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Compound externally applied tetrodotoxin ointment and its prepn

A technology of tetrodotoxin and puffer fish liver oil, which is applied to the delivery of medical preparations containing active ingredients, antiviral agents, ointments, etc.

Inactive Publication Date: 2007-11-07
苏振芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is reported in the literature (www.chinattx.com) that in addition to the effects of analgesia and detoxification, it is also effective for some skin diseases, but there is no report about the dosage form of the drug

Method used

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  • Compound externally applied tetrodotoxin ointment and its prepn
  • Compound externally applied tetrodotoxin ointment and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Prepare compound topical tetrodotoxin ointment by following raw material ratio (W%):

[0059] Puffer fish liver oil 27.00

[0060] Frankincense 1.65

[0061] Myrrh 1.65

[0062] Blood Scorpion 1.65

[0063] Panax notoginseng 2.15

[0064] Safflower 2.15

[0065] Catechin 2.15

[0066] ice flakes 1.00

[0067] Vaseline 54.00

[0068] Vitamin B1 1.10

[0069] Vitamin B2 1.10

[0070] Vitamin C 1.10

[0071] Virus 1.10

[0072] Dexamethasone 1.10

[0073] Lidocaine 1.10

[0074] Weigh the raw materials used according to the above formula, and pulverize the solid medicine except puffer fish liver oil and vaseline. When preparing, first put vaseline into a stainless steel batching container with a heating and stirring device, add frankincense, myrrh, blood scorpion, panax notoginseng, safflower, and catechu under stirring when the temperature is 90-100 ° C, and Stir at this temperature for 3 hours, cool down to 75-80°C, add puffer fish cod liver oil and stir un...

Embodiment 2

[0076] Prepare compound topical tetrodotoxin ointment by following proportioning (W%):

[0077] Puffer fish liver oil 29.00

[0078] Frankincense 1.50

[0079] Myrrh 1.50

[0080] Blood Scorpion 1.50

[0081] Notoginseng 2.30

[0082] Safflower 2.30

[0083] Catechin 2.30

[0084] Vaseline 54.80

[0085] Vitamin B1 0.80

[0086] Vitamin B2 0.80

[0087] Vitamin C 0.80

[0088] Virus 0.80

[0089] Dexamethasone 0.80

[0090] Lidocaine 0.80

[0091] Weigh the raw materials used according to the above formula, and crush the solid medicines except puffer fish liver oil and vaseline until they can pass through the 100-mesh sieve. When preparing, first put the weighed Vaseline into a stainless steel batching container with a heating and stirring device, add puffer fish cod liver oil under stirring when the temperature reaches 70-80°C, stir and dissolve, then cool down to 30-40°C and stir under stirring Add other medicines, stir for 5 hours and cool to a dark brown ointm...

Embodiment 3

[0093] Prepare compound topical tetrodotoxin ointment by following proportioning (W%):

[0094] Puffer fish liver oil 32.00

[0095] Frankincense 1.00

[0096] Myrrh 1.00

[0097] Blood Scorpion 1.00

[0098] Notoginseng 1.50

[0099] Safflower 1.50

[0100] Catechin 1.50

[0101] Borneol 0.50

[0102] Vaseline 60.00

[0103] The preparation method is the same as in Example 1, and light brown ointment and dark brown ointment with medicinal residues are obtained.

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Abstract

The externally applied compound tetrodotoxin ointment is prepared with globe fish liver oil, vaseline, frankincense, myrrh, dragon's blood, notoginseng, safflower, catechu, borneol, vitamin B1, vitamin B2, vitamin C, moroxydine, dexamethasone and lidocaine in certain weight proportion. It has very high curative rate on trauma and traumatic infection, including intractable ulcer and fistula, high effective rate and curative rate on skin diseases caused by bacteria, fungi, viruses, etc, and certain treating effect on serious furuncle, luetic balanitis, etc.

Description

technical field [0001] The medicine for treating skin diseases involved in the present invention is specifically an antibacterial, non-central analgesic, anti-inflammatory and anti-infection medicine for treating wounds, as well as an antiviral medicine for treating skin diseases such as herpes virus infection. The invention also relates to a medicine formulated mainly with tetrodotoxin. Background technique [0002] Trauma, especially the trauma caused by an emergency (accident), is very serious, often with large wounds, deep wounds, and even deep bones. It is very important for surgical medical staff to dispose of it in time. What Chinese patent ZL 90102545.3 (manufacturing method of hemostatic inflammation pain stop protective film aerosol) provides is a kind of film-forming aerosol containing commonly used analgesic and anti-inflammatory drugs. Spraying immediately forms a film to seal it. The drug dosage form is good, which can reduce the secondary pollution of water ...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K9/06A61P17/00A61P31/02A61P31/12A61P31/22A61K31/045A61K31/167A61K31/375A61K31/51A61K31/525A61K31/535A61K31/573A61K35/60
Inventor 苏振芳
Owner 苏振芳
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