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Preparation method of pesticide nanocapsule

A technology of nanocapsules and pesticides, applied in the field of pesticides, can solve the problems of low effective utilization rate of pesticides, dust drift, low activity, etc.

Active Publication Date: 2017-10-20
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional pesticide dosage forms are mostly open systems. Judging from the registration of pesticide dosage forms, traditional pesticide dosage forms such as emulsifiable concentrates, wettable powders, and microemulsions account for more than 70% of the domestic market. Most of these traditional dosage forms are open. In the process of use, there are losses such as droplet rolling, drifting, bouncing, and dust drift to varying degrees. The effective utilization rate of finally reaching the crop target is less than 30%, and the amount of drug reaching the pest is less than 0.1%. The effective utilization rate is low
When high-concentration microsphere / microcapsule preparations are prepared by interfacial polymerization, crystallization is prone to occur, and the crystallized irregular crystals will destroy the capsule wall, resulting in failure to exert drug effect
The spray drying method is a physical preparation method. The particle size of the pesticide microsphere / microcapsule preparation prepared by this method is relatively large, and it is difficult to achieve a nanometer particle size.
At present, the pesticide microsphere / microcapsule preparations prepared by traditional methods have the following defects: In terms of structure, the particle size of the currently commercially available pesticide microsphere / microcapsule preparations is generally around 5 microns, which has not reached the nanometer level, and the coarse particle size It is easy to cause droplets to roll off and dust to drift, making the adhesion, permeability and bioavailability to crop targets poor during use, and at the same time the activity is also low; in terms of particle dispersibility, the currently prepared pesticide microspheres / Microcapsule preparations have poor monodispersity, serious agglomeration, and uneven particle size distribution, and their surface properties and structural morphology have not been effectively regulated; in terms of controlled release of pesticides, the existing pesticide microspheres / microcapsules Most of the preparations can only achieve simple and qualitative slow release, and the release rate is unstable and controllable; in terms of process flow, traditional methods mostly use heating and heat preservation, gas protection and other processes, which are complicated, difficult to control and poor in repeatability

Method used

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  • Preparation method of pesticide nanocapsule
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  • Preparation method of pesticide nanocapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] The preparation of embodiment 1 pesticide nanocapsule powder 1

[0133] Disperse 0.8g of the active ingredient A thiamethoxam in the inner phase in 20ml of water to obtain the inner water phase, dissolve 2g of the active ingredient B emamectin benzoate in the outer phase in 50ml of the organic solvent dichloromethane, add 2g of capsules Wall material cellulose, to obtain the oil phase, using an ultrasonic pulverizer to drop the inner water phase into the oil phase at 585W, ultrasonic emulsification for 15min, to obtain a W / O emulsion; 2g emulsifying dispersant (1g polyvinyl alcohol and 1g ten Sodium dialkyl sulfonate) was dissolved in 150ml water to obtain the external water phase, and the W / O type emulsion obtained was added dropwise to the external water phase under 28000rmp using a high-pressure shearing machine, and sheared and emulsified for 15min to obtain the W / O / W-type primary emulsion, wherein the droplet size of the primary emulsion is 300nm.

[0134] The ab...

Embodiment 2

[0137] The preparation of embodiment 2 pesticide nanocapsules aqueous suspension 2

[0138] Disperse 0.8g of the active ingredient A thiamethoxam in the inner phase in 20ml of water to obtain the inner water phase, dissolve 2g of the active ingredient B emamectin benzoate in the outer phase in 50ml of the organic solvent dichloromethane, add 2g of capsules Wall material cellulose, to obtain the oil phase, using an ultrasonic pulverizer to drop the inner water phase into the oil phase at 585W, ultrasonic emulsification for 15min, to obtain a W / O emulsion; 2g emulsifying dispersant (1g polyvinyl alcohol and 1g ten Sodium dialkyl sulfonate) was dissolved in 150ml water to obtain the external water phase, and the W / O type emulsion obtained was added dropwise to the external water phase under 28000rmp using a high-pressure shearing machine, and sheared and emulsified for 15min to obtain the W / O / W-type primary emulsion, wherein the droplet size of the primary emulsion is 300nm.

...

Embodiment 3

[0142] The preparation of embodiment 3 pesticide nanocapsule powder 3

[0143] 0.5g internal phase active ingredient A emamectin benzoate is dispersed in 50ml water to obtain the inner water phase, and 2g external phase active ingredient B emamectin benzoate is dissolved in 100ml organic solvent two In the methyl chloride, add 3g polylactic acid, the capsule wall material, to obtain the oil phase, and use an ultrasonic pulverizer to add the inner water phase to the oil phase dropwise at 585W, and ultrasonically emulsify for 15min to obtain a W / O emulsion; emulsify and disperse 3.5g Agent (1g polyvinyl alcohol, 1.5g Nongru 600 and 1g Nongru 700) was dissolved in 300ml water to obtain the outer water phase, and the W / O type emulsion obtained was added dropwise to the outer water phase at 28000rmp using a high pressure shearing machine , and shear emulsified for 15 minutes to obtain a W / O / W type primary emulsion, wherein the droplet diameter of the primary emulsion is 300nm.

[...

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Abstract

The invention provides a preparation method of a pesticide nanocapsule. The method comprises the following steps: emulsifying a component of the pesticide nanocapsule to form primary emulsion, then homogenizing the primary emulsion at high temperature to form fine emulsion, thus preparing the pesticide nanocapsule. The preparation method of the pesticide nanocapsule, which is provided by the invention, is simple, easy to operate and high in repetitiveness; the prepared pesticide nanocapsule has a small particle size, is high in particle dispersity and high in slow release performance.

Description

technical field [0001] The invention belongs to the technical field of pesticides. Specifically, the present invention relates to a method for preparing pesticide nanocapsules. Background technique [0002] Pesticides are an important material basis for ensuring national food security. Traditional pesticide dosage forms are mostly open systems. Judging from the registration of pesticide dosage forms, traditional pesticide dosage forms such as emulsifiable concentrates, wettable powders, and microemulsions account for more than 70% of the domestic market. Most of these traditional dosage forms are open. In the process of use, there are losses such as droplet rolling, drifting, bouncing, and dust drift to varying degrees. The effective utilization rate of finally reaching the crop target is less than 30%, and the amount of drug reaching the pest is less than 0.1%. The effective utilization rate is low. [0003] When pesticides are prepared into dosage forms with different s...

Claims

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Application Information

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IPC IPC(8): A01N25/28A01N25/22A01N53/08A01N51/00A01N47/24A01N47/02A01N43/90A01N43/653A01N43/56A01N43/54A01N37/44A01N37/22
CPCA01N25/22A01N25/28A01N37/22A01N37/44A01N43/54A01N43/56A01N43/653A01N43/90A01N47/02A01N47/24A01N51/00A01N53/00
Inventor 崔海信王琰王安琪
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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