46 results about "Moroxydine" patented technology

The invention belongs to the technical field of poultry product detection and relates to a combined detection method of amantadine, rimantadine, ribavirin and moroxydine residues in eggs. The method comprises the following steps: carrying out low temperature repetitive freeze-thawing on a sample, adding a formic acid-methanol solution, mixing, centrifuging, taking a supernatant for standby, adding water saturated n-hexane, mixing, carrying out ultrasonic treatment, centrifuging to remove n-hexane floccules on the upper layer with an extracting solution left at the lower layer, purifying with a cation exchange solid-phase extraction column, measuring by a liquid chromatography-tandem mass spectrometer provided with an ESI source, and carrying out accurate qualitative and quantitative analysis on residues of the four antiviral drugs in eggs. The method provided by the invention has high specificity, can accurately and simultaneously measure residual quantity of amantadine, rimantadine, ribavirin and moroxydine without pollution, has high sensitivity, and provides technical support for guaranteeing quality safety of eggs.

The externally applied compound tetrodotoxin ointment is prepared with globe fish liver oil, vaseline, frankincense, myrrh, dragon's blood, notoginseng, safflower, catechu, borneol, vitamin B1, vitamin B2, vitamin C, moroxydine, dexamethasone and lidocaine in certain weight proportion. It has very high curative rate on trauma and traumatic infection, including intractable ulcer and fistula, high effective rate and curative rate on skin diseases caused by bacteria, fungi, viruses, etc, and certain treating effect on serious furuncle, luetic balanitis, etc.

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

The invention discloses a compound isatic root injection for animals and preparation technology, which is characterized by the following: allocating main medicine, adjunct and dissolvent; choosing the main medicine from isatic root, linbevelin, moroxydine and amantadine hydrochloride; choosing the adjunct from anti-oxidant, metal chelating agent and dissolvent for injection. This invention possesses advanced productive technology and long shelf life.

The present invention discloses a metapenaeus ensis cultivation method. The metapenaeus ensis cultivation method comprises: step 1, selecting a cultivation pond; after exposing the cultivation pond under the sun, wiping an inner wall of the cultivation pond by using kaempferiae slices and then exposing the cultivation pond under the sun again; coating the inner wall of the cultivation pond by medicine liquid and exposing the cultivation pond under the sun, and repeating the wiping and exposing for 3-4 times; blending quick lime with water and spraying on the inner wall of the cultivation pond, and then exposing the cultivation pond under the sun; step 2, controlling a water temperature, a pH value and salinity of pond water; then adding young shrimps into the cultivation pond; feeding young shrimp feed every day from the first day to the 20th day; adding adult shrimp feed every day after 20 days; and step 3, oxygenating the pond water of the cultivation pond every 2-3 days, replacing the water of the cultivation pond every 4-5 days, and adding moroxydine into the cultivation pond every 30-40 days. With the adoption of the metapenaeus ensis cultivation method, the immunity and resistance of metapenaeus ensis can be enhanced, the growth of the metapenaeus ensis is accelerated and the survival rate and meat quality of the metapenaeus ensis are improved.

The invention discloses a method for manufacturing a medicinal paper towel. According to the method, large roll toilet paper is produced by adopting the conventional papermaking process, and liquid medicament spraying, back rolling, cutting, folding or small roll sealed packing are performed. The method is characterized in that the liquid medicament is prepared by dissolving 1-2 parts of amantadine, 1-2 parts of vitamin C, 1-2 parts of moroxydine, 1-2 parts of chlorpheniramine maleate, 1-2 parts of isoniazid, 0.1-0.2 part of protease, 0.1-0.5 part of amylase and 1-2 parts of polyvinyl alcohol into 100 parts of water; and 3-5g of liquid medicament is added into 100g of paper by spraying. The paper towel is soft, and has high toughness; and the medicinal paper towel contains an anti-influenza-virus medicament, so that the medicinal paper towel can be taken as an anti-cold health-care paper towel.

The invention discloses a medicament for curing herpes zoster, which is mainly prepared from moroxydine, vitamins, dexamethasone and vaseline as auxiliary material according to certain proportion by parts. The medicament has the advantages of acesodyne, anti-inflammatory, toxin expulsion, sarcogenic convergence, ulceration healing promotion, and the like and also has quick effect, high cure rate and no toxic side effect and pain on curing the toxic side effect for curing herpes zoster. In addition, the medicament is mainly prepared from 6-12 portions of the moroxydine, 3-6 portions of vitamin C, 3-6 portions of the dexamethasone and the Vaseline as theauxiliary material.

