5 results about "Sulfachlorpyridazine" patented technology

The invention discloses an buckling bacterium strain and an application of the buckling bacterium strain in degradation of sulfachloropyridazine. The preservation information of the Ancylobacter sp. Sas-18 is as follows: the preservation unit is Guangdong Microbiological Culture Collection Center (GDMCC), the preservation date is November 25, 2025, the preservation address is Guangdong Institute of Microbiology on Floor 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou, the postal code is 510070, and the preservation number is GDMCC No. 67354. According to the invention, an Ancylobacter sp. SAs-18 with a good degradation effect on sulfachloropyridazine is separated from surface soil of a heavily polluted area of a wastewater discharge site of a pharmaceutical factory in Foshan City, Guangdong province, and can be used for degrading and removing sulfachloropyridazine. And an economic and green method is provided for removing the novel organic pollutants.

This invention relates to the field of pharmaceutical preparation technology, specifically to a sulfachlorpyridazine sodium-methotrexate suspension, its preparation method, and its application. The sulfachlorpyridazine sodium-methotrexate suspension of this invention comprises the following components per 100 ml: 20-50 g of sulfachlorpyridazine sodium, 4-10 g of methotrexate, 0.1-0.25 g of suspending agent, 0.05-0.125 g of wetting agent, 0.2-0.5 g of antioxidant, 0.1-0.25 g of disodium edetate, and purified water to a final volume of 100 ml. The suspension prepared by this invention can delay the in vivo clearance of sulfachlorpyridazine sodium, prolong the synergistic effect time, and improve its bioavailability; in the treatment of coccidiosis infection in chickens and sheep, it can significantly improve weight gain, reduce intestinal lesion values, rapidly clear oocysts, and maintain a long-lasting protective effect after drug withdrawal.

The invention discloses compound sulfachloropyrazine sodium soluble powder as well as a preparation method and application thereof, and belongs to the technical field of veterinary drugs. Every 100 g of the soluble powder comprises 15-30 g of sulfachloropyrazine sodium, 4-8 g of methamprine, 6-12 g of a carrier I, 3-6 g of a carrier II, a surfactant, a metal chelating agent, an antioxidant and a filler. The preparation method is characterized by comprising the following steps: dissolving the methampheline and the carrier I in absolute ethyl alcohol, adding the carrier II for dispersion, heating for volatilization, cooling for solidification and drying to prepare the methampheline composite carrier solid dispersion; and mixing the sulfachloropyrazine sodium with sulfachloropyrazine sodium and other auxiliary materials to obtain a finished product. The dissolving and dispersing performance of the methampheline is remarkably improved through a solid dispersion technology, synchronous dissolution of the methampheline and the sulfachloropyrazine sodium is ensured, the preparation is good in water solubility and high in stability, and the excellent synergistic interaction effect and the animal growth promoting effect are shown in chicken and sheep coccidiosis prevention and treatment.

The application discloses a synthesis process of high-purity sulfonamide chlorodiazine sodium, and belongs to the technical field of medicine industry synthesis, which comprises the following steps: synthesizing a condensate, synthesizing sulfonamide chlorodiazine, and synthesizing sulfonamide chlorodiazine sodium finished product; the condensate is synthesized by mixing an aromatic hydrocarbon solvent, 3,6-dichloropyridazine, p-acetamidobenzenesulfonamide, an acid-binding agent and a catalyst at 20-30 DEG C, and then performing a reflux water separation reaction at 100-120 DEG C; after 6-10 hours of reaction, the temperature is lowered to obtain a condensate liquid; and the catalyst is one of cuprous bromide, cuprous iodide and cuprous chloride. The synthesis process has the advantages of safety and environmental protection, cheap and easily available raw materials, simple process and low production cost, and the prepared sulfonamide chlorodiazine sodium has high yield and high purity.

This invention discloses a strain of *Tridentium flexneri* and its application in the degradation of sulfachlorpyridazine. *Tridentium flexneri* (… Ancylobacter The preservation information for *Sp.* SAs-18 is as follows: Depository Institution: Guangdong Provincial Microbial Culture Collection Center (GDMCC); Deposit Date: November 25, 2025; Address: 5th Floor, Building 59, No. 100 Xianlie Middle Road, Guangzhou, Guangdong Institute of Microbiology, Postcode: 510070; Accession Number: GDMCC No. 67354. This invention isolates a strain of *Vibrio parahaemolyticus* (sp.) SAs-18, which exhibits good degradation effects against sulfachlorpyridazine, from the topsoil of a heavily polluted area at a pharmaceutical factory wastewater discharge site in Foshan City, Guangdong Province. Ancylobacter SAs-18 (sp.) can be used for the degradation and removal of sulfachlorpyridazine, providing an economical and green method for removing this type of novel organic pollutant.