27 results about "Aminopropionitrile" patented technology

The invention discloses a preparation method of sodium polyacrylate, which belongs to the technical field of food processing, and comprises the following steps: weighing a certain amount of acrylic acid, diluting with deionized water, adding into a multi-neck flask, preparing a NaOH solution with a certain concentration, stirring, adding into the flask until a neutralization reaction is completed to obtain a sodium acrylate solution, and adding the sodium acrylate solution into a reaction kettle for reaction; taking a certain amount of activated carbon for adsorption treatment, carrying out suction filtration to obtain a sodium acrylate refined solution, and repeatedly vacuumizing for multiple times; according to the method, on the basis of a redox initiator (ammonium persulfate-sodium hydrogen sulfite), a high-efficiency chain extender dimethylaminopropionitrile is added to form a composite initiation system, and the influence of the addition amount of the composite initiator, the monomer concentration, the reaction time and the reaction temperature on the viscosity of the prepared sodium polyacrylate is discussed respectively. Then, optimal preparation process conditions are determined through an orthogonal test, and the performance of the prepared sodium polyacrylate is measured, so that the practical application effect of the whole method is greatly improved.

The invention discloses a golden triangular support anti-aging method. The method comprises the following steps: S1, barrier pretreatment; S2, active component delivery; S3, photocuring network shaping; according to the golden triangle support anti-aging method, synthesis and degradation balance of three core components of a skin extracellular matrix are synergistically regulated and controlled, and a golden triangle support system is formed. The small molecule peptide Pro-Hyp-Gly in the collagen activation component and the copper ion chelate act together, so that fibroblasts are promoted to secrete collagen, and the skin supporting force is enhanced; beta-aminopropionitrile serving as a lysyl oxidase inhibitor in the elastin protection component and vitamin E succinate have a synergistic effect, so that the degradation of elastin is inhibited, and the skin elasticity is maintained; the hyaluronic acid synergistic component is compounded by hyaluronic acid with different molecular weights to form a graded water locking network, so that the water content and plumpness of the skin are improved.

The invention provides a synthesis, production and preparation method of fatty acyl alkyl amino acid sodium, and relates to the technical field of organic synthesis.The synthesis, production and preparation method comprises the following steps that addition reaction is conducted, specifically, acrylonitrile is dropwise added into a monomethylamine aqueous solution, and an intermediate is obtained; carrying out acylation reaction, and then carrying out reaction on 3-methylaminopropionitrile and fatty acyl chloride to prepare fatty acyl methylaminopropionitrile; hydrolysis reaction: mixing the fatty acyl methylamino propionitrile with liquid alkali and ultrapure water, hydrolyzing, removing excessive alkali liquor, and filtering to obtain a target product; and absorbing the ammonia gas with water and collecting the ammonia gas. According to the method, high conversion rate is realized through step-by-step accurate operation. The side reaction is reduced by dropwise adding acrylonitrile at low temperature in combination with negative pressure distillation in the addition stage; sodium bicarbonate is used for mildly neutralizing HCl in acylation, so that the hydrolysis risk caused by strong base is avoided. The method has the advantages of high efficiency, environmental protection, low salt and low cost.

The invention provides a preparation method of a hydrogenation catalyst and a method for preparing trimethyl hydroxyethyl propane diamine by using the catalyst. A carrier of the catalyst is a bimetallic oxide carrier, active components of the catalyst are Pd and Ni, and auxiliaries are selected from chromium, manganese, lithium, tin, iron and cerium. The catalyst can be used for preparing trimethyl hydroxyethyl propane diamine by taking N, N-dimethylaminopropionitrile, N-methylethanolamine and hydrogen as raw materials, and is high in activity, high in selectivity, stable in performance and long in service life. In addition, a new reaction route is adopted, ethylene oxide is not used, the risk of the process can be reduced, in addition, raw materials are cheap and easy to obtain, reaction conditions are mild, the product yield is high, the production cost is low, economical efficiency is good, and good industrial application prospects are achieved.

