81 results about "Cefotiam Hydrochloride" patented technology

The present invention discloses a cefotiam hydrochloride medicament composition sterile powder injection, including 500 to 600 weight shares of cefotiam hydrochloride and 110 to 150 weight shares of anhydrous sodium carbonate. The cefotiam hydrochloride medicament composition sterile powder injection has advantages of a good stability and a high purity. The invention also discloses a method for preparing the cefotiam hydrochloride medicament composition sterile powder injection, including steps of weighing the cefotiam hydrochloride and the anhydrous sodium carbonate according to the formula amount separately and mixing them in a sterile container uniformly. The method is simple, and the cefotiam hydrochloride prepared by the above method has a good stability.

The invention relates to a hydrochloric acid cefotiam crystalline compound and a medicine combination containing the same. The crystalline compound is determined by a powder X-ray diffraction measurement method, and an X-ray powder diffraction pattern represented with a diffraction angle of 2theta+/-0.2 degree shows characteristic diffraction peak at the positions of 5.9 degrees, 7.9 degrees, 9.3 degrees, 13.0 degrees, 13.6 degrees, 15.7 degrees, 16.8 degrees, 20.4 degrees, 25.7 degrees, 27.0 degrees, 30.9 degrees and 32.9 degrees. The crystalline compound is high in purity, has good heat stability, and can hardly absorb moisture. Simultaneously, the invention further provides a preparation method of the crystalline compound and the medicine combination containing the crystalline compound. The method is simple in process, high in yield, strong in repeatability and suitable for industrial production. The medicine combination containing the crystalline compound is good in stability, thereby improving medication safety and effectiveness and reducing occurrence rate of adverse reactions.

The invention provides a cefotiam hydrochloride compound, which is highly purified and finally obtained by the way of achieving the refine and purification purposes through a specifically designed method of acid-base conversion and macroporous absorption resin adsorption, thus optimizing the quality of preparation products and the safety of clinical medication.

The invention relates to a cefotiam hydrochloride compound in a new path. The preparation method comprises the following steps: allowing 2-aminothiazole-4-acetic acid to react with methanoic acid to generate 2-formylaminothiazol-4-acetic acid, adding 7-ACMT and triethylamine, taking N, N-diisopropylethylamine and dimethylfomamide as solvent, taking p-toluene sulfonylchloride as a catalyst, stirring to react, and then adding hydrochloric acid to obtain the cefotiam hydrochloride.

The invention provides cefotiam hydrochloride/anhydrous sodium carbonate medicinal composition suspension injection and new use thereof. The preparation is prepared from 166 to 282.2 weight parts of biodegrading agent, 6.64 to 26.56 weight parts of emulsifying agent, 9.96 to 26.56 weight parts of stabilizer, 13.28 to 49.8 weight parts of additive, 83 weight parts of cefotiam hydrochloride and 17 weight parts of anhydrous sodium carbonate. The invention further discloses new use of the cefotiam hydrochloride suspension injection for treating subacute thyroiditis in clinic.

The invention discloses a method for preparing cefotiam hydrochloride. The method comprises the following steps: carrying out a condensation reaction by using 7-ACA and DMMT as raw materials, a boron trifluoride acetonitrile complex as a catalyst and acetonitrile as a reaction solvent to prepare a 7-ACMT reaction liquid; carrying out a 'one-pot' acylation on the reaction liquid with ATC.HCl after treatment of direct water addition and alkali regulation without separating and purifying 7-ACMT; extracting and separating organic impurities from the acylation reaction liquid by acidification and organic solvent, and adding hydrophilic solvent to separate high-purity cefotiam hydrochloride. According to the method, two reactions are carried out in one step, the equipment using efficiency and labor efficiency can be improved, the labor intensity is reduced, the product yield is improved on the premise of guaranteeing the product quality, and the production cost is reduced; all impurity separating operations are carried out after the acylation reaction, product loss caused by intermediate separating operation can be reduced, and the product purity can be guaranteed.

The invention discloses a method for preparing cefotiam hexetil hydrochloride by cefotiam hydrochloride, belonging to medicines. The method comprises the steps of leading the cefotiam hydrochloride and potassium bicarbonate or sodium bicarbonate to react to prepare cefotiam, wherein the cefotiam hydrochloride is produced in an industrialized scale manner andthe charging mol ratio of the cefotiam hydrochloride and potassium bicarbonate or sodium bicarbonate is 1:2.5-10; then reacting with carbonic acid 1-iodinated cyclohexyl ethyl ester to obtain cefotiam hexetil; and conducting purification and hydrochloric acid acidization to obtain cefotiam hexetil hydrochloride. According to the method, especially the cefotiam is prepared by reacting cefotiam hydrochloride with 2.5-10 times of mol ratio of potassium bicarbonate or sodium bicarbonate in water, the prepared cefotiam hexetil hydrochloride has high purity, the total quantity of related substances in the prepared product is smaller than 1.5% by adopting a HPLC (high performance liquid chromatograp) method for detection, the yield rate is larger than 90%, and the production cost is low, thus being beneficial to industrialized manufacturing.

