42results about How to "Low organic residue" patented technology

The invention discloses a method for purifying chenodeoxycholic acid. The method comprises the following steps: pretreatments such as degreasing, decoloration and impurity removal are carried out on commercially available crude bile paste or crude bile powder, so as to obtain a component to undergo chromatographic separation; the component to undergo chromatographic separation undergoes purification and separation by the use of a chromatographic column with a hydrophilic resin filler as a stationary phase; and separation products undergo concentration, acidification, washing and drying, so as to obtain chenodeoxycholic acid. In comparison with the prior art, the invention has the following beneficial effects: 1, content of the main component is high; 2, reappearance is high and operability is good; 3, short cycle: it only takes two days to prepare the high-purity chenodeoxycholic acid product from processing of the bile paste raw material; and 4, low content of organic residues: as processes such as solvent extraction, column chromatography on silica gel and the like in the traditional techniques are abandoned, an industrial chromatographic process with low dosage of an organic solvent is adopted and the final product undergoes drying process, the content of the residual organic solvent in the final product is especially low.

The invention belongs to the field of medical technology and relates to a new method for preparing xanthoceraside in shinyleaf yellowhorns. The highly purified xanthoceraside can be prepared efficiently with the preparation method. The preparation method is easy and convenient to use and reliable and reduces redundant intermediate operation steps, thus, product loss is reduced, and the yield of the preparation method is obviously increased compared with that of a former method. Crude extract is directly processed with a silica gel column, eluted with the chloroform / dichloromethane-methyl alcohol eluent with the volume ratio of 10:1-7:1, the ethyl acetate-methyl alcohol eluent with the volume ratio of 10:1-5:1 or the acetone-methyl alcohol eluent with the volume ratio of 10:1-6:1, and then eluted with the chloroform / dichloromethane-methyl alcohol eluent with the volume ratio of 6:1-2:1, the ethyl acetate-methyl alcohol eluent with the volume ratio of 4:1-1:1 or the acetone-methyl alcohol eluent with the volume ratio of 5:1-3:1, solvent recovery, purification and recrystallization are performed, and finally the xanthoceraside is obtained.

The present invention relates to the field of environmental protection, and specifically relates to a treatment process for resource utilization of medical waste salt at medium temperature pyrolysis; the present invention provides a process for resource utilization of waste medical salt at medium temperature pyrolysis. The principle is to use lower temperature to fully oxidize and decompose organic pollutants from the waste salt that has removed volatile substances, so as to achieve the purpose of harmless treatment of waste salt and then resource utilization; the invention adds an inorganic salt anti-caking agent, It can effectively prevent the waste salt from agglomerating in the fluidized bed reactor and ensure the sufficient oxidation and decomposition of organic pollutants, which is the key to the process; the waste salt obtained by the treatment method of medical waste salt of the present invention has extremely low organic residues and no agglomeration phenomenon. The organic matter is fully oxidized, and the energy saving is significantly reduced. The effective treatment of medical waste salt can not only protect the environment, but also reuse the main component sodium chloride salt to make up for the market gap, which has high economic value.

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of the salidroside; wherein, extracting solution is obtained by decocting the ground rhodiola with ten times of water, and then the extract (the relative density is from 1.10 to 1.15) is obtained after the extracting solution is concentrated, and then the ethanol is added for twice of alcohol precipitation, and then the eluate is collected by separating the solution with a 6000a molecular weight membrane separator and an efficient industrial chromatographic column and eluting themethanol water with gradients and then the salidroside is obtained by collecting, concentrating, freezing and drying the eluate. The method is high in product purity, large in preparation amount and stable and reliable in process and especially suitable for separating and preparing a great amount of highly purified salidroside compounds from the traditional Chinese medicine rhodiola.

The invention discloses a method for separating dichloropropanol from dichloropropanol hydrochloric acid azeotropic liquid. The specific operation steps are as follows: adding aromatic hydrocarbons and esters azeotropic with water to dichloropropanol hydrochloric acid azeotropic liquid Form a new azeotropic system with ethers as an organic water-carrying agent, heat the system to azeotrope, and realize the separation of hydrochloric acid and organic water-carrying agent through rectification, cooling, and water separation; unrectified components containing dichloropropanol High-purity dichloropropanol is obtained after distillation under normal pressure, and the water-carrying agent in the system can be recovered and recycled. The method has the advantages of simple operation, high separation efficiency of dichloropropanol and hydrochloric acid solution, high recovery rate, and high purity of obtained dichloropropanol and hydrochloric acid. Aromatic hydrocarbons, esters and ether organic water-carrying agents have high water-carrying efficiency, can be recycled, have low cost, and reduce environmental pollution.

The invention belongs to the technical field of pharmaceutical preparations and specifically relates to a temozolomide lyophilized powder preparation. The temozolomide lyophilized powder preparation comprises an active ingredient of temozolomide or a pharmaceutically acceptable salt thereof, and a solution before lyophilization further contains an excipient, a wetting agent, a buffer agent, an osmotic pressure regulating agent, a pH regulating agent, water for injection and an organic solvent, wherein the organic solvent is selected from one or any combination of ethanol, acetone, isopropanol, n-propanol, butanone, sec-butyl alcohol and methanol, and is preferably ethanol. The temozolomide lyophilized powder preparation provided by the invention has the advantages of stable quality, high re-dissolution speed and a small residual amount of the organic solvent. The invention further provides a method for preparing the preparation. The process provided by the invention is simple and convenient in preparation process and easy to control production links, the organic solvent accounts for a relatively small part of total volume of material liquid, the pollution to production equipment and environment caused by the organic solvent is reduced, and thus the method is suitable for large-scale production.

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of liquiritin; wherein, extracting solution is obtained by decocting the ground licorice plants with ten times of water, and then extract is obtained after the extracting solution is concentrated, and then ethanol is added for alcohol precipitation twice, and then a 6000Da molecular weight membrane separator is used for separating the extract, and then membrane separation permeation liquid is separated by X-5 macro-porous absorption resin and is eluted with the ethanol water, andthe obtained macro-porous resin separation components are separated by an efficient industrial chromatographic column and eluted with gradients with the methanol water and then the liquiritin is obtained by collecting, concentrating, freezing and drying the eluting solution. The method is high in product purity, great in preparation amount and stable and reliable in process and especially suitable for separating and preparing great amount of highly purified liquiritin compounds from the traditional Chinese medicine licorice.

The present invention provides a method for producing turmeric effective component. Turmeric material is ground and added with 70 to 95 percent of ethanol for extraction; the turmeric material is loaded on nonpolar macroporous adsorptive resin and ethanol / water is used for eluting; the eluent is collected, concentrated and dried to obtain turmeric macroporous resin component; then turmeric effective component is obtained through industrial production of chromatographic separation and mobile phase of methanol water. The main active ingredients are curcumin, demethoxycurcumin and bisdemethoxycurcumin and the total content is up to 97.3 percent. The turmeric effective component produced by the present invention gets rid of impurities and increases the content of the main active ingredients. In production, the present invention has high repeatability, good maneuverability, easy standardization and industrialization. At the same time, the present invention has certain directive significance for quality control of turmeric herb.