The invention discloses application of ACSS2 as an action target in screening or preparing a medicine for preventing or treating virus-induced vascular remodeling diseases, and belongs to the field of biological medicine. It is found that by inhibiting ACSS2 gene expression or protein activity, Zika virus induced vascular smooth muscle cell phenotypic transformation can be remarkably reversed, and occurrence and development of angiotensin II / aminopropionitrile induced aortic aneurysm / dissection are relieved. The invention provides a siRNA sequence (SEQ ID NO.1-2) specifically targeting ACSS2 and a pharmaceutical composition containing the siRNA, and provides a novel treatment target and a precise intervention tool for virus-related vascular remodeling diseases.

The invention discloses application of a CDC20 inhibitor in preparation of a medicine for preventing or treating aortic dissection, and belongs to the field of biological medicine. A mouse aortic dissection model is constructed by combining 3-aortic acid aminopropionitrile ester with angiotensin II, a CDC20 inhibitor Apcin is given for treatment, and experiments find that by inhibiting CDC20 activity through Apcin, the occurrence rate and the lesion area of the mouse aortic dissection can be remarkably reduced, the vascular degenerative change in the lesion of the mouse aortic dissection can be remarkably improved, and the mouse aortic dissection model can be used for treating the aortic dissection of the mouse. Inflammatory macrophage infiltration in the aortic dissection lesion of the mouse is also obviously reduced; the results show that the mouse aortic dissection process can be delayed by inhibiting CDC20. The CDC20 inhibitor (Apcin or similar drugs) is further researched and optimized, so that a novel treatment drug for the aortic dissection is expected to be developed, and the CDC20 inhibitor has important significance in improving early intervention and prognosis of clinical aortic dissection patients.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps of: adding an organic solvent into a reaction kettle, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of a material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine with the mass percentage content of more than 97%, reacting dipropylenetriamine with phthalic anhydride to generate a polyamide prepolymer, and reacting with epoxy chloropropane to obtain the dipropylenetriamine with the mass percentage content of more than 97%. The polyamide epoxy resin wet strength agent is obtained.

The invention provides a process for synthesizing enamine from 2-methyl-4-amino-5-formylaminomethylpyrimidine mother liquor and application of the process, and relates to the technical field of enamine condensation. Comprising the following steps: carrying out enamine condensation reaction on the 2-methyl-4-amino-5-formylaminomethylpyrimidine mother liquor and alpha-sodium formyl-beta-formylaminopropionitrile under an acidic condition, so as to obtain enamine; the 2-methyl-4-amino-5-formylaminomethylpyrimidine mother liquor is a mother liquor obtained by a reaction of alpha-(o-chloroaniline)-based methine-beta-formylaminopropionitrile and an acetamidine solution. The method solves the technical problems that in the prior art, the energy consumption for recovering o-chloroaniline from the 2-methyl-4-amino-5-formylaminomethylpyrimidine mother liquor is large, the recovery is not thorough, and enamine contained in the mother liquor cannot be recycled, and achieves the purposes of reducing the recovery energy consumption, thoroughly recovering o-chloroaniline, improving the recovery efficiency and the like. The enamine contained in the mother liquor is subjected to resource utilization; and the product yield is improved.

This invention provides a method for synthesizing 4-methoxypyrrole derivatives, relating to the field of organic chemical intermediate synthesis technology. The 4-methoxypyrrole derivative is prepared by first reacting m-difluorobenzene as a starting material with oxaloyl chloride monoester under Lewis acid catalysis. The reaction product then undergoes cyclization with aminopropionitrile under alkaline conditions. The subsequent product reacts with methanol in a boron trifluoride complex, followed by methylation with a methylating agent under alkaline conditions. This invention overcomes the shortcomings of existing technologies, providing a simple, low-cost, and easily industrialized method for preparing 4-methoxypyrrole derivatives. It offers advantages such as readily available raw materials, high yield, good quality, simple operation, and suitability for industrial production.

