Preparation technology of tylosin tartrate for injection

Abstract

The present invention relates to a preparation technology of tylosin tartrate for injection. The preparation technology comprises the following steps of: tylosin tartrate extraction: extracting by adopting chloroform to obtain an extraction liquid of an aqueous phase liquid and chloroform, sequentially performing dehydration by using anhydrous sodium sulfate and distillation at a reduced pressure on the extraction liquid of chloroform to eliminate the chloroform completely so as to obtain the tylosin tartrate; and drying the extracted tylosin tartrate and preparing the dried tylosin tartrate into powder. The preparation technology of the tylosin tartrate further comprises the following steps of: cleaning a reagent bottle, wherein the reagent bottle is immersed into a hydrochloric acid solution with condensation of 0.01mol / L-0.1mol / L; then subjecting the mixture to ultrasonic cleaning, spray-type flushing, drying and sterilization; packaging a certain amount of the tylosin tartrate powder to the cleaned reagent bottle according to specifications; inflating the reagent bottle with nitrogen; covering the bottleneck with a pre-treated rubber plug; performing cover-piercing treatment by using an aluminum cover. The preparation technology of tylosin tartrate for injection disclosed by the invention overcomes the problem that the existing preparation technology of tylosin tartrate for injection causes a relatively low production speed of the tylosin tartrate for injection.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology of tylosin tartrate for injection. Background technique [0002] Tylosin tartrate and Tylosin tartrate have special effects on mycoplasma and are used as the first choice for anti-mycoplasma disease. Tylosin tartrate belongs to macrolide antibiotics for animals. Its mechanism of action mainly plays a sterilizing effect by hindering the synthesis of bacterial protein. This product is easily absorbed in the body, excreted quickly, and remains in the tissue. It has special effects on Gram-positive bacteria and mycoplasma. In particular, it has very high activity against Actinobacillus pleurisy, and is the drug of choice for the treatment of chronic respiratory diseases in livestock and poultry caused by mycoplasma. [0003] How to improve the effect and safety of drug injections has always been a problem that drug manufacturers hope t...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by this invention is to provide a kind of preparation technology of tylosin tartrate for injection, to overcome the slow production speed of tylosin tartrate for injection caused by the existing preparation technology of tylosin tartrate for injection The problem