3results about How to "Improve atrophy" patented technology

The invention relates to application of OH-CATH30 in preparation of drugs for treating skeletal muscle atrophy, and belongs to the technical field of biological medicines. The OH-CATH30 is a king cobra antibacterial peptide, the molecular weight of the OH-CATH30 is 4693.71 Da, and the isoelectric point of the OH-CATH30 is 12.08. The skeletal muscle atrophy is caused by cachexia. The invention discovers that OH-CATH30 can improve skeletal muscle atrophy as a small molecular antibacterial peptide prepared from king cobra for the first time. Experiments prove that OH-CATH30 can effectively improve the expression of myosin MyHC in C2C12 myotubes induced by 4T1 cell culture supernatant, and increase the diameter of the myotubes. Besides, in a cachexia mouse model, the holding power of the mouse can be increased by exogenous injection of OH-CATH30, and skeletal muscle atrophy caused by cachexia is remarkably improved.

This invention relates to the field of traditional Chinese medicine (TCM) technology, and discloses a TCM composition for treating cachexia and its preparation method. The composition comprises five grains (a type of insect), Astragalus membranaceus, stir-fried Atractylodes macrocephala, Polygonatum sibiricum, Lycium barbarum, Ophiopogon japonicus, Citrus reticulata peel, Panax notoginseng, and Glycyrrhiza uralensis. Stir-fried Atractylodes macrocephala can be replaced with Poria cocos, Ophiopogon japonicus can be replaced with Polygonatum odoratum, and Citrus reticulata peel can be replaced with Amomum villosum. This formula is based on the principle of "strengthening the body's resistance, detoxifying and removing blood stasis," enhancing the effects of invigorating the spleen and stomach, promoting body fluid production and moistening dryness, while avoiding greasy and cloying substances that may hinder digestion. The preparation method involves cleaning, pulverizing, decocting, extracting, and drying the raw materials to obtain granules. This composition can be used to treat cachexia caused by various tumors such as lung cancer and liver cancer. Animal experiments have verified that it can significantly increase patients' food intake, improve cancer-related fatigue, inhibit tumor growth, alleviate muscle atrophy and splenomegaly, regulate blood routine, and improve anemia and immune function, providing a safe and effective option for the treatment of cachexia.

This invention discloses a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process, relating to the fields of cosmetics and scalp care technology. Specifically, it is a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process. The conditioning cream contains, by weight, herbal active ingredients such as ginseng, arborvitae leaf, duckweed, soapberry, angelica, chuanxiong, rosemary, ginger, asarum, and mulberry bark, as well as functional and matrix excipients such as sodium hyaluronate, cocoyl glucoside, carbomer 940, phenoxyethanol, and ethylhexylglycerin. Its preparation process employs low-temperature treatment throughout, including low-temperature extraction at room temperature to 50℃ and ultrasonic extraction at 200-800W, as well as low-temperature blending with low-speed stirring at 25-40℃, effectively preserving the active herbal ingredients. This product can improve scalp microcirculation, repair hair follicles, and regulate sebum secretion, suitable for various types of hair loss, while also relieving scalp itching and repairing damaged hair.