108results about How to "Play a slow-release effect" patented technology

The invention relates to composite hydrogel and a preparation method thereof. The composite hydrogel is hydrogel which takes a three-dimensional fiber network material as a skeleton, that is, the hydrogel comprises a three-dimensional fiber network material, wherein the three-dimensional fiber network material is a network structured material made of tingled fiber. As the three-dimensional fiber network material of the composite hydrogel is directly combined with the hydrogel, the purpose of strengthening the hydrogel can be achieved without changing the structure of the hydrogel self. Compared with a loosened and porous structure inside the hydrogel, the three-dimensional fiber network structure is dense, and medicines and active factors in the hydrogel can be densely coated, so that a slow-release effect can be achieved, the release velocities of the medicines can be reduced, and the utilization rates of the medicines can be increased.

The invention relates to a biological slow-release compound fertilizer, which comprises the following components in percentage by mass: 1 to 50 percent of animal blood membrane-forming agent, 40 to 90 percent of inorganic quick-acting fertilizer and 5 to 10 percent of binding agent, wherein the animal blood membrane-forming agent comprises the following components in percentage by mass: 10 to 50 percent of animal blood solid matter or derivatives thereof, 1 to 10 percent of high polymer membrane-forming agent, 1 to 20 percent of high polymer slow-release agent and the balance of water; the animal blood solid matter is animal blood powder prepared by drying animal blood; and the derivatives of the animal blood solid matter are chemically-modified animal blood powder prepared by performing chemical modification on the animal blood powder by using high polymer materials. The animal blood membrane-forming agent is water-insoluble and has the slow-release performance. Results of plot experiments in farm fields show that the biological slow-release compound fertilizer has obvious yield-increasing effect on crops, and improves the economical characters of the crops, especially vegetablesand lawns.

The present invention provides one kind of slow-releasing basic fibroblast growdth factor (bFGF) microsphere and its preparation and use. The microsphere has coated bFGF as medicine, and matrix of polylactide-co-glycolide (PLGa). The slow-releasing bFGF microsphere is prepared by using PVA or mixed PVA-PEG liquid as dispersing medium and through w / o / wt% re-emulsion and drying process and mechanical stirring. Its freeze dried power has good dispersivity and low organic solvent residue. The present invention can be used for local administration or vein administration of treating fracture, bone defect and other diseases.

The invention belongs to the field of fertilizer industry and discloses synergistic calcium superphosphate and a preparation method and application thereof. The preparation method comprises the steps of preparing organic acid, amino acid or other small-molecular organic matters containing a large number of low molecular weights by utilizing acid hydrolysis of agricultural wastes and secondary hydrolysis of wastes from a food processing plant, then taking the substance as a synergist I, then adding calcium superphosphate into the synergist I, and uniformly drying and crushing to obtain powdery sustained-release synergistic calcium superphosphate; or uniformly mixing the synergist I, a suspending agent and an emulsification coating agent to prepare a synergist II, then adding calcium superphosphate into the synergist II, and performing high-speed shearing and uniform mixing by a colloid mill to obtain liquid sustained-release synergistic calcium superphosphate. The synergistic calcium superphosphate obviously reduces the opportunity of adsorbing phosphorus by soil colloid or fixing phosphorus by iron ions and the like, increases the effectiveness of phosphorus and improves the utilization rate of fertilizer. The method has the advantages of simplicity, convenience, easiness in operation, capability of saving energy and raw materials and effect of reducing production cost. The synergistic calcium superphosphate disclosed by the invention can be applied to the field of agricultural production of vegetables, fruit trees and the like.

In the present invention the microsphere has coated bFGF as medicine, and matrix of lactic acid-glycol copolymer (PLA-PEG). The slow-releasing bFGF microsphere is prepared by using PVA-PEG mixed liquid as dispersing medium and through evaporation and mechanical stirring. It has excellent slow-releasing performance of over two-week releasing period. Its freeze dried powder has good dispersivity and low organic solvent residue. The present invention can be used for local administration or vein administration of treating fracture, bone defect and other diseases.

