Seabuckthorn oil-polylactide-coglycolide copolymer microspheres and preparation method thereof
A technology of glycolic acid copolymer and glycolic acid, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problem of seabuckthorn oil-free PLGA microspheres, etc., achieve good anti-oxidation effect and improve the effect of embedding
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Embodiment 1
[0023] (1) Preparation of the organic phase: pipette 4 ml of dichloromethane into a small beaker.
[0024] (2) Weighing and dissolving of PLGA: 125 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.
[0025] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.
[0026] (4) Preparation of the water phase: Weigh 2.5g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to dissolve the PVA completely .
[0027] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 10 min at a power of 150 W to obtain an O / W emulsion. Then carry out atmospheric pressure magnetic stirring a...
Embodiment 2
[0029] (1) Preparation of the organic phase: pipette 1 ml of dichloromethane and 3 ml of ethyl acetate to prepare 4 ml of the mixture, and add it to a small beaker.
[0030] (2) Weighing and dissolving of PLGA: 135 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.
[0031] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.
[0032] (4) Preparation of the water phase: Weigh 2.8g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to completely dissolve the PVA .
[0033] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 11 minutes with a power of 160W to obtain a...
Embodiment 3
[0035] (1) Preparation of the organic phase: pipette 1.5 ml of dichloromethane and 2.5 ml of ethyl acetate to prepare 4 ml of the mixture, and add it to a small beaker.
[0036] (2) Weighing and dissolving of PLGA: 145 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.
[0037] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.
[0038] (4) Preparation of water phase: Weigh 3.0g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to completely dissolve the PVA .
[0039] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 12 minutes with a power of 170W to obtain an ...
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