332results about How to "To achieve a sustained release effect" patented technology

The invention relates to a biological slow-release compound fertilizer, which comprises the following components in percentage by mass: 1 to 50 percent of animal blood membrane-forming agent, 40 to 90 percent of inorganic quick-acting fertilizer and 5 to 10 percent of binding agent, wherein the animal blood membrane-forming agent comprises the following components in percentage by mass: 10 to 50 percent of animal blood solid matter or derivatives thereof, 1 to 10 percent of high polymer membrane-forming agent, 1 to 20 percent of high polymer slow-release agent and the balance of water; the animal blood solid matter is animal blood powder prepared by drying animal blood; and the derivatives of the animal blood solid matter are chemically-modified animal blood powder prepared by performing chemical modification on the animal blood powder by using high polymer materials. The animal blood membrane-forming agent is water-insoluble and has the slow-release performance. Results of plot experiments in farm fields show that the biological slow-release compound fertilizer has obvious yield-increasing effect on crops, and improves the economical characters of the crops, especially vegetablesand lawns.

The invention provides a temperature-sensitive amphiphilic cyclodextrin polymer PCEC (polycaprolactone-polyethylene glycol-polycaprolactone, PCL-PEG-PCL). The polymer provided by the invention is the amphiphilic cyclodextrin polymer which is obtained by linking a PCL-PEG-PCL molecule with beta-CD (cyclodextrin) through utilizing the temperature-sensitive characteristic of a PCL-PEG-PCL triblock copolymer and the inclusion effect of beta-CD on a hydrophobic medicament, can effectively load and slowly release a hydrophobic or water-soluble medicament on the basis of the traditional hydrogel encapsulated water-soluble medicament, has proper critical gel temperature and can form in situ temperature-sensitive hydrogel after injection. According to the invention, the hydrophobic zone of the polymer is obviously enlarged, thereby effectively improving the loading capacity of the hydrogel on the hydrophobic medicament and obtaining high medicament encapsulation rate and medicament loading amount; and simultaneously, the controlled-release effect of the medicament after local injection delivery is realized by utilizing the temperature-sensitive gel performance of the polymer. The polymer provided by the invention has the following chemical structure shown in the specification.

The invention provides a biology-breathable cosmetic mask. The biology-breathable cosmetic mask is prepared from, 1%-5% of natural polymer material, 1%-10% of wetting agent, 0.12%-0.25% of cross-linking agent, 0.1%-5% of surface active agent, 0.1%-2% of preservative, 0.01%-1% of acid-base modifier, 0.01%-30% of medicine carrying functional component and the balance distilled water. The pH value of the biology-breathable cosmetic mask is 5.5-8.0. The invention further provides a preparation method of the biology-breathable cosmetic mask. The biology-breathable cosmetic mask can be dissolved quickly and completely in hot water of above 50 DEG C and is swelled only without being dissolved after being placed in normal temperature water; however, the mask can be dissolved gradually after several hours, complete biodegradation is achieved, and no pollution to the environment is caused. The biology-breathable cosmetic mask can be either a transparent thin film or a translucent or opaque thin film.

The invention discloses a method for preparing carbon and producing a controlled-release fertilizer by utilizing crop straws and the controlled-release fertilizer prepared by using the method, solving the problem that the straws can not be effectively utilized. The method mainly comprises the three steps of straw granulation, combustion carbon discharge and fertilizer preparation. By using the method, batch processing and effective utilization are carried out on the straws; the method is easy to grasp, has strong environmental suitability and is suitable for large-scale popularization and usein countries; by using the method, carbon can be prepared from the straws and then is used for preparing the fertilizer and the straws can also be prepared into biomass fuel for use; and production process is environmentally-friendly, thereby achieving cyclic utilization of energy and relieving the critical conditions of fertilizers and fuels in countries.

The invention discloses a paclitaxel loaded catenulate nano fiber and a preparation method thereof. At first, catenulate nano fiber is prepared, then paclitaxel is loaded on the beads to form a drug sustain-released system, and thus slow releasing of paclitaxel can be effectively controlled. Furthermore, the biocompatibility is good, the drug encapsulation rate is high, and the activity is strong. The provided dosage form of paclitaxel has the advantages of little side and toxic effect and sustained-release function, and can be applied to preparation of drugs for treating malignant tumors.

