50results about How to "Improve atrophy" patented technology

The invention aims at providing a pantoprazole sodium freeze-dried powder injection and comprises pantoprazole sodium and mannitol with the weight ratio of 1: 2 to 5. The invention is simple in formula and little in side effect; products prepared by the method are plump in appearance, good in complex solubility and excellent in quality with the adoption of an advanced freezing and drying process.

The invention provides a clindamycin phosphate freeze-dried powder injection, which is prepared by the steps that: clindamycin phosphate solution is added with NaOH and is freeze-dried, wherein, the weight ratio of clindamycin phosphate to the NaOH is between 12 and 18 to 1, and the preferred weight ratio is 16.5 to 1. The clindamycin phosphate freeze-dried powder injection has simple formula and less auxiliary materials, overcomes side effects due to the fact that the auxiliary materials are excessively added, and ensures that patients are safer for use.

The invention belongs to the field of food processing and discloses a porcine plasma antioxidant peptide. The porcine plasma antioxidant peptide is prepared by the following steps of: (1) preparing a porcine plasma albumin hydrolysate; (2) carrying out membrane separation on the antioxidant peptide fragment of a porcine plasma protein: leading a supernatant fluid obtained in the step (1) to pass through a flat membrane with the molecular weight of 3kDa, pressurizing by using high-purify nitrogen in the filtering process, wherein the pressure is 0.03-0.04Mpa, continuously stirring at low speed by using a magnetic stirrer to obtain the peptide fragment with the molecular weight of less than 3kDa through separation, i.e., the porcine plasma antioxidant peptide A5. Compared with hydrolysis products of other molecular weight fragments, the porcine plasma antioxidant peptide A5 has the strongest reduction capacity and more excellent capacities of inhibiting the liquid peroxidation and clearing free radicals, superoxide radicals and hydroxyl free radicals.

The invention discloses a traditional Chinese medicine composition for improving intestinal cancer cachexia and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-35 parts of astragalus membranaceus, 20-30 parts of codonopsis pilosula, 30-40 parts of curcuma zedoary, 15-25 parts of white hyacinth beans, 15-20 parts of raw semen coicis, 10-20 parts of honeysuckle, 5-10 parts of roasted rhizoma atractylodis macrocephalae and 5-10 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition is simple to prepare, plays roles in well carrying out whole regulation, improving cachexia muscle atrophy, suppressing muscle proteolysis, relieving and resisting progressive weight loss of cachexia, improving the survival quality of a patient, prolonging the life of the patient through collaborative working of the raw materials, and has a good effect on prevention and intervention of intestinal cancer cachexia.

The invention provides a folic acid lyophiled powder injection and a preparation method, comprising folic acid and mannitol, which is characterized in that the weight ratio of the folic acid and the mannitol is 1:2.5 to 10. The preparation method has the advantages of simple prescription, little side effect, and plump appearance, good double solubility and fine quality for the prepared product due to the adoption of the advanced freeze drying craft.

A stable naloxone hydrochloride lyophilized preparation comprises naloxone hydrochloride and mannitol in a weight ratio of 1 : 30 - 200. The lyophilized preparation has a simple formula and fewer side effects, and employs an advanced freeze-drying process. The prepared products have full appearance, good solubility, and excellent quality.

The invention discloses multifunctional lactobacillus casei CCFM1052 for relieving the PFOA toxic effect, and fermented food and application of the multifunctional lactobacillus casei CCFM1052. The strain has the high adsorbing effect on PFOA and is not subjected to field planting in the intestinal tract, liver oxidative stress injury caused by the PFOA is significantly relieved, the serum biochemical indices are significantly decreased, spleen atrophy caused by PFOA exposure is significantly relieved, imbalance of microorganisms in the intestinal tract due to PFOA exposure is relieved, intestinal flora metabolic disturbance caused by PFOA exposure is relieved, the content of acetic acid and propionic acid in the intestinal tract is significantly increased, the fecal moisture content of constipation mice is increased, the time of first melena of the constipation mice is shortened, proliferation of INS-1 cells and expression of MafA genes under the high glucose effect are improved, thepotential for relieving PFOA-related diabetes is achieved, occurrence of liver diseases, metabolic diseases and potential carcinogenicity is reduced, and wide application prospects are achieved.

The invention provides a stable naloxone hydrochloride freeze-dry preparation, comprising naloxone hydrochloride and mannitol, wherein the weight ratio of the naloxone hydrochloride to the mannitol is 1:(30-200). The freeze-dry preparation has the advantages of simple formula and fewer side effects; and moreover, by using an advanced freeze-drying process, the prepared product has the advantages of full appearance, good quick solubility and excellent quality.

