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Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets

A technology of tylosin tartrate and composition, which is applied in the direction of pharmaceutical formulations, antibacterial drugs, microcapsules, etc., can solve the problems of inability to effectively control the release efficiency of tylosin tartrate, avoiding light, poor palatability, and difficulty in industrial production, etc. problem, to achieve the effects of small fluctuations in blood concentration levels, small differences between products, and good palatability

Inactive Publication Date: 2017-01-11
乐山市佰尔特生物工程合伙企业(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a tylosin tartrate premix composition and a preparation method thereof for slow-release pellets, which solve the problem of low encapsulation efficiency, light protection and poor palatability of tylosin tartrate in the prior art, and cannot effectively control the tylosin tartrate. The release efficiency of myostatin, and it is not easy for industrial production and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Weigh each component of tylosin tartrate premix composition by weight percentage, pulverize the solid component in each component, make the powder sieve through 60-mesh~100-mesh sieving net respectively, each The components are stored separately, then take tylosin tartrate and microcrystalline cellulose and add them to the wet granulator. The agent is mixed evenly to obtain the tylosin tartrate filler mixture;

[0044] (2) adding the hydroxypropyl cellulose aqueous solution with a mass concentration of 2% to 10% in the tylosin tartrate filler mixture obtained in step (1), mixing evenly in a wet granulator, and stirring at a rotational speed of 800 r / min ~1800r / min, the shearing speed is 1200r / min~2500r / min, and the stirring time is 2min~3min to obtain tylosin tartrate soft material;

[0045] (3) Using the tylosin tartrate soft material made in step (2) to obtain long strips of material with an extruder, the aperture of the sieve plate is 0.4 mm to 0.6 mm, and passi...

Embodiment 2

[0050] (1) Weigh each component of tylosin tartrate premix composition by weight percentage, pulverize the solid component in each component, make the powder sieve through 60-mesh~100-mesh sieving net respectively, each The components are stored separately, then take tylosin tartrate and croscarmellose sodium and add them to the wet granulator, the stirring speed is 500r / min~1000r / min, and the stirring time is 1min~3min, so that Tylosin tartrate and croscarmellose sodium are added to the wet granulator. The tylosin tartrate filler mixture is obtained by mixing the bacteriocin and the filler evenly;

[0051] (2) adding a polyvinylpyrrolidone aqueous solution with a mass concentration of 2% to 10% in the tylosin tartrate filler mixture obtained in step (1), and uniformly mixed in a wet granulator, and the stirring speed is 800r / min~ 1800r / min, shearing speed 1200r / min~2500r / min, stirring time 2min~3min, to obtain tylosin tartrate soft material;

[0052] (3) Using the tylosin ta...

Embodiment 3

[0057] (1) Weigh each component of tylosin tartrate premix composition by weight percentage, pulverize the solid component in each component, make the powder sieve through 60-mesh~100-mesh sieving net respectively, each The components are stored separately, and then take tylosin tartrate and lactose into the wet granulator, the stirring speed is 500r / min~1000r / min, and the stirring time is 1min~3min, so that the tylosin tartrate and the filler are mixed evenly , to obtain tylosin tartrate filler mixture;

[0058] (2) adding hydroxypropyl cellulose with a mass concentration of 2% to 10% in the tylosin tartrate filler mixture obtained in step (1), and mixing evenly in a wet granulator, and the stirring speed is 800r / min~1800r / min, the shearing speed is 1200r / min~2500r / min, and the stirring time is 2min~3min to obtain tylosin tartrate soft material;

[0059] (3) Using the tylosin tartrate soft material made in step (2) to obtain long strips of material with an extruder, the ape...

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Abstract

The invention relates to a tylosin tartrate premix composition and a preparation method of tylosin tartrate sustained-released pellets, aiming at solving the problems in the prior art that the encapsulation efficiency of tylosin tartrate is low, the light-shielding property and the palatability are poor, the releasing efficiency of the tylosin tartrate cannot be effectively controlled and industrial production is not easy to realize and the like. The preparation method comprises: firstly crushing a solid component and sieving; mixing the tylosin tartrate and a filling agent; adding an adhesive and covering an enteric coating layer and a sustained-released layer on the tylosin tartrate through a granulator. According to the tylosin tartrate premix composition and the preparation method of the tylosin tartrate sustained-released pellets, provided by the invention, whole encapsulation is realized and the palatability is good; the releasing efficiency of the tylosin tartrate can be effectively controlled and the industrial production can be realized.

Description

technical field [0001] The invention relates to a tylosin tartrate premix composition and a preparation method of sustained-release pellets, belonging to the technical field of veterinary drug preparation. Background technique [0002] Tylosin tartrate belongs to macrolide antibiotics, which is a special antibiotic for poultry and an ideal drug for the treatment of mycoplasma veterinary disease. The usual method of use of tylosin tartrate is to mix it into the feed for administration or put it into the drinking water of animals, but the tylosin tartrate API has a strong odor, a bitter taste, and is easy to scatter, making it less palatable and affecting animals. For feeding, it is necessary to increase the number of administrations, which is not conducive to achieving an efficient treatment effect. The prior art CN103301144B discloses a preparation method of a veterinary acetylisovaleryl tylosin tartrate premix, which adopts acetylisovaleryl tartrate tylosin. Mix the bacter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/32A61K47/14A61K31/7048A61P31/04
CPCA61K9/0002A61K9/5015A61K9/5026A61K9/5089A61K31/7048
Inventor 李竹王莉田刚曹程明谌京梅
Owner 乐山市佰尔特生物工程合伙企业(有限合伙)
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