The invention relates to a monochamus alternatus imago attractant and a trap thereof, which belong to the technical field of pest control. The volume percents of the components of the attractant are 60 to 80 percent of oil of turpentine, 16 to 24 percent of alcohol, 2 to 10 percent of phenethyl alcohol and 2 to 6 percent of terpineol. The volume percents of each component of the attractant are 24.64 to 32.86 percent of alpha-pinene, 22.91 to 30.55 percent of beta-pinene, 6.51 to 8.68 percent of 3-carene, 2.97 to 3.96 percent of beta-phellandrene, 0.74 to 0.99 percent of terpinolene, 0.62 to 0.83 percent of laurene, others for 1.60 to 2.13 percent, 16 to 24 percent of alcohol, 2 to 10 percent of phenethyl alcohol and 2 to 6 percent of terpineol. The trap consists of a cylindrical body (3), a funnel-shaped imago picking device (6) arranged at the lower part of the body (3), and an imago collecting bottle (7) connected with the lower end of the funnel-shaped imago picking device (6). The attractant has the advantages of convenient preparation, simple usage and long lasting period, and is a nuisanceless plant protection product; and the trap has the advantages of simple structure, low cost, long service life and good attracting effect, and can be wildly applied to the monochamus alternatus imago control in the field.

The invention discloses an inhibitor with sustained release property and a preparation method thereof, and the inhibitor is characterized by comprising the following steps of preparing a polymer emulsion by evenly mixing 10-20% of polymer, 79-89% of solvent and 1% of surfactant according to the percentage of the total weight of the prepared emulsion, further adding 4-9 times of the weight of the polymer emulsion of an inorganic salt type inhibitor, stirring for 2-3 hours at the temperature of 40-50 DEG C, drying an obtained product for 6-8 hours at the temperature of 60-80 DEG C, smashing and then obtaining the inhibitor product with the sustained release property. The preparation method is simple and easy to operate, the obtained product can be sustainedly released during the prevention and control process of coal spontaneous combustion of a mine, thereby prolonging the time of flame retardance; the residual polymer is covered on a coal layer, thereby also playing the roles of oxygen isolation and inhibitation; furthermore, the polymer can utilize waste plastics, and the preparation and the using process can not cause harm to environment, thereby having great application prospect.

The invention provides a cigarette chrysanthemum morifolium perfume and a preparation method and application of a micro capsule thereof. The preparation method comprises the steps that dried chrysanthemum morifolium is pulverized, filtering and concentrating are conducted after percolation extraction is conducted to obtain mango extract; the extract is dissolved in ethanol, a ceramic microfiltration membrane and an organic ultrafiltration membrane are utilized to remove large and small molecular impurities respectively, and mango perfume is obtained after pressure reduction and recovery are conducted; water is added to dissolve the mango perfume, an emulsion agent is added to conduct high speed emulsion, a sodium alginate solution is added, uniformly mixed and poured into atomizing condensation equipment to prepare the micro capsule in an atomizing manner, and the micro capsule is received by a calcium chloride solution. The micro capsule is washed by ethanol and pure water, frozen anddried to obtain finished product micro capsule. The invention further provides the application of the micro capsule in cigarettes, the micro capsule is added to a composite filter rod, rolled and produced into a cigarette. After adding the micro capsule, the fragrance amount can be obviously increased, flower fragrance is outstanding, the fragrance is harmony, sweet taste is increased, irritationand impurity gas can be reduced, therefore smoking fume is gentle, and remaining smell is comfortable.

The invention relates to bionic tissue based on an acellular matrix-cell-three-dimensional fiber network and a preparation method of the bionic tissue. The bionic tissue based on the acellular matrix-cell-three-dimensional fiber network at least comprises composite acellular matrix hydrogel and epithelial cells. The composite acellular matrix hydrogel adopts a three-dimensional fiber network material good in biocompatibility as a framework. The three-dimensional fiber network material good in biocompatibility is a network structure material formed by winding fibers good in biocompatibility. The bionic tissue based on the acellular matrix-cell-three-dimensional fiber network can carry out simulation according to the tissue and organ structures, has good application prospects in tissue engineering, and can be widely applied to the field of biomedicine.

The invention discloses taxol long-circulating nanoparticles. The nanoparticle preparation comprises taxol, a copolymer, a cosolvent, water for injection and the like, wherein according to the nanoparticles, the taxol is 5 to 20 percent of the weight of the copolymer. The invention also discloses a method for preparing the taxol long-circulating nanoparticles. A water phase with cosolvent water soluble vitamin E (TPGS) is dropwise added into an oil phase with the taxol and the copolymer by adopting a method for reversely dropwise adding the solvent, and the nanoparticle preparation with uniform particle size, high entrapment efficiency and high stability can be obtained, and the average particle size is less than 200 nm. The nanoparticle preparation can be used for treating malignant tumors; and an animal experiment shows that the nanoparticle preparation is relatively high in safety and effectiveness.