The invention brings forward a prevention and treatment method for tobacco mosaic virus disease, reducing the morbidity of tobacco mosaic virus disease, increasing the production and grade of tobacco. The prevention and treatment method comprises following steps: 1. agricultural prevention and treatment; 2. biological prevention and treatment: spraying an antiviral agent 500 times solution; 3. physical prevention and treatment: keeping clean of the field, clearing up infected plant or weed and destroying them centrally; 4. chemical prevention and treatment: spraying 20% moroxydine copper acetate wettable powder 1000 times solution before morbidity. The method employs biological agent such as 0.5% lentinan AS 500 times solution; antiviral agents such as 20% moroxydine copper acetate wettable powder 1000 times solution are sprayed before morbidity to exterminate tobacco mosaic virus. Field tests have shown that by use of the integrated prevention and treatment method including agricultural and physical prevention and treatment, tobacco mosaic virus disease can be prevented, the average morbidity of tobacco mosaic virus disease is decreased, tobacco production and grade are increased, and economic benefit is achieved.

The invention provides a new hydrochloric acid 2-(1-ethyl propyl) moroxydine which can be obtained by chemical synthesis and has the advantages of low price of needed raw materials, easily obtained raw materials, simple and convenient preparation method, higher yield and suitability for industrialized production. The pharmacological activity experiment proves that compared with hydrochloric acid moroxydine, the hydrochloric acid 2-(1-ethyl propyl) moroxydine has the remarkably enhanced activity of in vivo resisting hepatitis B virus, hepatitis C virus, influenza virus, pneumovirus and herpes simplex virus, and the toxicity is one time lower than that of the hydrochloric acid moroxydine. Therefore, the new hydrochloric acid 2-(1-ethyl propyl) moroxydine can be applied to prepare antiviral drugs, especially anti-flu drugs, hepatitis C resisting drugs, hepatitis B resisting drugs, pneumovirus resisting drugs and herpes simplex viral keratitis resisting drugs.

The invention discloses a synthetic method of moroxydine hydrochlofide. The method comprises the following steps: adding diglycol, dicyandiamide, ammonium chloride and an aqueous sulfuric acid solution with the mass concentration of 20-30% to a high pressure reaction kettle according to amass ratio of (4-6):(4-6):(2-4):(1-2), heating the obtained solution in a sealed and stirring state to 120-130DEG C, reacting under a reaction kettle pressure of 0.3-0.5MPa for 1-2h, and cooling the obtained solution to room temperature to obtain a white milk; and transferring the white milk to a reaction kettle, adding 95% ethanol according to a volume ratio of the 95% ethanol to diglycol of (7-9):1, carrying out a heating refluxing reaction for 30min to obtain a mixed solution, carrying out hot filtration on the mixed solution through a filter cylinder to a crystallization kettle, cooling the obtained filtrate in the crystallization kettle to room temperature to precipitate white crystals, centrifuging and separating the white crystals, and drying the separated white crystals in a hot wind oven at 80-85DEG C to obtain moroxydine hydrochlofide.. Moroxydine hydrochlofide is obtained through a direct reaction of dicyandiamide and morpholine hydrochloride generated through in situ reaction of diglycol and ammonium chloride under the action of sulfuric acid, so the synthetic method is simplified, side reactions are reduced, the yield is improved, and environment is protected.

The invention relates to a method for preventing and controlling virus diseases of brassicaceous vegetables. The method includes the following steps: 1, ecological management, wherein microbial fertilizer Difulai is applied so as to activate soil, improve soil fertility, enhance the absorption capacity of plant roots, increase roots, strengthen seedlings and build plants; 2, agricultural prevention and control; 3, biological control, wherein 4000-fold 200 g / l imidacloprid dissoluble liquid is sprayed; 4, biological prevention and control, wherein a 500-fold 0.5% lentinan water agent is sprayed before occurrence of the diseases; 5, physical prevention and control; 6, chemical prevention and control, wherein chemical spraying protection is begun at the initial stage of the occurrence of the diseases, and 1000-fold 20% moroxydine.cupric acetate wettable powder is sprayed. The virus diseases of the brassicaceous vegetables can be effectively prevented; meanwhile, by taking the measures of agricultural prevention and control, physical prevention and control and the like for achieving integrated prevention and control, the average incidence rate of the virus diseases of the brassicaceous vegetables is decreased, the yield is increased, the plant grade is remarkably improved, and good economic benefits are obtained.

