5 results about "Hydrogen ion binding" patented technology

The invention discloses application of a negative hydrogen ion combined stem cell preparation in preparation of antidepressant drugs, and belongs to the technical field of biological medicines. The negative hydrogen ion combined stem cell preparation is used for preparing the anti-depression medicine for treating depression-like rats, pleasant sensation deficiency and despair-like behaviors of the depression-like rats can be remarkably improved, nerve cell energy supply is improved, oxidative stress injury is strongly inhibited, and the curative effect of the anti-depression medicine is remarkably superior to that of single negative hydrogen ion treatment or single stem cell treatment. Through the synergistic effect of negative hydrogen ion anti-oxidative stress combined with stem cell preparation neural restoration, the oxidative stress-nerve injury core pathological pathway of depression is specifically blocked, a new scheme with better effect and more comprehensive mechanism is provided for depression treatment, and the pharmaceutical composition has important clinical transformation value.

The application discloses a preparation for treating atherosclerosis based on negative hydrogen ions combined with stem cells and a preparation method thereof, and belongs to the technical field of biomedical engineering, and comprises a stem cell dispersion liquid, a negative hydrogen ion solution and a carrier. The preparation method comprises the following steps: S1, preparation of the stem cell dispersion liquid; S2, preparation of the negative hydrogen ion solution by using a photon energy cleavage technology; S3, preparation of the carrier; S4, preparation of a pre-injection injection; and S5, preparation of the injection. The application uses the negative hydrogen ion combined with the stem cell preparation and constructs the carrier for stably and targetedly delivering the negative hydrogen ions and the stem cells, reduces in-vivo oxidative stress, effectively eliminates inflammatory reactions caused by atherosclerosis, continuously reduces a plaque area, and solves the problem that in the prior art, due to the difficulty in maintaining the stability of the negative hydrogen ions and the stem cells in the delivery process, the negative hydrogen ions and the stem cells cannot be used for synergistically treating atherosclerosis. The application has the potential to be applied to the preparation of a drug for treating atherosclerosis.

The application provides application of anthracene fluorescent material in detection of pH value, preparation of lysosome and / or mitochondrion targeted reagent and diagnosis and treatment of tumor cells, and belongs to the technical field of fluorescent sensing. The anthracene fluorescent material has high fluorescence quantum yield and good light stability; the anthracene fluorescent material has protonation effect between amino groups and hydrogen ions, can be used as a combination site of protons, can realize quantitative detection of pH value, and can be used as a targeting group of lysosomes in cells; the amino groups combine with hydrogen ions to generate quaternary ammonium salt, which can increase hydrophilicity, and the generated positive charge can be used as a mitochondrion targeting group, so that the anthracene fluorescent material realizes dual-color visualization targeting lysosomes and mitochondria in cells; and based on the transformation between amino group protonation and non-protonation, the anthracene fluorescent material can be used as an acid triggered probe for tumor diagnosis, realizes high selectivity visualization tumor detection and tumor treatment in a living body.

The present invention relates to a method for manufacturing lithium hydroxide. Particularly, according to an embodiment of the present invention, a method for manufacturing lithium hydroxide may be provided, the method comprising: a solution preparation step in which a lithium hydroxide solution containing impurities and lithium ions is prepared; a bonding acidic solution passage step in which a bonding acidic solution is passed through a chelating resin so that hydrogen ions are bonded to the chelating resin; a distilled water passage step in which, to remove the acidic solution remaining in the chelating resin, distilled water is passed through the chelating resin; a lithium hydroxide passage step in which the lithium hydroxide solution is passed through the chelating resin so that ions included in the impurities are bonded to the chelating resin; and a separating acidic solution passage step in which a separating acidic solution is passed through the chelating resin to which the impurities are bonded, so that the impurities bonded to the chelating resin are separated from the chelating resin.

The invention provides a method for recovering polyethylene glycol terephthalate by bipolar membrane electrodialysis. The method comprises the following steps: S1, providing a bipolar membrane electrodialysis device; s2, mixing and heating polyethylene glycol terephthalate and a sodium hydroxide solution, and carrying out an alkali depolymerization reaction to obtain a feed liquid containing sodium terephthalate; s3, feeding the feed liquid obtained in the step S2 into a feed liquid chamber; introducing water into the acid chamber; introducing water or a dilute alkali solution into the alkali chamber; s4, direct current is applied to the bipolar membrane electrodialysis device for electrodialysis, and terephthalic acid radical ions penetrate through the anion membrane to enter the acid chamber and are combined with hydrogen ions hydrolyzed by the bipolar membrane to form terephthalic acid; sodium ions penetrate through the positive membrane to enter the alkali chamber, and are combined with hydroxyl ions hydrolyzed by the bipolar membrane and the sodium ions to generate sodium hydroxide. According to the method, the sodium terephthalate solution generated by alkali depolymerization of polyethylene glycol terephthalate can be directly converted into high-purity terephthalic acid and recyclable sodium hydroxide in situ.