Preparation methods for preparing tylosin-containing encapsulated core material with tylosin stripping solution and micro-capsule of tylosin-containing encapsulated core material

Abstract

The invention discloses preparation methods for preparing corncob powder and tylosin (tylosin tartrate or tylosin phosphate)-containing encapsulated core material by directly combining a purified tylosin stripping solution (an aqueous solution containing the tylosin tartrate or the tylosin phosphate) with corncob powder and a micro-capsule of the encapsulated core material. By using the preparation methods provided by the invention to prepare the tylosin / corncob powder-containing encapsulated core material and the micro-capsule of the encapsulated core material, the yield is higher, and the energy consumption is lower; without using an organic solvent, the flammable and combustible risks and the dust pollution are lowered, the intermediate manufacturing cost and the unnecessary pollution are reduced, and a product can be directly used for clinical veterinary medicine.

Description

technical field [0001] The present invention relates to preparation technology for veterinary preparations, in particular to the preparation of corn cob powder containing corn cob powder and Cystic cores of tylosin (tylosin tartrate or tylosin phosphate) and microcapsules thereof. Background technique [0002] Tylosin is a special antibacterial drug for livestock and poultry. Among the tylosin preparations that have been marketed, the most widely used is the premix containing tylosin, which is composed of tylosin tartrate with a purity greater than 80%. Or tylosin phosphate and pharmaceutical excipients are prepared. Tylosin is a liquid fermentation product of Streptomyces freundii. The post-treatment of its fermentation liquid is: adding a flocculant (such as aluminum sulfate or aluminum chloride) to the fermentation liquid, fully mixing, and separating the solid and liquid to obtain the fermentation filtrate; After adjusting the pH of the filtrate, carry out liquid-liqui...

AI Technical Summary

Problems solved by technology

[0004] 1. High energy consumption: producing 1 ton of tylosin tartrate or tylosin phosphate requires about 3000 kWh of electricity and about 3 tons of steam, equivalent to RMB 3000-4500 in total

[0005] 2. Large product loss: 4.5-9.6% of tylosin is lost during the spray drying process. Therefore, the production yield of tylosin is greatly reduced. A factory with an annual output of 1,000 tons of tylosin, In this production process alone, 45-96 tons of tylosin are lost every year, worth about 12-27 million yuan

[0006] 3. There is dust pollution in spray drying

The use of these organic solvents in production, in addition to cost factors, also has potential safety hazards (such as solvent poisoning of production personnel and increased risk of fire and explosion), and there are still shortcomings such as about 4% drug loss.