The invention discloses cinnamon essential oil loaded Pickering emulsion. The cinnamon essential oil loaded Pickering emulsion is characterized by comprising the following components in a volume ratio: 45-55% of compounded oil phases by using cinnamon essential oil as a main component, 18-23% of a zein solution, 7-12% of a pectin solution and 17-23% of a xanthan gum solution. The cinnamon essential oil loaded Pickering emulsion disclosed by the invention can be diluted with water to have different working concentrations, can still maintain stable and homogeneous state, and can be widely applied to sepsis resistance and fresh keeping of various fruits and vegetables after picking and during the shelf life in the effect manner of coating, soaking and the like.

The present invention relates to an acidifier for a piglet feed, and a preparation method thereof. The acidifier comprises the following components, by weight, 25-45% of phosphoric acid, 8-15% of lactic acid, 5-10% of fumaric acid, 5-10% of citric acid, 3-8% of calcium formate, 10-20% of white carbon black, 10-20% of calcium hydrogen phosphate, and 10-20% of stearic acid. According to the preparation method, the components are subjected to mixing, heating, granulation, screening and other process steps to prepare the acidifier for the piglet feed. Compared with the acidifier in the prior art, the acidifier of the present invention has advantages of good use effect, stable product performance, simple synthesis route, ensured acid-sensitive nutrient substance titer, and the like.

The invention relates to a controlled-release antibacterial dressing and a preparation method thereof and particularly discloses a compound. The compound contains a dressing carrier and microspheres loaded to the dressing carrier. The invention further discloses a composition, a dressing as well as a preparation method and use of the dressing. According to the composition and the dressing, the pharmaceutical burst release phenomenon of a common antibacterial dressing can be effectively improved, and the growth and reproduction of germs such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and Candida albicans can be steadily inhibited for a long time. The controlled-release antibacterial dressing provided by the invention is applicable to the treatment of operation cuts,wounds, burns, donor sites, pressure sores, diabetic ulcer and other wound surfaces.

The invention discloses embolization particles developable under X-rays. The particles contain a biocompatible material and iodized oil, and the iodized oil is coated by the biocompatible material to form microcapsule particles. The particles have high biocompatibility, can be monitored in embolization, and are convenient for checking the embolization effect after embolization, and the like; during entrapment of medicaments, the medicaments can be released slowly from the particles; relatively high medicament concentration can be kept for a long time on an embolization part; and compared with perfusion treatment, the embolization particles have the advantages: the toxic and side effects of medicaments on a whole body can be lowered, and treatment effect of embolization can be improved. Moreover, a preparation process of the embolization particles is simple, has low cost, and is suitable for large-scale industrial production.

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.

The invention provides a PCLm-PEG6000-PCLm thermo-sensitive self-assembled tri-block copolymer, wherein the copolymer presents two-phase transition characteristics, and can be applied to a controlled release drug delivery system as a drug carrier or can be applied to tissue engineering as a biodegradable material. The invention further provides a pharmaceutical composition containing the tri-block copolymer, and a preparation method and an application of the pharmaceutical composition. A system consisting of PCLm-PEG6000-PCLm tri-block copolymer and water can both load water-soluble drugs, and can efficiently load water-insoluble drugs, and has an excellent controlled-release effect.

The invention discloses a method for preparing novel silver ion molecular sieve as antiseptic, which includes: firstly, mixing and stirring a silicon source, an aluminum source, template agent, alkali and water according to a certain mole ratio to obtain mixed liquor, subjecting the mixed liquor to hydrothermal synthesis at 60-200 DEG C, taking out solid products after 6-240 hours, and washing and drying the solid products to obtain a crude molecular sieve; secondly, subjecting the crude product to thermal treatment in dilute alkali liquor to obtain a final molecular sieve product; and thirdly, subjecting the molecular sieve to sliver ion exchange prior to soaking in ionized water, and performing filtering and vacuum drying to obtain the silver ion molecular sieve as antiseptic. According to the specific regular nanopore structure of the molecular sieve, special formula and surface treatment techniques are used to implement different pore functional modifications and surface functional modifications, thereby implementing slow release of sliver ions, improving persistence of antibacterial property, and greatly improving stability of the additive and compatibility of the additive with paint.

