The invention discloses a targeted
liposome mediated by the
ligand molecule with biological affinity, and a preparation as well as the application thereof. The targeted
liposome of antitumor
drug prepared by the invention has little
toxicity, good tolerance for patients and enhanced water-
solubility and stability. And the invention also discloses the
processing technique of the preparation. Freeze-dry
liposome consists of natural or synthetic
phospholipid, charged
phospholipid, target material, antitumor drugs,
buffer solution and freeze-
drying protective agent. The
processing technique comprises the procedures of the preparation of
phospholipid membrane of the antitumor
drug, the homogenization of the liposome, the addition of the freeze-
drying protective agent, volume metering, sterilizing, split charging, freeze-
drying and storage, etc. The liposome is kept under
room temperature for 12 months with good stability. The
entrapment rate of the liposome is over 90 percent. The granule
diameter of the liposome is within 50 to 300mm. The liposome has little toxic and side effects and simple technique, thus facilitating the commercial process of the liposome.