Technology for adopting bipolar membrane electrodialysis for preparing beta-aminopropionic acid

A bipolar membrane electrodialysis and aminopropionic acid technology, applied in the field of electrochemistry, can solve the problems of low reaction yield, low yield, high raw material cost, etc., and achieve obvious economic effect, simple process operation, and good atom economy Effect

Inactive Publication Date: 2019-06-07
江西兄弟医药有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] Among these methods, the acrylic acid route process is relatively simple, but there is a dynamic equilibrium in the reaction, low reaction yield, and equipment corrosion; although the reaction conditions of the enzymatic process are mild, the cost of raw materials is high, and fermentation produces a large amount of wastewater, which is not conducive to industrialization; The cost of the acrylonitrile route is the lowest, and the raw materials are easy to obtain. The current process is generally as follows: hydrolyze β-aminopropionitrile under liquid alkali conditions, then neutralize it with hydrochloric acid, then concentrate and filter to obtain about 45% of the crude product of β-alanine; After dissolving in water, filter, and then cool down and crystallize and filter the filtrate to obtain about 70% of aminopropionic acid. The filter cake is sodium chloride, and the sodium chloride is washed with water. After washing

Method used

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  • Technology for adopting bipolar membrane electrodialysis for preparing beta-aminopropionic acid

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Experimental program
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Effect test

Embodiment 1

[0025] Add 6kg of liquid caustic soda with a mass fraction of 32% to the hydrolysis kettle, heat it to 95°C, add 1kg of refined aminopropionitrile with a chromatographic purity greater than 99%, dropwise at 100°C, dropwise for 2 hours, and control the vacuum degree - 0.02Mpa; After the dropwise addition, under the vacuum degree, 100°C for 1 hour to obtain the hydrolyzate, the hydrolyzate is passed through the bipolar membrane electrodialysis device, constant voltage electroosmosis, the current density is 40mA / cm 2 , control the pH of the acid chamber to 7.0, and stop until the conductivity of the hydrolyzed solution drops below 600 μS / cm. The acid chamber solution is collected as the GALA solution. The GABA solution is concentrated to 70% at -0.095Mpa at 60°C, and then Cool to 10°C to crystallize and centrifuge to obtain 1.22kg of β-alanine product with a yield of 96.06% and a purity of 99.97%. Among them, the bipolar membrane electrodialysis device includes a dialysis tank, an...

Embodiment 2

[0027] Add 1 kg of liquid caustic soda with a mass fraction of 32% to the hydrolysis kettle, heat it to 100°C, add 1 kg of refined aminopropionitrile with a chromatographic purity greater than 99%, dropwise at 100°C, dropwise for 3 hours, and control the vacuum degree to - 0.02Mpa; After the dropwise addition, under the vacuum degree, 100 ℃ for 1 hour to obtain the hydrolyzate, the hydrolyzate is passed through the bipolar membrane electrodialysis device, constant voltage electroosmosis, the current density is 20mA / cm 2 , control the pH of the acid chamber to 7.0, and stop until the conductivity of the hydrolyzed solution drops below 600 μS / cm. Collect the solution in the acid chamber, which is the aminopropionic acid solution. The aminopropionic acid solution is concentrated to 30% at -0.095Mpa, 60°C, and then Cool to 20°C to crystallize and centrifuge to obtain 1.207 kg of β-alanine product with a yield of 95.04% and a purity of 99.94%. Others are the same as in Example 1.

Embodiment 3

[0029] Add 10kg of liquid caustic soda with a mass fraction of 32% to the hydrolysis kettle, heat to 90°C, add 1kg of refined aminopropionitrile with a chromatographic purity greater than 99%, dropwise at 95°C, dropwise for 2 hours, and control the vacuum degree to - 0.02Mpa; After the dropwise addition, under the vacuum degree, the hydrolyzate was obtained after 90°C for 1 hour, and the hydrolyzate was passed through the bipolar membrane electrodialysis device, and the constant voltage electroosmosis, the current density was 80mA / cm 2 , control the pH of the acid chamber to 7.0, and stop until the conductivity of the hydrolyzed solution drops below 600 μS / cm. The acid chamber solution is collected to be the GALA solution. The GABA solution is concentrated to 80% at -0.095Mpa, 60°C, and then Cool to -10°C to crystallize and centrifuge to obtain 1.213kg of β-alanine product with a yield of 95.51% and a purity of 99.96%. Others are the same as in Example 1.

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Abstract

The invention discloses a method for using bipolar membrane electrodialysis for preparing beta-aminopropionic acid. The method comprises the steps of using 3-aminopropanenitrile and a sodium hydroxideaqueous solution or a potassium hydroxide aqueous solution as raw materials for reaction to obtain a sodium beta-aminopropionate solution, then making sodium beta-aminopropionate directly subjected to action of bipolar membrane electrodialysis equipment, forming sodium hydroxide by combining ionized sodium ions and hydroxyl, forming the beta-aminopropionic acid by combining aminopropionic acid radicals and hydrogen ions, and obtaining a high-purity product by conducting concentration and crystallization on the beta-aminopropionic acid. According to the production method, no hydrochloric acidor sulfuric acid is used for acidifying the sodium beta-aminopropionate, no wastewater is generated, no solvents need to be used in the crystallization process, solvent residues in the product are avoided, the purify can be over 99%, moreover, a generated sodium hydroxide solution can be recycled, thus an economic effect is good, moreover, the theoretical yield of the technology is 100%, and the actual yield can be over 90%.

Description

technical field [0001] The invention relates to the field of electrochemistry, in particular to a process for preparing β-alanine by bipolar membrane electrodialysis. Background technique [0002] β-alanine is a multi-purpose organic synthetic raw material, currently mainly used in the synthesis of calcium pantothenate, pantothenic acid, carnosine, guanidinopropionic acid, ethyl propionate hydrochloride, β-alanine nitrate, pamidronate Sodium, balsalazide, etc. are widely used in food, feed, medicine, etc., and are in great demand. At present, domestic manufacturers of β-alanine are mainly manufacturers of calcium pantothenate, including Brother Pharmaceutical, Yifan Pharmaceutical, Shandong Xinfa Pharmaceutical, Shandong Huachen Biology, and Hubei Xianlong. Its industrial production methods are mainly acrylonitrile ammonification hydrolysis method, acrylic acid ammonification method, biological enzyme catalysis (L-aspartic acid decarboxylase / nitrilase) method. [0003] Amo...

Claims

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Application Information

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IPC IPC(8): C07C229/08C07C227/02C07C227/40C07C227/42B01D61/44
Inventor 张秋华唐义彬周中平沈银元
Owner 江西兄弟医药有限公司
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