38 results about "Sulfachlorpyridazine" patented technology

The invention belongs to the field of antibiotic detection, and relates to a method for analyzing and determining four sulfonamide antibiotics in a water sample. A negative pressure suction filtrationmembrane solid phase extraction technology is utilized, and a metal organic framework material NH2-MIL-101(FE) membrane solid phase extraction-high performance liquid chromatography method is adoptedto determine four antibiotics such as sulfadiazine, sulfamethazine, sulfachloropyridazine and sulfamethoxazole in an environmental water sample. The method is simple, convenient, rapid and sensitiveto operate, and has the advantages of low detection limit, accuracy and good reproducibility; and moreover, the raw materials are cheap and easy to obtain, the material preparation process is simple,the reaction conditions are mild, the application environment is friendly, and the market prospect is wide.

The invention relates to soluble powder for preventing and treating colibacillosis of poultry, comprising sulfachlorpyridazine sodium, trimethoprim and auxiliary materials. The inventive medicament is mainly used to prevent and treat colibacillosis of poultry. The sulfachlorpyridazine sodium and trimethoprim have compatibility when used together. The trimethoprim is used as an antisepsis synergist of sulfonamides when resisting bacteria, thus strengthening medicament effect of sulfachlorpyridazine sodium. The sulfachlorpyridazine sodium and trimethoprim cooperate to effectively treat colibacillosis. The soluble powder has good absorption and relatively high safety when orally taken.

The invention provides a plant-immunity resistance inducer and application thereof. The active ingredients of the plant-immunity resistance inducer contain 2-amino-3,5-dichlorobenzoic acid, prinzone and chitosan. In this way, after the plant-immunity resistance inducer is used in harvested citrus, occurrence of harvested citrus immune penicilliosis can be induced, the damage effect of the penicilliosis on the quality of the harvested citrus can be effectively inhibited, and the preservative and fresh-keeping time of the harvested citrus can be prolonged. The plant-immunity resistance inducer is free of toxicity and pollution, capable of directly acting on the harvested citrus, and no pesticide residues are generated; the plant-immunity resistance inducer can effectively prevent anthracnoseof harvested mangoes.

The invention relates to compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry. The compound sulfachlorpyridazine sodium powder comprises the following components by weight: 60-65 parts of sulfachloropyridazine sodium, 2-4 parts of indometacin potassium, 10-25 parts of suspending agents, 2-4 parts of flavoring agents and acceptable carriers accounting for parts added to be 100 parts. The compound sulfachlorpyridazine sodium powder has definite effect on pasteurellosis of various animals and is suitable for being popularized and applied to breeding of livestock and poultry. According to the compound sulfachlorpyridazine sodium powder, the sulfachloropyridazine sodium and the indometacin potassium are compatible for use, so that when antibacterial and anti-inflammatory effects are achieved, the indometacin potassium serving as the antibacterial synergist of the sulfachloropyridazine sodium can have an synergistic effect to strengthen the drug effect of the main drug. The compound sulfachlorpyridazine sodium powder can be taken orally or mixed in feeds or drinking water, is good in absorption and safe in usage, does not produce drug resistance easily, can be used for health protection, prevention and treatment for a long time, has good palatability, flowability and suspension water-soluble performance, and is various in clinical dosing mode and convenient to dose.

The invention relates to a method of extracting medicine residues of seven sulfonamides from chicken by utilization of an ionic liquid and achieving an objective of purification during extraction purification, through adjusting the pH value, the water amount and the salt amount in the ionic liquid to achieve homogeneous phase extraction and layered purification, wherein the seven sulfonamides residues comprise sulfathiazole (ST), sulfamerazine (SMR), sulfamethizole (STZ), sulfadimidine (SDMD), sulfachlorpyridazine (SCP), sulfamethoxazolum (SMZ), and sulfisoxazole (SIX). Liquid chromatographic analysis results show that the recovery rate of each of the sulfonamides is 82.1%-108%, and the relative standard deviation is 0.5%-5.9%. The green and simple extracting method is established so as to reduce pollution or harm of traditional organic solvent extraction methods to the environment and to experiment persons.