The invention relates to the technical field of cosmetics, and in particular discloses a biotin hair loss preventing nutrient solution. The nutrient solution consists of the following active ingredients in percentage by weight: 0.1-1% of D-panthenol, 1-5% of an aloe extract and 3-10% of a hair growth promoting hormone solution. The hair growth promoting hormone solution can effectively prevent and treat alopecia caused by such reasons as (1) insufficient blood circulation and poor scalp micro-circulation, (2) hair follicle atrophy which is caused when testosterone is transformed into male sex hormone, namely dihydrotestosterone (DHT), by virtue of 5[alpha]-reductase, (3) hair can't be fixed into dermal papillae due to aging of hair follicles and the like; therefore, purposes of resisting aging of the hair follicles and preventing hair loss can be achieved.

The invention discloses application of Codonopsis pilosula oligosaccharide in preparation of a medicine for preventing or treating gastrointestinal injury caused by anoxia. The anoxia is plateau anoxia and/or tissue ischemic anoxia. The invention also provides a preparation method of the Codonopsis pilosula oligosaccharide. The Codonopsis pilosula oligosaccharide has the following advantages: themedicine prepared by adopting the application of the Codonopsis pilosula oligosaccharide in the preparation of the medicine for preventing or treating gastrointestinal injury caused by anoxia has a very good effect, is safe and effective, and has no toxic or side effect; experimental verification shows that the medicine containing the Codonopsis pilosula oligosaccharide can improve spleen atrophyand pulmonary emphysema caused by high-altitude anoxiaof rats, enhance the anti-oxidation level, improve inflammations, relieve intestinal mucosal damage and reduce EPO expression; and protein expression detection further shows that the Codonopsis pilosula oligosaccharide can reduce the expression of HIF-1 alpha in duodenum of a high-altitude hypoxic rat.

The invention provides a preparation method and application of an inula nervosa wall composite extract. The preparation method of the inula nervosa wall composite extract comprises the following stepsof crushing inula nervosa wall, adding an aqueous solution for ultrasonic extraction, performing centrifugation to obtain a supernatant, and performing concentration to obtain an inula nervosa wall aqueous extract; and then, uniformly mixing the inula nervosa wall aqueous extract, tartary buckwheat, camellia nitidissima, rhizoma gastrodiae, pueraria lobata and an ethanol solution, performing microwave-assisted extraction, performing centrifugation to obtain a supernatant, performing concentration, and performing drying to obtain the inula nervosa wall composite extract. The inula nervosa wallextract prepared by the preparation method has an excellent effect of improving inflammatory bowel diseases, and has the advantages of safety, health and easily available raw materials; and in combination with the reasons, the inula nervosa wall extract has relatively good development and utilization prospects in the preparation of drugs or functional foods for prevention and adjuvant treatment of ulcerative colitis and Crohn's disease.

Medical rehabilitation apparatus is provided, including a main body steel frame, a sliding seat, a master console and a foot rehabilitation device. The sliding seat is adjustably disposed on the mainbody steel frame and faces the master console. The master console is at the front end of the main body steel frame. The foot rehabilitation device is disposed on the main body steel frame and in frontof the sliding seat, and includes a pedaling mechanism, a leg motor and a fixing shoe. The pedaling mechanism is rotatably disposed on the main body steel frame. The leg motor is disposed on the mainbody steel frame and drives the pedaling mechanism to rotate. The fixing shoe is detachably disposed on the pedaling mechanism. Through the scheme, deformation of hands and feet caused by no movementfor long time of patients can be corrected, and upper and lower limbs of a patient are subjected to passive movement rehabilitation treatment at a fixed frequency, and therefore, extremities of upperand lower limbs of a patient can be supplied with blood normally, muscular atrophy can be improved, blood supply of heart and cerebral vessels of a patient is made normal, and insufficient blood supply for the heart and head, baldness and brain blood vessel blockage of patients can be improved.

The invention discloses a traditional Chinese medicine preparation for improving neuralgic amyotrophy. The traditional Chinese medicine preparation is prepared from 20-40 parts by weight of ligusticum wallichii, 3-7 parts by weight of scallion, 15-25 parts by weight of typhonium giganteum, 15-25 parts by weight of deerhorn glue, 10-20 parts by weight of herba asari, 6-18 parts by weight of rhizoma drynariae, 20-30 parts by weight of dragon bone, 25-40 parts by weight of acanthopanax root, 8-13 parts by weight of raw licorice root, 13-28 parts by weight of bark of ash and 15-25 parts by weight of Chinese angelica. The traditional Chinese medicine preparation has the characteristics of preparation simpleness, taking convenience, carrying convenience and long-term use feasibility. The traditional Chinese medicine preparation has effects of dispelling wind and dredging collaterals, relaxing muscles and tendons and promoting blood circulation, supporting body resistance, reinforcing qi and nourishing blood, and promoting blood circulation to remove blood stasis and relieving pain.