The invention belongs to the pharmacy field, particularly relating to a method for preparing a recombinant nattokinase specific oral preparation and an application thereof. The invention utilizes a supercritical CO2 fluid coating technology and takes methacrylate- ethylacrylate copolymer (Eudragit L100-55) as coating materials to coat recombinant nattokinase medicine particles to prepare the oral preparation. The particles of the recombinant nattokinase preparation have the advantages of regularity, smooth surface, uniform appearance, no adhesion and high drug-loading amount and entrapment rate, and the average particle diameter is between 105 and 165 mu m. The test results show that the method realizes the resistance of gastric acids and the slow release reaction of the recombinant nattokinase oral preparation.

The invention discloses a stable repairing agent for improving heavy metal soil. The stable repairing agent is prepared by compounding solidified microorganism slow-release particles, modified biomass charcoal and a chelating adsorbent, wherein the solidified microorganism slow-release particles are obtained by mixing and reacting an aqueous solution containing montmorillonite, diatomite and polyvinyl alcohol with an aqueous solution containing corn starch, a microbial agent and hydroxypropyl chitosan, the modified biomass charcoal is obtained by performing soaking pretreatment on organic matter powder through potassium chloride and magnesium chloride solutions and then performing carbonization, and the chelating adsorbent is prepared by grafting organosilane and tyrosine on the surface of hydroxyapatite. The invention further discloses a preparation method of the stable repairing agent and application of the stable repairing agent to improvement of heavy metal soil. According to the invention, natural porous mineral powder and organic matter materials are used as matrixes, the soil environment and plant survival conditions are improved, the metabolism function of microorganisms and plants is enhanced, heavy metal is solidified, stabilized and effectively reduced, and stable remediation of heavy metal soil is achieved.

The invention belongs to the technical field of tissue engineering biological scaffold materials and manufacturing thereof, and discloses an alginate / nano-clay composite microcarrier and a preparing method and device. The method comprises the steps of firstly, preparing a sodium alginate solution and nano-clay sol separately, and obtaining sodium alginate / nano-clay nano-composite hydrogel after the sodium alginate solution and the nano-clay sol are uniformly mixed. Furthermore, a stem cell suspension is mixed in the hydrogel, and besides, bioactive factors or drug ingredients can also be added. Then, the electrostatic drop method microcarrier preparing device which is mainly composed of a high-voltage power supply and a micro-injection pump is adopted, an open glass container containing acalcium chloride solution is used as a receiving device of the microcarrier, and proper injection speed and voltage are set. Compared with a pure alginate microcarrier, the prepared alginate / nano-claycomposite microcarrier has better mechanical performance, has the sustained drug release capability with which the alginate microcarrier is not endowed, and has an excellent application prospect in the field of stem cell treatment and tissue engineering.

The invention provides functionalized mesoporous bioglass porous scaffolds as well as a preparation method and an application thereof. The preparation method comprises the following steps: (1) providing mesoporous bioglass powder; (2) uniformly mixing the mesoporous bioglass powder, a binding agent and a pore-foaming agent in a mass ratio of (0.3-0.5): (0.05-0.15): (0.3-0.5) so as to obtain mixed powder, putting the mixed powder into a mold, and pressing at the pressure of 2-5 Mpa; (3) putting and baking materials obtained by pressing in a muffle furnace so as to obtain porous scaffolds; (4) respectively putting the scaffolds into a methylbenzene solution containing a silane coupling agent APS (aminopropyltriethoxysilane) and a methylbenzene solution containing 3-(triethoxysilyl)propylsuccinic anhydride (TESPSA), refluxing, and drying in a vacuum so as to respectively obtain the amination mesoporous bioglass porous scaffold and the carboxylation mesoporous bioglass porous scaffold. The porous scaffolds provided by the invention have the advantages that the mesoporous structure of mesoporous bioglass is maintained, and the porous scaffolds are relatively high in porosity and large in capacity, have relatively high strength and can be used for bone tissue repairing.