The invention relates to a sterilization preparation with functions of killing diversified pathogenic bacteria. The sterilization preparation is prepared from herba dendrobii extract, xinjunan-moroxydine, chitosan, rhein, radix glycyrrhizae and matrine. The sterilization preparation has the advantages that most highly hazardous pathogenic bacteria such as mycobacterium tuberculosis, influenza viruses, streptococcus pneumoniae and aspergillus fumigatus in haze can be effectively killed by the sterilization preparation, discomfort due to the haze can be effectively relieved, and the sterilization preparation is harmless to human bodies.

The invention relates to a method, which serially connects ultrahigh performance liquid chromatography (UPLC)-electrospray ionization (ESI) with mass spectrum (MS) to detect the residual quantity of amantadine, rimantadine, and moroxydine in hairs of livestock and poultry.

The invention discloses a product adopting compound plant amino acid, in particular plant amino-acid medical fertilizer and a method of preparing same, aiming at overcoming the defect that the prior animal amino acid is easy to result in anthropozoonosis. The plant amino-acid medical fertilizer contains compound plant amino acid, alginic acid (sulphur), moroxydine, potassium iodide (KI), phosphorus pentoxide (P2O5), potassium oxide (K2O), compound potassium (sodium) nitrophenolate or DA-6 and thickening agent. The plant amino-acid medical fertilizer can rapidly kill the pathogen such as the fungus, the bacterium and the virus, can prevent and treat various plant viruses resulted from the fungus, the bacterium and the virus at the effective rate of 85-99 percent and the curative rate of over 95 percent and can provided enough nutrients for the plants to prevent diseases and rapidly recover from the diseases so as to reduce the loss resulted from the diseases to the minimum extent, promote the healthy growth and enhance the adversity resistance of the plants, improve the quality of the agricultural product and increase the yield of the agricultural product by 10-30 percent.

The invention belongs to the technical field of control of plant virus diseases, and concretely relates to a composition for preventing and controlling a sweet potato virus disease. The composition isprepared from 40 to 50g of biological product containing active bacillus subtilis, and 30 to 50g of propiconazole.moroxydine, wherein the biological product containing the active bacillus subtilis isa biological product adsorbing the active bacillus subtilis, and the required activity number of the bacillus subtilis in the biological product is 8 to 10 hundred million / g. By adopting the composition for preventing and controlling the sweet potato virus disease, and a cultivation method of the composition for preventing and controlling the sweet potato virus disease provided by the invention,a preliminary experiment result shows that sweet potato leaves are plump and dark green, a root system is developed, the later-period maturing is slow, potato tubers are big, a root tuber is thick andshort in shape in order, the skin color is bright, the taste is good, the surface is smooth, and the storage endurance is good; compared with a control group, the virus disease morbidity can be reduced by 70 to 80 percent, the yield can be improved by 40 to 60 percent, and a better production increase and income increase effect is achieved.

The invention discloses a method for detecting the residual quantity of morpholine in a bulk drug and application of the method, and relates to the technical field of medicine analysis and detection. The bulk drug is moroxydine or moroxydine hydrochloride. The detection method detects the residual quantity of morpholine in the bulk drug through pre-column derivatization and high performance liquid chromatography. The method comprises the following steps: dissolving a bulk drug sample by use of a diluent to obtain a diluted solution, adding an acid-binding agent and a derivatization reagent into the diluted solution, carrying out a derivatization reaction to obtain the morpholine derivative, analyzing the content of the morpholine derivative by using a high performance liquid chromatograph, and carrying out simple conversion to obtain the content of morpholine in a sample. The method is high in sensitivity and accurate in detection data. The problems of serious trailing and low sensitivity when the morpholine content is detected by the existing gas chromatography are solved.

The invention provides application of moroxydine in preparing a myocardial infarction therapeutic drug. According to the application of the moroxydine in preparing the myocardial infarction therapeutic drug, the regulating effect of the moroxydine on the cardiovascular system is examined through an experimental method, and the fact that the moroxydine can reduce blood viscosity, reduce serum creatine kinase activity and reduce thromboxane A2 (TXA2) level in plasma and also can up-regulate prostacyclin (PGI2) level in the plasma and improve serum superoxide dismutase (SOD) activity, so as to regulate angiotasis and promote blood fluidity is innovatively found. On the basis of the new properties of the moroxydine, by using the moroxydine as the myocardial infarction therapeutic drug, a protection effect on myocardial ischemic reperfusion damage can be realized, and cerebral infarction volume is reduced, so as to realize the treatment for myocardial infarction. The application provided by the invention is significant in drug therapeutic effect, rapid in effect and free of side effect, clinical experiments show that a higher cure rate is realized, and a huge popularization prospect is realized.

