Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of tylosin tartrate microspheres

A technology of tylosin tartrate and microspheres, which is applied in the field of preparation of tylosin tartrate microspheres, can solve the problems of frequent medication and short elimination half-life, and achieve extended elimination half-life, no immunogenicity, and no adverse reactions Effect

Active Publication Date: 2011-01-19
ZHENGZHOU HOUYI PHARMA
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conventional dosage form of the drug has a short elimination half-life, frequent medication, and wide distribution in the body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation method of the tylosin tartrate microsphere of the present embodiment, every 1g tylosin tartrate is made into the tylosin tartrate microsphere according to the following steps:

[0014] 1) Take 1g of gelatin, add secondary water to make 5mL of gelatin solution, swell completely in a warm water bath at 50°C, then add 1g of tylosin tartrate, stir well to obtain the water phase;

[0015] 2) Take 24mL of liquid paraffin and 6mL of 1.0-2.0% Span-80 and mix them to obtain 30mL of oil phase;

[0016] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), and stir evenly at a speed of 500 r / min, cool to 5°C, add 2 mL of glutaraldehyde cross-linking agent for cross-linking and solidification , the curing time is 20 minutes;

[0017] 4) Wash away the excess cross-linking agent with isopropanol, and then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and dry them in vacuum to obtain tylosin tartrate m...

Embodiment 2

[0020] The preparation method of the tylosin tartrate microsphere of the present embodiment, every 1g tylosin tartrate is made into the tylosin tartrate microsphere according to the following steps:

[0021] 1) Take 0.8g of gelatin, add secondary water to make 5mL of gelatin solution, swell completely in a warm water bath at 50°C, then add 1g of tylosin tartrate, stir well to obtain the water phase;

[0022] 2) Take 25mL of liquid paraffin and 5mL of 1.0-2.0% Span-80 and mix them to obtain 30mL of oil phase;

[0023] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), and stir evenly at a speed of 600 r / min, cool to 4°C, and add 3 mL of glutaraldehyde cross-linking agent for cross-linking and solidification , the curing time is 30 minutes;

[0024] 4) Wash away the excess cross-linking agent with isopropanol, and then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and dry them in vacuum to obtain tylosin tart...

Embodiment 3

[0027] The preparation method of the tylosin tartrate microsphere of the present embodiment, every 1g tylosin tartrate is made into the tylosin tartrate microsphere according to the following steps:

[0028] 1) Take 1.5g of gelatin, add secondary water to make 5mL of gelatin solution, swell completely in a warm water bath at 50°C, then add 1g of tylosin tartrate, stir well to obtain the water phase;

[0029] 2) Take 30mL of liquid paraffin and 5mL of 1.0-2.0% Span-80 and mix them to obtain 35mL of oil phase;

[0030] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), and stir evenly at a speed of 800 r / min, cool to 3°C, and add 4 mL of glutaraldehyde cross-linking agent for cross-linking and solidification , the curing time is 40 minutes;

[0031] 4) Wash away the excess cross-linking agent with isopropanol, and then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and dry them in vacuum to obtain tylosin tart...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
encapsulation rateaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of tylosin tartrate microspheres. The method uses gelatin as the carrier, liquid paraffin and Span-80 as the oil phase, and glutaraldehyde as the crosslinking agent to prepare tylosin tartrate microspheres. The tylosin tartrate microspheres prepared by the invention use gelatin as the carrier material, have no adverse reactions and no immunogenicity, have biodegradability and wide application range and can be taken by mouth or through injection. liquid paraffin and Span-80 are used as the oil phase, thus increasing the drug-loading rate and the encapsulation rate, facilitating the crosslinking and curing of glutaraldehyde, prolonging the elimination half life of the microsphere medicine and performing drug controlled release in animals. In addition, the preparation method of the invention has simple operation, the adopted reagent is common, the preparation cost is lower and the method is easy to popularize and apply.

Description

technical field [0001] The invention relates to a preparation method of tylosin tartrate microspheres, belonging to the technical field of veterinary medicine. Background technique [0002] In recent years, with the development of large-scale and intensive pig farming, the frequent introduction of breeds in different regions and countries has led to an increase in pig respiratory diseases, which has become a major problem in pig farming. Among them, swine asthma, porcine reproductive and respiratory syndrome, porcine circovirus type 2, and swine influenza virus are common in China, causing economic losses to farmers. People have carried out a lot of reports for the treatment of porcine respiratory disease, and proposed a lot of treatment schemes to the disease, but because the complexity of the cause of the disease and the multiple of the disease, it brings difficulties to the treatment, and the treatment effect is not good. And the prognosis is bad. Tylosin is commonly us...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7048A61K47/42A61K47/44A61K47/22A61P31/04A61K47/06
Inventor 吴红云李建正班曼曼
Owner ZHENGZHOU HOUYI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com