12 results about "Sulfachlorpyridazine" patented technology

The utility model relates to the related technical field of veterinary drug processing equipment, and provides an efficient crushing unit for processing sulfachlorpyridazine sodium, which comprises an equipment frame and a grinding roller, the grinding roller is arranged in the equipment frame, a door-shaped frame is fixed at the top of the equipment frame, a first crushing assembly is arranged between the door-shaped frame and the equipment frame, and a second crushing assembly is arranged between the equipment frame and the door-shaped frame. The driving and grinding assembly is arranged between the equipment frame and the grinding roller, the smashing assembly comprises a feeding cover, the feeding cover is connected to the top of the equipment frame, a driving motor is installed at the top of the n-shaped frame, a driving shaft is arranged at the output end of the driving motor, and the driving shaft is slidably connected with a smashing tool rest in a sleeving mode. By means of the technical scheme, the problems that in the prior art, a crusher only conducts primary crushing, particles are not uniform after crushing, crushing is not thorough, secondary treatment is needed, the treatment process is increased, and the efficiency is reduced are solved.

The present invention relates to a heterogeneous iron-based catalyst FeOOH@WS2, a preparation method thereof, and a method for degrading antibiotics. The heterogeneous iron-based catalyst FeOOH@WS2 is a composite material prepared by a chemical precipitation method using NH4Fe(SO4)2 and WS2 as raw materials, and is used for activating persulfate (PS) to degrade sulfachloropyridazine (SCP) in water. It exhibits excellent catalytic performance without the need for external energy, has a high SCP removal rate, and also has the advantages of good stability, simple process, and recyclability.

The invention discloses an buckling bacterium strain and an application of the buckling bacterium strain in degradation of sulfachloropyridazine. The preservation information of the Ancylobacter sp. Sas-18 is as follows: the preservation unit is Guangdong Microbiological Culture Collection Center (GDMCC), the preservation date is November 25, 2025, the preservation address is Guangdong Institute of Microbiology on Floor 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou, the postal code is 510070, and the preservation number is GDMCC No. 67354. According to the invention, an Ancylobacter sp. SAs-18 with a good degradation effect on sulfachloropyridazine is separated from surface soil of a heavily polluted area of a wastewater discharge site of a pharmaceutical factory in Foshan City, Guangdong province, and can be used for degrading and removing sulfachloropyridazine. And an economic and green method is provided for removing the novel organic pollutants.

The invention relates to high-water-solubility compound sulfachlorpyridazine sodium powder, which is mainly prepared from the following raw materials in percentage by weight: 55 to 65 percent of sulfachlorpyridazine sodium, 10 to 15 percent of trimethoprim, 15 to 25 percent of hydroxypropyl-beta-cyclodextrin, 3 to 8 percent of polyvinylpyrrolidone, 0.02 to 0.05 percent of xanthan gum, 0.1 to 0.3 percent of sodium alginate, 0.5 to 1.0 percent of glyceryl monooleate and the balance of water. And 1-2% of citric acid-sodium citrate buffer salt. The compound sulfachlorpyridazine sodium powder can significantly improve the solubility and dissolution rate of TMP in water, improve the absorption synchronism of sulfachlorpyridazine sodium and TMP in animal bodies, enhance the physical stability of a preparation, prevent precipitation after storage and dissolution, effectively cover the bitter taste of TMP, and improve the palatability of drinking water for livestock and poultry.

The invention discloses a synthesis process of high-purity sulfachlorpyridazine sodium, and belongs to the technical field of synthesis in the medical industry, and the synthesis process comprises the following steps: synthesizing a condensation compound, synthesizing sulfachlorpyridazine, and synthesizing a finished product of sulfachlorpyridazine sodium. The synthetic condensation compound is prepared by the following steps: mixing an aromatic solvent, 3, 6-dichloropyridazine, p-acetamidobenzenesulfonamide, an acid-binding agent and a catalyst at 20-30 DEG C, carrying out a reflux water diversion reaction at 100-120 DEG C, and cooling after the reaction is carried out for 6-10 hours, so as to obtain a condensation material liquid; the catalyst is one of cuprous bromide, cuprous iodide and cuprous chloride. The synthesis process disclosed by the invention has the advantages of safety, environmental protection, cheap and easily available raw materials, simple process and low production cost, and the prepared sulfachloropyridazine sodium is high in yield and high in purity.

The invention relates to the technical field of solid-phase microextraction probes and veterinary drug detection, in particular to a Ru-coated Ni-MOF material, a preparation method of the Ru-coated Ni-MOF material, a solid-phase microextraction probe and application. According to the preparation method, Ni-MOF is taken as a matrix, a solvothermal method is adopted, a metal node Ru is partially doped and introduced into the Ni-MOF, a Ru-coated Ni-MOF nanosheet with a Ni-O-Ru coordination bond is synthesized under the assistance of foamed nickel, and a Ru-coated Ni-MOF material is obtained; the adsorption capacity of the material to enrofloxacin, norfloxacin, sulfachlorpyridazine and phthalocyanine thiazole is 34.64 mg / g to 113.31 mg / g. A Ru-coated Ni-MOF material is used as a raw material, in a solvent system, the Ru-coated Ni-MOF material and polyacrylonitrile are mixed, an extraction coating is formed on the surface of a substrate through an electrostatic spinning method, then the substrate is soaked in ethyl alcohol, and the solid-phase microextraction probe is obtained after drying.