The invention discloses a slow-release asphalt modified regenerant and a preparation method thereof. The regenerant comprises the following components in parts by mass: 30-80 parts of modified base oil, 30-50 parts of matrix asphalt, 10-30 parts of an added oil, 1-5 parts of a plasticizer, 1-5 parts of an anti-aging agent, 1-5 parts of a modifier and 1-10 parts of a capsule modifier. The regenerant provided by the invention is capable of adjusting the viscosity of new and old asphalt and mixture systems, enhancing the anti-stripping performance of systems, slowly releasing light components, realizing lasting regeneration, saving the dosage of new asphalt, increasing the compatibility of the new and old asphalt through active points, improving the performance of the asphalt, resisting agingand the like. In addition, the regenerant provided by the invention can realize waste recycling, and solve the problems of single performance and poor long-term regeneration effect of traditional regenerants. In addition, the regenerant is simple in preparation process and convenient for industrial production.

The invention relates to a bladder acellular matrix-cell-three-dimensional fiber network based bionic tissue and a preparation method thereof, and specifically relates to a bladder acellular matrix-cell-three-dimensional fiber network based bionic tissue for repairing a urinary system and a preparation method thereof. The bladder acellular matrix-cell-three-dimensional fiber network based bionic tissue at least comprises composite bladder acellular matrix hydrogel and epithelial cells; the composite bladder acellular matrix hydrogel is bladder acellular matrix hydrogel with a three-dimensional fiber network material having good biocompatibility as a framework; the three-dimensional fiber network material having good biocompatibility is a network structure material formed by winding fiber with good biocompatibility. The bladder acellular matrix-cell-three-dimensional fiber network based bionic tissue provided by the invention can perform simulation according to the structure of a bladder, and has a good application prospect in the urinary system.

A preparation method of a core-shell structure collagen polypeptide chelated calcium nanoparticle relates to a preparation method of a nanometer calcium supplementing product. A preparation method of a core-shell structure collagen polypeptide chelated calcium nanoparticle is provided which does not require special equipment and is simple in operation. Soluble alginates are dissolved in water to obtain an alginate solution with a concentration of 0.1-2.0 g / L; a soluble bivalent cation aqueous solution A is prepared with a concentration of 0.01-0.1 mol / L; a collagen polypeptide chelated calcium aqueous solution is prepared with a concentration of 0.01-0.1 mol / L; the collagen polypeptide chelated calcium aqueous solution is added into the solution A, and the pH is adjusted to 5.5-8.0 so as to obtain a solution B; the pH of the alginate solution is adjusted to 5.5-8.0, and the solution B is added and stirred to obtain the core-shell structure collagen polypeptide chelated calcium nanoparticle.

The invention discloses an asphalt regenerant with a slow-release function and a preparation method thereof. The regenerant is prepared from the components in parts by mass: 30 to 80 parts of modifiedbase oil, 30 to 50 parts of matrix asphalt, 10 to 30 parts of added oil, and 1 to 10 parts of a capsule modifier. The regenerant has many advantages that viscosity of new and old asphalt and mixturesystems can be adjusted, the anti-stripping performance of the systems can be improved, long-lasting regeneration of slow-release lightweight components is realized, the using amount of the new asphalt is saved, and compatibility of the new and old asphalt is improved by active sites; moreover, reuse of waste can be realized by the regenerant, and the problems of single performance and poor long-term regeneration effect of traditional regenerant are further overcome; and in addition, the preparation technology of the regenerant is simple, and industrial production is convenient.

The invention discloses functional and environment-friendly compounded planting nutritional soil and a preparation method thereof. The nutritional soil comprises raw materials in parts by weight as follows: 5-7 parts of modified biochar, 15-25 parts of modified filled earth, 5-7 parts of shell powder, 10-15 parts of cake fertilizer, 1-3 parts of a botanical insecticide, 8-12 parts of livestock excrement, 7-11 parts of agricultural straw, 0.1-0.3 parts of a growth regulator, 2-4 parts of a sterilization additive, 4-6 parts of rare earth micro-fertilizer and 6-10 parts of a moisture preserving additive. The nutritional soil is rich in nutrients, further has various functions of killing pests and bacteria, preserving moisture, improving soil and promoting growth and has higher practical valueand good application prospect, productivity of a land can be improved or restored, industrial and agricultural waste is abundantly used as the raw material and is environmentally friendly and safe, and operation and industrial production are easy.

