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A kind of preparation method of high all-trans carotenoid microcapsules

A carotene, all-trans technology, applied in microcapsules, capsule delivery, medical preparations with inactive ingredients, etc., can solve the problems of low solubility of beta-carotene, difficulty in obtaining beta-carotene microcapsules, etc. The effect of good embedding effect, avoiding organic solvent residues and low preparation cost

Active Publication Date: 2022-08-02
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The above-reported nano-methods all use solvents with very low solubility to β-carotene, so it is difficult to obtain nano-dispersed β-carotene microcapsules with industrial value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1) Weigh 100 g of beta-carotene crystals with an all-trans isomer content of 96%, 100 g of corn porous starch, 8 g of antioxidant BHT, and 80 g of sunflower oil, and grind them in a ball mill for 30 min to a crystal particle size of 2 to 5 μm, Made of beta-carotene oil suspension;

[0059] 2) Weigh 432 g of gelatin, 144 g of glucose, and 1056 g of deionized water, and mix them with a high-speed shearing machine for 30 min at 60° C. to obtain a protective colloidal aqueous solution;

[0060] 3) Slowly adding the β-carotene oil suspension to the protective colloid aqueous solution, and adjusting the pH of the emulsion to 5.5 with 10wt% sodium hydroxide solution and 10wt% acetic acid solution, and shearing at high speed for 25min at 65°C to obtain β-carotene water The oil-in-oil (O / W) type primary emulsion was homogenized for 3 times at 40MPa by a high-pressure homogenizer to obtain a β-carotene emulsion with a particle size of less than 1um, and the solid content rate was...

Embodiment 2

[0063] 1) Weigh 100 g of astaxanthin with an all-trans isomer content of 96%, 130 g of corn porous starch, 10 g of antioxidant tocopherol, and 140 g of perilla oil, and grind them in a ball mill for 30 minutes to a crystal particle size of 2 to 5 μm. into astaxanthin oil suspension;

[0064] 2) Weigh 1140 g of gelatin, 380 g of glucose, and 2850 g of deionized water, and mix them with a high-speed shearing machine for 40 min at 60° C. to obtain a protective colloidal aqueous solution;

[0065] 3) Slowly adding the astaxanthin oil suspension into the protective colloid aqueous solution, and adjusting the pH of the emulsion to 6.0 with 10wt% sodium hydroxide solution and 10wt% acetic acid solution, and shearing at high speed for 35min at 70°C to obtain oil-in-water astaxanthin (O / W) type primary emulsion, and then homogenized twice at 40MPa in a high-pressure homogenizer to obtain an astaxanthin emulsion with a particle size of less than 1um, with a solid content of 40%;

[006...

Embodiment 3

[0068] 1) Weigh 100 g of lycopene with an all-trans isomer content of 97%, 120 g of wheat porous starch, 10 g of antioxidant BHT, and 100 g of perilla oil, and grind them in a ball mill for 30 minutes to a crystal particle size of 2 to 5 μm to prepare tomatoes. Red oil suspension;

[0069] 2) Weigh 866 g of gelatin, 288 g of glucose, and 1485 g of deionized water, and mix at 60° C. for 40 min with a high-speed shearing machine to obtain an aqueous protective colloid solution;

[0070] 3) Slowly adding the lycopene oil suspension into the protective colloid aqueous solution, and adjusting the pH of the emulsion to 7.0 with 30wt% sodium hydroxide solution and 30wt% acetic acid solution, and shearing at high speed for 35min at 70°C to obtain oil-in-water lycopene (O / W) type primary emulsion, then use macroporous D113 weakly acidic acrylic cation exchange resin to filter and adjust the pH to 6.5 to obtain a secondary emulsion, which is then homogenized for 2 times by a high-pressu...

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Abstract

The present invention provides a method for preparing high all-trans carotenoid microcapsules, comprising: 1) passing carotenoid crystals, porous starch, vegetable oil and antioxidants with an all-trans isomer content of more than 96% through a ball mill Grind to make a carotenoid oil suspension; 2) Mix the protective colloid, carbohydrates, and deionized water to obtain a protective colloid aqueous solution; 3) Slowly add the carotenoid oil suspension to the protective colloid aqueous solution, adjust the pH value, high-speed The oil-in-water type primary emulsion of carotenoid is obtained by shearing, and then homogenized to obtain a carotenoid emulsion; 4) the above emulsion is spray-dried to obtain a carotenoid microcapsule product. The advantages of the method are: the use of porous starch as the core material carrier can effectively avoid the oxidation of carotenoids, ensure the all-trans structure of carotenoids, and adjust the pH of the emulsion during the preparation of the emulsion, thereby improving the microcapsules. Embedding rate and product quality.

Description

technical field [0001] The invention relates to a preparation method of carotenoid microcapsules, and belongs to the technical field of formulation of nutritional chemical products. Background technique [0002] Carotenoids are widely found in nature. At present, the commercial carotenoid products mainly include β-carotene, astaxanthin, lycopene, canthaxanthin, lutein, etc. These substances are used as nutritional fortifiers and colorants. It is widely used in the fields of food, cosmetics, feed and pharmaceutical industries. In addition, β-carotene is also a precursor of vitamin A and has the effect of vitamin A. All carotenoids are water-insoluble and similarly low in solubility in fats and oils. This limited solubility and extreme sensitivity to oxidation preclude direct application of synthesis in the coloring of human or animal foods. A relatively coarse-grained product is obtained because the coarse-grained crystalline form of the material is poorly absorbed and thus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/01A61K31/015A61K31/122A61K47/36A61K47/42A61P3/02
CPCA61K31/122A61K31/015A61K31/01A61K9/5052A61K9/5057A61K47/36A61P3/02
Inventor 李莉张涛吕英东刘英瑞高洪坤姜天岳
Owner WANHUA CHEM GRP CO LTD
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