78 results about "TYLOSIN TARTRATE" patented technology

The invention relates to a process for preparing 20,23-bi-piperidyl-5-O-carbon mould amine glycosyl-tylosin lactone. Tylosin tartrate serves as a raw material, an intermediate product of 23-oxhydryl-5-O-carbon mould amine glycosyl-tylosin lactone is obtained through hydrolyzation, an organic phase is extracted through phase inversion, and an intermediate product of 20-piperidyl-23-oxhydryl-5-O-carbon mould amine glycosyl-tylosin lactone is produced through combination with piperidine under the effect of methanoic acid. A final product of the 20,23-bi-piperidyl-5-O-carbon mould amine glycosyl-tylosin lactone is formed by ammonization with the piperidine through iodination. By the aid of the process, the production technology is simplified, the dosage of auxiliary raw materials such as the piperidine, iodine and an organic solvent is greatly reduced, the purity of the obtained product is higher than 98%, the yield of the final product of the 20,23-bi-piperidyl-5-O-carbon mould amine glycosyl-tylosin lactone reaches 58.7%, and the process has good industrial application prospects.

The invention relates to a method for extracting super-tylosin from fermentation products of microorganism. The method adopts the secondary crystallization method, abandons the organic solvent extraction method in the prior art, can obtain products the purity of which is equivalent to that of extract of the solvent extraction method while simultaneously reducing the environmental pollution, simplifying the purification step and reducing the production cost, and is more suitable for industrial production. The products prepared by the method can be taken as bulk drugs of super-tylosin tartrate.

The invention relates to soluble powder for treating respiratory diseases of poultry, comprising tylosin tartrate, trimethoprim and auxiliary materials. As an antibiotic medicine, the inventive medicament is mainly used to prevent and treat various respiratory tract infections and chronic respiratory diseases of poultry. The tylosin tartrate and the trimethoprim have compatibility when used together. The soluble powder simultaneously acts on different sensitive organisms and mycoplasma, solves the problem of medicament tolerance caused by solely using tylosin to treat, has good absorption and relatively high safety when orally taken.

The invention improves a spray drying step in the tylosin production process in the prior art. The improvements are as follows: extracting tylosin tartrate or tylosin phosphate into an organic phase from a reextraction liquid (a water phase) by using trichloromethane or dichloromethane (an organic phase); then removing a solvent to obtain tylosin tartrate or tylosin phosphate; or after removal of most solvent, adding petroleum ether or ethyl acetate or butyl acetate into a concentrate, so as to precipitate the tylosin tartrate or tylosin phosphate. The method for the preparation of tylosin tartrate and phosphate tylosin has lower energy consumption and higher product yield than a spray drying dehydration method, and can increase the output value by more than 10 thousand yuan calculated by production of per ton of products.

The invention discloses a long-acting compound ceftiofur suspension injection and its preparation technology. According to the invention, the compound ceftiofur suspension injection is prepared by using ceftiofur hydrochloride and tylosin tartrate as main drugs with assistance of appropriate auxiliary drugs. The suspension contains 5-20% (W/V) of ceftiofur hydrochloride, 5-20% (W/V) of tylosin tartrate, 0.5-2% (W/V) of a suspending agent, 0.01-0.5% (W/V) of an anti-oxidant, 0.1-3% (W/V) of a dispersant, and injection oil which is added to 100%. In comparison with a ceftiofur single preparation, the long-acting compound ceftiofur suspension injection has a strong antibacterial activity for Gram-negative bacteria and simultaneously has a strong effect of inhibiting Gram positive bacteria and mycoplasma. In addition, the preparation method provided by the invention provides a feasible approach for extended reproduction, and can be used to minimize times of drug administration and save manpower and material resources.

The invention relates to an aivlosin injection for swine. Each 100ml of tylosin injection contains 20g of acetylisovaleryl tylosin tartrate, 20-35g of propylene glycol, 10-15g of N,N-dimethyl acetamide, 2-4g of benzyl alcohol, 0.1-1.0g of di-tert-butyl-4-methylphenol and balance of glyceryl triacetate. The preparation method comprises the following steps of: mixing the glyceryl triacetate, the propylene glycol, the benzyl alcohol and the N,N-dimethyl acetamide evenly to obtain an oil phase; adding an antioxidant to the oil phase and stirring until the added particles are dissolved; and adding the aivlosin and stirring to dissolve. The aivlosin injection for swine adopts the oily solvent as a solvent, the medicament is dissolved in the oily solvent, and the elimination half life of the medicament in an animal body is prolonged by the characteristic of slow elimination of the oily solvent after intramuscular injection.

