42results about How to "Low organic residue" patented technology

The invention discloses a method for purifying chenodeoxycholic acid. The method comprises the following steps: pretreatments such as degreasing, decoloration and impurity removal are carried out on commercially available crude bile paste or crude bile powder, so as to obtain a component to undergo chromatographic separation; the component to undergo chromatographic separation undergoes purification and separation by the use of a chromatographic column with a hydrophilic resin filler as a stationary phase; and separation products undergo concentration, acidification, washing and drying, so as to obtain chenodeoxycholic acid. In comparison with the prior art, the invention has the following beneficial effects: 1, content of the main component is high; 2, reappearance is high and operability is good; 3, short cycle: it only takes two days to prepare the high-purity chenodeoxycholic acid product from processing of the bile paste raw material; and 4, low content of organic residues: as processes such as solvent extraction, column chromatography on silica gel and the like in the traditional techniques are abandoned, an industrial chromatographic process with low dosage of an organic solvent is adopted and the final product undergoes drying process, the content of the residual organic solvent in the final product is especially low.

The invention belongs to the field of medical technology and relates to a new method for preparing xanthoceraside in shinyleaf yellowhorns. The highly purified xanthoceraside can be prepared efficiently with the preparation method. The preparation method is easy and convenient to use and reliable and reduces redundant intermediate operation steps, thus, product loss is reduced, and the yield of the preparation method is obviously increased compared with that of a former method. Crude extract is directly processed with a silica gel column, eluted with the chloroform / dichloromethane-methyl alcohol eluent with the volume ratio of 10:1-7:1, the ethyl acetate-methyl alcohol eluent with the volume ratio of 10:1-5:1 or the acetone-methyl alcohol eluent with the volume ratio of 10:1-6:1, and then eluted with the chloroform / dichloromethane-methyl alcohol eluent with the volume ratio of 6:1-2:1, the ethyl acetate-methyl alcohol eluent with the volume ratio of 4:1-1:1 or the acetone-methyl alcohol eluent with the volume ratio of 5:1-3:1, solvent recovery, purification and recrystallization are performed, and finally the xanthoceraside is obtained.

The present invention relates to the field of environmental protection, and specifically relates to a treatment process for resource utilization of medical waste salt at medium temperature pyrolysis; the present invention provides a process for resource utilization of waste medical salt at medium temperature pyrolysis. The principle is to use lower temperature to fully oxidize and decompose organic pollutants from the waste salt that has removed volatile substances, so as to achieve the purpose of harmless treatment of waste salt and then resource utilization; the invention adds an inorganic salt anti-caking agent, It can effectively prevent the waste salt from agglomerating in the fluidized bed reactor and ensure the sufficient oxidation and decomposition of organic pollutants, which is the key to the process; the waste salt obtained by the treatment method of medical waste salt of the present invention has extremely low organic residues and no agglomeration phenomenon. The organic matter is fully oxidized, and the energy saving is significantly reduced. The effective treatment of medical waste salt can not only protect the environment, but also reuse the main component sodium chloride salt to make up for the market gap, which has high economic value.

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of the salidroside; wherein, extracting solution is obtained by decocting the ground rhodiola with ten times of water, and then the extract (the relative density is from 1.10 to 1.15) is obtained after the extracting solution is concentrated, and then the ethanol is added for twice of alcohol precipitation, and then the eluate is collected by separating the solution with a 6000a molecular weight membrane separator and an efficient industrial chromatographic column and eluting themethanol water with gradients and then the salidroside is obtained by collecting, concentrating, freezing and drying the eluate. The method is high in product purity, large in preparation amount and stable and reliable in process and especially suitable for separating and preparing a great amount of highly purified salidroside compounds from the traditional Chinese medicine rhodiola.

The invention discloses a preparation method of functional silver flakes, which includes the following steps of (A), preparing microcrystalline micro-silver powder containing silver oxide by means of primary reduction; (B), grinding silver flakes with a ball mill and then filtering the same to obtain silver slurry containing ball-milled dispersant; (C), treating the silver powder by etching and secondary reduction to obtain stereoscopic cross-linked structural silver flakes with 3-12% micro-silver powder, wherein a reducing agent A is an alcohol weak reductant while a reducing agent B is a strong reductant. The preparation method is simple in process, easy to realize mass production and applicable to large-scale production in the industry. The functional silver flakes prepared by the method have stereoscopic cross-linked reticular space structures, small in grain size and low in apparent density. Besides, since the functional silver flakes contain 3-10% of monocrystal or flocculent silver powder, point-surface contact among the silver powder and filling capability of the silver powder are improved, and conductivity is high.

The invention belongs to the technical field of medicines, and relates to a novel method for preparing shiny-leaved yellowhorn total saponins from shiny-leaved yellowhorn and an application of the shiny-leaved yellowhorn total saponins. According to the method, a coarse extract of the shiny-leaved yellowhorn is directly separated and purified by a macroporous resin method to obtain shiny-leaved yellowhorn total saponins; the yield of the total saponins is over 5 percent, and the content of the total saponins in a product is over 60 percent and far higher than that in products prepared by other processes. The prepared shiny-leaved yellowhorn total saponins can be applied to preparation of medicines or health-care products for preventing and treating memory deterioration, hypophrenia and cranial nerve injury caused by neurodegenerative diseases and acute and chronic cerebral injury diseases, and can be used for treating cerebral diseases caused by alzheimer disease, acute disease and subacute stage of cerebral arterial thrombosis, vascular dementia and other ischemia and hypoxia of neurodegenerative diseases and acute and chronic cerebral injury diseases.

