Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing shiny-leaved yellowhorn total saponins and application of shiny-leaved yellowhorn total saponins

A technology of total saponins and Wenguanguo is applied in the field of medicine to achieve good medicinal value, reduce losses and organic residues, and improve learning and memory disorders.

Active Publication Date: 2014-06-04
SHENYANG PHARMA UNIVERSITY
View PDF5 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the fact that the main component of X. radix sorbifolium husk has been reported in the literature to have the application value of treating neurodegenerative diseases such as Alzheimer's dementia, and the total saponins of X. There is no report on the prevention and treatment of total saponins of X. xanthophylla in the prevention and treatment of neurodegenerative diseases and acute or chronic brain injury diseases. Therefore, the application of total saponins of X. xeritidis will promote the in-depth development of X. xantha resources and produce good economic and social benefits.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing shiny-leaved yellowhorn total saponins and application of shiny-leaved yellowhorn total saponins
  • Method for preparing shiny-leaved yellowhorn total saponins and application of shiny-leaved yellowhorn total saponins
  • Method for preparing shiny-leaved yellowhorn total saponins and application of shiny-leaved yellowhorn total saponins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take 1000g of Xanthos sorbifolia husks crushed into 20 meshes, use 10 times the volume of 50% ethanol, temperature 65°C, heat and reflux extraction 3 times for 3 hours / time, recover the solvent, and concentrate to obtain the extract After D-101 macroporous resin, eluted with water, 30% ethanol / water by volume, and 60% ethanol / water by volume as the elution solvent, heated to reflux, recovered the solvent under reduced pressure, and enriched 60% ethanol / water The eluate obtained the total saponins fraction of X. sorbifolium, and the solvent was recovered under reduced pressure, and placed at room temperature to obtain 92.0 g of total saponins of X. sorbifolium with a yield of 9.2%, wherein the saponin content was 73.5%.

Embodiment 2

[0042] Take 1,500 g of radix radix sorbifolia husks crushed into 30 meshes, use 8 times the volume of 70% ethanol by volume, and heat to reflux for extraction at a temperature of 70°C. The time is 2 hours / time, extract twice, heat to reflux, and recover the solvent under reduced pressure. The concentrated extract was eluted successively with HPD-100 macroporous resin, respectively with water, 40% ethanol / water by volume, and 80% ethanol / water by volume, and enriched by 80% ethanol / water washing. After decompression, the solvent was recovered under reduced pressure, and placed at room temperature to obtain 115.5 g of total saponins of X. sorbifolium. The yield was 7.7%, and the saponin content was 87.0%.

Embodiment 3

[0044] Take 1,500 g of radix sorbifolia husks crushed into 30 meshes, use 8 times the volume of ethanol with a concentration of 65% by volume, and heat and reflux at a temperature of 70°C for 2.5 hours / time, extract 3 times, heat and reflux, and recover the solvent under reduced pressure. The extract obtained after concentration is eluted with AB-8 macroporous resin, respectively, with water, 40% ethanol / water by volume, and 75% ethanol / water by volume as the elution solvent, and enriched by 75% ethanol / water for elution The solvent was recovered under reduced pressure, and placed at room temperature to obtain 130.5 g of total saponins of X. sorbifolium. The yield was 8.7%, and the saponin content was 83.5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and relates to a novel method for preparing shiny-leaved yellowhorn total saponins from shiny-leaved yellowhorn and an application of the shiny-leaved yellowhorn total saponins. According to the method, a coarse extract of the shiny-leaved yellowhorn is directly separated and purified by a macroporous resin method to obtain shiny-leaved yellowhorn total saponins; the yield of the total saponins is over 5 percent, and the content of the total saponins in a product is over 60 percent and far higher than that in products prepared by other processes. The prepared shiny-leaved yellowhorn total saponins can be applied to preparation of medicines or health-care products for preventing and treating memory deterioration, hypophrenia and cranial nerve injury caused by neurodegenerative diseases and acute and chronic cerebral injury diseases, and can be used for treating cerebral diseases caused by alzheimer disease, acute disease and subacute stage of cerebral arterial thrombosis, vascular dementia and other ischemia and hypoxia of neurodegenerative diseases and acute and chronic cerebral injury diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new preparation method and application of total saponins of radix sorbifolium radicis radix radicis. Background technique [0002] Xanthocerassorbifolia Bunge is a plant of Sapindaceae (Sapindaceae), a shrub or tree, distributed in Liaoning, Hebei, Shaanxi and other provinces in my country. Its heartwood, stems and fruits can be used as medicine. It has the effects of expelling wind and dampness, reducing swelling and relieving pain, and astringing dry yellow water. It was once listed in the 2005 edition of "The Pharmacopoeia of the People's Republic of China". [0003] After retrieving domestic and foreign literature, there is no good enrichment method for total saponins of X. sorbifolium. Studies in recent years have shown that the total saponins of X. sorbifolium are the main active ingredients of X. sorbifolium (l. Li Zhanlin, Li Xian, Li Ning, Li Wen, Sha Yi. Chemical con...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A23L1/29A61P25/28A61P9/10A61P25/00A23L33/00
Inventor 邹莉波孟大利迟天燕纪雪飞
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com