The invention discloses antibacterial leather and a preparation method thereof. The leather takes organic silica gel as the main component, silver carboxymethyl chitosan serves as an antibacterial factor, modified nano-silica and modified layered bimetallic oxide serve as the flame retardant factors, by means of the synergistic effect of all components, such as a good combination effect of silvercarboxymethyl chitosan and a substrate, a synergistic flame retardant effect between the flame retardant factors, a bonding effect between modified nano-silica and dimethyl silicone oil and a synergistic effect between high-viscous dimethyl silicone oil and low-viscous dimethyl silicone oil, the process is improved, good antibacterial and flame retardant properties and other properties are obtained, both the mechanical property and environmental protection requirements of the material are achieved, the performance requirements of leather materials such as bags, shoes and clothing, sports equipment and medical equipment can be met, and the leather has broad market prospects.

The invention discloses a formula of a floating urea sustained release expanded feed for cattle and sheep. The feed comprises urea, an energy feed, a protein feed, mineral salt, an adsorbent, an antioxidant and a mildewproof agent. The floating urea sustained release expanded feed for cattle and sheep is prepared by the steps of: crushing the raw materials, metering according to a certain proportion, mixing, hardening and tempering, performing extrusion puffing and granulating, and drying. The feed has the advantages that: the feed suspends in water and does not sink, the basic shape is kept in a longer time, and the detention time in rumens is relatively longer, so the feed cannot enter rear digestive tracts of the rumens due to the external flow of rumen fluid; the utilization efficiency of urea nitrogen is improved and the ammonia poisoning caused by the rapid decomposition of urea is avoided; meanwhile, protein feed sources are saved, and the raising cost is reduced.

The invention provides a tolterodine sustained release microsphere preparation containing a small molecular additive and a preparation method thereof. The method consists of: weighing tolterodine, the small molecular additive and polylactide-glycolide, dissolving them in 0.2-5ml of dichloromethane, under a homogeneous condition, injecting the mixture into an aqueous solution, maintaining the homogeneous condition for 5min, then conducting 1000rpm stirring to volatilize the solvent for 4h, performing filtering with sieves with a pore diameter of 25 micrometers and 125 micrometers respectively, washing the microspheres with distilled water three times, and performing freeze-drying. The invention utilizes fatty acid or fatty acid ester as the additive of the biological sustained release microsphere preparation, the drug release can last for nearly one month, thus greatly reducing the medication frequency, improving the drug bioavailability and therapeutic efficacy, reduce the toxic and side effect, and greatly alleviating the suffering of patients, and improving the quality of life. Encapsulation of tolterodine with polylactide-glycolide can delay the release of tolterodine and reach a sustained release effect. Adding of the small molecular additive changes the existence and distribution form of tolterodine in microspheres, further delays the release of tolterodine, and improves the drug loading capacity.

The invention currently provides a high-mechanical-strength coal-based agriculture and forestry water-retaining agent and a preparing method thereof; raw materials include lignite, a polymer monomer, a crosslinking agent and an initiator; the raw materials are polymerized in an aqueous solution to become the high-mechanical-strength coal-based agriculture and forestry water-retaining agent; the water-retaining agent comprises the raw materials by the weight percentage: 10 to 90% of the lignite; 5 to 50% of the polymer monomer; 0.01 to 0.5% of the crosslinking agent; and 0.05 to 0.5% of the initiator. Experiments prove that the coal-based agriculture and forestry water-retaining agent has the advantages of high water absorption multiplying power, fast water absorption speed, strong electrolyte resistance ability and high mechanical strength.

The invention relates to an efficient bionic bait comprising a bait body. The surface of the bait body is provided with a hanging ring, a cavity is arranged in the interior of the bait body and is provided with capillary tubes communicated with the surface of the bait body and a bait unit inside. Since the bait unit is arranged in the bait body, the bait unit emits smell to bring fish to the lure, the lure capability of the bionic bait is improved, and the bait swallowing rate is increased.