The invention relates to a traditional Chinese medicine for improving the cancer cachexia life quality. The traditional Chinese medicine is prepared from the following components by the weight percentage: 16-30% of radix astragali, 6-18% of ginseng, 6-18% of radix aconiti carmichaeli, 10-20% of honeysuckle, 12-26% of angelica sinensis, and 12-26% of raw liquorice root. A preparation method of the traditional Chinese medicine comprises the steps: according to the weight percentage, weighing 6-18% of ginseng and 6-18% of radix aconiti carmichaeli, putting into an earthen pot, adding a proper amount of water, and soaking for 60 min; weighing 16-30% of radix astragali, 10-20% of honeysuckle, 12-26% of angelica sinensis and 12-26% of raw liquorice root, adding a proper amount of water, and soaking for 30 min; firstly rapidly heating ginseng and radix aconiti carmichaeli to boil with big fire, then keeping a slight boiling state for 30 min, next adding radix astragali, honeysuckle, angelica sinensis and raw liquorice root, decocting for 20 min, and pouring out a first medicine liquid; and adding a proper amount of water for second time, decocting for 20 min, pouring out a second medicine liquid, and merging and mixing the second medicine liquid with the first medicine liquid to obtain the decoction medicine. The traditional Chinese medicine has efficacies of overall adjusting, improving cachectic muscle atrophy, inhibiting muscle protein decomposition, resisting progressive reduction of the cachexia body weight and the like, and has an obvious effect of improving the life quality of cancer cachexia patients.

The invention discloses a preparation method of beautyberry herbal toothpaste. The preparation method comprises the following steps of: (1) placing medicinal materials of beautyberry, honeysuckle, stevia rebaudianum, mulberry leaf and peppermint leaf in a cooking vacuum tank, adding water and cooking for two hours to take liquid medicine; (2) sieving the liquid medicine with gauze to remove residue and fading with active carbon to obtain liquid medicine for later use; (3) pouring pure water into the dried vacuum tank, then heating to 60 DEG C and adding the liquid medicine extracted by the step (2); (4) continuously stirring a mixture of the pure water and the liquid medicine in the step (3); (5) continuously stirring the mixture of the step (4), heating to 85 DEG C and stopping heating; (6) pouring the mixed liquid in the step (5) into a large container for storage, cooling to a constant temperature and performing steps of preparing and sub-package and the like. The beautyberry herbal toothpaste has the characteristics of bacteriostatic effect, hemostasis, pain easing, inflammation diminishing, improvement on gum bleeding, gum swelling and aching, dental ulcer, gingival atrophy and periodontitis and tooth protection.

The invention belongs to the technical field of medical apparatus and instruments, and discloses a rehabilitation training device for nursing of an old people. The device comprises a chair plate. A horizontally arranged assembling plate is integrally arranged on the edge of one side of the chair plate, and an exercise mechanism is mounted at the upper part of the assembling plate through a bracket; and the exercise mechanism is used for performing rehabilitation exercise on atrophic oral occlusal muscles and tongue muscles. According to the rehabilitation training device for nursing of the old people, oral occlusal muscles and tongue muscles are frequently exercised, the situation of atrophy of the oral occlusal muscles and the tongue muscles can be effectively improved, therefore the normal chewing function and the clear voice function of old people are guaranteed, and applicability is good; and the height of the exercise mechanism can be adjusted according to the height of the old people so that the height of the exercise mechanism can be well matched with the height of the old people, the chair plate can rotate, the old people can conveniently rotate the body in the using process, the using requirements of the old people can be well met, and the device is particularly suitable for the old people with fat body types.

The invention relates to the technical field of biology, and discloses an STAT3 inhibitor and an application thereof. The structure of the STAT3 inhibitor is shown as S-I (See the specification for reference). The invention provides an application of the STAT3 inhibitor in preparation of a medicine for treating tumor cachexia. The STAT3 inhibitor provided by the invention is simple in separation and purification method, can inhibit STAT3 activation and further improve skeletal muscle atrophy, and provides a new strategy for preparing drugs for treating or improving tumor cachexia.

