35results about How to "Improve learning and memory impairment" patented technology

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

A Chinese medicine for treating senile dementia, dizziness, disturbed sleep, etc is prepared from fleece flower root, lotus leaf, cistanche, earthworm and uniflower swisscentaury root through respective extracting, and proportional mixing.

The present invention provides the application of curcumin in preparing medicine for treating HIV-1 relevant cognitive disorder. Curcumin may be used in preparing medicine for treating HIV-1 relevant cognitive disorder alone or through combination with other memory improving medicine. Experiment shows that curcumin can improve the memory capacity of rat with memory disorder caused by HIV-1gp120, with curcumin in low dosage (50 mg/kg) possessing higher effect.

The present invention provides a medicine for presenile dementia treatment, which takes dehydrogenation evodiamine as the active component. Studies proves that the dehydrogenation evodiamine has an inhibiting effect in notable pathological change of presenile dementia patients, which can not only reduce the senile plaque quantity of the presenile dementia, but also can reduce the phosphorylation tau protein level, therefore learning and memory impairment are dramatically improved. The medicine is an effective medicine for presenile dementia prevention and treatment.

The invention discloses TAT-LBD-PEP fusion protein and application of the TAT-LBD-PEP fusion protein in treatment of central nervous system lesion. The TAT-LBD-PEP fusion protein is combined with myelin inhibiting factors MAG, Nogo-66 and OMgp, accordingly the axon regenerative capacity is promoted through antagonism PirB effect, and the TAT-LBD-PEP fusion protein has the advantages of being high transduction efficiency and easily transmitting a blood-spinal barrier and a blood brain barrier, can transduce targeting to a hurt region and has the enrichment effect on an ischemic region. The problems that additional harm of nervous tissues is caused by the protein injection in a micro-injection mode or other injection modes and macromolecule cannot transmit the blood-spinal barrier and the blood brain barrier are solved, and the shortcoming that corresponding biological concentration cannot be met is overcome, and the targeting is transduced to the ischemic region through a ligand binding domain (LBD). The TAT-LBD-PEP fusion protein can be prepared in large-scale mode, is low in cost and high in activity, and is used for treatment of various brain and spinal cord injury including cerebral ischemia hypoxia, cerebral hemorrhage, cerebral trauma, spinal cord injury and the like and promoting regeneration of nervous tissues and neural functional recovery.

The invention discloses a composition for preventing and/or delaying old people with mild cognitive impairment and a use method thereof; the composition comprises the following components in parts by weight: 3000-6000 parts of a coffee powder, 0.2-0.4 part of folic acid, 15000-30000 parts of coconut oil, 15000-30000 parts of semen cannabis, and 3-5 parts of melatonin, wherein the coffee powder contains 3.6-4.2 wt% of caffeine. The composition can improve the antioxidant capacity of brain tissues and prevents the brain tissues from being damaged by free radicals. Animal experiments indicate that the composition can effectively improve learning and memory impairment in Alzheimer's disease model mice; human body test-meal experiments indicate that the old people with mild cognitive impairment take the composition at a specific point in time, and have a significant improving effect on memory improvement. With regular effective taking of the composition, the old people with mild cognitive impairment can be prevented from suffering from Alzheimer's disease, or the incidence time can be delayed.

The invention discloses a traditional Chinese medicine composition for preventing and treating vascular dementia. The traditional Chinese medicine composition for preventing and treating vascular dementia comprises ginseng, gastrodia elata, Euonymus alatus and Ligusticum wallichii. The composition can be prepared into Chinese herbal preparation crude drug for preventing and treating vascular dementia. The ginseng and the Ligusticum wallichii are extracted with alcohol, the gastrodia elata and the Euonymus alatus are extracted with water, the obtained alcohol extract and the obtained water extract are mixed, the mixture is dried under vacuum and then is pulverized to obtain the final product, and the composition can be directly taken orally or is prepared into other dosage forms such as granules, capsules, soft capsules, electuaries, pills and decocted extracts. The composition is completely prepared from natural medicinal plants, does not contain hormones, and does not contain other chemical synthetic products such as pigment, and even if a patient orally takes the composition continuously, no toxic and side effect is performed on the human body. The traditional Chinese medicine composition contains various easily absorbable ingredients such as ginsenoside, chuanxiongol, chuanxiongzine, gastrodin and quercetin, can be effectively used for treating the vascular dementia, increases cerebral blood flow, reduces cerebral vascular resistance, improves body immunocompetence, and has effects of tonifying deficiency, promoting intelligence, suppressing the hyperactive liver, subsiding Yang, dispelling blood stasis and dredging collaterals.

The invention discloses a pabular health tea electuary for nourishing brain, which belongs to the field of nutritious foods and has the advantages of good effect and rapid effect. The pabular health tea electuary is made from the raw materials such as sealwort, mulberry, taurine, gastrodia elata, black tea and the like, has the functions of supporting body resistance, reinforcing qi, nourishing blood, promoting blood circulation, removing blood stasis and nourishing brain, and has the advantages of good effect and rapid effect.

The invention discloses a medicinal composite for treating Alzheimer's disease. The medicinal composite for treating the Alzheimer's disease comprises procyanidine and cysteine, wherein the mass ratio of the procyanidine to the cysteine is (0.1-10):1, preferably (1-3):1; and the procyanidine is preferably lotus procyanidine. The medicinal composite for treating the Alzheimer's disease can improve the oxidation resistance of brain tissue, avoid free radical injury to the brain tissue, inhibit MAO-B and AchE activity and enhance the oxidation resistance of brain and hippocampal anti-oxidation system and serum so as to improve the learning and memory function. According to animal tests, the medicinal composite for treating the Alzheimer's disease can effectively improve mouse learning and memory injury induced by ethanol and scopolamine, and the curative effect is more excellent than that of piracetam and procyanidine.

The invention relates to an active part extracted from Chinese herb rhizome bletillae, a preparation method of the active part and an application of the active part in treating Alzheimer's disease (AD) and vascular dementia (VD). The animal test shows that the active part can apparently improve the memory acquisition disorder of cholinergic injury imitative dementia mouse caused by scopolamine, can improve the spatial learning and memory disorder of AD mouse caused by intracerebroventricular injection of Abeta and the spatial learning and memory disorder of the VD mouse caused by bilateral cervical general artery permanent ligation, and has an effect for apparently improving the animal learning memory disorder.