The invention discloses a lettuce plantation fertilizer and a lettuce plantation method thereof. The method is characterized in that plant leaves, sugarcane, urea, potassium dihydrogen phosphate, ammonium sulfate, calcium superphosphate, a carbendazim solution, a dimethomorph solution, and an antiviral preparation are mixed to prepare the fertilizer. The invention also provides a greenhouse plantation method by taking fermented bagasse as a main material and taking a phosphate fertilizer, a nitrogenous fertilizer, a potash fertilizer, polyether polyol and water as the auxiliary materials. The lettuce plantation fertilizer and the lettuce plantation method can guarantee the nutrition component required by the vegetation pollution due to an additional fertilizer applied during the lettuce plantation process can be avoided, humiture can be controlled by using greenhouse, virus disoperation is reduced; the lettuce plantation fertilizer has good water retention, can effectively reduce the water spray frequency, avoids the defect of seedling and transplant required during traditional plantation, shortens the growing period, realizes multiple plantation in one year, realizes a purpose of high yield, and has obvious effects for increasing yield, resisting virus, and disinfecting.