The invention discloses a method for separating dichloropropanol from dichloropropanol hydrochloric acid azeotropic liquid. The specific operation steps are as follows: adding aromatic hydrocarbons and esters azeotropic with water to dichloropropanol hydrochloric acid azeotropic liquid Form a new azeotropic system with ethers as an organic water-carrying agent, heat the system to azeotrope, and realize the separation of hydrochloric acid and organic water-carrying agent through rectification, cooling, and water separation; unrectified components containing dichloropropanol High-purity dichloropropanol is obtained after distillation under normal pressure, and the water-carrying agent in the system can be recovered and recycled. The method has the advantages of simple operation, high separation efficiency of dichloropropanol and hydrochloric acid solution, high recovery rate, and high purity of obtained dichloropropanol and hydrochloric acid. Aromatic hydrocarbons, esters and ether organic water-carrying agents have high water-carrying efficiency, can be recycled, have low cost, and reduce environmental pollution.

The invention relates to the technical field of preparation of hydrophilic drug microspheres, in particular discloses a method for preparing a hydrophilic drug microsphere through a spray drying process. The method comprises preparation steps of: uniformly dispersing hydrophilic drug powder into an isolation oil phase to form an S / O1 type suspension, and then slowly adding into a spray solution (O2) which contains a macromolecular carrier, an anti-sticking agent and a plasticizing agent, homogeneously emulsifying to form an S / O1 / O2 type spray emulsion, decompressing and drying at 60 DEG C or less through a spray drying technology after collecting the microspheres in a cyclone separator, and screening with a sieve of 80 meshes so as to prepare the hydrophilic drug twice-embedded sustained-release microsphere. The microsphere prepared by spray drying have the advantages of round shape, smooth surface, good mobility, uniform grain size distribution, high encapsulating rate, capability ofeffectively controlling burst release, and accordance with the characteristics of a long-acting preparation; and the method has the advantages of reducing consumption of a great quantity of oil substances and volatile organic solvents , greatly shortening drying time and being remarkable in effect, and is applicable to industrial production.

The invention relates to a method for purifying panax notoginseng total saponins and a preparation of the panax notoginseng total saponins, and aims to provide a purifying method capable of preparing panax notoginseng total saponins with higher efficiency and higher purity and overcoming the defects of the prior art. The purifying method breaks through the conventional method for purifying the panax notoginseng total saponins; impurity removal, decolorization and enrichment of the total saponins can be effectively implemented by fully combining different purifying effects of macroporous resin, polyamide and active carbon; and the polyamide is filtered by one step of washing operation, so the process is simple, an organic solvent is saved and industrialized production is easily realized. The invention also comprises the medicinal preparation of the panax notoginseng total saponins, and the preparation can be prepared into power injection, injection, tablets or capsules.

The invention belongs to the technical field of pharmaceutical preparations and specifically relates to a temozolomide lyophilized powder preparation. The temozolomide lyophilized powder preparation comprises an active ingredient of temozolomide or a pharmaceutically acceptable salt thereof, and a solution before lyophilization further contains an excipient, a wetting agent, a buffer agent, an osmotic pressure regulating agent, a pH regulating agent, water for injection and an organic solvent, wherein the organic solvent is selected from one or any combination of ethanol, acetone, isopropanol, n-propanol, butanone, sec-butyl alcohol and methanol, and is preferably ethanol. The temozolomide lyophilized powder preparation provided by the invention has the advantages of stable quality, high re-dissolution speed and a small residual amount of the organic solvent. The invention further provides a method for preparing the preparation. The process provided by the invention is simple and convenient in preparation process and easy to control production links, the organic solvent accounts for a relatively small part of total volume of material liquid, the pollution to production equipment and environment caused by the organic solvent is reduced, and thus the method is suitable for large-scale production.

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of liquiritin; wherein, extracting solution is obtained by decocting the ground licorice plants with ten times of water, and then extract is obtained after the extracting solution is concentrated, and then ethanol is added for alcohol precipitation twice, and then a 6000Da molecular weight membrane separator is used for separating the extract, and then membrane separation permeation liquid is separated by X-5 macro-porous absorption resin and is eluted with the ethanol water, andthe obtained macro-porous resin separation components are separated by an efficient industrial chromatographic column and eluted with gradients with the methanol water and then the liquiritin is obtained by collecting, concentrating, freezing and drying the eluting solution. The method is high in product purity, great in preparation amount and stable and reliable in process and especially suitable for separating and preparing great amount of highly purified liquiritin compounds from the traditional Chinese medicine licorice.

The present invention provides a method for producing turmeric effective component. Turmeric material is ground and added with 70 to 95 percent of ethanol for extraction; the turmeric material is loaded on nonpolar macroporous adsorptive resin and ethanol / water is used for eluting; the eluent is collected, concentrated and dried to obtain turmeric macroporous resin component; then turmeric effective component is obtained through industrial production of chromatographic separation and mobile phase of methanol water. The main active ingredients are curcumin, demethoxycurcumin and bisdemethoxycurcumin and the total content is up to 97.3 percent. The turmeric effective component produced by the present invention gets rid of impurities and increases the content of the main active ingredients. In production, the present invention has high repeatability, good maneuverability, easy standardization and industrialization. At the same time, the present invention has certain directive significance for quality control of turmeric herb.