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Decolorization method of tylosin tartrate

A technology of tylosin tartrate and secondary decolorization, which is applied in the field of decolorization of tylosin tartrate, can solve the problems of affecting the yield and purification effect of tylosin, difficult control of the operation process, and incomplete decolorization effect, etc. Achieve good decolorization effect, increase yield and purification effect, long life effect

Pending Publication Date: 2020-09-04
NINGXIA TAIYICIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, methods such as physical adsorption, flocculant method, precipitation method, and extraction method are used for the decolorization of tylosin tartrate. The decolorization effect of these methods is not complete, and there are more or less defects: (1) using Physical adsorption decolorization is simple and cost-effective, but the selectivity is relatively low, and only lipophilic pigments or hydrophilic pigments can be removed only; Due to the influence of many factors such as pH and stirring speed, the operation process is not easy to control; (3) the precipitation method is simple to remove the pigment and the cost is low, but it can adsorb substances such as tannic acid, some proteins, organic acids, polar pigments and polysaccharides, (4) The extraction method to remove the pigment is to use the solubility difference of the pigment in different solvents for decolorization. Due to the low selectivity of a single solvent, it can only remove one aspect of the pigment, so it is necessary to use more than two different polarizers. Alternative extraction and decolorization with neutral solvents
The above defects seriously affect the yield and purification effect of tylosin

Method used

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  • Decolorization method of tylosin tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Tylosin tartrate is decolorized with 3‰ activated carbon-3‰ silica gel-ultrafiltration membrane

[0026] Take 150g of tylosin tartrate powder (potency 6250μg / ml), add 2400ml of purified water and stir to dissolve. The clarity of the dissolved sample solution is Y3 (as a control group), and then add 3‰ of tylosin tartrate solution The activated carbon was stirred and allowed to stand for 30 minutes, the pH value of the solution was controlled to 4.5, and the temperature was 65°C, and then diatomaceous earth with a quality of 3‰ of tylosin tartrate solution was added for filter aid, and the activated carbon decolorization solution was obtained by filtration; to the activated carbon decolorization solution Add silica gel with a quality of 3‰ of tylosin tartrate solution to the mixture, stir, let it stand for 30min, then add diatomaceous earth with a quality of 3‰ of tylosin tartrate solution for filter aid, and filter to obtain silica gel decolorization solution;...

Embodiment 2

[0027] Embodiment 2: Tylosin tartrate is decolorized with 2‰ activated carbon-2‰ silica gel-ultrafiltration membrane

[0028] Take 150g of tylosin tartrate powder (potency 6250μg / ml), add 2400ml of purified water and stir to dissolve. The clarity of the dissolved sample solution is Y3 (as a control group), and then add tylosin tartrate solution with a quality of 2‰ The activated carbon was stirred and allowed to stand for 30 minutes, the pH value of the solution was controlled to 4.5, and the temperature was 65°C, and then diatomaceous earth with a quality of 2‰ of tylosin tartrate solution was added to filter, and the activated carbon decolorization solution was obtained by filtration; to the activated carbon decolorization solution Add 2‰ silica gel with the quality of tylosin tartrate solution to the mixture, stir, let it stand for 30min, then add 2‰ diatomaceous earth with the quality of tylosin tartrate solution for filter aid, and filter to obtain the silica gel decoloriz...

Embodiment 3

[0029] Example 3: Decolorization of tylosin tartrate with 4‰ activated carbon-4‰ silica gel-ultrafiltration membrane

[0030] Take 150g of tylosin tartrate powder (potency 6250μg / ml), add 2400ml of purified water and stir to dissolve. The clarity of the dissolved sample solution is Y3 (as a control group), and then add 4‰ of tylosin tartrate solution The activated carbon was stirred and allowed to stand for 30 minutes, the pH value of the solution was controlled to 4.5, and the temperature was 65°C, and then diatomaceous earth with a quality of 4‰ of tylosin tartrate solution was added to filter, and the activated carbon decolorization solution was obtained by filtration; to the activated carbon decolorization solution Add 4‰ of tylosin tartrate solution to silica gel and stir for 30 minutes, then add diatomaceous earth with 4‰ of tylosin tartrate solution to aid in filtration, and filter to obtain silica gel decolorization solution; finally, decolorize silica gel The liquid w...

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Abstract

The present invention provides a decolorization method of tylosin tartrate. The method includes the following steps: dissolving tylosin tartrate in water, first decolorizing with activated carbon, then decolorizing with silica gel, and finally using ultrafiltration membrane for decolorizing three times. This method uses a combination of physical adsorption technology and ultrafiltration membrane separation technology, can effectively remove pigments in tylosin tartrate, has good separation effect, thus can improve yield and purification effect of tylosin, and has technical advantages such as no destruction of active ingredients, no secondary pollution, repeated use of adsorbents and ultrafiltration membranes, and convenient operation.

Description

technical field [0001] The invention relates to an antibiotic refining technology, in particular to a decolorization method of tylosin tartrate. Background technique [0002] Tylosin, also known as Tylosin, is a fermentation product of Streptomyces freundii. It is a special macrolide antibiotic for poultry and livestock. It can effectively prevent and treat various frequently-occurring diseases of poultry and livestock. are widely used as feed additives. [0003] At present, for the separation and purification of tylosin, tylosin tartrate is usually obtained by flocculation and impurity removal of tylosin fermentation liquid, butyl acetate extraction, and tartaric acid back extraction, and then tylosin tartrate is subjected to Decolorization treatment to obtain purified tylosin tartrate. In the prior art, methods such as physical adsorption, flocculant method, precipitation method, and extraction method are used for the decolorization of tylosin tartrate. The decolorizatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06C07C51/42C07C51/47C07C59/255
CPCC07H17/08C07H1/06C07C51/42C07C51/47C07C59/255
Inventor 于荣刘万礼郭佳王晓宁张少峰
Owner NINGXIA TAIYICIN BIOTECH CO LTD
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