolidone, 0.02 to 0.05 percent of xanthan gum, 0.1 to 0.3 percent of sodium alginate, 0.5 to 1.0 percent of glyceryl monooleate and the balance of water. And 1-2% of citric acid-sodium citrate buffer salt. The compound sulfachlorpyridazine sodium powder can significantly improve the solubility and dissolution rate of TMP in water, improve the absorption synchronism of sulfachlorpyridazine sodium and TMP in animal bodies, enhance the physical stability of a preparation, prevent precipitation after storage and dissolution, effectively cover the bitter taste of TMP, and improve the palatability of drinking water for livestock and poultry.

The invention discloses a lipid liquid crystal and application of the lipid liquid crystal in controlled release of anthocyanin. The lipid liquid crystal is prepared from an oil phase, anthocyanin and water, wherein the oil phase is prepared from glyceryl monolinoleate, glyceryl monooleate, mannosylerythritol lipid and linoleic acid; wherein the oil phase part contains the following components in percentage by mass: 1.0-3.6% of linoleic acid and the balance of a mixture of glyceryl monolinoleate, glyceryl monooleate and mannosylerythritol lipid, and the mass ratio of the glyceryl monolinoleate to the glyceryl monooleate to the mannosylerythritol lipid is 8.5: 1: 0.5; 25-40% of an aqueous solution containing anthocyanin; the change of the crystal form structure of the lipid liquid crystal is induced by adjusting the pH condition to control the release rate difference of the anthocyanin, so that the controlled release is realized. The lipid liquid crystals of the present invention are particularly suited for shipping and targeted delivery of anthocyanins.

This invention belongs to the field of pharmaceutical formulations and provides an assembly material and preparation method for transdermal and mucosal drug delivery of poorly soluble active ingredients. The invention utilizes lipid cubic phase nanoparticles composed of monooleate glycerol, cholesterol, dioleate glycerol, and caprylic / capric triglycerides. Combined with the surface stabilization and ion-synergistic regulation design of DSPE-PEG2000, a continuous process of melting-hydration-high pressure homogenization-cubic phase curing surface treatment is employed to achieve high drug loading and nanoscale particle size control. This invention solves the technical problems of balancing high loading of poorly soluble active ingredients with long-term colloidal stability, the contradiction between cubic phase structure stability and surface charge controllability in tissue-friendly environments, and the difficulty of achieving high drug loading and preventing crystallization coupling under low-temperature processing windows. It has broad application value in the fields of transdermal and mucosal local drug delivery.

The invention discloses a skin wound nursing ointment based on fish scale gelatin and a preparation method thereof, particularly relates to the technical field of skin nursing, and relates to the skin wound nursing ointment based on the fish scale gelatin and the preparation method thereof. The skin wound nursing ointment based on the fish scale gelatin is prepared from glyceryl monooleate, deionized water, docosyl, Span 60, a fish scale gelatin protein extract, an antibacterial component extract and sodium silicate. According to the method, the fish scale collagen is subjected to directional enzymolysis under the low-temperature condition by adopting the restrictive endonuclease extracted from deep-sea psychrophilic bacteria, the collagen peptide with the ultra-small molecular weight is accurately prepared, the active peptide fragments have excellent cell permeability and migration guiding capacity, the wound healing speed is remarkably increased, and the treatment effect is remarkably improved.

The application belongs to the technical field of lubricating grease, and particularly relates to a kind of lubricating grease and its preparation method and application. The components of the lubricating grease include, by weight, 100 parts of base oil; 25-35 parts of thickening agent; 4-8 parts of OD modified h-BN; 2-4 parts of monolein glyceride modified MoS2@ laminated mica; 3-5 parts of anti-rust agent; 0.4-0.8 parts of antioxidant; and 1-3 parts of dispersant. The application improves the dispersibility and stability of h-BN and MoS2@ laminated mica in the lubricating grease by using OD modified h-BN and monolein glyceride modified MoS2@ laminated mica, and the components cooperate with each other to promote the lubricating grease to have excellent wear resistance and other properties.

The invention relates to the technical field of biology, and particularly provides a lipid nanoparticle editing system and pharmaceutical application thereof. The system comprises (a) LNP formed by compounding cationic lipid RD007, 1, 2-dioleoyl-3-trimethyl ammonium-propane, glyceryl oleate, DMG-PEG2000 and DMG-PEG2000-MAL and mRNA capable of compositely coding dCas9-DNMT3A, (b) lipid nanoparticles formed by coupling a macrophage surface marker F4 / 80 antibody and the LNP and specifically targeting macrophages, and (c) the LNP has the characteristic of high expression in lung tissues. The system disclosed by the invention can be used for preparing a drug and delivering the nano editing system to lung macrophages in a targeting manner, so that dCas9-DNMT3A expression is realized, epigenetic silencing is induced, macrophage metabolism is reprogrammed, pathogenic gene expression is reduced, and the purpose of treating lung fibrosis diseases is achieved.

