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Acetylisovaleryl tylosin tartrate granular preparation and preparation method thereof

A technology of tivalamectin and granule preparations, which is applied in the field of veterinary medicine, can solve the problems that powders are difficult to mask taste, low production efficiency, and increase the physical burden of operators, so as to improve fluidity and dispersibility, satisfy assembly line production, and improve The effect of bioavailability

Active Publication Date: 2017-02-01
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, premixes and powders have poor fluidity and low dispersibility; general powders are difficult to achieve the purpose of taste masking, and the powders are small and easy to scatter to form dust, which increases the physical burden of operators
CN 105616383 A discloses a kind of tyvalactin tartrate enteric-coated pellets and a preparation method thereof. The preparation method is a fluidized bed coating method. Particle adhesion and electrostatic adsorption often occur during the preparation process. The coating process requires Long time, high production cost and low production efficiency, and no researcher pays attention to the uniformity of the preparation
[0004] Mixed feed administration is relatively simple for the prevention and treatment of highly infectious diseases, but tyvalanin tartrate itself tastes bitter and has poor palatability to animals, so it is difficult to directly mix feed administration with existing tylamectin formulations

Method used

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  • Acetylisovaleryl tylosin tartrate granular preparation and preparation method thereof
  • Acetylisovaleryl tylosin tartrate granular preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of tyvalactin tartrate granule preparation, comprising the following steps:

[0031] 1) Preparation: weigh each component according to the following raw material formula, and set aside;

[0032] Tylvalosin Tartrate 20%;

[0033] Stearic acid 40%;

[0034] Paraffin 40%;

[0035] 2) Mixing: First heat stearic acid and paraffin wax at 75°C to melt and stir evenly, then mix tyvalamectin tartrate and melted carrier excipients, shear and stir evenly to form a uniform dispersion system to obtain a mixed solution;

[0036] 3) Condensation spray granulation: The mixed liquid in step 2) is sent to the condensation spray granulation granulation system through the transmission pump, and centrifugal spray granulation is obtained to obtain tivalamectin tartrate granules, which are cooled and oscillated through 20-120 mesh Sieve and sieve to collect, and finally obtain the tyvalactin tartrate granule preparation; the condensing spray granulation granulation sys...

Embodiment 2

[0039] A preparation method of tyvalactin tartrate granule preparation, comprising the following steps:

[0040] 1) Preparation: weigh each component according to the following raw material formula, and set aside;

[0041] Tylvalosin Tartrate 5%;

[0042] Monoglyceride Stearate 70%;

[0043] Stearyl Alcohol 25%;

[0044] 2) Mixing: first heat stearic acid and paraffin at 80°C to melt and stir evenly, then mix tyvalamectin tartrate with the melted carrier excipients, shear and stir evenly to form a uniform dispersion system to obtain a mixed solution;

[0045] 3) Condensation spray granulation: The mixed liquid in step 2) is sent to the condensation spray granulation granulation system through the transmission pump, and centrifugal spray granulation is obtained to obtain tivalamectin tartrate granules, which are cooled and oscillated through 20-120 mesh Sieve and sieve to collect, and finally obtain the tyvalactin tartrate granule preparation; the condensing spray granulatio...

Embodiment 3

[0048] A preparation method of tyvalactin tartrate granule preparation, comprising the following steps:

[0049] 1) Preparation: weigh each component according to the following raw material formula, and set aside;

[0050] Tylvalosin Tartrate 30%;

[0051] Hydrogenated Castor Oil 45%;

[0052] Fat powder 25%;

[0053]2) Mixing: first heat stearic acid and paraffin at 90°C to melt and stir evenly, then mix the raw material of tyvanectin tartrate with the melted carrier auxiliary materials, shear and stir evenly to form a uniform dispersion system to obtain a mixed solution;

[0054] 3) Condensation spray granulation: The mixed liquid in step 2) is sent to the condensation spray granulation granulation system through the transmission pump, and centrifugal spray granulation is obtained to obtain tivalamectin tartrate granules, which are cooled and oscillated through 20-120 mesh Sieve and sieve to collect, and finally obtain the tyvalactin tartrate granule preparation; the cond...

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Abstract

The invention discloses an acetylisovaleryl tylosin tartrate granular preparation and a preparation method thereof. The acetylisovaleryl tylosin tartrate granular preparation comprises the following steps: (1) preparing, namely, respectively weighing acetylisovaleryl tylosin tartrate and a carrier auxiliary material according to a formula ratio for later use; (2) mixing, namely, heating to melt the carrier auxiliary material, uniformly stirring, mixing acetylisovaleryl tylosin tartrate with the molten carrier auxiliary material, shearing, uniformly stirring so as to obtain a uniform dispersed system, and preparing mixed liquid; and (3) performing condensation spraying pelletization, namely, pumping the mixed liquid of step (2) to a condensation spray granulation system, performing centrifugal spray pelletization so as to prepare acetylisovaleryl tylosin tartrate granules, cooling, screening by using an oscillation sieve being 20-120 meshes, and collecting, thereby obtaining a product. According to the acetylisovaleryl tylosin tartrate granules prepared by the invention, the main medicine is uniformly distributed, the granules are round and tidy, the flowability and the dispersity of the granular preparation can be improved, and the acetylisovaleryl tylosin tartrate granular preparation can be easily mixed with feed; in addition, the acetylisovaleryl tylosin tartrate granular preparation adopts a simple production process, and is good in smell masking effect and good in slow-release effect.

Description

technical field [0001] The invention relates to a preparation of tyvanectin tartrate, in particular to a granule preparation of tyvanectin tartrate and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique [0002] Tyvalerin tartrate, also known as acetylisovaleryl Tylosin tartrate (Acetylisovaleryl TylosinTartrate), is a new type of macrolide animal-specific antibiotic developed by the British Eco Animal Health Co., Ltd. It is Tylosin (Tylosin) Derivatives. It is characterized by a wider antibacterial spectrum (strong antibacterial activity against mycoplasma, spirochetes, most gram-positive bacteria and some gram-negative bacteria; special effect on tylosin-resistant bacteria), antibacterial activity High (the activity is 3-10 times that of Tylosin), the dosage is small, and the residue in animals is low. It has a new molecular structure, bacteria are not easy to develop resistance to it, and it is effective against o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7048A61K47/06A61K47/14A61K47/44A61P31/04
CPCA61K9/1617A61K9/1694A61K31/7048
Inventor 张桂君方炳虎陈瑞爱姬竹玲吴志玲梁劲康
Owner GUANGDONG WENS DAHUANONG BIOTECH
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