The invention discloses a Alzheimers disease treatment compound polygonatum granule and preparation method, adopting polygonatum as the main material, then supplementing with the 18 raw materials of ginseng, ganodorma lucidu, astragalus root, radix ophiopogonis, Sichuan dendrobium, polygala root, rhizoma acori graminei, bryozoatum, rhizoma gastrodiae, angelica sinensis, leech, ligusticum wallichii, fossil fragments, tortoiseshell, stir-baked semen ziziphi spinosae, medlar, herba epimedii, and radix aconite carmichaeli, after the steps of digesting, concentrating and drying, making soft wood, making granule, desiccating, organizing granule, sterilizing and packaging, preparing into granule powder; the granule can mend the functions of kidney, profit the essence, increase blood circulation, dissipate blood stasis, dispel phlegm, disseminate the stagnation, lighten up the eyes, and gain memory; clinical studies show that the granule has better treatment function for Alzheimer's disease; has better remedy effects for senile vascular dementia and senile dementia as well as cerebral arteriosclerosis.