The invention relates to a quetiapine sustained release tablet which at least comprises quetiapine taken as active ingredient or pharmaceutically acceptable salt thereof, ethylcellulose taken as sustained release framework material, and water-soluble binding agent with low viscosity, wherein the ethylcellulose has the average grain diameter less than or equal to 80 mu m, and the preferable average grain diameter is less than or equal to 40 mu m. The invention also relates to a preparation method of the quetiapine sustained release tablet. The product of the invention has good sustained release property, and has the advantages of simple production technique, no use of organic solvent in the technique process and easy cleaning of production equipment and field.

The invention provides a novel preparation method for hydrothermal carbon-based sustained-release nitrogenous fertilizer prepared from waste biomass in consideration of the current situation that the utilization rate of fertilizer is low due to excess application of chemical nitrogenous fertilizer and the amount of waste biomass in China is great. The novel preparation method comprises the following steps: 1) subjecting waste biomass to hydrothermal treatment so as to convert waste biomass into hydrothermal carbon; and 2) adding a certain amount of chemical nitrogenous fertilizer into hydrothermal carbon and carrying out adequate mixing and drying successively. The hydrothermal carbon-based sustained-release nitrogenous fertilizer prepared from waste biomass in the invention can effectively delay the dissolving-out rate of elemental nitrogen of the fertilizer in soil and improves the utilization efficiency of nutrients; and the sustained-release fertilizer carrier hydrothermal carbon is prepared from waste biomass, so the fertilizer has the characteristics of environmental protection, low price, etc.

The invention relates to an anti-dental-ulcer allicin medicinal composition and a preparation method thereof. The allicin medicinal composition is divided into two layers, which are respectively a medicine-containing adhesive layer and a waterproof protective layer, wherein an allicin cyclodextrin inclusion compound is prepared from allicin and cyclodextrin or derivative thereof in the medicine-containing adhesive layer, so that the solubility and stability of allicin can be improved; the content of allicin is 0.1-2 percent of the weight of the composition. According to the two-layer composition, solution of the medicine to the opposite side of the oral mucosa and two-way adhesion of a tablet between the gum and the oral mucosa can be reduced, and the medicine is concentrated in the affected part, so that the drug effect is improved. The allicin medicinal composition prepared by the method has the advantages of reliable quality, stable property and good curative effect.

The invention provides propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and a preparation method thereof, and belongs to a preparation method for a periodontal treatment local slow-release medicament. The gel comprises a blank matrix thermo-sensitive in-situ gel of a chitosan acetic acid solution and an aqueous solution of beta-sodium glycerophosphate in a volume ratio; and an aqueous solution of propolis-coated hydroxypropyl beta-cyclodextrin in a mass ratio is used as a slow-release micro capsule of propolis / hydroxypropyl beta-cyclodextrin. The invention also provides the preparation method of the propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel. Preferably, the chitosan of which the deacetylation degree is 90 percent and the molecular weight is 0.5 million Doyle is used as a medicament-carrying slow-release gel preparation. The gel forming temperature of the thermo-sensitive gel is 36 DEG C, the gel forming time is 65 seconds, the gel is released slowly and stably, the release degree reaches over 99 percent in 24 hours at the temperature of 37+ / -0.5 DEG C, and a sudden release effect is avoided.