The invention discloses a production process of N, N-dimethyl propane diamine, which comprises the following steps: carrying out addition reaction on dimethylamine and acrylonitrile in the absence of a catalyst to obtain an intermediate dimethylaminopropionitrile and a small amount of addition byproducts; carrying out hydrogenation reaction on the intermediate under the conditions of a hydrogenation catalyst, an alkaline auxiliary agent and an alcohol solvent to produce a target product N, N-dimethyl propane diamine, a small amount of byproducts such as tetramethyl propane diamine (TMAPA) and propylamine, and reaction slurry containing the hydrogenation catalyst; reaction slurry enters a catalyst filter to be filtered; carrying out flash evaporation on the filtered reaction clear liquid in a hot high-pressure separation tank; further separating a liquid-phase reaction product in the light component removal tower; and further separating the mixture in a product refining tower to obtain a qualified product N, N-dimethyl propane diamine, and the like. According to the production process, the qualified product N, N-dimethyl propane diamine can be continuously produced, the purity of the product is 99.5% or above, and the yield is 95% or above.

The application discloses a method for efficiently preparing beta-amino propionic acid calcium from beta-amino propionitrile, and comprises the following steps: beta-amino propionitrile and a calcium salt solution are reacted in the presence of a catalyst and an additive, and microwave radiation is used to promote the reaction; after the reaction solution is filtered and deaminated, the solution is concentrated, cooled and alcohol crystallized to obtain beta-amino propionic acid calcium crystals which can be used for the production of calcium pantothenate; wherein the catalyst is a transition metal complex, and the additive is a phase transfer catalyst or a buffer metal salt. The application has the advantages of simple process, high yield and high reaction efficiency.

Aminopropionitrile rectified high-boiling oil generated in an aminopropionitrile preparation section when acrylonitrile is used as a raw material to produce VB1 is subjected to reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification, so that dicyanoethylamine distillate with the mass percentage content of dicyanoethylamine greater than 97% is obtained at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil. The method comprises the following steps: dissolving dicyanoethylamine distillate by using an organic solvent, and carrying out catalytic reduction on the dicyanoethylamine distillate by using one or a mixture consisting of more of NH2NH2, NHNH, NaBH4, KBH4 and NaBH3CN in proportion under an alkaline condition in the presence of a catalyst, so as to obtain a reduced material containing dipropylenetriamine. Centrifuging or filtering the obtained hydride material containing dipropylenetriamine to separate out the catalyst and insoluble substances, then distilling to recover the organic solvent, rectifying under reduced pressure, and collecting the rectified fraction according to the relational expression t = 92.42 + 9.645 / (1.573-lgP) between the boiling point t (DEG C) of the material and the corresponding external pressure P (mmHg), therefore, a dipropylenetriamine product with the mass percentage content of more than 97% is obtained.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps: preparing a raw material into an organic solvent, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of the material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine with the mass percentage of more than 97%, reacting dipropylenetriamine with sebacic acid to generate a polyamide prepolymer, reacting with epichlorohydrin, and obtaining the dipropylenetriamine with the mass percentage of more than 97%. The polyamide epoxy resin wet strength agent is obtained.