The invention discloses a method for simultaneous determination of nine sulfonamide antibiotics on suspended particles in water. The method comprises the following steps: taking a target water sample,filtering, and collecting a filtered membrane and particles retained on the surface; adding a quantitative internal standard substance; cutting and placing in a centrifuge tube after freeze drying; adding an appropriate amount of extractant; performing constant temperature oscillation, ultrasonic treatment and centrifuging; transferring supernatant to a K-D concentration bottle; purging the extraction liquid to less than 1ml by nitrogen gas; filtering with an organic microporous filter membrane; and measuring with an ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometer. The method has the advantages of short sample pretreatment time, simple steps, simultaneous determination of the contents of nine sulfonamide antibiotics such as sulfadiazine, sulfapyridine, sulfamethazine, sulfisomidine, sulfachlorpyridazine, sulfamerazine, sulfamethoxazole, sulfaquinoxaline and trimethoprim adsorbed on the suspended particles in water, and more accurate and true reflection of the contents of the sulfonamide antibiotics in water more.

The invention relates to soluble powder for preventing and treating coccidiosis of poultry, comprising sulphaquinoxaline sodium, trimethoprim and auxiliary materials. The inventive medicament is mainly used to prevent and treat coccidiosis of poultry, rabbits, lambs etc. The sulphaquinoxaline sodium and trimethoprim have compatibility when used together. The trimethoprim is used as an antisepsis synergist of sulphaquinoxaline sodium when resisting coccidian, thus strengthening medicament effect of sulphaquinoxaline sodium. The sulfachlorpyridazine sodium and trimethoprim have synergetic effect during different growing periods of coccidian, simultaneously kill ova and imagoes, thus effectively treating colibacillosis. The soluble powder has good absorption and relatively high safety when orally taken.

The invention provides a method for sulfonamide medicine extraction and analysis by utilizing a DPX pipette tip type dispersive solid-phase extraction microcolumn, and relates to sulfonamide medicineresidue detection methods for animal-sourced foods. The method is provided to overcome a problem that there is no effective method for sulfonamide medicine detection for animal-sourced foods, especially quantitative, high-precision, high-throughput and low-consumption determination. A high performance liquid chromatography-tandem mass spectrometry manner for residue analysis of twelve sulfonamidemedicines in animal-sourced foods is established in the method. The method is suitable for residue amount detection of one or a plurality of medicines selected from sulfacetamide, sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxypyridazine, sulfamonomethoxine, sulfochloropyridazine, sulfamethoxazole, sulfadimethoxypyridazine, sulfadimethisoxazol, sulfabenzamide and sulfaquinoxalin in animal-sourced foods.

The invention discloses a preparation method of an immunoaffinity column. The immunoaffinity column is a compound affinity column which is mainly prepared from three types of immunoaffinity columns through mixed packing in a volume ratio being 1:1:1, and the three types of immunoaffinity columns are prepared from three antibodies and a coupling matrix through coupling and wet packing. The column capacity of the immunoaffinity column is 2,500 ng, the immunoaffinity column is good in purification effect and can be repeatedly used three times, and average recovery rate is 67%-107%. The compound immunoaffinity column has good specific adsorption property for at least 12 sulfonamides including sulfaquinoxaline, sulfadiazine, sulfapyridine, sulfametoxydiazine, sulfadimidine, sulfamethoxazole, sulfafurazole, sulfadimethoxypyrimidine, sulfathiazole, sulfamerazine, sodium N-sulphanilamidate and sulfamonomethoxine. The immunoaffinity column which is high in coupling rate, specific adsorption property, column capacity and recovery rate is prepared, and a sensitive, rapid and simple analysis method capable of detecting residues of the 12 sulfonamides simultaneously is provided.

