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Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins

A technology of Panax notoginseng saponins and a purification method, which is applied in the field of traditional Chinese medicine chemistry to achieve the effects of high purity, low irritation and convenient use

Active Publication Date: 2014-04-23
北京中海康医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a purification method for preparing more efficient and higher-purity Panax notoginseng total saponins, while solving the deficiencies and defects of the existing production technology

Method used

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  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins
  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins
  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins

Examples

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Effect test

preparation Embodiment 1

[0026] Take 20.0 kg of dried Panax notoginseng taproot, crush it with a Chinese herbal medicine pulverizer (purchased from Tianjin Test Instrument Co., Ltd.), pass through a No. 3 sieve, and extract with a 60% ethanol solution 12 times the weight of the medicinal material under reduced pressure at 55°C. Seconds, each time for 2.0 hours, combine the extracts, recover the ethanol to the end, add 1 volume of purified water to the concentrated solution, stir evenly, and place in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, the filtrate is adsorbed on HPD-700 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.), first eluted with deionized water, and controlled the elution endpoint with Molish reaction and thin layer chromatography, and discarded the elution Then use 12 times the column volume of 70% ethanol solution to elute, collect the eluate, concentrate at low temperature and reduced pressure to 0.2g medicinal materials / ml, t...

preparation Embodiment 2

[0028] Take 20.0 kg of dried Panax notoginseng taproot, crush it with a Chinese herbal medicine pulverizer (purchased from Tianjin Test Instrument Co., Ltd.), pass through a No. 3 sieve, and extract with a 60% ethanol solution 12 times the weight of the medicinal material under reduced pressure at 50°C. Seconds, each time for 2.0 hours, combine the extracts, recover the ethanol to the end, add 1 volume of purified water to the concentrated solution, stir evenly, and place in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, the filtrate is adsorbed on HPD-400 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.), eluted with deionized water first, and controlled the elution end point with Molish reaction and thin layer chromatography, and discarded the elution Then use 12 times the column volume of 70% ethanol solution to elute, collect the eluate, concentrate at low temperature and reduced pressure to 0.2g medicinal materials / ml, ...

preparation Embodiment 3

[0030] Take 20.0 kg of dried Panax notoginseng taproot, crush it with a Chinese herbal medicine pulverizer (purchased from Tianjin Test Instrument Co., Ltd.), pass through a No. 3 sieve, and extract 1 with a 70% ethanol solution containing 10 times the weight of the medicinal material under reduced pressure at 55°C. Seconds, each time for 3.0 hours, combine the extracts, recover the ethanol to the end, add 1 volume of purified water to the concentrated solution, stir evenly, and place in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, the filtrate is adsorbed on AB-8 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.), eluted with deionized water first, and controlled the elution endpoint with Molish reaction and thin layer chromatography, and discarded the elution Then use 10 times the column volume of 80% ethanol solution to elute, collect the eluate, concentrate at low temperature and reduced pressure to 0.2g medicinal mater...

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Abstract

The invention relates to a method for purifying panax notoginseng total saponins and a preparation of the panax notoginseng total saponins, and aims to provide a purifying method capable of preparing panax notoginseng total saponins with higher efficiency and higher purity and overcoming the defects of the prior art. The purifying method breaks through the conventional method for purifying the panax notoginseng total saponins; impurity removal, decolorization and enrichment of the total saponins can be effectively implemented by fully combining different purifying effects of macroporous resin, polyamide and active carbon; and the polyamide is filtered by one step of washing operation, so the process is simple, an organic solvent is saved and industrialized production is easily realized. The invention also comprises the medicinal preparation of the panax notoginseng total saponins, and the preparation can be prepared into power injection, injection, tablets or capsules.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine chemistry, and particularly relates to a method for purifying panax notoginseng saponins and a preparation thereof. Background technique [0002] Panax notoginseng is the dry roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen, a plant in the Araliaceae family. It is warm in nature, sweet in taste, slightly bitter, and enters the stomach meridian. The main function is to remove blood stasis and stop bleeding, reduce swelling and relieve pain. Used for hemoptysis, vomiting blood, blood in the stool, metrorrhagia, traumatic bleeding, chest and abdomen tingling, swelling and pain. Mainly produced in Yunnan Wenshan, Yanshan, Guangnan, Maguan and Guangxi Jingxi, Mubian, Baise and other places. [0003] Panax notoginseng contains many components, among which the total saponins of Panax notoginseng are the main active components of Panax notoginseng, which are mainly distributed in the roots...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P3/06A61P3/10A61P7/02A61P9/10A61P37/02
Inventor 孙武兴李青原黄海秦玉霞
Owner 北京中海康医药科技发展有限公司
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