The invention discloses soluble compound sulfachlorpyridazine sodium powder and a preparation method thereof. The soluble compound sulfachlorpyridazine sodium powder comprises sulfachlorpyridazine sodium, a trimethoprim inclusion compound and a filling agent. Aiming at the problem of acetic acid residue in a process for preparing soluble compound sulfachloropyridazine sodium in the prior art, trimethoprim is included by adopting a cyclodextrin derivative, and a product obtained by spray drying is subjected to acetic acid removal treatment by utilizing a high-temperature blast drying oven, so that the negative influence caused by dissolving trimethoprim by utilizing acetic acid is effectively solved, and the yield of soluble compound sulfachloropyridazine sodium is improved. And cost reduction and benefit increase are realized.

This invention relates to the field of pharmaceutical preparation technology, specifically to a sulfachlorpyridazine sodium-methotrexate suspension, its preparation method, and its application. The sulfachlorpyridazine sodium-methotrexate suspension of this invention comprises the following components per 100 ml: 20-50 g of sulfachlorpyridazine sodium, 4-10 g of methotrexate, 0.1-0.25 g of suspending agent, 0.05-0.125 g of wetting agent, 0.2-0.5 g of antioxidant, 0.1-0.25 g of disodium edetate, and purified water to a final volume of 100 ml. The suspension prepared by this invention can delay the in vivo clearance of sulfachlorpyridazine sodium, prolong the synergistic effect time, and improve its bioavailability; in the treatment of coccidiosis infection in chickens and sheep, it can significantly improve weight gain, reduce intestinal lesion values, rapidly clear oocysts, and maintain a long-lasting protective effect after drug withdrawal.

The invention belongs to the technical field of water pollution control, and discloses a Ni and Co bimetallic derivative catalytic material which is a novel Prussian blue bimetallic derivative catalyst. The prepared catalyst provides a feasible preparation thought for synthesizing a bimetallic Prussian blue derivative catalytic material, under the condition that the pH is neutral, the performance of activating peroxymonosulfate by the synthesized nickel-cobalt oxide catalyst is optimal, 100% degradation of sulfachloropyridazine (SCP) can be achieved within 5 min under the set experiment condition, the kinetic constant k1 is 0.76 min <-1 >, and the catalyst can be widely applied to the field of biodegradation of sulfachloropyridazine (SCP) in the field of biodegradation of sulfachloropyridazine (SCP) in the field of biodegradation of sulfachloropyridazine (SCP). Under set experimental conditions, 100% of bisphenol B (BPB) can be degraded within 2 min, and the dynamic constant k1 is 3.6 min <-1 >. The excellent catalytic performance of the material provides reference for preparation of other MOFs materials and degradation of sulfonamides and bisphenol pollutants by a peroxymonosulfate system.

The invention discloses compound sulfachloropyrazine sodium soluble powder as well as a preparation method and application thereof, and belongs to the technical field of veterinary drugs. Every 100 g of the soluble powder comprises 15-30 g of sulfachloropyrazine sodium, 4-8 g of methamprine, 6-12 g of a carrier I, 3-6 g of a carrier II, a surfactant, a metal chelating agent, an antioxidant and a filler. The preparation method is characterized by comprising the following steps: dissolving the methampheline and the carrier I in absolute ethyl alcohol, adding the carrier II for dispersion, heating for volatilization, cooling for solidification and drying to prepare the methampheline composite carrier solid dispersion; and mixing the sulfachloropyrazine sodium with sulfachloropyrazine sodium and other auxiliary materials to obtain a finished product. The dissolving and dispersing performance of the methampheline is remarkably improved through a solid dispersion technology, synchronous dissolution of the methampheline and the sulfachloropyrazine sodium is ensured, the preparation is good in water solubility and high in stability, and the excellent synergistic interaction effect and the animal growth promoting effect are shown in chicken and sheep coccidiosis prevention and treatment.

The application discloses a synthesis process of high-purity sulfonamide chlorodiazine sodium, and belongs to the technical field of medicine industry synthesis, which comprises the following steps: synthesizing a condensate, synthesizing sulfonamide chlorodiazine, and synthesizing sulfonamide chlorodiazine sodium finished product; the condensate is synthesized by mixing an aromatic hydrocarbon solvent, 3,6-dichloropyridazine, p-acetamidobenzenesulfonamide, an acid-binding agent and a catalyst at 20-30 DEG C, and then performing a reflux water separation reaction at 100-120 DEG C; after 6-10 hours of reaction, the temperature is lowered to obtain a condensate liquid; and the catalyst is one of cuprous bromide, cuprous iodide and cuprous chloride. The synthesis process has the advantages of safety and environmental protection, cheap and easily available raw materials, simple process and low production cost, and the prepared sulfonamide chlorodiazine sodium has high yield and high purity.

This invention discloses a strain of *Tridentium flexneri* and its application in the degradation of sulfachlorpyridazine. *Tridentium flexneri* (… Ancylobacter The preservation information for *Sp.* SAs-18 is as follows: Depository Institution: Guangdong Provincial Microbial Culture Collection Center (GDMCC); Deposit Date: November 25, 2025; Address: 5th Floor, Building 59, No. 100 Xianlie Middle Road, Guangzhou, Guangdong Institute of Microbiology, Postcode: 510070; Accession Number: GDMCC No. 67354. This invention isolates a strain of *Vibrio parahaemolyticus* (sp.) SAs-18, which exhibits good degradation effects against sulfachlorpyridazine, from the topsoil of a heavily polluted area at a pharmaceutical factory wastewater discharge site in Foshan City, Guangdong Province. Ancylobacter SAs-18 (sp.) can be used for the degradation and removal of sulfachlorpyridazine, providing an economical and green method for removing this type of novel organic pollutant.