The invention relates to a synthetic method of long-acting sulfonamide. The synthetic method comprises the following steps: (a) sequentially adding methyl alcohol, caustic soda flakes and sulfachloropyridazine sodium into a reaction kettle, stirring for reaction for 1-15 hours at the pressure of 0.1-1.0 MPa and the temperature of 50-160 DEG C to obtain a first mixed solution, cooling the reaction kettle to a normal temperature, and depressurizing the reaction kettle to normal pressure, wherein the mass ratio of the methyl alcohol to the caustic soda flakes to the sulfachloropyridazine sodium is (1-3): (0.1-0.8): 1; (b) evaporating the first mixed solution to dryness, adding first deionized water for dissolution, adjusting the pH value to be 5.4-6.3 for product crystal precipitation, and carrying out suction filtration to obtain a crude product, wherein the ratio of the methyl alcohol to the first deionized water is (2-3) g: (1.5-2) ml; (c) adding the crude product into a decoloration 3-mouth bottle, adding second deionized water for dissolution, adjusting the pH value to be 12-14, adding activated carbon, stirring for 10-60 minutes at the temperature of 0-100 DEG C, filtering, adjusting the pH of the filtrate to be 5.4-6.3 for product crystal precipitation, carrying out suction filtration, and drying, wherein the ratio of the methyl alcohol to the second deionized water to the activated carbon is (2-3) g: (4-6) ml: (0.05-0.2) g. According to the synthetic method, the yield of the long-acting sulfonamide can be improved, and the cost is reduced.

The invention relates to a soluble powder for treating livestock and poultry coccidiosis, comprising sulfachlorpyridazine sodium, sulfachlorpyridazine sodium and auxiliary materials. The medicament of the invention has positive effect for treating livestock and poultry coccidiosis and can be suitable for popularization and application. In the invention, the sulfachlorpyridazine sodium and the sulfachlorpyridazine sodium are compatible with each other for using and generating cooperating effect, the invention can be acted on different periods of coccidia growth, can kill ova and imago simultaneously, can effectively treat the coccidiosis, has good oral administration absorption effect and high safety.

The invention discloses a seven-into-one sulfanilamide detection method which comprises a kit and reagents, wherein the reagents comprise sulfathiazole, trimethoprim, sulfaquinoxaline, phthalylsulfathiazole, sulfamethythiadiazole, sulfamethazine, sulfamethoxazole, sulfamerazine, sulfadimethoxypyrimidine, a sulfachlorpyridazine carrier, m-sulfamethoxydiazine, sulfaquinoxaline, sulfadiazine, sulfamethoxypyridazine and sulfametoxydiazine. According to the seven-into-one sulfanilamide detection method and the kit, the sulfathiazole, the trimethoprim, the sulfaquinoxaline, the phthalylsulfathiazole, the sulfamethythiadiazole, the sulfamethazine, the sulfamethoxazole, the sulfamerazine, the sulfadimethoxypyrimidine, the sulfachlorpyridazine carrier, the m-sulfamethoxydiazine, the sulfaquinoxaline, the sulfadiazine, the sulfamethoxypyridazine and the sulfametoxydiazine in a proportioning part of a weight unit are combined in match in a glass container, and convenience can be brought to seven-into-one sulfanilamide detection.

The invention discloses compound sulfachlorpyridazine sodium powder and a preparation method thereof. The compound sulfachlorpyridazine sodium powder is prepared from the raw materials in parts by weight of 59-65 parts of sulfachlorpyridazine sodium, 11-13 parts of sulfanilamide synergist, 11-26 parts of inclusion compound, 1-2 parts of cosolvent and the balance filler. The compound sulfachlorpyridazine sodium powder is obtained by adopting an inclusion technology and spray drying. The inclusion compound is used after being dried for 8-12 hours, so that the inclusion space of the inclusion compound is increased, trimethoprim can be better included, the bad smell and bitter taste of trimethoprim are covered, the palatability of traditional compound sulfachlorpyridazine sodium powder is improved, the solubility of sulfachlorpyridazine sodium powder is increased, active ingredients are stably released, and the bioavailability is improved.

