41 results about "Cytisine" patented technology

The invention discloses a new process for preparing cytisine. The process comprises the steps of crushing a raw material, i.e., Thermopsis lanceolate grass, then, carrying out soaking extraction by 85% ethanol, carrying out filtrating, concentrating the filtrate to obtain an extract, subjecting the extract to double extraction to obtain a concentrate chloroform layer, concentrating the chloroform layer to obtain total alkaloids, carrying out dissolving by using acetone, carrying out crystallization to obtain crude cytisine crystals, dissolving the crude cytisine crystals with ethyl acetate, carrying out cooling recrystallization, carrying out dissolving by using acetone, carrying out cooling recrystallization, carrying out filtrating, carrying out vacuum drying, carrying out crushing, and then, carrying out screening and uniform mixing, thereby finally obtaining finished cytisine. According to the new process, the steps are simple, the operation is convenient, the crystallization rate is high, standing is not required, column chromatography is not required, the loss is low, the yield is high, and the obtained product is high in purity.

The invention relates to cytisine and matrine insecticide water emulsion, which belongs to the water emulsion obtained through compounding 15 to 20 volume percent of gorse cytisine extract liquid with 8 to 10 volume percent of matrine extract liquid, wherein 1ml of medicine liquid of gorse cytisine extract liquid equals to 2g of crude drugs, and 1ml of medicine liquid of matrine extract liquid equals to 2g of crude drugs. The two kinds of plant source alkaloid of the cytisine and the matrine are mixed, so biopesticide with the advantages of high efficiency, low toxicity and little environment pollution is obtained. Major ingredients such as the cytosine and the matrine are natural products extracted from plants, and both the cytisine and the matrine have the insecticidal action, so strong killing effects are realized on pests, the drug resistance is not easy to occur, no harmful chemical pesticide ingredients are contained, the toxicity on people and livestock is low, no residue is left, and the environment is not polluted.

The invention relates to a cytisine derivative maleate or its pharmaceutically acceptable solvate and an application of the cytisine derivative maleate or its pharmaceutically acceptable solvate in preparation of medicines for treating tumors.

The invention discloses alkaloid fuming particles for low-temperature heating non-combustible products. The alkaloid fuming particles comprise the following components in parts by weight: 0.1-15 partsof alkaloid, 30-60 parts of Chinese herbal medicines and 10-30 parts of a smoke agent, wherein the alkaloid is any one of cytisine, leonurine, sophocarpidine, notoginsenoside and lobeline. The invention also discloses a preparation method of the alkaloid fuming particles. According to the invention, the fuming particles adopt alkaloid and natural Chinese herbal medicine formulas and can replace nicotine-containing tobacco, so that addiction and health hazards are reduced, and meanwhile, the effects of refreshing, decompressing and medicine health care are achieved.

The present invention relates to substituted cytisine compounds that are useful in treating diseases impacted by a nicotinic ACh receptor. One aspect of the invention relates to 10-substituted cytisine compounds. In certain instances, the cytisine is substituted in the 10-position by an alkyl, aryl or aralkyl group. The present invention also relates to a pharmaceutical composition comprises the substituted cytisine compound or the 10-substituted cytisine compound. The invention also relates to a method of modulation a nicotinic ACh receptor in a mammal, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine. In certain instances, the substituted cytisine is a 10-substituted cytisine. Another aspect of the present invention relates a method of treating a disease impacted by a nicotinic ACh receptor, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine. In certain instances, the substituted cytisine is a 10-substituted cytisine.

The invention discloses a method for extracting and purifying cytisine from Sophora tonkinensis. The method comprises the following steps: extraction: a Sophora tonkinensis medicinal material is pulverized, an aqueous solution of an organic solvent is used for extraction with ultrasound, the extract is filtered, filtrate is condensed, and a macroporous resin column is used for separating a Sophora tonkinensis total alkaloid extract product; separation: the alkaloid extract product is absorbed and separated by silica gel, and recrystallization is carried out in order to obtain the product. The method has the advantages of simple process, simple operation, and low cost; the materials used for separation are simple to regenerate without toxicity and pollution; the method is suitable for industrial large-scale production.

