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Preparation process avoiding the reduction of tylosin tartrate original drug potency

A technology of tylosin tartrate and preparation process, which is applied to the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems such as the reduction of the efficacy of the original drug of tylosin tartrate, and avoid the problems of tylosin tartrate. The effect of reducing the efficacy of the original drug, avoiding the reduction of the efficacy, and avoiding the performance impairment

Inactive Publication Date: 2015-09-23
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by this invention is to provide a kind of preparation technology that avoids reducing the original drug properties of tylosin tartrate, so that the preparation technology of existing tylosin tartrate is easy to cause the original drug of tylosin tartrate The problem of reduced potency

Method used

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  • Preparation process avoiding the reduction of tylosin tartrate original drug potency

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Embodiment

[0024] Such as figure 1 As shown, to avoid reducing the preparation process of tylosin tartrate technical drug properties, including

[0025] Include the following steps:

[0026] (1) Extraction of tylosin tartrate: in the back extraction of tylosin tartrate

[0027] Add sodium chloride or sodium sulfate of dissolved saturation concentration in the solution, then add chloroform, the addition of chloroform is 4 times of the volume of tylosin tartrate; stir for 30min, static phase separation, to obtain the aqueous phase liquid and The extract of chloroform, the aqueous phase liquid was extracted with chloroform for many times, the extract obtained each time was combined with the extract of chloroform, and the combined extract was dehydrated with anhydrous sodium sulfate and distilled under reduced pressure in turn. Remove chloroform to obtain tylosin tartrate;

[0028] (2) Dry the extracted tylosin tartrate and prepare it into a powder, mix the tylosin tartrate powder and aux...

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Abstract

The invention relates to a preparation process avoiding the reduction of tylosin tartrate original drug potency. The method comprises the following steps: tylosin tartrate is extracted, wherein a back extraction liquid containing tylosin tartrate is extracted with trichloromethane, such that water-phase liquid and a trichloromethane extraction liquid are obtained; the trichloromethane extraction liquid is dehydrated with anhydrous sodium sulfate and is subjected to reduced-pressure distillation, such that trichloromethane is removed, and tylosin tartrate is obtained; the extracted tylosin tartrate is dried and prepared into powder; the tylosin tartrate is powder is well mixed with auxiliary materials according to a certain ratio in a shaking bed with a temperature control function; reagent bottles are cleaned; the tylosin tartrate powder is added into the reagent bottles according to a specified amount, and the bottles are filled with nitrogen gas; the bottles are covered by pretreated rubber plugs; and the plugs are capped with aluminum caps. With the process provided by the invention, a problem of injection-use tylosin tartrate original drug potency reduction caused by existing tylosin tartrate preparation processes is overcome.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology which avoids reducing the drug property of the original drug of tylosin tartrate. Background technique [0002] Tylosin tartrate and Tylosin tartrate have special effects on mycoplasma and are used as the first choice for anti-mycoplasma disease. Tylosin tartrate belongs to macrolide antibiotics for animals. Its mechanism of action mainly plays a sterilizing effect by hindering the synthesis of bacterial protein. This product is easily absorbed in the body, excreted quickly, and remains in the tissue. It has special effects on Gram-positive bacteria and mycoplasma. In particular, it has very high activity against Actinobacillus pleurisy, and is the drug of choice for the treatment of chronic respiratory diseases in livestock and poultry caused by mycoplasma. [0003] How to improve the effect and safety of drug injections has alway...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H17/08C07H1/06
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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