FIELD: cosmetics.SUBSTANCE: cosmetic composition in the form of a cream-gel for skin cleansing contains purified water; an emulsifier consisting of cetyl alcohol, glyceryl stearate, PEG-75 stearate, ceteth-20 and steareth-20; glycerin; coco-glucoside; a co-surfactant consisting of purified water, glyceryl oleate and coco-glucoside; cetearyl alcohol; caprylic / capric triglyceride; panthenol; butylene glycol; squalane; oat extract; sodium acrylate / sodium acryloyldimethyl taurate copolymer; cocamidopropyl betaine; cholesterol; ceramide complex including: ceramides NP, AP, AS, NG, glycosphingolipids, hydrogenated lecithin and auxiliary components; fructooligosaccharides; hydroxyacetophenone; preservative consisting of 1,2-hexanediol and caprylyl glycol; tocopheryl acetate; fragrance; arginine and disodium EDTA, in a certain ratio of components, wt.%.EFFECT: relisble removal of impurities from the skin's surface, restoration of the damaged protective barrier of the skin during washing without causing excessive dryness of the skin, relief of irritation and moisturization of the skin.1 cl, 3 tbl, 4 ex

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses an anti-schizophrenia lyotropic liquid crystal long-acting injection and a preparation method and application thereof, and the anti-schizophrenia lyotropic liquid crystal long-acting injection is composed of an anti-schizophrenia drug, an amphiphilic compound and an organic solvent; the anti-schizophrenia medicine is selected from any one of brexpiprazole, cariprazine and aripiprazole; the amphiphilic compound is selected from any one or more of soybean phosphatidylcholine, egg yolk phosphatidylcholine, glyceryl monooleate, glyceryl monopalmitate, glyceryl dioleate, glyceryl trioleate, vitamin E acetate and phytantriol; the organic solvent is selected from one or more of ethanol, N-methyl pyrrolidone, dimethyl sulfoxide and 1, 2-propylene glycol. The anti-schizophrenia lyotropic liquid crystal in-situ gel long-acting injection forms a stable semi-solid drug reservoir through solvent exchange after administration so as to play a therapeutic effect in long-acting treatment of positive schizophrenia and negative schizophrenia and prevention of schizophrenia relapse.

A rubber composition according to an embodiment contains a diene rubber, silica, a plant-derived glyceryl oleate, and a mineral oil that is an optional component. The glyceryl oleate includes glyceryl monooleate as a part thereof. The mineral oil (including an extender oil) is contained such that the mass ratio of the mineral oil to the glyceryl oleate is 0 or more and 5.0 or less.

To provide a metal oxide dispersion composition having excellent temporal stability, excellent stickiness-free property, and satisfactory usability.SOLUTION: A metal oxide dispersion composition contains the following components (A) to (C): (A) polyhydroxystearic acid; (B) silicone-treated metal oxide; and (C) glyceryl oleate, where metal oxide of the component (B) is zinc oxide, the content mass ratio (B) / (C) of the component (B) to the component (C) is 1 to 30, and / or the content mass ratio (A) / (C) of the component (A) to the component (C) is 0.1 to 3.0.SELECTED DRAWING: None

The invention discloses a hesperetin multilevel lipid nanoparticle delivery system based on glyceryl dioleate and a preparation method of the hesperetin multilevel lipid nanoparticle delivery system. The blank lipid nanoparticles with stable physicochemical properties are successfully prepared by systematically optimizing key parameters such as the composition proportion of the glyceryl dioleate and the Tween 80, the ultrasonic emulsification time and the like. On the basis, the lipid-drug ratio and the coating concentration of the chitosan and the bovine serum albumin are further accurately regulated and controlled, and three delivery systems of the hesperetin lipid nanoparticles, the chitosan modified hesperetin lipid nanoparticles and the bovine serum albumin-chitosan double-layer coated hesperetin lipid nanoparticles are sequentially constructed. The series of nanoparticles have the characteristics of uniform particle size distribution, high encapsulation efficiency, good stability and the like, and show a remarkable'gastric stagnation intestinal release 'intelligent switching effect in simulated gastrointestinal fluid. The delivery system can significantly improve the dissolution rate and bioavailability of hesperetin, and provides an effective nanotechnology strategy for solving the problems of poor water solubility, low oral absorption rate and the like of hesperetin.