The invention discloses a slow release type feed acidifying agent preparing method. Packaging materials with different release rates are prepared firstly, and then the packaging materials are mixed and packaged at proportion. When the packaging materials are prepared, the following steps are conducted: firstly adsorbing liquid acid by silicon dioxide, then mixing with solid acid, and pulverizing so as to obtain a powder material; dividing the powder material into two parts, adding one part into a centrifugal granulator, then spraying part of molten fatty acid and ester of the fatty acid into the powder material in the centrifugal granulator, and spraying liquid while adding the rest part of the powder material so as to obtain needed particles; adding the obtained particles into a fluidized bed, conducting coating on the particle material by the part of molten fatty acid and ester of the fatty acid through a fluidized bed spraying system, and screening after the coating so as to obtain the packaging material with certain release rate, wherein the release rates are controlled by the total quantity of the fatty acid and the ester of the fatty acid. The preparation process is low in energy consumption, the prepared acidifying agent is free of corrosion, the cost is low, the effective constituent content is high, and staged release can be realized.

The invention relates to the field of window nets, and in particular, relates to an anti fog and haze window net. The anti fog and haze window net provided by the invention includes an outer-layer dedusting window net and an inner-layer purifying window net; the outer-layer dedusting window net mainly filters dust in air, and the inner-layer purifying window net mainly plays roles in adsorbing and filtering bacteria in the air and harmful chemical gases in automobile exhaust gas, so the anti fog and haze window net provided by the invention not only has the dedusting function, but also has the functions of filtering the bacteria and the harmful chemical gases. The anti fog and haze window net provided by the invention can effectively control and improve the high-altitude indoor air quality in a haze weather, absorbs harmful bacteria, microorganisms and dust in the air to a greatest extent, plays a great role in protecting body health of indoor occupants, is of great significance to maintain the body health of all urban residents in future urban construction, and also plays a key role in improvement of the urban living environment in the future.

The invention discloses a slow-release asphalt modified regenerant and a preparation method thereof. The regenerant comprises the following components in parts by mass: 30-80 parts of modified base oil, 30-50 parts of matrix asphalt, 10-30 parts of an added oil, 1-5 parts of a plasticizer, 1-5 parts of an anti-aging agent, 1-5 parts of a modifier and 1-10 parts of a capsule modifier. The regenerant provided by the invention is capable of adjusting the viscosity of new and old asphalt and mixture systems, enhancing the anti-stripping performance of systems, slowly releasing light components, realizing lasting regeneration, saving the dosage of new asphalt, increasing the compatibility of the new and old asphalt through active points, improving the performance of the asphalt, resisting agingand the like. In addition, the regenerant provided by the invention can realize waste recycling, and solve the problems of single performance and poor long-term regeneration effect of traditional regenerants. In addition, the regenerant is simple in preparation process and convenient for industrial production.

The invention discloses an emulsion with functions of persistently moisturizing and removing wrinkles and a preparation method thereof. The emulsion belongs to a w / o / w structure, and meanwhile loads a moisturizing active component and a wrinkle-resistant active component. The emulsion comprises the following components: moisturizing and wrinkle-resistant active components, an emollient, a surfactant, a cosurfactant, mesoporous silicon, a pH adjustor and deionized water. A shell is formed at the oil-water interface of the mesoporous silicon due to characteristic that structurally, oxygen atoms easily form hydrogen bonds with hydrophyllic terminals of the amphipathic surfactant, so that the release time of the active components is postponed. The emulsion with functions of persistently moisturizing and removing wrinkles provided by the invention has very good stability, is simple in preparation method, and has an abroad market when being applied to the field of cosmetics.

The invention relates to a method for compounding and entrapping tea polyphenols through debranched starch and xanthan gum. The method comprises the following steps of (1) making starch raw materials into starch milk and performing sufficient gelatinizing; (2) lowering the temperature to the appropriate temperature of debranching enzymes, adding the debranching enzymes for enzymolysis, and then performing ion exchange, decoloring and concentration on enzymatic hydrolysate; (3) enabling the xanthan gum to dissolve in the water, and performing compounding with the concentrated enzymatic hydrolysate of the debranched starch; (4) maintaining the temperature of a compounding system solution to be 70-80 DEG C, maintaining the temperature to be the temperature range, under the stirring condition, adding the tea polyphenols, and performing uniform stirring; and (5) uniformly stirring the solution, then sending the uniformly-stirred solution into a high-pressure homogenizer for homogenizing for several times, then sending the homogenized solution into a spray drying system, and under the condition of being away from light, performing stirring and spray drying at the same time so as to obtain tea polyphenol microcapsules. The method is simple to operate, the starch is used as a main raw material, and through compounding with the xanthan gum, so that the stable state of the tea polyphenols is realized; and the tea polyphenols can be slowly released in the digestive tract of human bodies, so that the bioavailability of the tea polyphenols is improved, and the application range of the starch is extended.