The invention relates to a medicament for controlling swine fever, which consists of the following components in part by weight: 0.1 to 0.5 part of moroxydine, 0.5 to 1.5 parts of bezoar antitoxic bolus, 3 to 11 parts of weeping forsythiae, 1 to 8 parts of golden thread, 5 to 14 parts of licorice, 1 to 7 parts of bupleurum, and 2 to 12 parts of amur corktree bark. In the medicament, the moroxydine has an inhibitory action on a plurality of viruses such as influenza virus, parainfluenza virus, rhinovirus, corona virus, adenovirus and the like. Calculus bovis artifactus has an effect of allaying a fever and resisting inflammation. The weeping forsythiae has an effect of resisting bacteria. The golden thread has an effect of detoxifying. The licorice is neutral in nature and sweet in taste, acts on twelve regular channels, and has pharmacological effects of detoxifying, eliminating phlegm, relieving pains, relieving spasm or even resisting cancer and the like. The medicament has the principle indications of dispersing to allay a fever, and invigorating vital functions to soothe the liver, and is used for treating cold fever, alternate attacks of chills and fever, malaria, stagnation of qi due to depression of the liver, and sternal rib swelling pain. The medicament can enhance the immunity of a pig and the disease resistance of the pig, and can effectively control the swine fever.

A method for improving the detoxification efficiency of fructus momordicae seedlings includes: step 1, preparing a rapid fructus momordicae propagation culture medium containing a virus inhibitor; step 2, transferring the fructus momordicae seedlings into the culture medium of the step 1 to subculture at 25-30 DEG C; step 3, cultivating the fructus momordicae seedlings of the step 2 at 35-39 DEG C, and cutting off stem tips of the seedlings; and step 4, inoculating a common rapid propagation culture medium with the stem tips of the fructus momordicae seedlings of the step 3 to obtain virus-free fructus momordicae plants. The culture medium containing the virus inhibitor at least comprises one of 10-60 ppm of virazole, 100-500 ppm of moroxydine and 20-100 ppm of oseltamivir. The method hasthe advantages that the virus inhibitor and a stem-tip detoxification method are combined to perform secondary detoxification on the fructus momordicae seedlings, and accordingly, the detoxification efficiency of the fructus momordicae seedlings is remarkably improved; the detoxification culture method is simple, the operation process is simplified, the production cost is low, and the method is suitable for industrial production.

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

A method for improving the detoxification efficiency of Luo Han Guo seedlings, the method comprising: Step 1, preparing a rapid propagation medium for Luo Han Guo seedlings containing virus inhibitors; Step 2, transferring Luo Han Guo seedlings to the medium described in step 1 Subculture at 25-30°C; Step 3: Cultivate the Luo Han Guo seedlings in Step 2 at 35-39°C, and cut the stem tips of the seedlings; Step 4: Inoculate the Luo Han Guo seedlings in Step 3 into conventional rapid propagation The culture medium is cultured for 30-45 days to obtain detoxified Luo Han Guo plants; wherein, the virus inhibitor medium contains at least one of the following: ribavirin 10-60ppm, morpholinidine 100-500ppm, and Tamiflu 20-100ppm. The invention uses the virus inhibitor and the stem tip detoxification method in combination to carry out secondary detoxification on the grosvenoria seedlings, which significantly improves the detoxification efficiency of the grosvenoria seedlings. At the same time, the detoxification culture method of the present invention is simple, simplifies the operation procedure, has low production cost, and is suitable for industrial production.