The invention discloses a franchet peashrub flower root sauce lentinus edodes stem floss, which is prepared from the following raw materials by weight part: 50-65 of lentinus edodes stem, 8-12 of meat sauce, 13-15 of hawthorn, 7-8 of ginger, 2-5 of champagne, 1-2.1 of franchet peashrub flower root, 2-2.2 of Chinese wolfberry leaf, 2.1-3.2 of radix isatidis, and proper amounts of cellulase, protease, a 30%-35% sugar soution, a 0.02%-0.03% cysteine solution, refined salt, monosodium glutamate, and pine needles. The lentinus edodes stem floss prepared by the invention adopts pine needle fumigating to increase aroma, is fragrant and pure, has long aftertaste, good taste and quality, and maximumly reserves the nutritional components of lentinus edodes stem. Also, the formaldehyde component in the lentinus edodes stem is removed by cysteine solution treatment. Franchet peashrub flower root, Chinese wolfberry leaf, radix isatidis and other Chinese herbal medicines are also added in the invention, and endow the lentinus edodes stem floss with the health care functions of nourishing liver and tonifying kidney, helping produce saliva and slaking thirst.

The invention provides a method for extracting and separating cytisine. The method comprises the following steps: extracting, namely grinding thermopsis lanceolata seeds, adding an organic solvent water solution with the mass being 4-10 times that of the ground thermopsis lanceolata seeds, carrying out reflux extraction for 1-4 hours, and concentrating an extracting solution until the mass concentration is 0.5-1.5 g/ml so as to obtain a concentrated solution; carrying out macroporous resin combination separation, namely carrying out primary separation by polystyrene nonpolar resin with the aperture of 130-300 angstroms and the specific surface area of 480-600 m<2>/g, and carrying out secondary separation by polystyrene nonpolar resin with the aperture of 50-80 angstroms and the specific surface area of 800-1100 m<2>/g; re-crystallizing to obtain cytisine. The method is simple in process and easy and convenient to operate, adopts high available raw materials and is low in cost; the separation materials are easy to regenerate, nontoxic and pollution-free; the method is suitable for industrialization mass production.

The invention discloses a shrimp shiitake mushroom stem floss with fragrance of roses and capable of nourishing bodies. The shrimp shiitake mushroom stem floss is made from the following raw materials in parts by weight: 50-65 parts of shiitake mushroom stems, 8-12 parts of malt, 14-15 parts of shelled shrimps, 15-17 parts of rose flowers, 4-6 parts of pinenut kernels, 3-4 parts of white spirit, 3-4 parts of chopped green onions, 0.9-1.3 parts of shrub chastetree fruits, 1-1.5 parts of ginseng flowers, 2.5-2.6 parts of honeysuckle flowers, an appropriate amount of cellulase, an appropriate amount of protease, an appropriate quantity of a cysteine solution of 0.02-0.03%, an appropriate amount of refined salt, an appropriate amount of gourmet powder, an appropriate amount of white sugar, and an appropriate quantity of pine needles. According to the shiitake mushroom stem floss made by the preparation method disclosed by the invention, the pine needles are smoked for flavoring, so that the shiitake mushroom stem floss is clean and pure in aroma, long in aftertaste and good in mouth feel and quality, the nutrient components of the shiitake mushroom stems are furthest preserved, and through the treatment of the cysteine solution, methanal components in the shiitake mushroom stems are removed; traditional Chinese medicines including the shrub chastetree fruits, the ginseng flowers, the honeysuckle flowers and the like are also added, so that the shiitake mushroom stem floss has the health care functions of clearing heat, removing toxicity, removing summer-heat, relieving restlessness and complementing vigour for human bodies.

The invention relates to the technical field of medicines, in particular to a novel cytisine tablet and a preparation method thereof. The novel cytisine tablet is characterized by comprising cytisine, in addition to a filling agent, a disintegrating agent, a lubricating agent and a flavoring agent. The invention further discloses the preparation method, According to the preparation method, and direct compression of powder is adopted, the technical process is stable, mature, simple and suitable for large-scale production. The cytisine tablet provided by the invention has the advantages of rapid disintegration and the like. The quality of the prepared cytisine tablet is controllable, and the stability of the product is ensured.