The invention discloses a cefotiam-hydrochloride-containing medicine preparation which is composed of an active component cefotiam hydrochloride, basic amino acid, and anhydrous sodium carbonate. The weight ratio of cefotiam hydrochloride (calculated according to cefotiam) to basic amino acid to anhydrous sodium carbonate is 1:0.4-0.6:0.05-0.15. A preparation method provided by the invention is substantially advantaged in that: (1) vacuum pumping is not needed after product sub-packaging, such that processes are reduced; (2) when the medicine is dissolved, the generation of a large amount of carbon dioxide is prevented, such that the danger for cefotiam medicine liquid to be sprayed from a bottle is avoided; (3) when the cefotiam preparation is diluted into various fluid replacements (including glucose solutions, electrolyte solutions or amino acid preparations), the amount of generated carbon dioxide is extremely low, such that clarity observation of intravenous infusion is not affected; (4) the dosage of anhydrous sodium carbonate is low, such that the possibility of alkalosis is avoided; and (5) the dosage of sodium ions is reduced, such that the preparation is suitable for patients with cardiac or renal insufficiency, edema patients, neonates, pregnant women, and the aged. Therefore, the application scope of the preparation is expended.

The invention discloses a preparation method of cefotiam hydrochloride for injection. A recrystallization method is adopted, an appropriate reagent is selected for carrying out soaking treatment, and high-purity cefotiam hydrochloride can be prepared. The preparation method of cefotiam hydrochloride for injection has the advantages that technology is simple and technological conditions are strictly controlled, so that a pharmaceutical preparation with high stability and good quality can be obtained.

The invention provides a preparation method of cefotiam hexetil hydrochloride. The method comprises: subjecting cefotiam hydrochloride and 1-iodoethyl cyclohexyl carbonate to an esterification reaction so as to obtain a cefotiam hexetil crude product, which is then purified into hydrochloride, thus obtaining cefotiam hexetil hydrochloride. In the esterification reaction, potassium carbonate is added, and cefotiam hydrochloride, potassium carbonate and 1-iodoethyl cyclohexyl carbonate are in a reaction mole ratio of 1:2.2-2.5:2.5-3. The method provided in the invention can reach a yield of 66% and make the isomer ratio less than 2%, or even to 1.3%. Employment of the preparation method in the invention can avoid usage of a chromatographic column and simplify the purification method, so that the method can be more suitable for industrial production needs.

The invention discloses a monohydrate cefotiam hydrochloride compound and a preparing method thereof. One mole of cefotiam hydrochloride contains one mole of water, and an x-ray diffraction spectrogram of the compound has characteristic peaks at the positions with the diffraction angles 2theta of 14.82-15.22 degrees, 29.92-30.32 degrees, 31.48-31.88 degrees, 35.01-35.41 degrees and 37.79-38.19 degrees. 7-amino-cephalosporanic acid (7ACA) serving as a starting material is condensed with 1-(2-dimethylaminoethyl)-5-thiotetrazole under the catalytic effect of organic solvents dimethyl carbonate boron trifluoride and the like to prepare an intermediate at a C-3 site; then 2-(2-aminothiazol-4-yl) acetic acid hydrochloride reacts with methylene chloride and concentrated hydrochloric acid gas to prepare acyl chloride at a 7 site, and the one-water cefotiam hydrochloride compound is synthesized. The operation is simple and environmentally friendly, the reactants are easily obtained, the reaction conditions are mild, and the yield is high. The one-water cefotiam hydrochloride compound has low hygroscopicity and impurity content, good fluidity and thermodynamic stability and wider applicationprospects.

The invention relates to a medicine cefotiam hydrochloride composition for treating the bacterial infection, and belongs to the technical field of medicines. The composition is composed of cefotiam hydrochloride and sodium dihydrogen phosphate. The cefotiam hydrochloride is a crystal. An X-ray powder diffraction pattern obtained through measurement by means of Cu-K alpha ray is shown in a figure 1. The novel crystal form of the hydroxyfasudil is different from a crystal form structure in the prior art. According to experimental verification, surprisingly, it is found that the novel crystal-form compound is high in purity, good in mobility and stability, low in polymer content and not prone to moisture absorption, the obtained powder injection is matched with a 0.9% sodium chloride injection, 5% glucose injection and 5% sodium chloride and dextrose injection and the stability of the solution is good after the solution is placed at the room temperature for 4 h.