The invention relates to a preparation method of tylosin phosphate or a tartrate crystal. The method comprises the steps that tylosin tartrate or phosphate powder is sufficiently dissolved in ethyl acetate; butyl acetate is slowly and dropwise added in a stirring state and at 0-5 DEG C, and is sufficiently mixed; the stirring state is kept for 1-2h after the adding is completed; centrifugal separation is performed; and the obtained crystal is subjected to drip washing by cold butyl acetate, and then subjected to vacuum drying until the drying loss is less than 1%. According to the preparation method, tylosin phosphate or tartrate is prepared into crystalline particles, and the crystalline particles replace powder; the specific gravity of the crystalline particles is greater, so that dust pollution is avoided in packaging and using processes; the particles are added to animal drinking water and can sink into the water bottom easily; the particles are better in dispersity, faster in dissolution rate and higher in content, can be directly added to animal feed or the animal drinking water; a solvent is very easy to recover; and the preparation method has a certain application prospect in a production process.

The invention relates to a compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as a preparation method of the compound doxycycline hydrochloride composition. The compound doxycycline hydrochloride composition is prepared by uniformly mixing the following components by weight: 10-15 parts of doxycycline hydrochloride, 10-20 parts of colistin sulfate, 5-15 parts of tylosin tartrate, 5-10 parts of trimethoprim lactate and 40-70 parts of anhydrous dextrose. The compound doxycycline hydrochloride composition has the beneficial effects of reasonable formula, easiness in preparation, remarkable treatment effect and clinically proven special effect for treating colibacillosis and chronic respiratory disease of the poultry.

The invention relates to a powder agent for treating livestock and poultry mycoplasma infection, comprising tylosin tartrate, sulfadimidine sodium and auxiliary materials. The medicament of the invention can be mainly used for preventing and treating the mycoplasma disease of the livestock and poultry, meanwhile the sulfadimidine sodium is added in the preparation for controlling the secondary infection mixed infection caused by the mycoplasma, the medicament has good oral administration absorption effect and high safety, can be suitable for popularization and application in the animal production.

The invention belongs to the technical field of pharmaceuticals, and discloses a method for synthesizing tilmicosin through low-quality tylosin. The method comprises the steps that tylosin tartrate and 3,5-dimethylpiperidine are subjected to an amination reaction by taking isoamyl acetate as solvent under the certain acidity and temperature conditions, acidic hydrolysis is conducted, hydrolysate passes through a Beta molecular sieve, impurities produced by a D component in tylosin are adsorbed, alkali adjustment and crystallization are conducted, and high-quality tilmicosin is obtained. According to the method for synthesizing tilmicosin through low-quality tylosin, low-quality tylosin tartrate can be adopted, the quality requirement of the raw material is lowered, the raw material cost is reduced, the applied Beta molecular sieve is easy to separate and capable of being recycled, economical efficiency and environmental protection are achieved, operation is easy, the method is suitable for industrial production, and the quality of the obtained product is superior to that of the product based on Pharmacopeia 2010.

The invention relates to a method for recrystallizing tylosin tartrate. The method comprises the following process steps: firstly extracting a tylosin tartrate refined solution by using dichloromethane, slowly and dropwise adding sec-butyl acetate in a dichloromethane phase obtained after phase splitting until separating out crystal; then centrifuging and drying the crystal. According to the characteristic that the tylosin tartrate can be dissolved in the dichloromethane but not be dissolved in the sec-butyl acetate, the tylosin tartrate refined solution is subjected to recrystallization treatment by adopting a dichloromethane extracting and sec-butyl acetate crystallization separation method; the yield of a product obtained through the method disclosed by the invention is up to 97.0 percent or more, and the content of a tylosin component A is up to 94.0 percent or more; the method has the characteristics that technological treatment is simple, no pollution is generated, the cost is low, the period is short, the yield of the obtained product is high, the content of the tylosin component A is high, the quality is high, and the like.