The present invention provides a process for preparing cytisine from thermopsis lanceolata glasses or seeds. The process comprises: crushing thermopsis lanceolata glasses into coarse powder (1-3 cm) or breaking thermopsis lanceolata seeds, weighing a certain amount of thermopsis lanceolata glass coarse powder or broken thermopsis lanceolata seeds, adding an alkaline solution to moisten for 6-8 h, adding chloroform to carry out reflux extraction, mixing the extraction solutions, carrying out reduced pressure concentration to recover the chloroform, adding ethanol to dissolve, adopting a decoloration agent to carry out decoloration, filtering, carrying out reduced pressure recovery of ethanol, adding acetone to carry out crystallization to obtain a cytisine crude product, and adding petroleum ether to carry out re-crystallization to obtain the cytisine fine product. The process method has characteristics of simpleness, practicality, low cost and high purity, and is suitable for industrial production.

The invention discloses dried yin-nourishing cocoa and sesame mushroom stem floss. The floss is prepared from the following raw materials in parts by weight: 50-65 parts of shii-take mushroom stems, 10-12 parts of water chestnut juice, 7-13 parts of sesame powder, 4-7 parts of soybean residues, 12-13 parts of cocoa powder, 8-9 parts of coriander, 2-1.8 parts of evening primrose, 2.4-3.5 parts of lotus leaf base, 2.3-3 parts of root of murdannia simplex and a proper amount of cellulase, protease, syrup having a concentration of 30-35 percent, a cysteine solution having a concentration of 0.02-0.03 percent, refined salt, monosodium glutamate and pine needles. The dried yin-nourishing cocoa and sesame mushroom stem floss has pure fragrance, long aftertaste and good taste quality since the pine needles are used for smoking to enhance the fragrance, the nutrition of shii-take mushroom stems is furthest maintained, and the formaldehyde ingredient in the shii-take mushroom stems can be removed by means of treatment of the cysteine solution. The dried yin-nourishing cocoa and sesame mushroom stem floss has functions of nourishing yin, clearing heat and strengthening tendons and bones by adding the evening primrose, lotus leaf base, the root of murdannia simplex and other traditional Chinese medicinal materials.

The invention discloses milk tea and shiitake mushroom stem dried meat floss capable of clearing the lung. The milk tea and shiitake mushroom stem dried meat floss is prepared from the following raw materials in parts by weight: 50-65 parts of shiitake mushroom stems, 22-23 parts of goat milk, 8-9 parts of pork fillet, 19-20 parts of white tea, 8-10 parts of purple corn, 13-14 parts of hypsizygus marmoreus, 12-15 parts of water chestnuts, 1-2.2 parts of phymatopsis crenato-pinnata, 2-3.3 parts of figwirt roots, 0.5-1.3 parts of China roses, an appropriate amount of cellulase, an appropriate amount of protease, an appropriate quantity of a citric acid solution of 1-2%, an appropriate quantity of a cysteine solution of 0.02-0.03%, an appropriate amount of refined salt, an appropriate amount of gourmet powder, an appropriate quantity of pine needles, and an appropriate amount of honey. According to the shiitake mushroom stem dried meat floss prepared by the preparation method disclosed by the invention, the pine needles are used for smoking and flavoring, so that the shiitake mushroom stem dried meat floss is clean and pure in aroma, long in aftertaste and good in mouth feel and quality, the nutrient components of the shiitake mushroom stems are furthest preserved, and through the treatment of the cysteine solution, methanal components in the shiitake mushroom stems are removed; traditional Chinese medicines including the phymatopsis crenato-pinnata, the figwirt roots, the China roses and the like are also added, so that the shiitake mushroom stem dried meat floss has the health care functions of nourishing yin, clearing heat, clearing the lung, benefitting the spleen, promoting digestion, resolving stagnation, relieving rigidity of muscles and activating collaterals.

