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Preparation for effective component of turmeric

A technology for effective components and turmeric, applied in the field of extraction and preparation of effective components of turmeric, can solve the problems of inability to large-scale production, low product purity, poor reproducibility, etc., and achieves suitable for industrialized large-scale production and small organic solvent residues. , highly reproducible effect

Inactive Publication Date: 2008-12-10
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reports about the extraction and separation preparation of curcumin compounds in literature basically all take methods such as traditional solvent extraction and silica gel chromatography (Wang Ping, Chen Xiaolong, etc., Chinese Journal of Modern Applied Pharmacy, 2005, 22 (4), 328- 330; Nong Keliang, Wei Liangxing, etc., Chemical Technology and Development, 2006, 35(2)3-5; Apichart S etc., Phychemistry, 1996, 36(6), 1505-1508; So-Young Park ect., J NatProd , 2002, 65(9), 1227-1231), these methods have shortcomings such as low product purity, poor reproducibility, long time consumption, serious organic residues, and inability to produce on a large scale

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  • Preparation for effective component of turmeric
  • Preparation for effective component of turmeric
  • Preparation for effective component of turmeric

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Grind the original medicinal material of turmeric, weigh 1 kg quantitatively, put it in a 20-liter extraction tank, add 10 liters of 95% ethanol to soak for 1 day, filter, save the filtrate for later use, add 10 liters of 95% ethanol to the filter residue and soak for 1 day, filter , the filtrate was combined with the first time, and the filter residue was discarded. The extract was concentrated to 150 ml by rotary evaporation to obtain the alcohol-extracted fraction of curcuma.

[0020] Load 10 L of processed Rohm and Haas XAD-4 macroporous resin into the macroporous resin chromatography system, and dry-load the curcumin alcohol extraction fraction on the macroporous resin chromatography column. First use 4 times column volume 40L 50% ethanol to elute the column body, discard the eluate, then use 4 times column volume 40L 80% ethanol to elute, save the eluate, and concentrate to a solid content of 0.3 g / ml, pass 0.22 micron filter membrane, obtains 50 milliliters of t...

Embodiment 2

[0031] Grind the original turmeric medicinal material, weigh 0.5 kg quantitatively, put it in a 10-liter extraction tank, add 6 liters of 70% ethanol to soak for 2 days, filter, save the filtrate for later use, add 6 liters of 70% ethanol to the filter residue and soak for 1 day, filter , the filtrate was combined with the first time, and the filter residue was discarded. The extract was concentrated to 70 ml by rotary evaporation to obtain the alcohol-extracted fraction of curcuma.

[0032] Put 5 L of processed Rohm and Haas XAD-4 macroporous resin into the macroporous resin chromatography system, and dry-load the curcumin alcohol extraction fraction on the macroporous resin chromatography column. First, the column was eluted with 6 times column volume of 30L 40% ethanol, and the eluate was discarded, then eluted with 6 times column volume of 30L 85% ethanol, and the eluate was stored and concentrated to a solid content of 0.2 g / ml. Cross 0.22 micron filter membrane, obtain ...

Embodiment 3

[0035] Grind the original medicinal material of turmeric, weigh 5 kg quantitatively, put it in a 100-liter extraction tank, add 60 liters of 80% ethanol to soak for 2 days, filter, save the filtrate for later use, add 60 liters of 80% ethanol to the filter residue and soak for 2 days, filter , the filtrate was combined with the first time, and the filter residue was discarded. The extract was concentrated by rotary evaporation to 700 ml to obtain the curcumin alcohol-extracted fraction.

[0036] Load 50 L of processed Rohm and Haas XAD-4 macroporous resin into the macroporous resin chromatography system, and dry-load the curcumin alcohol extraction fraction on the macroporous resin chromatography column. First use 3 times the column volume of 150L 60% ethanol to elute the column body, discard the eluate, and then use 3 times the column volume for 150L 95% ethanol to elute, save the eluate, and concentrate it to a solid content of 0.5 g / ml. 0.45 micron filter membrane, obtains...

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Abstract

The present invention provides a method for producing turmeric effective component. Turmeric material is ground and added with 70 to 95 percent of ethanol for extraction; the turmeric material is loaded on nonpolar macroporous adsorptive resin and ethanol / water is used for eluting; the eluent is collected, concentrated and dried to obtain turmeric macroporous resin component; then turmeric effective component is obtained through industrial production of chromatographic separation and mobile phase of methanol water. The main active ingredients are curcumin, demethoxycurcumin and bisdemethoxycurcumin and the total content is up to 97.3 percent. The turmeric effective component produced by the present invention gets rid of impurities and increases the content of the main active ingredients. In production, the present invention has high repeatability, good maneuverability, easy standardization and industrialization. At the same time, the present invention has certain directive significance for quality control of turmeric herb.

Description

technical field [0001] The invention relates to the separation of natural medicines, in particular to a method for extracting and preparing effective components of turmeric. The main active components of the components are three compounds: curcumin, demethoxycurcumin and bisdemethoxycurcumin. Background technique [0002] Turmeric is the dry rhizome of Curcuma longa L., a plant in the family Zingiberaceae, which is a commonly used traditional Chinese medicine. It was first recorded in "Tang Materia Medica". It has the functions of breaking blood and promoting qi, dredging menstruation and relieving pain. Traditional Chinese medicine is used for blood stasis and qi stagnation, chest pain, amenorrhea abdominal pain, postpartum stasis, abdominal mass, bruises, swelling and pain, Wind arthralgia arm pain (" Pharmacopoeia of the People's Republic of China ", edition one in 2005). Mainly produced in Sichuan, Hubei, Guangdong, Guangxi, Fujian, Taiwan and other places. At present,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066C07C45/79A61P3/06A61P9/10A61P29/00A61P35/00A61P39/06A61K125/00
Inventor 梁鑫淼李伟丰加涛张慧徐青
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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