The application provides a cyclic carbonate esterified monoglycerol monooleate and a preparation method thereof, adopts a cyclic carbonate esterification design of glycerol monooleate and dimethyl carbonate under the catalysis of an organic base, realizes the synergistic control of an acid value, a zinc form and a cyclic carbonate esterification degree through a zinc complex intermediate strategy, the cyclic carbonate esterification degree of the product reaches 0.70 to 0.80, the acid value is controlled to be 0.02 to 0.10 mgKOH / g, the zinc carboxylate form accounts for not less than 80% of the total zinc mass fraction, meanwhile, the viscosity at 40 DEG C is 100 to 800 mPa s, and the reaction with aliphatic diamine can realize gelation within 24 hours at 25 to 40 DEG C, the contradictions between the processing fluidity and the room temperature curing rate, the green and mild process and the narrow range structure control, the zinc complex stability and the low metal residue demand of the non-isocyanate polyurethane precursor are solved, and the cyclic carbonate esterified monoglycerol monooleate has wide application value in the fields of environment-friendly polyurethane coatings, adhesives, sealants and the like.

The invention provides a preparation and purification method of glyceryl dioleate, which adopts a synergistic catalysis system consisting of immobilized lipase and a mild chemical catalyst to catalyze esterification reaction of glycerol and oleic acid at medium and low temperature (50-70 DEG C). According to the invention, through organic combination of a low-temperature concerted catalytic reaction and a combined purification process, the proportion and reaction parameters of the composite catalyst are adjusted, so that the proportion of 1, 2-isomer to 1, 3-isomer in the product can be accurately regulated and controlled in a specific range; the flexibility is difficult to realize by an existing purification chemical method (uncontrollable isomerization caused by high temperature) or a pure enzyme method (generally fixed bias to 1, 3-site), and the requirements of different downstream applications on specific isomers are met.

The invention relates to the field of organic synthesis, in particular to a synthesis method of glyceryl dioleate. The synthesis method of the glyceryl dioleate comprises the following steps: mixing 1, 3-dihydroxy acetone, oleic acid, a catalyst and a first solvent, and carrying out condensation reaction to obtain 1, 3-dioleoyl acetone; and mixing the 1, 3-dioleoyl acetone, sodium borohydride and a second solvent, carrying out reduction reaction and post-treatment, and crystallizing and purifying to obtain the glyceryl dioleate. The synthesis method of glycerol dioleate provided by the invention has the advantages of short process route, mild conditions, simplicity and convenience in operation, high product purity and the like, and is suitable for large-scale production.

A saccharide sustained-release composition and a preparation method therefor. Provided is the saccharide sustained-release composition. The composition comprises a saccharide substance and a sustained-release agent, the sustained-release agent comprising at least two selected from hydroxypropyl methylcellulose, sodium alginate, cellulose, methyl cellulose, ethyl cellulose, microcrystalline cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyethylene oxide, a carboxyvinyl polymer, polyoxyethylene, a polyvinyl acetate aqueous dispersion, glycerol monooleate, glycerol monostearate, a carbomer homopolymer, a carbomer interpolymer, carrageenan, shellac, guar gum, xanthan gum, alginic acid and starch.

The present application belongs to the technical field of daily chemical products, and discloses a sebum biomimetic composition, a preparation method and application thereof.The sebum biomimetic composition comprises components: squalane, PEG-80 sorbitan laurate, glycerol, a sugar isomer and glyceryl oleate.The sebum biomimetic composition obtained by reasonable collocation of squalane, PEG-80 sorbitan laurate, glycerol, a sugar isomer and glyceryl oleate has synergistic effects among the components, has the effects of moisturizing and enhancing skin barrier function, is non-irritating and safe and mild to infant skin, and can be applied to washing and caring products, especially infant washing and caring products, so as to reduce the irritation of infant washing and caring products, form a biomimetic sebum layer on the skin surface, and thus enhance the skin barrier function, fundamentally solving the problem of great irritation of infant washing and caring products.

To provide a water-in-oil emulsion cosmetic with excellent makeup retention and powder dispersibility. [Solution] A water-in-oil emulsion cosmetic comprising (A) glyceryl oleate, (B) an ester of a fatty acid having 10 or more carbon atoms or a polymer thereof with a polyhydric alcohol having a degree of polymerization of 2 or more and having 4 or more hydroxyl groups in the molecule, (C) an amino acid and / or a salt thereof, and (D) a hydrophobically treated colorant.