The invention provides a throat lozenge as well as a preparation method and application thereof. The throat lozenge comprises the following components in parts by weight of 60-120 parts of full grassor roots of ainsliaea pertyoides, 20-50 parts of heartleaf houttuynia herb, 20-50 parts of flos lonicerae and 220.1-551 parts of an auxiliary material, and further comprises 20-50 parts of white tea,10-30 parts of radix platycodonis and 10-30 parts of radix glycyrrhizae, wherein the full grass or roots of ainsliaea pertyoides contains rich flavonoids, phenolic acids, nucleosides, sesquiterpene lactones and other compounds, has a synergistic effect after being compounded with heartleaf houttuynia herb and other traditional Chinese medicinal materials, and can effectively relieve inflammation,cough and other symptoms caused by throat dryness, and the prepared throat lozenge has the effect of obviously improving atrophic and dry pharyngitis. Besides, in order to improve the content stability of all medicinal components such as flavonoids and terpenoids and the like of the throat lozenge, a volatile oil recovery step is added on the basis of a conventional technical scheme, the transferrate of all the effective components reaches 90-95% through detection of the medicinal components, the throat lozenge has the advantages of economy and environmental protection, and the prepared throat lozenge is safe, effective and controllable in quality.

A multifunctional whitening and tooth strengthening toothpaste is made through the following steps: weighing the following cleaned main materials: mulberry leaf, mint leaf, panax notoginseng, Herba Taraxaci, barbed skullcap herb, safflower, green tea, cedar leaves, argy wormwood and orange according to a ratio of 6-4:4-6:5-4:4-5:3-4:4-3:2-3:3-2:2-3:1-2 with 10 as a base, refining the main materials, micro-screening the refined main materials to form main material powder, weighing the following ingredients: onion, mustard, rice vinegar, borax and refined salt according to a ratio of 0.5-0.6:0.6-0.5:2-1:0.5-0.4:0.4-0.5 with 10 as a base, refining the ingredients, micro-filtering the refined ingredients to form a mixed solution, weighing the main material powder, the ingredient mixed solution and purified water according to a ratio of 8-6:6-5:1-3 with 100 as a base, uniformly stirring all above weighed materials to form a mixed slurry, carrying out heating boiling disinfection for 0.6-1h, packaging the obtained material, and sealing the packaged material. The toothpaste has the advantages of advanced preparation technology, high grade, high quality, high efficiency, delicate matching of plant fruits, environmental protection, convenience, economy, suitableness for people of all ages and both sexes, and substantial comprehensive economic and social benefits in promotion and use.

The invention discloses application of Tauroursodeoxycholic acid (TUDCA) in preparing medicine for treating conversion from acute kidney injuries to chronic kidney diseases. Due to TUDCA treatment, some kidney functions injured by acute kidney injuries are recovered; tubular atrophy caused after acute kidney injuries, contralateral kidney compensatory hypertrophy, renal interstitial fibrosis, kidney chronic inflammation and tubular cell death are improved. Then, the conversion process from the acute kidney injury (AKI) to the chronic kidney disease (CKD) is delayed, and the medicine can be used for preventing the conversion from AKI to CKD.

The invention provides an application of a nano-micelle-hydrogel preparation of an HDAC inhibitor with double targets in a medicine for treating acute kidney injury. The S-SAHA small molecule is a known HDAC inhibitor; the invention proves that the preparation has the activity of inhibiting LTA4H for the first time. On the basis, the invention provides a hydrogel dosage form taking a prodrug SAHA-Ac of S-SAHA as an active loading drug, and proves that the hydrogel can inhibit LTA4H and down-regulate LTB4 through in-situ injection, so that the hydrogel has a new application in treating kidney inflammation.

The invention relates to a healthy food composition with an effect of regulating breasts, as well as a preparation method and application thereof. The composition is prepared from the following components: radix fici hirtae, dandelion, kudzu vine roots, mulberries, rosa rugosa var plena, deer skin gelatin, donkey-hide gelatin, corn stigma, honeysuckle flowers, licorice roots, poria cocos, spina date seeds, platycodi radix, pericarpium citri reticulatae and ginseng. The healthy food composition has the effects of dredging breast collaterals and improving microcirculation of breasts, is suitablefor breast maintenance, enables the breasts to be plump to achieve an effect of breast-up, has a remarkable effect for improving mammary dysplasia and postpartum mastatrophy, can be used for preventing and treating breast diseases, such as hyperplasia of mammary glands, fibroadenoma of breasts and the like, and has a good clinical effect.