The invention discloses compound sulfachloropyridazine. The compound sulfachloropyridazine is prepared from sulfachloropyridazine or salt thereof and ormetoprim, wherein the mass ratio of the sulfachloropyridazine or the salt thereof to the ormetoprim ranges from (20 to 1) to (1 to 1); the invention further discloses a preparation method of the compound sulfachloropyridazine; the preparation method comprises the following step: sufficiently mixing the sulfachloropyridazine or the salt thereof and the ormetoprim to prepare the compound sulfachloropyridazine. The compound sulfachloropyridazine has the advantages that the ormetoprim is added into the sulfachloropyridazine or the salt thereof, and the ormetoprim is used for inhibiting bacterial dihydrofolate reductase to interfere the synthesis of tetrahydrofolic acid, so as to inhibit the growth of bacteria; the ormetoprim has a relatively strong self bacterium-inhibiting capability, is combined with the sulfachloropyridazine or the saltthereof to have a stronger antibacterial synergistic effect and has a synergistic effect; the ormetoprim more easily penetrates through a tissue barrier and the compound sulfachloropyridazine more easily enters endometrium to express better medicinal performance.

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

The present invention involves a test note and its preparation method for fast detection of sulfa chloride. The bottom layer is the support layer, the middle layer is the adsorption layer, and the protective layer is fixed on the adsorption layer.The golden standard antibody fiber layer, cellulose membrane layer and water absorption material layer. On the fibrin membrane layer, there is a detection mark printed on the protein solution printed by the protein solution of the protein solution of sulfa.Anti -rabbit IgG antibody solution printed in the control seal, the golden standard antibody is a sulfonamine antibody marked by colloidal gold.The test strips of the present invention are strong, high, simple, intuitive, accurate, wide, wide, low in cost, simple operation, can meet the needs of personnel at different levels, have broad market prospects, and are easy to promote and applied.

The invention discloses a cleaning agent for a glass curtain wall and a preparation method thereof. The cleaning agent comprises the following raw materials: fatty alcohol polyoxyethylene ether sodium sulphate, 1,8-terpadiene, lauroyldiethanolamine, sulfachlorpyridazine sodium, polyvinylpyrrolidone, disodium 5'-guanylate, ethanol, water, sodium polyacrylate, bis(3-dimethylaminopropyl)aminoisopropanol, 2-hydroxyisobutyramide, sucrose fatty acid ester and sorbitan monooleate. The invention has the following beneficial effects: the purpose of cleaning agent can be rapidly achieved; duration of cleanness is long after cleaning; cleaning frequency of the glass curtain wall is effectively reduced; labor force is saved; and cleaning cost is reduced.

The invention relates to a bamboo rat breeding method in a large-scale farm, which belongs to the technical field of wild animal breeding. 2 males and 5 females or 4 males and 10 females. Rat concentrate feed contains corn sand, wheat bran, bean curd, rice, rice bran and em bacteria, and is naturally fermented. Add vitamin E within 3 to 5 days of starting to feed the concentrate feed, and then add calcium, phosphorus, and zinc for 3 to 5 consecutive days. After stopping for 2 to 3 days, add compound vitamin B and 21 gold vitamins; During the period from before to farrowing, antiviral Chinese medicine is added. The mother mice were fed with glucose for 1 to 6 days postpartum, and dandelion, buliuxing and Houttuynia cordata for 3 to 5 days. After 20 days, the young rats ate some bamboo powder and yellow bamboo grass leaves, and were weaned after 35 to 40 days. Feed a preventive medicine every 60 days. The preventive medicine is Siwei Shuanghuanglian, plus Yinqiaosan, dandelion, astragalus polysaccharide, etc., and the compound sulfachlordazine liver gallbladder granule is fed once every six months. The litter rate is not less than 98%, the survival rate of the young rats is high, and the growth is good, which can significantly improve the economic benefits of large-scale bamboo rat farms.

