Preparation method of high-all-trans carotenoid microcapsule

A carotene, all-trans technology, applied in microcapsules, capsule delivery, medical preparations of inactive ingredients, etc., can solve the problems of difficulty in obtaining beta-carotene microcapsules, low solubility of beta-carotene, etc. The product has high storage stability, improved embedding rate, and good embedding effect.

Active Publication Date: 2020-07-17
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The above-reported nano-methods all use solvents with very low solubility to β-carotene, so it is difficult to obtain nano-dispersed β-carotene microcapsules with industrial value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1) Weigh 100g of β-carotene crystals with an all-trans isomer content of 96%, 100g of corn porous starch, 8g of antioxidant BHT, and 80g of sunflower oil, and grind them with a ball mill for 30 minutes until the crystal particle size is 2-5 μm. Make β-carotene oil suspension;

[0059] 2) Weigh 432g of gelatin, 144g of glucose, and 1056g of deionized water, and mix them with a high-speed shear for 30min at 60°C to obtain an aqueous protective colloid solution;

[0060] 3) Slowly add the β-carotene oil suspension into the aqueous protective colloid solution, adjust the pH of the emulsion to 5.5 with 10wt% sodium hydroxide solution and 10wt% acetic acid solution, and shear at 65°C for 25 minutes at high speed to obtain the aqueous solution of β-carotene The oil-in-oil (O / W) type primary emulsion is homogenized for 3 times by a high-pressure homogenizer at 40MPa to obtain a β-carotene emulsion with a particle size of less than 1um, and the solid content is 45%;

[0061] 4)...

Embodiment 2

[0063] 1) Weigh 100g of astaxanthin with an all-trans isomer content of 96%, 130g of corn porous starch, 10g of antioxidant tocopherol, and 140g of perilla oil, and grind them in a ball mill for 30 minutes until the crystal particle size is 2-5 μm. into astaxanthin oil suspension;

[0064] 2) Weigh 1140g of gelatin, 380g of glucose, and 2850g of deionized water, and mix them with a high-speed shear for 40min at 60°C to obtain an aqueous protective colloid solution;

[0065] 3) Slowly add the astaxanthin oil suspension into the protective colloid aqueous solution, adjust the pH of the emulsion to 6.0 with 10wt% sodium hydroxide solution and 10wt% acetic acid solution, and shear at high speed for 35 minutes at 70°C to obtain astaxanthin oil-in-water (O / W) type primary emulsion, after being homogenized twice under 40MPa of a high-pressure homogenizer, an astaxanthin emulsion with a particle size of less than 1um is obtained, and the solid content is 40%;

[0066] 4) The above-me...

Embodiment 3

[0068] 1) Weigh 100g of lycopene with an all-trans isomer content of 97%, 120g of wheat porous starch, 10g of antioxidant BHT, and 100g of perilla oil, and grind them in a ball mill for 30 minutes until the crystal particle size is 2-5 μm to make a tomato Red pigment oil suspension;

[0069] 2) Weigh 866g of gelatin, 288g of glucose, and 1485g of deionized water, and mix them with a high-speed shear for 40min at 60°C to obtain an aqueous protective colloid solution;

[0070] 3) Slowly add the lycopene oil suspension into the protective colloid aqueous solution, adjust the pH of the emulsion to 7.0 with 30wt% sodium hydroxide solution and 30wt% acetic acid solution, and shear at high speed for 35min at 70°C to obtain the oil-in-water solution of lycopene (O / W) type primary emulsion, then use macroporous D113 weakly acidic acrylic cation exchange resin to filter and adjust the pH to 6.5 to obtain a secondary emulsion, and then homogenize twice under a high-pressure homogenizer a...

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Abstract

The invention provides a preparation method of a high-all-trans carotenoid microcapsule. The method comprises the following steps: 1) grinding carotenoid crystals with an all-trans isomer content of more than 96 percent, porous starch, vegetable oil and an antioxidant into carotenoid oil suspension through a ball mill; 2) mixing a protective colloid, carbohydrates and deionized water to obtain a protective colloid aqueous solution; 3) slowly adding the carotenoid oil suspension into the protective colloid aqueous solution, adjusting pH value, performing shearing at a high speed to obtain an oil-in-water primary emulsion of the carotenoid, and performing homogenization to obtain a carotenoid emulsion; and 4) spray drying the emulsion to obtain the carotenoid microcapsule. The method has theadvantages that: the porous starch is used as a core material carrier, oxidation of the carotenoid is effectively avoided, an all-trans structure of the carotenoid is ensured, the pH value of the emulsion is adjusted in the emulsion preparation process, and the embedding rate of the microcapsule and the product quality are improved.

Description

technical field [0001] The invention relates to a method for preparing carotenoid microcapsules, which belongs to the technical field of preparation of nutritional chemical products. Background technique [0002] Carotenoids widely exist in nature, and the current commercial carotenoid products mainly include β-carotene, astaxanthin, lycopene, canthaxanthin, lutein, etc. These substances are used as nutritional enhancers and coloring agents It is widely used in food, cosmetics, feed and pharmaceutical industries and other fields. In addition, β-carotene is the precursor of vitamin A and has the function of vitamin A. All carotenoids are water-insoluble, and their solubility in fats and oils is also very low. This limited solubility and extreme sensitivity to oxidation prevent the direct application of synthetic carotenoids in the coloring of human or animal foods. Relatively coarse-grained products are obtained, since the coarse-grained crystalline form of the substances i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/01A61K31/015A61K31/122A61K47/36A61K47/42A61P3/02
CPCA61K31/122A61K31/015A61K31/01A61K9/5052A61K9/5057A61K47/36A61P3/02
Inventor 李莉张涛吕英东刘英瑞高洪坤姜天岳
Owner WANHUA CHEM GRP CO LTD
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