The utility model relates to a short-range evaporator and a beta-aminopropionitrile refining system applying the short-range evaporator. The short-range evaporator comprises a lower barrel, an inclined groove is formed in the inner wall of the lower barrel, a flow guide sleeve is arranged in the inclined groove and is in a circular tube shape with an axial opening, the lower end of the flow guide sleeve abuts against the groove bottom of the inclined groove, and the upper end of the flow guide sleeve extends into the upper barrel and is attached to the inner wall of the upper barrel; and the axial opening of the flow guide sleeve is over against the propionitrile residue outlet. The system further comprises a pipeline system, a propionitrile residue buffer tank, a propionitrile positive fraction buffer tank and a non-condensable gas condenser; the lower cylinder body is provided with a positive fraction outlet and a vacuum interface; the propionitrile residue outlet is communicated with a propionitrile residue buffer tank through a propionitrile residue discharge pipe; the positive fraction outlet is communicated with a propionitrile positive fraction buffer tank through a propionitrile positive fraction discharge pipe; the vacuum interface is communicated with the non-condensable gas condenser through an evaporator gas phase discharge pipe; and the condensed propionitrile collecting pipe is communicated with the non-condensable gas condenser and the propionitrile positive fraction buffer tank. The short-range evaporator is applied to a beta-aminopropionitrile refining system, so that the system structure is simplified.

The invention relates to a method for synthesizing a diaveridine intermediate, which comprises the following steps: (a) adding dimethyl sulfoxide, potassium hydroxide and 3-dimethylaminopropionitrile into a reaction container, and heating to 65-75 DEG C; then adding veratraldehyde, and stirring to react for 2-3 hours to obtain a first reaction solution; and (b) adding ethanol and aniline into the first reaction solution, then dropwise adding an acid-containing solution, carrying out heat preservation reaction at 75-85 DEG C for 2-3 hours, cooling, crystallizing, and drying to obtain the diaveridine intermediate. Therefore, the side reaction for synthesizing the diaveridine intermediate can be inhibited, so that the reaction conditions are simplified, and the yield of the product is improved.

The application provides a beta-amino propionitrile purification device, and belongs to the technical field of purification devices. The device comprises a distillation tower, a steam outlet pipe is arranged at the top of the distillation tower, the steam outlet pipe is connected with a heat exchange box, a first serpentine pipe and a second serpentine pipe are arranged in the heat exchange box, a first discharge pipe is arranged on the heat exchange box, a reflux pipe is arranged at the bottom of the heat exchange box, one end of the first serpentine pipe is connected with an ammonia removal box, a second discharge pipe is arranged at the bottom of the ammonia removal box, the second discharge pipe is connected with the distillation tower, an exhaust pipe is arranged at the top of the ammonia removal box, a first heating element is arranged in the ammonia removal box, 3-amino propionitrile low-temperature mixture generated in the reaction is heated through the heat exchange box, then is further heated and ammonia is removed through the ammonia removal box, so that the mixture is heated and ammonia is removed by using high-temperature steam in the distillation tower, energy consumption is reduced, the removed ammonia can be made into ammonia water and reused, and raw material waste is reduced.

The invention provides a process for co-production of alpha-(o-chloroaniline)-based methenyl-beta-formylaminopropionitrile through chlorine ester synthesis and application of the process, and relates to the technical field of alpha-chloro-alpha-acetyl-gamma-butyrolactone production.The process comprises the following steps that in the process that chlorine is introduced into an alpha-acetyl-gamma-butyrolactone aqueous solution for a reaction, the alpha-(o-chloroaniline)-based methenyl-beta-formylaminopropionitrile is added into the alpha-chloro-alpha-acetyl-gamma-butyrolactone aqueous solution; the preparation method comprises the following steps: taking o-chloroaniline as an acid binding agent to obtain alpha-chloro-alpha-acetyl-gamma-butyrolactone and o-chloroaniline hydrochloride; the preparation method comprises the following steps: carrying out enamine condensation reaction on o-chloroaniline hydrochloride and alpha-sodium formyl-beta-formylamino propionitrile, so as to obtain alpha-(o-chloroaniline) methylene-beta-formylamino propionitrile. The technical problems of high chlorine consumption and high tail gas treatment cost in the existing alpha-chloro-alpha-acetyl-gamma-butyrolactone synthesis process are solved, and the technical effects of effectively reducing the chlorine consumption, reducing the liquid alkali consumption, effectively utilizing the byproduct hydrogen chloride and reducing chlorine ester layering water discharge are achieved.

