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Cefdinir granule and preparation method thereof

A technology of cefdinir granules and granules, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and bulk delivery.

Inactive Publication Date: 2014-10-29
南京亿华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cefdinir as a third-generation cephalosporin, cefdinir on G ＋ , G － Bacteria have broad-spectrum antibacterial activity and can inhibit 90% to 100% of clinical isolates, such as methicillin-sensitive Staphylococcus aureus (MSSA), Staphylococcus epidermidis (MSSE), Streptococcus (including Streptococcus pneumoniae), influenza Haemobacterium, Klebsiella pneumoniae, Moraxella catarrhalis, Escherichia coli, and even Neisseria gonorrhoeae, Branham catarrhalis, and indole-positive Proteus have good curative effects, but Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas cepacia not effective

Method used

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  • Cefdinir granule and preparation method thereof
  • Cefdinir granule and preparation method thereof
  • Cefdinir granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Cefdinir 100g

[0049] Lactose 600g

[0050] Sucrose 600g

[0051] Low-substituted hydroxypropyl cellulose 250g

[0052] Orange flavor 10g

[0053] Sodium saccharin 10g

[0054] Micronized silica gel 5g

[0055] Hydroxypropyl Cellulose Q.S.

[0056] Talc Q.S.

[0057]

[0058] Made into 1000 pieces

[0059] Preparation:

[0060] The excipients are crushed through 100 sieves, and set aside; the active ingredient is micronized so that the particle size is less than 10 μm, set aside. The active ingredient cefdinir and the prescribed amount of lactose, sucrose, low-substituted hydroxypropyl cellulose, orange essence, saccharin sodium, and micropowder silica gel are added in equal amounts, and mixed evenly through a 100-mesh sieve to obtain a mixed powder, hydroxypropyl cellulose The soft material is made of cellulose-based 70% alcohol solution, and the pellets are prepared by extrusion and spheronization technology. The mesh size of the pellets is selected to be a...

Embodiment 2

[0062] Cefdinir 100g

[0063] Lactose 600g

[0064] Sucrose 600g

[0065] Low-substituted hydroxypropyl cellulose 250g

[0066] Orange flavor 10g

[0067] Sodium saccharin 10g

[0068] Micronized silica gel 5g

[0069] Hydroxypropyl Cellulose Q.S.

[0070] Talc Q.S.

[0071]

[0072] Made into 1000 pieces

[0073] Preparation:

[0074] The excipients are crushed through 100 sieves, and set aside; the active ingredient is micronized so that the particle size is less than 10 μm, set aside. The active ingredient cefdinir and the prescribed amount of lactose, sucrose, low-substituted hydroxypropyl cellulose, orange essence, sodium saccharin, and micropowder silica gel are added in equal amounts, and mixed evenly through a 100-mesh sieve to obtain a mixed powder, which is centrifuged Prepare granules by granulation, select the granules with a mesh size of about 40 mesh, coat the granules with a colored film, and pack them in one-piece tapes to obtain the product.

Embodiment 3

[0076] Cefdinir 100g

[0077] Lactose 1200g

[0078] Croscarmellose Sodium 150g

[0079] Tartaric acid 50g

[0080] Sodium bicarbonate 50g

[0081] Cherry essence 10g

[0082] Sodium saccharin 10g

[0083] Micronized silica gel 5g

[0084] Hydroxypropyl Cellulose Q.S.

[0085] Talc Q.S.

[0086]

[0087] Made into 1000 pieces

[0088] Preparation:

[0089] The excipients are crushed through 100 sieves, and set aside; the active ingredient is micronized so that the particle size is less than 10 μm, set aside. The active ingredient cefdinir and the prescribed amount of lactose, croscarmellose sodium, tartaric acid, sodium bicarbonate, cherry essence, sodium saccharin, and micropowder silica gel are added in equal amounts and mixed evenly through a 100-mesh sieve to obtain Mixed powder, soft material made of 70% hydroxypropyl cellulose alcohol solution, granules are prepared by extrusion and spheronization technology, the mesh size of the granules is about 40 mesh, t...

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Abstract

The invention relates to the technical field of medicinal preparations, and discloses a cefdinir granule and a preparation method thereof. The cefdinir granule comprises an active component cefdinir, a filler, a disintegrating agent, a flavoring, a perfume and a flow aid. The cefdinir granule is characterized in that small balls with the size of about 40 meshes are prepared by adopting an extrusion-spheronization technology or a centrifugation granulation technology, the small balls are coated by a colored film, and packaging is carried out by adopting a line-shaped band. The cefdinir granule prepared in the invention has the advantages of good mouthfeel, fast oral absorption, high bioavailability, and improvement of the medication compliance of patients especially children patients by the mixed use of the flavoring, the perfume and the colored film coating.

Description

1. Technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a cefdinir granule and a preparation method thereof. 2. Technical background [0002] Cephalosporin antibiotics are a powerful new force in anti-infective drugs. They have the characteristics of high curative effect, small side effects, broad antibacterial spectrum and strong antibacterial activity. Cephalosporins are a class of antibiotics obtained from the natural cephalosporin C obtained from the cultivation of Cephalosporins coronatum as raw material and semi-synthetic modification of its side chain. Cephalosporin antibiotics are semi-synthetic antibiotics containing cephem in their molecules, which belong to β-lactam antibiotics and are derivatives of 7-aminocephalosporanic acid in β-lactam antibiotics. Cephalosporins play a bactericidal effect by inhibiting the synthesis of bacterial cell walls and are stable to most β-lactamases. [0003] Cefdinir ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/546A61P31/04
Inventor 靳静杨鹏辉王兵成
Owner 南京亿华药业有限公司
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