Thermo-sensitive self-assembled tri-block copolymer, pharmaceutical composition, and preparation method and application of pharmaceutical composition
A technology of copolymer and triblock, which is applied in the field of temperature-sensitive self-assembled triblock copolymer and pharmaceutical composition and preparation thereof, can solve the problem of difficulty in achieving drug release, limiting the loading of water-insoluble drugs, and poor hydrophilicity of the carrier. and other problems, to achieve the effect of accurate and controllable molecular weight of the product, good application value and good hydrophilic performance
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0043] Example 1: PCL 1050 -PEG 6000 -PCL 1050 Synthesis of Triblock Copolymers
[0044] Configure 0.2 g / mL of stannous octoate toluene solution, weigh 6.0 g of polyethylene glycol with a number average molecular weight of 6000 and 2.1 g of caprolactone after dewatering and purification, add 0.12 mL of stannous octoate toluene solution, and place in a 100 mL circle In a bottom flask under nitrogen protection, react in an oil bath at 130°C for 24 hours.
[0045] After the reaction, the temperature of the flask was lowered to room temperature, and the reaction product was dissolved in 5 mL of anhydrous dichloromethane and then precipitated by magnetic stirring in 150 mL of ether. PCL 1050 -PEG 6000 -PCL 1050 . PCL 1050 -PEG 6000 -PCL 1050 The powder was dissolved in 5 mL of dimethylformamide (DMF), placed in a dialysis bag (MWCO=7000), dialyzed in 1 L of deionized water for 24 hours to remove residual small molecules, and freeze-dried to obtain purified PCL 1050 ...
Embodiment 2
[0048] Example 2: PCL 1250 -PEG 6000 -PCL 1250 Synthesis of Triblock Copolymers
[0049] Take by weighing 6.0 g of polyethylene glycol with a number-average molecular weight of 6000 and 2.5 g of caprolactone after dewatering and purification, add 0.15 mL of stannous octoate toluene solution configured in Example 1., place in a 100 mL round-bottomed flask, Under nitrogen protection, react in an oil bath at 130°C for 24 hours.
[0050] All the other aftertreatments are identical with embodiment 1, make PCL 1250 -PEG 6000 -PCL 1250 Triblock copolymer, yield 93.8%.
[0051] The NMR spectrum of the triblock copolymer is shown in Figure 4 (B), the number average molecular weight of the PCL block can be obtained by NMR calculation.
Embodiment 3
[0052] Example 3: PCL 1350 -PEG 6000 -PCL 1350 Synthesis of Triblock Copolymers
[0053] Take by weighing 6.0 g of polyethylene glycol with a number average molecular weight of 6000 after water removal and purification, and 2.7 g of caprolactone, add 0.17 mL of stannous octoate toluene solution configured in Example 1., place in a 100 mL round-bottomed flask, Under nitrogen protection, react in an oil bath at 130°C for 24 hours.
[0054] All the other aftertreatments are identical with embodiment 1, make PCL 1350 -PEG 6000 -PCL 1350 Triblock copolymer, yield 90.7%.
[0055] The NMR spectrum of the triblock copolymer is shown in Figure 4 (C), the number average molecular weight of the PCL block can be obtained by NMR calculation.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com