Aminopropionitrile rectified high-boiling oil generated in an aminopropionitrile preparation section when acrylonitrile is used as a raw material to produce VB1 is subjected to reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification, so that dicyanoethylamine distillate with the mass percentage content of dicyanoethylamine greater than 97% is obtained at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil. The method comprises the following steps: dissolving dicyanoethylamine distillate with an organic solvent, and carrying out catalytic hydrogenation under an alkaline condition in the presence of a catalyst to obtain a hydride material containing dipropylenetriamine. The method comprises the following steps: separating a catalyst from a hydride material containing dipropylenetriamine through centrifugation or filtration, recovering an organic solvent in the hydride material through distillation, carrying out reduced pressure rectification, and carrying out rectification fraction collection according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of the material and a corresponding external pressure P (mmHg) so as to obtain a dipropylenetriamine product with a mass percentage of more than 97%.

Use of a serine / arginine-rich splicing factor 1 (SRSF1) as a therapeutic target for aortic dissection is provided, which belonging to the technical field of biomedicine. The SRSF1 can be used as a target to screen a drug for preventing and / or treating aortic dissection. SRSF1 expression is upregulated in both β-aminopropionitrile (BAPN)-induced aortic dissection model mice and aortic dissection patients. Mice with SRSF1 knockdown in vascular smooth muscle cells (VSMCs) are less susceptible to aortic dissection and elastic fiber degradation induced by BAPN. Mice with high expression of SRSF1 in VSMCs are more susceptible to aortic dissection and elastic fiber degradation induced by BAPN. Mechanistically, the SRSF1 can regulate the inflammatory phenotype of vascular smooth muscle and promote the degradation of vascular extracellular matrix. Knocking down the SRSF1 may improve the above phenomenon, thereby providing a new target for the treatment of aortic dissection.

The invention provides a synthesis method of a vitamin B1 pyrimidine intermediate. The synthesis method comprises the following steps: under the action of a catalyst A, 3-aminopropionitrile and methyl formate react to obtain 3-formylaminopropionitrile; the method comprises the following steps: in a solvent A, under the action of a catalyst B, reacting 3-formylaminopropionitrile with triester orthoformate to obtain N-(2-cyano-3-alkoxy allyl) formamide; in a solvent B, N-(2-cyano-3-alkoxy allyl) formamide and acetamidine are subjected to a condensation reaction, and the vitamin B1 pyrimidine intermediate is obtained. A novel synthesis route is adopted, the reaction condition is mild, and the equipment requirement is low; ortho-chloroaniline with carcinogenicity does not need to be used, no toxic gas is generated, the amount of generated waste water is small, and the method is more environmentally friendly and safer; sodium methoxide is only a catalytic amount, so that the cost is low; the reaction selectivity is good, and the target product yield and purity are high.

The invention provides a process for synthesizing alpha-sodium formyl-beta-formylaminopropionitrile by using liquid sodium methoxide and application of the process, and relates to the technical field of synthesis of alpha-sodium formyl-beta-formylaminopropionitrile, the process comprises the following steps: pre-acylating beta-aminopropionitrile and methyl formate to obtain beta-formylaminopropionitrile, adding methyl formate into the beta-formylaminopropionitrile, and reacting to obtain alpha-sodium formyl-beta-formylaminopropionitrile; the method comprises the following steps: taking beta-formylaminopropionitrile, adding liquid sodium methoxide into the beta-formylaminopropionitrile, mixing to obtain beta-formylaminopropionitrile sodium salt, and formylating the beta-formylaminopropionitrile sodium salt and methyl formate to obtain the alpha-sodium formyl-beta-formylaminopropionitrile. The invention solves the technical problems of high loss rate of methyl formate, high process safety risk caused by carbon monoxide, and difficult control of operation environment caused by moisture absorption spontaneous combustion of solid sodium methylate and dust drifting during synthesis of alpha-sodium formyl-beta-formylaminopropionitrile in the prior art.

