Infection contamination resistance pharmaceutical combination containing optimum proportioning cefoperazone natrium and sulbactam sodium and method of preparing the same

Abstract

The invention relates to an anti-infective pharmaceutical composition comprising cefoperazone sodium and sulbactam sodium in optimal proportion. In the pharmaceutical composition, the weight ratio of the cefoperazone sodium and the sulbactam sodium is (2-4):1, preferably 4:1. The pharmaceutical composition with the weight ratio is excellent in antibacterial activity to drugs containing equal amounts (1:1) of cefoperazone sodium and sulbactam sodium in clinic. The dosage of sulbactam sodium in the inventive pharmaceutical composition is reduced by more than two times than the existing similar drugs, which improves safety of kidney and reduces production cost. The raw materials used in the invention meet the standards of Chinese Pharmacopoeia. Therefore, the pharmaceutical composition has good quality, safety and stability.

Description

technical field [0001] The invention relates to an anti-infection pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition containing optimal ratio of cefoperazone sodium and sulbactam sodium and a preparation method thereof. Background technique [0002] About 25% to 75% of patients with Gram-negative bacterial infection who fail or relapse are caused by bacteria producing β-lactamases. Therefore, facing the increasingly serious problem of bacterial drug resistance caused by bacterial enzymes, It is necessary to develop new antibacterial drugs to deal with it. In addition to continuing to work on screening effective antibacterial drugs with new chemical structures, new mechanisms of action, or new targets for drug-resistant bacteria, the most economical and effective means is to choose a combination of appropriate antibiotics and β-lactamase inhibitors. Drugs are used to suppress drug-resistant bacteria and enable antibioti...

AI Technical Summary

Problems solved by technology

This temporary addition of cefoperazone sodium dose brings trouble to the timely preparation of the drug, the dose is not easy to control, and it also increases the chance of drug contamination, which is extremely unsafe

The pharmacokinetics of sulbactam sodium shows that sulbactam sodium is metabolized by the kidneys, and high content of sulbactam sodium not only aggravates the damage of the kidneys, but also the high price of sulbactam sodium makes anti-infection treatment less effective. Fee increases that make it unacceptable or unaffordable for economically disadvantaged areas or families in financial distress

[0005] Chinese patent application number: 200610034315.3 discloses a stable cefoperazone-sulbactam drug compound preparation, which is composed of cefoperazone acid as raw material, sulbactam and sodium bicarbonate. The invention has the following obvious shortcomings : 1. The raw materials do not meet the requirements of Pharmacopoeia and injection preparations

Cefoperazone acid contains a large amount of impurities harmful to the human body. It cannot meet the requirements of the Chinese Pharmacopoeia for content, clarity, and pH value without purification. the poison of

2. Lack of scientific theoretical basis for prescription design

Cefoperazone acid and cefoperazone sodium are t

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