Method for detecting Jingfang granules

A detection method and particle prevention technology, applied in the field of Jingfang particle detection, can solve the problems of interference, complex components, and decreased drug efficacy.

Active Publication Date: 2014-07-30
九寨沟天然药业股份有限公司
View PDF7 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no complete set of detection methods for the corresponding detection of its active ingredients, which may lead to unscrupulous manufacturers not strictly following the prescription dosage ingredients in the production of drugs, wantonly reducing high-priced raw materials, resulting in the curative effect of the drug. Significant decline, affecting the safety and effectiveness of drugs, seriously damaging the interests of patients
On the other hand, the medicinal material Bupleurum bupleurum is used in the prescription. Because of its large amount of use and its limited output, its counterfeit product, Bupleurum bupleurum is also used intentionally or unintentionally. However, Bupleurum bupleurum contains bupleurum toxin and acetylbupleurum toxin, these two components are poisonous substances, there have been many poisoning incidents caused by taking medicines mixed with Bupleurum bupleurum, so it is necessary to control the Bupleurum bupleurum
"Shandong Pharmaceutical Indu

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting Jingfang granules
  • Method for detecting Jingfang granules
  • Method for detecting Jingfang granules

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0084] Example 1:

[0085] [Prescription] Nepeta 75g, Wind-proof 75g, Qianghuo 75g, Alcohol 75g, Bupleurum 75g, Qianhu 75g, Chuanxiong 75g, Citrus aurantium 75g, Poria cocos 75g Platycodon 75g Licorice 25g

[0086] [Preparation method] The above eleven flavors, Nepeta, Dioscorea chinensis, Qianghuo, Lihuo, Peucedanum, Chuanxiong and Fructus Aurantii respectively extract volatile oil, and collect the distilled aqueous solution of Chuanxiong and Fructus aurantium in a separate container; the dregs of Chuanxiong and Fructus Aurantii and Poria cocos , According to the percolation method under the item of the liquid extract and the extract, use the above aqueous solution to prepare a 25% ethanol solution as a solvent for percolation; the dregs of Nepeta, Radix, Qianghuo, Duhuo and Qianhu and other Bupleurum, The three flavors of Platycodon grandiflorum and licorice are decocted twice with water for 1.5 hours each time. Combine the decoction, filter, and concentrate the filtrate into a t...

Example Embodiment

[0102] Example 2:

[0103] In this embodiment, except for the different identification methods, the other detection methods are the same as in Example 1. The specific identification methods are as follows:

[0104] (1) Identification of Nepeta

[0105] Take 10g of this product, add 50ml of ether, sonicate for 15 minutes, filter, evaporate the filtrate, add 1ml of ethanol to the residue to dissolve, as the test solution, take another 1g of Nepeta control medicinal material, add 50ml of ether, and ultrasonicate for 15 minutes , Filter, evaporate the filtrate to dryness, add 1ml of ethanol to the residue to dissolve it, as a medicinal solution, according to thin-layer chromatography test, absorb 5μl of each of the above two solutions, respectively spot on the same silica gel G thin layer plate, with petroleum ether: Chloroform: methanol = 10:3:2 as the developing agent, unfold, take out, dry, spray with 5% vanillin sulfuric acid solution, heat at 105°C until the spots appear clear, in ...

Example Embodiment

[0114] Example 3:

[0115] In this embodiment, except for the different identification methods, the other detection methods are the same as in Example 1. The specific identification methods are as follows:

[0116] (1) Identification of Nepeta

[0117] Take 10g of this product, add 50ml of ether, sonicate for 15 minutes, filter, evaporate the filtrate, add 1ml of ethanol to the residue to dissolve, as the test solution, take another 1g of Nepeta control medicinal material, add 50ml of ether, and ultrasonicate for 15 minutes , Filter, evaporate the filtrate to dryness, add 1ml of ethanol to the residue to dissolve it, as a medicinal solution, according to thin layer chromatography test, draw 5μl of each of the above two solutions, respectively spot on the same silica gel G thin layer plate, with petroleum ether: Chloroform: methanol=11:4:2.5 is the developing agent, unfold, take out, dry, spray with 5% vanillin sulfuric acid solution, heat at 105℃ until the spots are clear. In the ch...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Apertureaaaaaaaaaa
Login to view more

Abstract

The invention relates to a method for detecting Jingfang granules. The method comprises the steps of character identifying, checking and measuring content, wherein the step of identifying comprises identification of schizonepeta, radix angelicae pubescentis, ligusticum wallichii, fructus aurantii and bupleurum longiradiatum; the step of measuring content refers to a step of measuring content of ephedrine hydrochloride. Aiming at the problem that the condition that fewer raw materials are added or corresponding raw materials are not added by illegal manufacturer or a counterfeit drug bupleurum longiradiatum is mixed cannot be monitored because active ingredients of the granules cannot be correspondingly detected by a set of perfect detection method at present, a scientific, reasonable, practical and feasible component identification and content measurement method is formulated, the clinical effects of the Jingfang granules are guaranteed, quality indexes of several medicinal materials are clear, and application of various medicinal materials in the Jingfang granules is ensured, so that the curative effect of the drug is guaranteed. Moreover, the counterfeit drug bupleurum longiradiatum in radix bupleuri can be effectively detected, and a phenomenon that health of patients is endangered by two toxic ingredients, including bupleurotoxin and acetylbupleurotoxin, contained in bupleurum longiradiatum is avoided.

Description

technical field [0001] The invention relates to a method for detecting Jingfang particles. Background technique [0002] Jingfang (Granules) Granules is a variety recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-0328-90. Peucedanum, Rhizoma Chuanxiong, Citrus aurantium, Poria, Campanulaceae, Licorice are pure traditional Chinese medicine and granules. It has the effects of sweating, relieving the exterior, dispersing wind and dampness. It is clinically used to treat cold, wind and cold, headache and body pain, aversion to cold without sweating, stuffy nose and runny nose, and cough. It is a common medicine currently on the market for treating common cold, wind and cold, headache and body pain, aversion to cold without sweating, nasal congestion and runny nose, and cough. But so far, there is no complete set of detection methods for the corresponding detection of its a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N30/90G01N30/02
Inventor 钟茂团黎勇吴诗惠古莉
Owner 九寨沟天然药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap