42results about How to "Low organic residue" patented technology

The invention discloses an extraction process of a high purity phlorizin, comprising the following steps: (1) the raw materials are added with 4-8 times pure water, marinated for 1-3 hours, heated to boiling and micro boiling is kept for 2-3 hours so as to obtain an extracting solution; residue is heated to boiling by using 2-6 times pure water and micro boiling is kept for 2-3 hours so as to obtain a secondary extracting solution; the extracting solutions are merged, cooled and filtered and then the filtered liquid is collected; (2) the filtered liquid is adsorbed by macroporous resin and subjected to gradient elution by using 20 DEG and 50 DEG ethanol; the effluent liquid is collected in subsection, concentrated in vacuum, placed in a quiescence way and cooled, dissolves out crystal at 0-4 DEG C, and dehydrates by high-speed centrifugation; and (3) re-dissolving of pure water, vacuum concentration, re-crystallization, high-speed centrifugation dehydration and drying are carried out so as to obtain the finished product. By adopting pure water for extraction, the organic-residue is decreased and simultaneously the product content is more than 99 percent.

The invention relates to a spreading hedyotis herb extract and a separation and preparation method thereof. The main components of the extract are paederoside methyl ester, deacetylasperulosidic acid methyl ester, asperulosidic acid and asperuloside, and the total content of the four main components is 60 to 75 percent. The extract is obtained from the spreading hedyotis herb through steps of extracting, depositing in alcohol, membrane separation, non-polar macroporous resin separation, industrial chromatographic resolution, and the like. The preparation method can effectively remove the impurities such as glycoprotein, polysaccharide, amino acid, and the like, and improve the content of the main active components. The preparation process has high repeatability and good operability, is easy to realize standardization and industrialization, and simultaneously has certain directive significance for the quality control of the spreading hedyotis herb.

The invention belongs to the technical field of pharmaceutical preparations and specifically relates to a temozolomide lyophilized powder preparation. The temozolomide lyophilized powder preparation comprises an active ingredient of temozolomide or a pharmaceutically acceptable salt thereof, and a solution before lyophilization further contains an excipient, a wetting agent, a buffer agent, an osmotic pressure regulating agent, a pH regulating agent, water for injection and an organic solvent, wherein the organic solvent is selected from one or any combination of ethanol, acetone, isopropanol, n-propanol, butanone, sec-butyl alcohol and methanol, and is preferably ethanol. The temozolomide lyophilized powder preparation provided by the invention has the advantages of stable quality, high re-dissolution speed and a small residual amount of the organic solvent. The invention further provides a method for preparing the preparation. The process provided by the invention is simple and convenient in preparation process and easy to control production links, the organic solvent accounts for a relatively small part of total volume of material liquid, the pollution to production equipment and environment caused by the organic solvent is reduced, and thus the method is suitable for large-scale production.

The invention relates to a high efficiency extraction method of T-acid mother liquor, and belongs to the field of an H-acid production waste water treatment. Tri(octyl-decyl)amine, sulfonated kerosene and n-octyl alcohol are respectively measured and uniformly mixed for obtaining an extractant, the extractant is thrown into the T-acid mother liquor, a heating stirring is carried out, simultaneously sulfuric acid is added, after stirring, standing and layering, the upper layer is an extract, and lower layer is an inorganic salt water phase; after the lower layer inorganic salt water phase is separated, the upper layer extract is heated, sodium hydroxide is added, after stirring and standing, the oil and water separation is carried out. The invention is applied into the H-acid production, thereby avoiding generation of solid waste with simple operation and effectively reducing the production cost.

The invention discloses an extraction process of high-purity phloridzin. The process includes the steps of: (1) stock solution extraction: adding water that is 8 times the amount of a phloridzin-containing mashed raw material into the same, conducting soaking for 3h, performing heating to boiling, maintaining slight boiling for 2h to obtain an extracted solution; adding purified water that is 6 times the amount of residue into the same and performing heating to boiling, maintaining slight boiling for 2h to obtain a secondary extracted solution; merging the extracted solutions, carrying out cooling and filtering, and collecting the filtrate; (2) preliminary extraction of a finished product: subjecting the filtrate to adsorption by macroporous resin D101, controlling the column pass flow at 80L/H, using 20-50degree ethanol to conduct gradient elution, performing fractional collection on the outflow solution, carrying out vacuum concentration, standing and cooling, conducting crystal precipitation at 0-4DEG C, and carrying out high-speed centrifugal dehydration; and (3) finished product extraction: conducting pure water redissolution, vacuum concentration, recrystallization, high-speed centrifugal dehydration and drying, thus obtaining a finished product. The extraction process of high-purity phloridzin provided by the invention has easily available raw materials, not only solves the environmental problem, but also improves the product yield, and greatly reduces the cost, and has the advantages of simple reaction process, convenient operation and no pollution.

The invention relates to a treatment process combining an H acid mother solution and a T acid mother solution and belongs to the technical field of treatment of H acid production wastewater. The treatment process comprises the following steps: adding an acidic complexing agent into collected wastewater and pre-treating; extracting an obtained water phase; directly adding the water phase into MVR equipment, and concentrating and crystallizing; centrifuging and separating to obtain inorganic salt; adding sodium hydroxide into an extracting solution except the water phase and adjusting temperature and pH to carry out reverse extraction; separating a reverse extraction product obtained by the reverse extraction from an extraction agent, and drying the reverse extraction product to obtain an organic byproduct. The treatment process is applied to the production of H acid, so that the production of solid wastes is avoided and the operation is simple and convenient; recycled products also can be put into secondary utilization so that the production cost is effectively reduced.

The invention discloses a method for separating dichloropropanol from dichloropropanol and hydrochloric acid azeotrope. The method specifically comprises the following steps: adding arenes, esters andethers which are azeotropic with water as an organic water-carrying agent to the dichloropropanol and hydrochloric acid azeotrope to form a new azeotropic system, heating and enabling the system to be azeotropic, through rectifying, cooling and distributing water, realizing separation of hydrochloric acid and the organic water-carrying agent; performing atmospheric distillation on an unrectifiedcomponent containing dichloropropanol to obtain the high-purity dichloropropanol, and recovering and recycling the water-carrying agent of the system. The method is simple in operation, high in separating efficiency of dichloropropanol and hydrochloric acid solution, high in recovery rate, and high in purity of the obtained dichloropropanol and hydrochloric acid. The organic water-carrying agent of arenes, esters and ethers is high in water-carrying efficiency, recycled, and low in cost, and capable of reducing environment pollution.

The invention discloses a method for purifying Rhododendron, which is characterized in that: the round leaves of Rhizoma chinensis are used as raw materials, crushed, and 55-70% ethanol is added for ultrasonic extraction 1-3 times, the extract is concentrated under reduced pressure, and the concentrated solution is adjusted to pH 3- 4. Filtrate, add polyamide resin to the filtrate for adsorption, elute with ethanol water, concentrate the collected solution to recover ethanol, filter the concentrated solution through a high-speed centrifuge, and separate the filtrate through a membrane separator. The obtained components are separated by high-speed countercurrent chromatography and detected by an ultraviolet detector , collect the target components, and dry under reduced pressure to obtain Rhodorin. The method of the invention has the advantages of simple operation, short production period, large preparation amount and high efficiency, and is suitable for the preparation of high-purity rhodium.

The invention discloses a preparation method and application of indocyanine green polymer nano particles. The preparation method comprises the following steps: (1) dissolving indocyanine green in a first organic solvent, dropwise adding a second organic solvent, and obtaining a mixture; (2) pumping the mixture into a supercritical granulation autoclave, and after the mixture is pumped, continuously flushing by using supercritical carbon dioxide, thus obtaining the indocyanine green nano particles; and (3) ultrasonically dispersing the indocyanine green nano particles in a sodium chloride solution comprising polycations, stirring, then centrifuging, washing obtained precipitates by using ultrapure water, and then freeze drying, thus obtaining the indocyanine green polymer nano particles. The indocyanine green polymer nano particles prepared in the invention are good in stability, an optical absorption wavelength range is at a near-infrared waveband, the high penetration performance of the near-infrared rays for biological tissues can be well utilized, and the indocyanine green polymer nano particles can be better used for treating tumors.

According to the scheme, a liquid phase reduction method is firstly adopted, silver nitrate and a reducing agent are adopted according to the main principle, and a certain amount of water-based dispersing agent or oil-based dispersing agent is added, so that the silver powder with certain dispersing performance is obtained, and in order to guarantee that the silver powder with high dispersity and uniform particle size can be obtained, the preparation method is simple, and the cost is low. The water-based dispersing agent is selected, meanwhile, the reducing agent is any one or more of ascorbic acid, formaldehyde, hydrazine hydrate and hydrogen peroxide, after the reduction reaction is finished, alkali liquor continues to be added, the pH of the suspension C is adjusted to be 8-14, hydroxyl ions are contained in the system in the process, the structure of the dispersing agent can be destroyed through strong alkalinity, and therefore the dispersing effect is improved. Therefore, the dissociation effect is achieved; the method can be applied to any preparation method of the silver powder using the water-based dispersing agent, complete sedimentation of the silver powder can be achieved, organic residues on the surface of the obtained silver powder are lower than those of the silver powder not using the method by 0.3% or above, and high practicability is achieved.

The invention discloses environment-friendly cooling liquid for cutting a hard brittle material, as well as a preparation method and a using method thereof. Based on the total amount of 100 weight percent, the environment-friendly cooling liquid contains the following components in percentage by weight: 30 to 50 percent of a cleaning agent, 10 to 30 percent of a nonionic surfactant, 2 to 10 percent of a wetting agent, 15 to 30 percent of an emulsifier and 0 to 10 percent of a solvent. According to the environment-friendly cooling liquid, as well as the preparation method and the using method thereof, lubrication effects in a cutting process are enhanced, and a cutting tool is favorably protected, so that cutting force is increased; in addition, low-foam effects are maintained in the whole cutting process, so that cutting is facilitated, the undesirable phenomena of edge breakage and the like of a cut product are avoided, and the cutting yield is greatly improved.

The invention provides an amorphous cefodizime sodium, which is characterized in that an amorphous X-ray diffraction pattern is free from having an X-ray diffraction peak; and in an amorphous differential thermogram, the endothermic peak stays at 57 to 68 DEG C, and the exothermic peak stays at 250 to 258 DEG C. The organic residual value in the cefodizime sodium is low, so the cefodizime sodium is free from entering into a hard lamp during the drying and is easy to operate; the obtained product presents in an apparent granular shape, and the fluidity is good; and when the cefodizime sodium is used for the preparation, the cefodizime sodium is free from being crushed and can be directly homogenized to be prepared, thereby saving device, power and labor cost for the industrialized production, and shortening the production period.