The invention relates to application of sivelestat in preparation of a medicine for treating aortic endothelial cell injury, and belongs to the field of biological medicine. Specifically, the sivelestat reduces the formation of neutrophil extracellular traps (NETs) by inhibiting the activity of neutrophil elastase (NE), thereby reducing the aortic endothelial inflammation injury. In-vitro experiments show that sivelestat can significantly inhibit generation of NETs induced by S100A12 and expression of endothelial inflammatory factors; in-vivo experiments prove that the compound has the effects of reducing the aortic dilatation rate and rupture rate and improving the survival rate on AD model mice induced by beta-aminopropionitrile (BAPN). The invention provides a new treatment strategy for the aortic dissection.

Use of p55γ as a therapeutic target for aortic dissection (AD) is provided, belonging to the technical field of biomedicine. Over-expression of the p55γ inhibits formation of the AD and degradation of elastic fibers in mice induced by β-aminopropionitrile fumarate (BAPN); whereas knockdown of the p55γ in vascular smooth muscle cells (VSMCs) promotes the formation of the AD and the degradation of the elastic fibers induced by the BAPN. Mechanistically, the p55γ plays a role by maintaining phenotypic switching of the VSMCs, and knocking down the p55γ promotes phenotypic switching of the VSMCs from a contractile phenotype to a synthetic phenotype. The p55γ is used as a target in screening a drug for prevention and / or treatment of AD, such that a selected drug can effectively prevent and / or treat the AD, thus providing a new target for treating the AD.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps of: adding an organic solvent into an organic solvent, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of a material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine of which the mass percentage content is greater than 97%, reacting dipropylenetriamine with adipic acid to generate a polyamide prepolymer, and reacting with epoxy chloropropane to obtain the dipropylenetriamine. The polyamide epoxy resin wet strength agent is obtained.

This invention discloses a four-step method for preparing 4-trifluoromethylnicotinic acid from 2-chloroacrylonitrile, belonging to the field of chemical pharmaceutical intermediate synthesis. Using 2-chloroacrylonitrile as a raw material, an amination reagent is added to prepare 3-amino-2-chloropropionitrile, which is then reacted with 4-ethoxy-1,1,1-trifluorobut-3-en-2-one to prepare 2-chloro-3-((4,4,4-trifluoro-3-oxobut-1-en-1-yl)amino)propionitrile. Finally, a two-step method involving cyclization and hydrolysis with the addition of an alkali yields the target product 4-trifluoromethylnicotinic acid. This method yields a product with high purity and high yield, low raw material cost, a short and efficient route, mild reaction conditions, and is environmentally friendly, making it more suitable for industrial production.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps of: adding an organic solvent into a reaction kettle, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of a material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine of which the mass percentage content is greater than 97%, reacting dipropylenetriamine with terephthalic acid to generate a polyamide prepolymer, and reacting with epoxy chloropropane to obtain dipropylenetriamine of which the mass percentage content is greater than 97%. The polyamide epoxy resin wet strength agent is obtained.

The application provides application of an SLFN5 inhibitor in preparation of a drug for preventing and / or treating aortic dissection, and belongs to the technical field of aortic dissection prevention and treatment.The application provides application of an SLFN5 inhibitor in preparation of a drug for preventing and / or treating aortic dissection, and first proposes that SLFN5 genes or SLFN5 proteins can be used as target points for preparation of a drug for preventing and / or treating aortic dissection.The application first proposes that overexpression of SLFN5 promotes formation of aortic dissection and degradation of elastic fibers of a mouse induced by 3-aminopropionitrile fumarate (BAPN); and knockdown of SLFN5 inhibits formation of aortic dissection and degradation of elastic fibers of a mouse induced by BAPN.The application uses SLFN5 as a target point for preparation of a drug for preventing and / or treating aortic dissection, can effectively prevent and / or treat aortic dissection, and provides a new target point for treating aortic dissection.