The invention relates to the field of organic-inorganic composite materials, and in particular relates to a slow-release double-effect pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating MCPA-(2-Methyl-4-chlorophenoxyacetic acid radical) into a hydrotalcite precursor, intercalating chlorpyrifos into the hydrotalcite precursor, and finallytreating the hydrotalcite precursor in a mixed solution containing hydrogen peroxide, n-propanol and water to obtain a slow-release double-effect pesticide; the chemical formula is: [(M<2 +>) 1-x (M<3 +>) x (OH) 2) x +( MCPA-)x (CPF) y.mH2O, wherein x = 0.25-0.33, y = 0.08-0.10, m = 3-6, m is the number of interlayer crystalline water molecules, M<2 +> is a divalent metal ion, M<3 +> is a trivalent metal ion, MCPA-is 2-Methyl-4-chlorophenoxyacetic acid radical, and CPF is chlorpyrifos. The slow-release double-effect pesticide of the invention has stable intercalation structure, can release the MCPA-and the chlorpyrifos l for a long time, and plays a slow-release effect.

The invention relates to the field of organic-inorganic composite materials, in particular to a sustained-release phoxim pesticide and a preparation method thereof. The method includes: low-release phoxim pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating a naphthylacetic acid group into a hydrotalcite precursor; and then intercalating phoxim into the hydrotalcite precursor to obtain phoxim / naphthylacetic acid intercalated hydrotalcite; and putting the hydrotalcite into a mixed solution containing hydrogen peroxide, ethanol and waterfor ultrasonic treatment, thus obtaining the sustained-release phoxim pesticide, the chemical formula of which is shown as [(M<2+>)1-x(M3<+>)x(OH)2]<x+>(NAA<->)x(Phoxim)y.mH2O, wherein x=0.25-0.33, y=0.04-0.05, m=3-6, m is the number of interlayer crystal water molecules, M<2+> is a divalent metal ion, M<3+> is a trivalent metal ion, and Phoxim is phoxim. The sustained-release phoxim pesticide provided by the invention has a stable intercalation structure, can release phoxim for a long time and reach a sustained-release effect, and the preparation method is easy to realize.

The present invention discloses highly active SOD enriched compound vitamin buccal tablets and a preparation method thereof. The buccal tablets are prepared from the following components in parts by weight: 1 part of superoxide dismutase, 0.2-0.3 part of sialic acid, 3-4 parts of hydroxypropyl-beta-cyclodextrin, 12-15 parts of collagen liquid, 30-40 parts of sugarcane juice, 15-30 parts of starch and 50-70 parts of compound vitamins. The superoxide dismutase, and sugars (sucrose, glucose, fructose, etc.), amino acids, vitamins, etc. rich in the sugarcane juice are clathrated together with the hydroxypropyl-beta-cyclodextrin, and an encapsulation effect of the collagen is combined, so that the buccal tablets can effectively improve a stability of SOD and can maintain a relatively high activity for a long time. A small amount of the sialic acid is added and nutrients of the sugars, amino acids, vitamins, etc. rich in the sugarcane juice are supplemented, so that the buccal tablets can play synergistic effects and enhance oxidation resistance of the superoxide dismutase.

The invention discloses a preparation method of a Camellia oleifera fertilizer with high utilization rate. The method comprises the following steps: bentonite, Chinese medical stone powder, and diatomite are mixed and grinded, water, brassinolide, mint essential oil, and forchlorfenuron are added with stirring, and spray drying is carried out in order to obtain a first material; turfy soil, coppersulphate, magnesium nitrate, gypsum powder, and wollastonite powder are mixed, and water is added with uniform mixing in order to obtain a second material; biogas residues, cassava residues, cottonseed meal, fermented peanut meal and wheat bran are added into the first material with mixing, water is added with uniform mixing, a second material, urea, potassium nitrate, and diammonium phosphate are added with uniform mixing, granulation is carried out, and drying is carried out in order to obtain the Camellia oleifera fertilizer with high utilization rate.