The invention discloses an Amoxicillin capsule which is prepared from the following raw materials in parts by weight: 200 parts of Amoxicillin, 5-10 parts of sodium carboxymethylcellulose, 1-1.5 partsof talcum powder and 0.5-3.5 parts of magnesium stearate. Compared with the prior art, the Amoxicillin capsule is enabled to have higher dissolution rate through regulating the particle sizes of Amoxicillin particles as raw materials and the proportion of auxiliary materials, the use of carboxymethyl starch, cross-linked polyvinylidone and other disintegrating agents is avoided, the size of the Amoxicillin capsule is reduced, and the raw materials and the auxiliary materials can be held by using a No. 1 capsule; the process steps of the Amoxicillin capsule are simplified, the production costis reduced, and the production efficiency is improved.

The invention relates to a method for preparing a hollow fiber cigarette filter tip, which comprises the following steps of: (1) after doping hollow fibers into acetate fibers, bundling, curling and drying to obtain a mixed fiber bundle, wherein the mixed fiber bundle comprises 25-50 percent of hollow fibers and 50-75 percent of acetate fibers in percentage by weight: adding 0.5-5 percent by mass of fruit extract liquid or 0.5-5 percent of Chinese herbal medicine extract liquid into the hollow fibers; (2) sizing, forming and cutting the mixed fiber bundle off to obtain a mixed fiber filter core; and (3) coating forming paper and Chinese cypress paper on the mixed fiber filter core once. The cigarette filter tip prepared by using the method disclosed by the invention has high air permeability and can effectively filter harmful substances in smoke and meet the slow release of aroma so as to maintain the aroma for a long time.

The invention discloses a preparation method of a grafting modified beta-cyclodextrin aromatic finishing agent. The preparation method comprises the following steps: first, using acrylic acid to carry out grafting modification on beta-cyclodextrin so as to obtain a beta-cyclodextrin-g-polyacrylic acid graft polymer, and then adding an essence solution into the beta-cyclodextrin-g-polyacrylic acid graft polymer solution to carry out reactions so as to obtain the grafting modified beta-cyclodextrin aromatic finishing agent. In the preparation method, the acrylic acid is grafted on beta-cyclodextrin to modify the beta-cyclodextrin, the modified beta-cyclodextrin comprises polycarboxylic acids which can carry out esterification reactions with the hydroxyl groups in the cellulose of fabrics, thus the cyclodextrin is crosslinked with the cellulose, so the shortage that essence cannot stay too long on fabrics is solved, a sustain-releasing effect is achieved, the problems that beta-cyclodextrin cannot carry out reactions with fabrics and the fragrance staying time of beta-cyclodextrin aromatic finishing agent is short are solved, and a better fragrance-lasting effect is achieved.

The present invention belongs to the technical fields of biomedical medicine and nano-medicine, and relates to a stem cell tumor targeting system with internal nano prodrug and a preparation method thereof. The method uses stem cells as cell carriers to prepare an anti-tumor targeting system with general formula of Stem cells-(RGD-PPCD)n through endocytosis and inner load of nano prodrug. The nano prodrug has the characteristics of targeting, sustained release and acid sensitivity release; and the stem cell carrier can remotely target primary lesion and metastasis of tumor. In vitro experimental results show that the stem cells after drug load can retain the proliferation capacity and tumor migration characteristics; and the constructed system is stable to ensure that the drug stays in the form of nano-prodrug for several days in the cells, and can slowly release the drug. In vivo experimental results show that the constructed stem cell targeting system can significantly prolong the survival time of tumor-bearing animals and can maintain normal neurobehavioral characteristics of tumor-bearing animals in comparison with the original drug and nano prodrugs, so as to play the efficient, secure and long-lasting anti-tumor effect.