The invention provides a method for preparing high-purity cefotiam hexetil as shown in formula (I). The method is as follows: cefotiam hydrochloride taken as a raw material reacts with carbonic acid-1-iodine ethyl ester cyclohexyl in an organic solvent in the presence of carbonates to obtain the high-purity cefotiam hexetil. The invention also provides a method for preparing dihydrochloride of the cefotiam hexetil, comprising the following steps: the cefotiam hexetil is dissolved in a reaction solvent containing hydrogen chloride and a devitrification solvent to carry out crystallization for 1-2h at the temperature of 5-30 DEG C. The methods of the invention are simple and practicable, are suitable for industrial production, special equipment is not required, and the cost is low; and the cefotiam hexetil and the dihydrochloride of the cefotiam hexetil have high purity, low impurity content and high yield.

The invention belongs to the technical field of medicines and discloses a synthesis method of cefotiam hydrochloride. The synthesis method comprises the steps: carrying out a condensation reaction ina mixed solvent by taking 7-aminocephalosporanic acid and 1-[2-(dimethylamino)ethyl]-1H-tetrazole-5-thiol as raw materials and a high-concentration boron trifluoride and dimethyl carbonate complexingcompound as a catalyst to prepare a three-position intermediate; and then, reacting the three-position intermediate with (2-aminothiazole-4-yl)acetyl chloride to obtain cefotiam hydrochloride. The method provided by the invention is stable and soft in reaction and few in byproducts, and the yield and purity of the produced cefotiam hydrochloride are relatively ideal.

The invention relates to an antibiotic drug, in particular to cefotiam hydrochloride for reducing anaphylaxis. The compound has the advantages of high yield, high purity and the like, and is suitable for industrial production, and product stability and anaphylaxis reducing and clinic application of a preparation are all obviously improved.

The invention belongs to the technical field of medicine, and particularly relates to a cefotiam hydrochloride compound, a method for preparing the same and a pharmaceutical composition with the cefotiam hydrochloride compound. The cefotiam hydrochloride compound is cefotiam hydrochloride trihydrate, and a structural formula of the cefotiam hydrochloride compound is shown. The cefotiam hydrochloride compound, the method and the pharmaceutical composition have the advantages that crystals of the cefotiam hydrochloride trihydrate are good in flowability, injection cefotiam hydrochloride made of the crystals of the cefotiam hydrochloride trihydrate, 0.9% sodium chloride injection, 5% glucose injection and 5% glucose and sodium chloride injection can be compatible with one another to obtain liquor, and the liquor is excellent in stability after being placed at the room temperature for 4h.

The invention discloses a method for preparing cefotiam hexetil hydrochloride. The method comprises the following steps: preparing cefotiam hexetil free alkali through choride iodination and one-pot esterification method by taking stable raw materials such as cefotiam hexetil hydrochloride and chlorinated carbonate as initial materials; performing low-temperature concentration, devitrification and other processes, thereby obtaining the purified cefotiam hydrochloride free alkali; and finally, carrying out a hydrochloride formation reaction, thereby obtaining the cefotiam hexetil hydrochloride. The method has the characteristics of high reaction stability and controllability, low product impurity content, simplicity in industrialized production and the like.

The invention relates to a method for preparing cefotiam hydrochloride. The method comprises the following steps: performing double trisphenylation on 2-aminothiazol-4-acetic acid (called ATA for short) used as raw material to obtain triphenylmethyl 2-triphenylaminothiazol-4-acetate (called 2TrATA for short), connecting the 2TrATA with 7-ACMT to obtain triphenyl cefotiam (called TrCEFO for short),and finally removing a triphenyl group to obtain the target product cefotiam hydrochloride (called CEFO for short). The preparation method has the advantages of simple and easily available raw materials, simplicity in post-treatment operation, and easiness in industrial production.

The invention discloses an antibacterial cefotiam hydrochloride drug composition, belongs to the technical field of medicines. The drug composition comprises cefotiam hydrochloride and arginine, wherein cefotiam hydrochloride is crystalline, and the X-ray powder diffraction pattern measured by Cu-K-alpha rays is shown in the figure 1 (in the description). The new crystalline form of cefotiam hydrochloride provided by the invention is different from the crystal structure in the prior art, by experimental verification, the purity of the crystalline compound is high, the fluidity is good, the stability is good, the polymer content is low, hygroscopicity is avoided, and the stability of solution is good after being left to stand for 4 h at room temperature, wherein the solution is obtained by compounding the prepared powder injection with 0.9% sodium chloride injection, 5% glucose injection, and 5% sodium chloride and dextrose injection.