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides a preparation method of compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

The invention discloses a compound sulfachloropyridazine sodium dry suspension and preparation method thereof, and belongs to the technical field of veterinary drugs. Each 100 kg of the dry suspensioncontains: 60-70 kg of sulfachloropyridazine sodium, 10-15 kg of trimethoprim, 0.02-0.05 kg of a suspending aid, 0.6-0.8 kg of a surfactant, and 14.15-29.38 kg of a filling additive. The high-efficiency suspending aid used in the invention is one or a combination of xanthan gum and hydroxypropyl methyl cellulose; the surfactant is one or a combination of sodium lauryl sulfate and N-cetyl-N-ethyl morpholinium ethosulfate; and the filling additive is one ingredientof maltodextrin, anhydrous glucose and water-soluble starch or a combination of two ingredients of maltodextrin, anhydrous glucose and water-soluble starch. The compound sulfachloropyridazine sodium dry suspension has good suspension stability, and the prepared suspension can be uniform with no layers for a long time. In clinical use of mixing or drinking, the dry suspension is uniform in administration, has good synchronous absorption effect, has less drug residue, has short withdrawal time, is convenient to use, and can helpreduce culture cost to the maximum.

The invention relates to a synthetic method of long-acting sulfonamide. The synthetic method comprises the following steps: (a) sequentially adding methyl alcohol, caustic soda flakes and sulfachloropyridazine sodium into a reaction kettle, stirring for reaction for 1-15 hours at the pressure of 0.1-1.0 MPa and the temperature of 50-160 DEG C to obtain a first mixed solution, cooling the reaction kettle to a normal temperature, and depressurizing the reaction kettle to normal pressure, wherein the mass ratio of the methyl alcohol to the caustic soda flakes to the sulfachloropyridazine sodium is (1-3): (0.1-0.8): 1; (b) evaporating the first mixed solution to dryness, adding first deionized water for dissolution, adjusting the pH value to be 5.4-6.3 for product crystal precipitation, and carrying out suction filtration to obtain a crude product, wherein the ratio of the methyl alcohol to the first deionized water is (2-3) g: (1.5-2) ml; (c) adding the crude product into a decoloration 3-mouth bottle, adding second deionized water for dissolution, adjusting the pH value to be 12-14, adding activated carbon, stirring for 10-60 minutes at the temperature of 0-100 DEG C, filtering, adjusting the pH of the filtrate to be 5.4-6.3 for product crystal precipitation, carrying out suction filtration, and drying, wherein the ratio of the methyl alcohol to the second deionized water to the activated carbon is (2-3) g: (4-6) ml: (0.05-0.2) g. According to the synthetic method, the yield of the long-acting sulfonamide can be improved, and the cost is reduced.

The invention discloses a catalyst for catalytic ozonation degradation of sulfachlorpyridazine sodium wastewater and a preparation method and application thereof, activated carbon is used as a carrier, a supported metal oxide catalyst Ce-Fe-Zn / AC is prepared through a chemical coprecipitation method, Ce, Fe and Zn are proportioned according to a certain molar ratio, the activated carbon carrier is washed, dried and then subjected to high-temperature calcination, and the sulfachlorpyridazine sodium wastewater is obtained. And adding the obtained carrier into different metal ions, stirring, standing, precipitating and calcining to obtain the required catalyst. The catalyst is high in catalytic activity, nontoxic and pollution-free in the production process, convenient to separate and reusable, and has a good application prospect.

The invention relates to gallic acid sulfanilamide derivatives and an application thereof in anti-liver cancer. The gallic acid sulfanilamide derivatives comprise the following three compounds: 3,4,5-triethyl galloyl sulfachloropyridazine, 3,4,5-triethyl galloyl sulfadiazine and 3,4,5-triethyl galloyl sulfadimidine. The antitumor activity of the gallic acid sulfanilamide derivative series compounds is detected, and it is proved that the gallic acid sulfanilamide derivative series compounds have inhibitory effect on the activity of liver tumor cells. The invention provides a mechanism for achieving anti-tumor effect through immunoregulation, and provides a new idea for screening compounds with anti-tumor activity generated through immunoregulation. The gallic acid sulfonamide derivative series compounds can be used for preparing medicines for resisting liver cancer tumor cells.