The invention provides a grafting water-retaining agent containing the super-high humic acid content for agriculture and forestry. The water-retaining agent is prepared from, by weight, 30%-70% of humate, 5%-30% of starch, 5%-35% of main cross-linking agent, 0.01%-0.5% of auxiliary cross-linking agent and 0.05%-0.5% of initiator, and the raw materials are polymerized in an aqueous solution. A surface structure of the grafting water-retaining agent containing natural polymer of humic acid and the like for the agriculture and the forestry has ionic type hydrophilic groups of -COOH and -COO<-> and various non-ionic type hydrophilic groups of -NH2, -NH-CO-, -COO- and -OH; meanwhile, structural characteristics of the humic acid are achieved, and the characteristic of an amorphous state is embodied.

The invention discloses a cultivation method of camphor trees. Reasonable arrangement is performed through the steps of seed treatment, nursery selection, sowing, seedling culturing, fertilizer application, irrigation, management and the like. By means of the cultivation method of the camphor trees, seed treatment is simple and low in cost, termination of seed dormancy is facilitated by means of the synergistic effect of gibberellin and cytokinin and adjustment of environmental factors such as humidity and temperature, and the dormant state of seeds is broken by taking full advantage of interactions among all hormones and interactions between the hormones and the environment; and a camphor tree special fertilizer is used for topdressing, expanded perlite and carbonized wood residuals in the fertilizer are applied to the soil so as to improve the adsorption structure in the soil, nutrient elements released out of the compound fertilizer are advantageously adsorbed and released, adherent spaces can be provided for the fertilizer, therefore, the slow-release effect of the fertilizer can be achieved in the using process, slow release of nutrients and microelements in the fertilizer in all growing stages of hackberries is effectively improved, and the requirement that the fertilizer can sufficiently supply the nutrients and the elements needed in all growing stages is met.

The invention belongs to the field of medicinal preparations, and relates to a core-shell structured bioadhesive polymer nanoparticle for vaginal administration, and a preparation method and an application thereof. The polymer nanoparticle adopts a silver nanoparticle as a core, and is prepared through copolymerizing an acrylamide cross-linking agent and a mono-olefin phenyl boric acid function monomer on the surface of the silver nanoparticle to form a shell. The polymer nanoparticle has good affinity to mucoproteins, has a long in-vivo retention time after mucosal administration, and has good practical values and application prospect in the vaginal administration field.

The invention relates to the technical field of fertilizer, and discloses a fertilizer bag and a use method thereof. The fertilizer bag comprises a fertilizer bag body, fertilizer and super absorbentresin, wherein the fertilizer and the super absorbent resin are put in the fertilizer bag. The fertilizer and the super absorbent resin are put in the fertilizer bag, dissolved fertilizer is adsorbedby the super absorbent resin in the fertilizer bag body so as to achieve a slow release effect of the fertilizer, the use ratio of plants for the fertilizer is improved, the quality and the yield of an agricultural product are improved, and the functions of plants on the aspects of disease resistance ability, stress resistance ability and the like can be improved.

The invention discloses plastic wax. The plastic wax comprises the following components according to weight percentage content: 10-85% of paraffin, 0-85% of microcrystalline wax, 0-20% of mineral waxand / or vegetable wax, 0-30% of tackifying resin, 4-20% of grease or Vaseline, 0-10% of a high-molecular polymer and 0.25-5% of a phase solvent. The plastic wax is safe in raw material without side effects. The prepared plastic wax is strong in plasticity, can be made into arbitrary shapes, has interestingness, and can be arbitrarily converted to different shapes for using according to need of a used part. Substances capable of acting on the skin surface can be added to the plastic wax. The plastic wax can be directly used without using a special device for heating, is safe and convenient, andhas the slow-release effect. So the substances are effective for a long time, general people can enjoy kerotherapy easily, and a pore can be opened while the plastic wax is used for skin, the skin ispromoted to absorb these substances. The invention further discloses an application of the plastic wax in hairdressing, health-care and aromatherapy.

The invention relates to seabuckthorn oil-polylactide-coglycolide copolymer microspheres and a preparation method thereof; the coated effective component in microspheres is seabuckthorn oil and the matrix component of wrappage is polylactide-coglycolide copolymer (PLGA). Polyving alcohol (PVA) is used as modifier, and the slow release PLGA microspheres can be prepared by the W / O / W double emulsion method (aka solvent evaporation method, solvent solidification method or solvent extraction method) under the action of mechanical agitation. Smooth microspheres surface, round and normal spheres, uniform particle size and good embedding can be observed under a microscope.