The invention discloses a new method for purifying cytisine from raw plant extracts that yields high purity. The method comprises the steps of dissolving raw plant material with a lower alcohol, such as methanol or ethanol, then acidifying with mineral acid to a pH between 1.5 and 3.5. The combined alcohol-aqueous extracts are concentrated under vacuum distillation until the alcohol is eliminated and after filtration they are extracted with chloroform, methylene chloride, butyl acetate or normal butanol in a ratio of 1:1. The purified from ballast substances acid aqueous concentrate is alkalized to a pH of between 9 and 12 with alkaline hydroxide or ammonium hydroxide and the resulting alkaline aqueous concentrate is extracted at least twice with chloroform, methylene chloride, butyl acetate or normal butanol in a ratio of concentrate to extractant of from 1:5 to 1:10. The combined organic extracts are evaporated to dryness, then acetone or ethyl acetate are added to obtain a suspension which is allowed to crystallize completely at a temperature of from 5-10° C., then it is filtered and dried. The isolated final cytisine product has high purity and yield than otherwise known methods in the art.

The invention relates to a novel dimeric alkaloid and preparation and application thereof, the chemical structural formula of the novel dimeric alkaloid is shown in the specification, the alkaloid is a cytisine type dimeric alkaloid newly found in sophora alopecuroides, and the activity of Topo I can be obviously inhibited; the natural topoisomerase inhibitor with high selectivity can be designed and developed into a novel anti-tumor drug, and has a wide application prospect in the field of research and development of new drugs.

The present invention relates to the use of pyrroloquinoline quinine (PQQ), its derivatives and/or salts for the preparation of drugs for the treatment and/or prevention of endometriosis including adenomyosis, chocolate cyst of ovary, deeply infiltrating endometriosis and other type of endometriosis. In addition, the present invention relates to the use of PQQ in combination with one or more the following antioxidants: N-Acetyl-L-cysteine (NAC), resveratrol, epigallocatechin gallate, vitamin E or vitamin C for the preparation of drugs for inhibiting the proliferation, oxidative stress status, invasion and migration of endometrial stromal cell. The use of PQQ in combination with NAC shows a synergistic effect on inhibiting cell proliferation: significantly inhibiting the proliferation of endometrial stromal cell in vitro; significantly reducing the damaged size of tissue caused by endometriosis in vivo; significantly reducing the infiltration of endometrial stroma and glands; significantly reducing the dose of NAC as well. PQQ is beneficial for fertility, and increases the chances of getting pregnant. PQQ alone or PQQ in combination with NAC generally shows no side effects and will not interfere with pregnancy.

This invention is related to an oral pharmaceutical composition that contains a cholinergic agent, a natural plant alkaloid in particular, selected from the group of lobeline, anabasine, cytisine, galantamine or their acceptable salts, in the form of tablets and capsules. The excipients of the developed oral composition include cellulose powder, calcium sulphate, silica colloidal and magnesium stearate, the total content of cellulose powder and calcium sulphate dihydrate being from 64,5 to 97,5 % of the mass of the dosage form and at least 90% of the alkaloid particles being < 100um. The oral composition contains also at least one biologically active amino acid selected from: L-carnitine, tryptophan or a combination of them. The oral composition according to this invention achieves uniform distribution of the active substance in the composition, as well as stability of the composition due to the included excipients selected so as to react to a minimum with the alkaloid to form the qualitative and quantitative related substances admissible for the pharmaceutical composition. The composition according to this invention is applicable in the treatment of dependency and addiction to nicotine, tobacco products and alcohol.

The invention relates to the technical field of medicines, in particular to a cytisine orally disintegrating tablet and a preparation method thereof, and is characterized in that the cytisine orally disintegrating tablet contains cytisine and also contains a filling agent, a disintegrating agent, a lubricating agent and a flavoring agent. In addition, the disclosed preparation method adopts wet granulation, the technical technology is stable and mature, the preparation technology is simple, and therefore, the preparation method is suitable for large-scale production. The cytisine orally disintegrating tablet provided by the invention has the advantages of a high disintegration speed, an excellent taste, no grit feeling, good compliance and the like.

The invention discloses an insecticide composition containing cytisine. The insecticide composition includes the cytisine and dodine according to the weight part ratio of 1:1-30:1. In the insecticide, the cytisine and the dodine are combined at certain ratio, and the composition is found to have excellent synergistic prevention and killing effects on cnaphalocrocis medinalis; especially, when the weight part ratio of the cytisine to the dodine is 15-16:1, the synergistic effect is very significant.