The invention relates to a sulfachlorpyridazine slow-release nano colloidal particle. Every 100g of the nano colloidal particle is prepared from the following components by weight: 0.1 to 6.0 g of sulfachlorpyridazine, 5.0 to 15.0 g of butyl lactate, 1.0 to 5.0 g of propylene glycol alginate, 0.1 to 1.0 g of polyethylene glycol 12000, 1.0 to 3.0 g of beeswax, 15.0 to 25.0 g of polyoxyethylene ether (40) hydrogenated castor oil, 2.0 to 8.0 g of propylene glycol monostearate, 2.0 to 10.0 g of polyvinyl alcohol, 4.0 to 20.0 g of boric acid and the balance of sucrose powder. The particle size of the sulfachlorpyridazine sustained-release nano colloidal particle drug ranges from 10 nm to 200 nm, the sustained-release effect is achieved after oral administration, the toxic and side effects of the drug can be remarkably reduced, and meanwhile the drug effect is exerted to the maximum extent. The invention further discloses a preparation method, the process operability is high, the technology is easy to transform, and the market prospect is wide.

The invention relates to compound sulfachlorpyridazine sodium powder for preventing and treating pasteurella infection of livestock and poultry. The compound sulfachlorpyridazine sodium powder comprises the following components by weight: 60-65 parts of sulfachloropyridazine sodium, 2-4 parts of indometacin potassium, 10-25 parts of suspending agents, 2-4 parts of flavoring agents and acceptable carriers accounting for parts added to be 100 parts. The compound sulfachlorpyridazine sodium powder has definite effect on pasteurellosis of various animals and is suitable for being popularized and applied to breeding of livestock and poultry. According to the compound sulfachlorpyridazine sodium powder, the sulfachloropyridazine sodium and the indometacin potassium are compatible for use, so that when antibacterial and anti-inflammatory effects are achieved, the indometacin potassium serving as the antibacterial synergist of the sulfachloropyridazine sodium can have an synergistic effect to strengthen the drug effect of the main drug. The compound sulfachlorpyridazine sodium powder can be taken orally or mixed in feeds or drinking water, is good in absorption and safe in usage, does not produce drug resistance easily, can be used for health protection, prevention and treatment for a long time, has good palatability, flowability and suspension water-soluble performance, and is various in clinical dosing mode and convenient to dose.

The invention discloses a production process of sulfachloropyridazine. The production process comprises the following steps: S1, stirring and mixing 3, 6-dichloropyridazine, sulfanilamide, potassium carbonate and tri-n-propylamine, heating to 140-150 DEG C, and keeping the temperature for 4-5 hours; S2, carrying out high performance liquid chromatography detection, and terminating the condensation reaction if the mass content of sulfanilamide in the material is less than 10%; S3, adding water and activated carbon, controlling the temperature to 90-95 DEG C, keeping the temperature for 2 hours, decolorizing, then taking out the material, filtering, collecting filtrate, adjusting the pH value of the filtrate to 5-6 at 20-30 DEG C so as to separate out crystals, and centrifugally drying to obtain a crude product; S4, adding water into the crude product, adjusting the pH value of the crude product to 13-14, adding activated carbon, heating to 90-95 DEG C, keeping the temperature for 2 hours, decolorizing, taking out the material, filtering, collecting filtrate, adjusting the pH value of the filtrate to 5-6 at a temperature of 20-30 DEG C so as to separate out crystals, and centrifugally drying to obtain fine sulfachlorpyridazine; and S5, cooling the crude product mother liquor to 0-5 DEG C to separate out sulfanilamide, wherein the refined mother liquor is recycled and mixed with the water and the activated carbon in the step S3.