The invention provides an efficient flame-retardant cable material and a preparation method thereof, the efficient flame-retardant cable material comprises low-density polyethylene, ethylene-vinyl acetate copolymers, modified aluminum hypophosphite, moroxydine, glycol monostearate, polypropylene wax, photocatalysts, aluminum magnesium alloy powder and antioxidants, the modified aluminum hypophosphite is prepared by mixing aluminum hypophosphite with methylene methylenedicarbamate, phenyl silicone oil and polyimide according to the mass ratio of 6:2:9:1, the preparation method of the efficientflame-retardant cable material includes the following steps of S1, weighing raw materials; S2, dispersing moroxydine into modified aluminum hypophosphite; S3, mixing the raw materials; S4, performingdrawing, dicing, squeezing and pelleting to obtain the efficient flame-retardant cable material, the efficient flame-retardant cable material and the preparation method thereof have the advantages that the formula is reasonable, the addition quantity of the raw materials playing a flame-retardant role is low, the preparation method is simple, and the obtained cable material has high resistance toageing, bacteria, corrosion and fire and excellent mechanical property.

The invention discloses a synthetic method of moroxydine hydrochlofide. The method comprises the following steps: adding diglycol, dicyandiamide, ammonium chloride and an aqueous sulfuric acid solution with the mass concentration of 20-30% to a high pressure reaction kettle according to amass ratio of (4-6):(4-6):(2-4):(1-2), heating the obtained solution in a sealed and stirring state to 120-130DEG C, reacting under a reaction kettle pressure of 0.3-0.5MPa for 1-2h, and cooling the obtained solution to room temperature to obtain a white milk; and transferring the white milk to a reaction kettle, adding 95% ethanol according to a volume ratio of the 95% ethanol to diglycol of (7-9):1, carrying out a heating refluxing reaction for 30min to obtain a mixed solution, carrying out hot filtration on the mixed solution through a filter cylinder to a crystallization kettle, cooling the obtained filtrate in the crystallization kettle to room temperature to precipitate white crystals, centrifuging and separating the white crystals, and drying the separated white crystals in a hot wind oven at 80-85DEG C to obtain moroxydine hydrochlofide.. Moroxydine hydrochlofide is obtained through a direct reaction of dicyandiamide and morpholine hydrochloride generated through in situ reaction of diglycol and ammonium chloride under the action of sulfuric acid, so the synthetic method is simplified, side reactions are reduced, the yield is improved, and environment is protected.

The invention belongs to the technical field of preparation of fluorescent nano materials and visual probes, and particularly relates to a preparation method of a moroxydine ratiometric fluorescent probe based on a copper nano-cluster / fluorescein composite. The method mainly includes the steps of: 1) preparing bovine serum albumin stabilized red fluorescence emitting copper nano-cluster through ahydrothermal method; 2) preparing the copper nano-cluster / fluorescein nano composite through a carboxamide coupling method; 3) adding the moroxydine molecules, which is combined with the BSA, so as toinduce red fluorescence quenching of the copper nano-cluster, while green fluorescence of the fluorescein is not significantly influenced; 4) establishing a linear relationship between the ratio of intensities of fluorescence-emission peaks of the copper nano-cluster and the fluorescein and the molar concentration of the moroxydine, and a correspondence relationship between the molar concentration of the moroxydine and the fluorescent color of same, thus preparing the ratiometric fluorescent visual probe for detection of the moroxydine. The probe is simple in preparation method and low in preparation cost, has high sensitivity, and is suitable for ratiometric fluorescent visual detection of the moroxydine in a biosample.

The invention relates to a ginger mosaic virus disease control method comprising the following steps: 1, ecology treatment: applying difulai microbe fertilizer and woyiduo microbe fertilizer to activate soil and enhance soil fertility, thus promoting root growth and fertilizer conservation; 2, agriculture control; 3, biotic control: applying 200g / liter imidacloprid soluble liquid formulation 4000times spray so as to control aphid and reduce virus propagation harms; 4, biological control: applying 0.5% lentinan aqua 500times liquid before disease; 5, physical control; 6, chemical control: applying spray protection in a disease initial stage, and spraying 20% moroxydine cupric acetate wettability pulvis 1000times liquid; the control method can effectively prevent ginger mosaic virus, thus reducing ginger mosaic virus disease average incidence rate, increasing output, obviously improving ginger level, and gaining good economic benefit.

The invention belongs to the technical field of pesticides, and relates to a morpholine, copper, and manganese aqueous emulsion for preventing and treating plant virus diseases. The active ingredients of the morpholine, copper, and manganese aqueous emulsion are morpholine hydrochloride, copper glycinate and manganese glycinate. The morpholine quatrazine copper-manganese water emulsion of the present invention has the following characteristics: it is not easy to produce phytotoxicity, small dosage, good absorption, quick effect, resistant to rain erosion, broad-spectrum, safe and efficient, and improves plant quality.