The invention discloses a preparation technology of a tylosin tartrate premix based on uniform mixing effect improvement. The preparation technology includes the steps of 1), extracting tylosin tartrate, namely adopting trichloromethane for extracting reextraction liquid containing the tylosin tartrate, and subjecting the trichloromethane extraction liquid to anhydrous sodium sulfate to dehydration and reduced pressure distillation to remove the trichloromethane completely so as to obtain tylosin tartrate; 2) drying the extracted tylosin tartrate and preparing the dried tylosin tartrate into powder; 3) preparing the tylosin tartrate premix by uniformly mixing the tylosin tartrate powder with minor ingredients through a mixing device, and bagging according to specifications. The preparation technology of the tylosin tartrate premix based on uniform mixing effect improvement has the advantages that since a V-shaped feeding port allowing simultaneous addition of two different raw materials is arranged, the fed raw materials pass through a primary mixing chamber and a secondary mixing chamber sequentially to be subjected to two-time mixing, and accordingly raw material mixing uniformity is improved, the uniformly-mixed raw materials are discharged out of a discharging port, and continuous uniform mixing and outputting of active pharmaceutical ingredients are achieved.

The invention provides a preparing method of an Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation. The preparing method comprises the steps of clathration of Acetylisovaleryl Tylosin Tartrate in hydroxypropyl-beta-cyclodextrin, Acetylisovaleryl Tylosin Tartrat is directly used for being manufactured into a medicine carrying inner core, and then the medicine carrying inner core is covered with an isolating layer and a coating layer separately to prepare the Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation. Compared with the prior art, the coating and pelletizing technology of Acetylisovaleryl Tylosin Tartrate is implemented at a time, the operation is simple, and the production cost is saved. Meanwhile, the influence generated by gastric acid is avoided, the preparation can be targetedly released in the intestinal part, and the clinical treatment effect is better.

Belonging to the technical field of sample pretreatment and pollutant analysis and detection, the invention discloses an aqueous phase preparation method and application of a tylosin tartrate surfacemolecularly imprinted polymer. The technical scheme includes the key points that: 2-acrylamide-2-methylpropane sulfonic acid and/or 1, 4-butanediyl-3, 3'-bis-1-vinyl imidazolium chloride can be adopted as the functional monomer, tylosin tartrate is taken as the template molecule, pure water is adopted as the preparation solvent, the crosslinking agent N, N'-methylene bisacrylamide and the initiator azobisisobutyronitrile are utilized for thermal initiation of polymerization reaction to prepare the tylosin tartrate surface molecularly imprinted polymer on a styrene-divinyl benzene granular carrier surface. The tylosin tartrate surface molecularly imprinted polymer has action sites for specific recognition of tylosin tartrate, and can be used for selective adsorption of trace tylosin tartrate in environmental samples. According to the invention, the preparation process is simple and the cost is low, and the polymer adsorbent material has uniform particle size, large adsorption capacity and high mass transfer rate.

The invention aims at providing a preparation method of a synergistic tylosin tartrate soluble powder compound medicine. The synergistic tylosin tartrate soluble powder compound medicine has a rapid and definite curative effect on respiratory system infections and complications of livestock and poultry. The preparation method comprises the following steps of: mixing 0.2 part of trimethoprim and 0.2 part of cosolvent, then crushing, and sieving by using a 120 meshes sieve or a finer sieve; and then uniformly mixing with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 part of pain alleviant by an equivalently successive increase method, thus obtaining the synergistic tylosin tartrate soluble powder compound medicine. The cosolvent is citric acid or succinic acid or the mixture of citric acid and succinic acid and the pain alleviant is procaine hydrochloride or lidocaine hydrochloride or the mixture of procaine hydrochloride and lidocaine hydrochloride. The animal synergistic tylosin tartrate soluble powder compound medicine for injection contains three medical components which are tylosin tartrate, kanamycin sulfate and trimethoprim, can be used for solving the problems that the secondary infection cannot be controlled very well during the treatment of mycoplasma infection due to the narrow antibacterial spectrum of the tylosin tartrate, and the trimethoprim is insoluble in water, has a synergistic effect on tylosin tartrate and kanamycin sulfate and has an obvious medicine curative effect.

The invention belongs to the technical field of veterinary medicaments, and particularly relates to a compound emulsion for animals and a preparation method thereof. The compound emulsion for animals comprises tylosin tartrate, azithromycin, emulsifier, poloxamer, propylene glycol, soybean oil for injection and water for injection. The compound emulsion for animals has high safety; and because the emulsion contains no organic solvent, the toxicity of the organic solvent is reduced, and the emulsion has good environmental friendliness.